Sholom Wacholder

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Precursors in cancer epidemiology: aligning definition and function
    Sholom Wacholder
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, Room 5050, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:521-7. 2013
  2. pmc Invited commentary: more surprises from a gene desert
    Sholom Wacholder
    National Institutes of Health National Cancer Institute, Rockville, MD 20852, USA
    Am J Epidemiol 175:488-91. 2012
  3. pmc A population-based cross-sectional study of age-specific risk factors for high risk human papillomavirus prevalence in rural Nigeria
    Megan A Clarke
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Infect Agent Cancer 6:12. 2011
  4. pmc Multi-center feasibility study evaluating recruitment, variability in risk factors and biomarkers for a diet and cancer cohort in India
    Rashmi Sinha
    National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    BMC Public Health 11:405. 2011
  5. pmc Performance of common genetic variants in breast-cancer risk models
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
    N Engl J Med 362:986-93. 2010
  6. pmc Risk of miscarriage with bivalent vaccine against human papillomavirus (HPV) types 16 and 18: pooled analysis of two randomised controlled trials
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
    BMJ 340:c712. 2010
  7. pmc Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections
    Ana Cecilia Rodriguez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS, Rm 5032, Rockville, MD 20852, USA
    J Natl Cancer Inst 100:513-7. 2008
  8. pmc Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 5104, Rockville, MD 20852 7234, USA
    J Infect Dis 199:20-30. 2009
  9. pmc A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 41:579-84. 2009
  10. pmc Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinants
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5104, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 18:113-20. 2009

Detail Information

Publications107 found, 100 shown here

  1. pmc Precursors in cancer epidemiology: aligning definition and function
    Sholom Wacholder
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, Room 5050, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:521-7. 2013
    ....
  2. pmc Invited commentary: more surprises from a gene desert
    Sholom Wacholder
    National Institutes of Health National Cancer Institute, Rockville, MD 20852, USA
    Am J Epidemiol 175:488-91. 2012
    ....
  3. pmc A population-based cross-sectional study of age-specific risk factors for high risk human papillomavirus prevalence in rural Nigeria
    Megan A Clarke
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Infect Agent Cancer 6:12. 2011
    ..abstract:..
  4. pmc Multi-center feasibility study evaluating recruitment, variability in risk factors and biomarkers for a diet and cancer cohort in India
    Rashmi Sinha
    National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    BMC Public Health 11:405. 2011
    ..The aim of this feasibility study was to evaluate whether a diet-focused cohort study of cancer could be established in India, providing insight into potentially unique diet and lifestyle exposures...
  5. pmc Performance of common genetic variants in breast-cancer risk models
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
    N Engl J Med 362:986-93. 2010
    ..Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown...
  6. pmc Risk of miscarriage with bivalent vaccine against human papillomavirus (HPV) types 16 and 18: pooled analysis of two randomised controlled trials
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
    BMJ 340:c712. 2010
    ..To assess whether vaccination against human papillomavirus (HPV) increases the risk of miscarriage...
  7. pmc Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections
    Ana Cecilia Rodriguez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS, Rm 5032, Rockville, MD 20852, USA
    J Natl Cancer Inst 100:513-7. 2008
    ..These findings suggest that the medical community should emphasize persistence of cervical HPV infection, not single-time detection of HPV, in management strategies and health messages...
  8. pmc Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 5104, Rockville, MD 20852 7234, USA
    J Infect Dis 199:20-30. 2009
    ..We examined host genetic factors to identify those more common in individuals whose human papillomavirus (HPV) infections were most likely to persist and progress to cervical intraepithelial neoplasia grade 3 (CIN3) and cancer...
  9. pmc A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 41:579-84. 2009
    ..1 (rs999737; P = 1.74 x 10(-7)) localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway. We also confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1...
  10. pmc Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinants
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5104, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 18:113-20. 2009
    ..Investigations on the molecular distinctions along the disease continuum of cervical pathogenesis by HPV type are needed...
  11. ncbi request reprint The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice
    Michelle J Khan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 7074, Rockville, MD 20852, USA
    J Natl Cancer Inst 97:1072-9. 2005
    ....
  12. pmc Chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohort
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    J Natl Cancer Inst 102:1794-804. 2010
    ..In a large prospective cohort, we assessed the role of C trachomatis in cervical premalignancy and addressed confounding by HPV...
