Paul A Wade

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover
    Aleksandra B Adomas
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, 111 T, W, Alexander Dr, 27709 Research Triangle Park, NC, USA
    BMC Cancer 14:278. 2014
  2. pmc The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer
    Archana Dhasarathy
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e26514. 2011
  3. pmc MBD3 Localizes at Promoters, Gene Bodies and Enhancers of Active Genes
    Takashi Shimbo
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS Genet 9:e1004028. 2013
  4. pmc DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas
    Anne Y Lai
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Exp Med 207:1939-50. 2010
  5. doi request reprint Cancer biology and NuRD: a multifaceted chromatin remodelling complex
    Anne Y Lai
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina NC 27709, USA
    Nat Rev Cancer 11:588-96. 2011
  6. pmc DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation
    Anne Y Lai
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genome Res 23:2030-41. 2013
  7. pmc The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha
    Archana Dhasarathy
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, P O Box 12233, 111 TW Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 21:2907-18. 2007
  8. pmc Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin
    Jennifer K Sims
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Biol Cell 22:3094-102. 2011
  9. pmc The MBD protein family-reading an epigenetic mark?
    Archana Dhasarathy
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Science, Research Triangle Park, NC 27517, USA
    Mutat Res 647:39-43. 2008
  10. pmc The Mi-2/NuRD complex associates with pericentromeric heterochromatin during S phase in rapidly proliferating lymphoid cells
    Lisa Helbling Chadwick
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Chromosoma 118:445-57. 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover
    Aleksandra B Adomas
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, 111 T, W, Alexander Dr, 27709 Research Triangle Park, NC, USA
    BMC Cancer 14:278. 2014
    ..To elucidate the contribution(s) of GATA3 alterations to cancer, we studied two breast cancer cell lines, MCF7, which carries a heterozygous frameshift mutation in the second zinc finger of GATA3, and T47D, wild-type at this locus...
  2. pmc The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer
    Archana Dhasarathy
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e26514. 2011
    ..We propose that there are two regulatory modules embedded within EMT: one that involves repression of cell junction molecules, and the other involving cell migration via TGF-beta and/or other pathways...
  3. pmc MBD3 Localizes at Promoters, Gene Bodies and Enhancers of Active Genes
    Takashi Shimbo
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS Genet 9:e1004028. 2013
    ....
  4. pmc DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas
    Anne Y Lai
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Exp Med 207:1939-50. 2010
    ..These data indicate that BCL6 expression is maintained during lymphomagenesis in part through DNA methylation that prevents CTCF-mediated silencing...
  5. doi request reprint Cancer biology and NuRD: a multifaceted chromatin remodelling complex
    Anne Y Lai
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina NC 27709, USA
    Nat Rev Cancer 11:588-96. 2011
    ....
  6. pmc DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation
    Anne Y Lai
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genome Res 23:2030-41. 2013
    ..These findings provide insights into the methylation dynamics of the genome during cellular differentiation in an immune response. ..
  7. pmc The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha
    Archana Dhasarathy
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, P O Box 12233, 111 TW Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 21:2907-18. 2007
    ..Thus, cross-talk among ER-alpha, Snail, and the TGF-beta pathway appears to control critical phenotypic properties of breast cancer cells...
  8. pmc Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin
    Jennifer K Sims
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Biol Cell 22:3094-102. 2011
    ..These findings implicate Mi-2β in the maintenance of chromatin structure and proper cell cycle progression...
  9. pmc The MBD protein family-reading an epigenetic mark?
    Archana Dhasarathy
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Science, Research Triangle Park, NC 27517, USA
    Mutat Res 647:39-43. 2008
    ..These observations suggest that existing models probably do not explain the entire gamut of biological functions performed by this very interesting protein family...
  10. pmc The Mi-2/NuRD complex associates with pericentromeric heterochromatin during S phase in rapidly proliferating lymphoid cells
    Lisa Helbling Chadwick
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Chromosoma 118:445-57. 2009
    ..We propose that Mi-2/NuRD constitutes an enzymatic component of a pathway for assembly and maturation of chromatin utilized by rapidly proliferating lymphoid cells for replication of constitutive heterochromatin...
  11. ncbi request reprint Obesity, rather than diet, drives epigenomic alterations in colonic epithelium resembling cancer progression
    Ruifang Li
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cell Metab 19:702-11. 2014
    ..The interrogation of enhancer alterations by diet in colonic epithelium provides insights into the biology underlying high-fat diet and obesity as risk factors for colon cancer. ..
  12. ncbi request reprint MeCP2 in Rett syndrome: transcriptional repressor or chromatin architectural protein?
    Lisa Helbling Chadwick
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Curr Opin Genet Dev 17:121-5. 2007
    ..The recent identification of two MeCP2 targets, BDNF and DLX5, are suggestive of two very different roles for this protein--one as a classical repressor protein, and the other as a mediator of a complex, specialized chromatin structure...
  13. pmc Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity
    Johannes M Freudenberg
    Systems Biology Section, Biostatistics Branch, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 40:3364-77. 2012
    ....
  14. pmc NuRD and pluripotency: a complex balancing act
    Guang Hu
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cell Stem Cell 10:497-503. 2012
    ..Recent findings have implicated the NuRD chromatin remodeling complex in the sophisticated choreography of ESC regulatory pathways...
  15. pmc Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells
    Jakub Kwintkiewicz
    Reproductive Medicine Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Biol Reprod 86:1-8. 2012
    ..These findings provide the first evidence to date that MTA3 interacts with NuRD and cohesin complex proteins in the ovary in vivo and regulates G2/M progression in proliferating granulosa cells...
  16. ncbi request reprint INO80 Facilitates Pluripotency Gene Activation in Embryonic Stem Cell Self-Renewal, Reprogramming, and Blastocyst Development
    Li Wang
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cell Stem Cell 14:575-91. 2014
    ....
  17. ncbi request reprint MBD family proteins: reading the epigenetic code
    Mehrnaz Fatemi
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Science, 111 TW Alexander Drive, Mail Drop D4 04, Research Triangle Park, NC 27709, USA
    J Cell Sci 119:3033-7. 2006
    ..Recent genetic and molecular experiments have shed considerable light on these and other issues relevant to the chromosomal biology of this interesting protein family...
  18. pmc Epigenetics and the adaptive immune response
    Hrisavgi D Kondilis-Mangum
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Aspects Med 34:813-25. 2013
    ..While the immune system benefits from the dynamic nature of the epigenome, such benefit comes at a cost - increased likelihood of disease-causing mutation...
  19. pmc DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines
    Mitsutoshi Kadowaki
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Int J Cancer 130:267-77. 2012
    ..We concluded from these data that methylation of specific promoter sequences causes transcriptional silencing of the NAG-1 locus in glioma and may ultimately contribute to tumor progression...