  13. pmc Common genetic variation in TP53 and risk of human papillomavirus persistence and progression to CIN3/cancer revisited
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7248, USA
    Cancer Epidemiol Biomarkers Prev 18:1631-7. 2009
    ..Although genetic variation in TP53 might affect the natural history of HPV and cervical cancer, further work is needed to elucidate the possible mechanism...
  14. pmc Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e33619. 2012
    ..Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer, to persistent HPV infection, and hence to cervical precancer and cancer...
  15. pmc Switch from cytology-based to human papillomavirus test-based cervical screening: implications for colposcopy
    Carolina Porras
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 130:1879-87. 2012
    ..Our data support the need for a nonvisual diagnostic method to guide management and treatment of HPV-positive women...
  16. pmc Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression
    Melissa Rotunno
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e5652. 2009
    ..Our findings emphasize the necessity of post-GWAS fine mapping and SNP functional assessment to further elucidate cancer risk associations...
  17. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009
    ..In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma...
  18. pmc Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort study
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    BMJ 339:b2569. 2009
    ....
  19. pmc Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20854 7234, USA
    Int J Cancer 124:964-9. 2009
    ..We are now using these sharpened diagnostic categories to search for novel biomarkers predicting the risk of progression and invasion...
  20. ncbi request reprint CIN2 is a much less reproducible and less valid diagnosis than CIN3: results from a histological review of population-based cervical samples
    Joseph D Carreon
    Division of Cancer Epidemiology and Genetics, The National Cancer Institute, National Institutes of Health, Department of Health and Human Services Rockville, Maryland 20852, USA
    Int J Gynecol Pathol 26:441-6. 2007
    ..The CIN3 is a substantially more reproducible diagnosis that can be validated more frequently with HPV tests and cytological interpretations than CIN2...
  21. pmc Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate, and pancreatic cancers, and melanoma
    Phuong L Mai
    Clinical Genetic Branch, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 4:e4812. 2009
    ..Further, possible effect of BRCA mutations on non-cancer mortality risk has not been examined...
  22. ncbi request reprint Age-related changes of the cervix influence human papillomavirus type distribution
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, Bethesda, MD 20892 7234, USA
    Cancer Res 66:1218-24. 2006
    ..These patterns need to be confirmed in other studies and populations. We suggest that these genetically distinct groups of HPV types may differ in tissue preferences, which may contribute to their differences in carcinogenic potential...
  23. ncbi request reprint Relationships of human papillomavirus type, qualitative viral load, and age with cytologic abnormality
    Melinda Butsch Kovacic
    Division of Cancer Epidemiology and Genetics and Cancer Prevention Fellowship Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:10112-9. 2006
    ..The lack of evident severe abnormalities associated with HPV18 and related HPV types might have implications for screening for poorly detected glandular and alpha7-related lesions...
  24. pmc Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 4:e7380. 2009
    ..Chronic obstructive pulmonary disease (COPD) has been consistently associated with increased risk of lung cancer. However, previous studies have had limited ability to determine whether the association is due to smoking...
  25. pmc Genetic background comparison using distance-based regression, with applications in population stratification evaluation and adjustment
    Qizhai Li
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Genet Epidemiol 33:432-41. 2009
    ....
  26. pmc Long-term persistence of prevalently detected human papillomavirus infections in the absence of detectable cervical precancer and cancer
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7234, USA
    J Infect Dis 203:814-22. 2011
    ..Detailed descriptions of long-term persistence of human papillomavirus (HPV) in the absence of cervical precancer are lacking...
  27. pmc Neither one-time negative screening tests nor negative colposcopy provides absolute reassurance against cervical cancer
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7234, USA
    Int J Cancer 125:1649-56. 2009
    ....
  28. pmc Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5024, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 104:1738-49. 2012
    ..However, the extent of methylation in other HPV types and its role in progression to cancer is poorly understood...
  29. ncbi request reprint Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:46-52. 2003
    ..We evaluated whether simultaneous screening with a Pap test and human papillomavirus (HPV) testing is useful for assessing the risk for cervical intraepithelial neoplasia (CIN) 3 or cervical cancer...
  30. pmc A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia
    Mark Schiffman
    Divisions of Cancer Epidemiology and Genetics and Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA
    Cancer Res 70:3159-69. 2010
    ..Larger viral genomic studies are warranted, especially to identify the genetic basis for HPV16's unique carcinogenicity...
  31. pmc Human papillomavirus infection with multiple types: pattern of coinfection and risk of cervical disease
    Anil K Chaturvedi
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072 Rockville, MD 20852, USA
    J Infect Dis 203:910-20. 2011
    ..We investigated coinfection patterns for 25 human papillomavirus (HPV) types and assessed the risk conferred by multiple HPV types toward cervical disease...
  32. pmc Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility
    Hong Lou
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 106:7933-8. 2009
    ..Further investigation is warranted to determine whether rs10993994 alone or in combination with additional variants contributes to prostate cancer susceptibility...
  33. pmc Alcohol consumption and lung cancer risk in the Environment and Genetics in Lung Cancer Etiology (EAGLE) study
    Vincenzo Bagnardi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7114, Bethesda, MD 20892 7236, USA
    Am J Epidemiol 171:36-44. 2010
    ..Although residual confounding by tobacco smoking cannot be ruled out, this finding may reflect interplay between alcohol and smoking, emphasizing the need for preventive measures...
  34. ncbi request reprint Risk of precancer and follow-up management strategies for women with human papillomavirus-negative atypical squamous cells of undetermined significance
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
    Obstet Gynecol 109:1325-31. 2007
    ....
  35. doi request reprint Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
    Ju Hyun Park
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland, USA
    Nat Genet 42:570-5. 2010
    ..However, for BPC cancers, which have modest familial aggregation, our analysis suggests that risk models based on common variants alone will have modest discriminatory power (63.5% area under curve), even with new discoveries...
  36. ncbi request reprint A population-based study of vaginal human papillomavirus infection in hysterectomized women
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
    J Infect Dis 190:458-67. 2004
    ..e., A3/A4/A15) may have a predilection for vaginal epithelium...
  37. ncbi request reprint A prospective study of age trends in cervical human papillomavirus acquisition and persistence in Guanacaste, Costa Rica
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
    J Infect Dis 191:1808-16. 2005
    ..In some populations, HPV prevalence demonstrates a second peak in older women. Longitudinal data may help to explain this second peak...
  38. pmc Evaluation of the polyclonal ELISA HPV serology assay as a biomarker for human papillomavirus exposure
    Sarah E Coseo
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Sex Transm Dis 38:976-82. 2011
    ..Overall performance of these assays, as a measure of HPV exposure, has not been evaluated...
  39. pmc Are women who smoke at higher risk for lung cancer than men who smoke?
    Sara De Matteis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Epidemiol 177:601-12. 2013
    ..g., tobacco type, inhalation depth, Fagerström-assessed nicotine dependence). These findings do not support a higher female susceptibility to tobacco-related lung cancer...
  40. pmc Assessing disease risk in genome-wide association studies using family history
    Arpita Ghosh
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Epidemiology 23:616-22. 2012
    ....
  41. pmc Hypertension and risk of renal cell carcinoma among white and black Americans
    Joanne S Colt
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Epidemiology 22:797-804. 2011
    ..We investigated the hypertension-renal cancer association by race, and we assessed the role of hypertension in the racial disparity of renal cancer incidence...
  42. pmc Longitudinal analysis of carcinogenic human papillomavirus infection and associated cytologic abnormalities in the Guanacaste natural history study: looking ahead to cotesting
    Sarah Coseo Markt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    J Infect Dis 205:498-505. 2012
    ..The aim of this analysis was to assess the longitudinal relationship of abnormal cytology and HPV positivity in a 7-year prospective study of 2500 women in Guanacaste, Costa Rica...
  43. pmc Large-scale fine mapping of the HNF1B locus and prostate cancer risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 20:3322-9. 2011
    ..This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk. Further studies are needed to investigate the biological basis of the association of variants in 17q12 with prostate cancer...
  44. pmc Determinants of seropositivity among HPV-16/18 DNA positive young women
    Carolina Porras
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    BMC Infect Dis 10:238. 2010
    ..We evaluated determinants of seropositivity among 646 women infected with HPV-16 and/or HPV-18...
  45. ncbi request reprint Human papillomavirus prevalence in women who have and have not undergone hysterectomies
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    J Infect Dis 194:1702-5. 2006
    ..5% for WH) between the 2 groups of women. Although WH have a similar prevalence of carcinogenic HPV infection, compared with WNH without a cervix, they have minimal risk of HPV-induced cancer and are unlikely to benefit from HPV testing...
  46. pmc Epidemiological study of anti-HPV16/18 seropositivity and subsequent risk of HPV16 and -18 infections
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Ste 550, Rockville, MD 20852, USA
    J Natl Cancer Inst 102:1653-62. 2010
    ..Infection with human papillomavirus (HPV) 16 or HPV18 elicits an antibody response, but whether the elicited antibodies protect women against subsequent infection by a homologous HPV type compared with seronegative women is unknown...
  47. pmc A long-term prospective study of type-specific human papillomavirus infection and risk of cervical neoplasia among 20,000 women in the Portland Kaiser Cohort Study
    Mark Schiffman
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 20:1398-409. 2011
    ..Adding HPV testing to cytology is recommended for women ≥30 but long-term prospective studies of HPV testing are rare...
  48. ncbi request reprint The natural history of human papillomavirus infection and cervical intraepithelial neoplasia among young women in the Guanacaste cohort shortly after initiation of sexual life
    Ana Cecilia Rodriguez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville, Maryland 20859, USA
    Sex Transm Dis 34:494-502. 2007
    ..We wanted to explore early HPV natural history and CIN 3 prospectively...
  49. pmc Human papillomavirus testing in the prevention of cervical cancer
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 103:368-83. 2011
    ..The greatest potential for reduction in cervical cancer rates from HPV screening is in low-resource regions that can implement infrequent rounds of low-cost HPV testing and treatment...
  50. pmc Serum leptin and adiponectin levels and risk of renal cell carcinoma
    Linda M Liao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Obesity (Silver Spring) 21:1478-85. 2013
    ..Adipokines, such as leptin and adiponectin, may link obesity and cancer, with different quantitative effects by race...
  51. doi request reprint Multiple loci identified in a genome-wide association study of prostate cancer
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Genet 40:310-5. 2008
    ..Our findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals...
  52. pmc Prevalence of and risk factors for anal human papillomavirus infection among young healthy women in Costa Rica
    Felipe A Castro
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Infect Dis 206:1103-10. 2012
    ..Anal cancer is caused by human papillomavirus (HPV), yet little is known about anal HPV infection among healthy young women...
  53. pmc A flexible Bayesian model for studying gene-environment interaction
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    PLoS Genet 8:e1002482. 2012
    ....
  54. pmc Methylation of human papillomavirus type 16 genome and risk of cervical precancer in a Costa Rican population
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS 7101, Rockville, MD 20892, USA
    J Natl Cancer Inst 104:556-65. 2012
    ....
  55. pmc A gene expression signature from peripheral whole blood for stage I lung adenocarcinoma
    Melissa Rotunno
    Division of Cancer Epidemiology and Genetics, NCI, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Prev Res (Phila) 4:1599-608. 2011
    ..81, 95% CI = 0.74-0.87). Our finding suggests the use of gene expression from PWB for the identification of early detection markers of lung cancer in the future...
  56. pmc Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk
    Tram Kim Lam
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 31:634-42. 2010
    ..Our findings suggest an interplay between quercetin intake, tobacco smoking, and lung cancer risk. Further research on this relationship is warranted...
  57. pmc Comparison between prototype hybrid capture 3 and hybrid capture 2 human papillomavirus DNA assays for detection of high-grade cervical intraepithelial neoplasia and cancer
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Microbiol 41:4022-30. 2003
    ..68 to 0.79). In conclusion, we suggest that HC3 (>/=0.6 RLU/PC) may be slightly more sensitive than and equally specific test as HC2 (>/=1.0 RLU/PC) for the detection of CIN3+ over the duration of typical screening intervals...
  58. pmc Proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent HPV16/18 vaccine
    Aimee R Kreimer
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7084, Rockville, MD 20852, USA
    J Natl Cancer Inst 103:1444-51. 2011
    ..Three-dose regimens for human papillomavirus (HPV) vaccines are expensive and difficult to complete, especially in settings where the need for cervical cancer prevention is greatest...
  59. pmc Efficacy of a bivalent HPV 16/18 vaccine against anal HPV 16/18 infection among young women: a nested analysis within the Costa Rica Vaccine Trial
    Aimee R Kreimer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Lancet Oncol 12:862-70. 2011
    ..Human papillomavirus (HPV) 16 and 18 infections cause most cases of anal cancer. We assessed efficacy of an AS04-adjuvanted HPV 16 and HPV 18 vaccine against anal infection with HPV 16, HPV 18, or both (HPV 16/18)...
  60. ncbi request reprint Human papillomavirus testing following loop electrosurgical excision procedure identifies women at risk for posttreatment cervical intraepithelial neoplasia grade 2 or 3 disease
    Aimee R Kreimer
    National Cancer Institute, NIH, 6130 Executive Boulevard, Bethesda, MD 20892 7333, USA
    Cancer Epidemiol Biomarkers Prev 15:908-14. 2006
    ....
  61. pmc Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer
    Ying Gao
    Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
    Int J Cancer 125:146-52. 2009
    ..23-1.80) and decreased (OR = 0.73, 95% CI = 0.61-0.87) lung cancer risk, respectively. FH of lung cancer and nonmalignant lung diseases affected lung cancer risk independently, and did not appear to be modified by FH of smoking...
  62. pmc A case-control study of occupation/industry and renal cell carcinoma risk
    Sara Karami
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, MSC 7242, Bethesda, MD 20892 7242, USA
    BMC Cancer 12:344. 2012
    ..Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC)...
  63. pmc Elevated methylation of HPV16 DNA is associated with the development of high grade cervical intraepithelial neoplasia
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Int J Cancer 132:1412-22. 2013
    ..Higher methylation in CIN2+ cases was not explained by higher viral load. We conclude that elevated levels of HPV16 DNA methylation may be useful to predict concurrently diagnosed as well as future CIN2+...
  64. pmc Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry
    Zhaoming Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Genet 131:1173-85. 2012
    ....
  65. pmc A large, population-based study of age-related associations between vaginal pH and human papillomavirus infection
    Megan A Clarke
    Division of Cancer Epidemiology and Genetics, DHHS, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    BMC Infect Dis 12:33. 2012
    ..We examined vaginal pH and the risk of HPV infection, cytological abnormalities, and C. trachomatis infection...
  66. pmc The age-specific prevalence of human papillomavirus and risk of cytologic abnormalities in rural Nigeria: implications for screen-and-treat strategies
    Julia C Gage
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Int J Cancer 130:2111-7. 2012
    ....
  67. pmc A competitive serological assay shows naturally acquired immunity to human papillomavirus infections in the Guanacaste Natural History Study
    Nicolas Wentzensen
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Infect Dis 204:94-102. 2011
    ..A competitive Luminex Immunoassay (cLIA) has been developed to measure neutralizing antibodies against human papillomavirus (HPV) types 6, 11, 16 and 18...
  68. pmc Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer
    Charles C Chung
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute NIH, 8717 Grovemont Circle, Bethesda, MD 20892, USA
    Hum Mol Genet 20:2869-78. 2011
    ..We estimate that at least 63 common variants should be considered in future studies designed to investigate the biological basis of the multiple association signals...
  69. ncbi request reprint BRCA1 and sex ratio
    Jeffery P Struewing
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5060, USA
    Eur J Hum Genet 12:663-7. 2004
    ..Nonetheless, these observations do not support the idea that BRCA1 mutation carriers have a lower ratio of male offspring than BRCA2 mutation carriers...
  70. ncbi request reprint A study of the impact of adding HPV types to cervical cancer screening and triage tests
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7234, USA
    J Natl Cancer Inst 97:147-50. 2005
    ..The minimal increases in sensitivity and in negative predictive value achieved by adding HPV types to DNA tests must be weighed against the projected burden to thousands of women falsely labeled as being at high risk of cervical cancer...
  71. pmc Invited commentary: efficient testing of gene-environment interaction
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Epidemiol 169:231-3; discussion 234-5. 2009
    ..The development of new approaches to testing for interaction is an example of methodological progress leading to practical advantages...
  72. ncbi request reprint Restricted cross-reactivity of hybrid capture 2 with nononcogenic human papillomavirus types
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:1394-9. 2002
    ....
  73. pmc Influence of loop electrosurgical excision procedure on subsequent acquisition of new human papillomavirus infections
    Philip E Castle
    Divisions of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Infect Dis 199:1612-20. 2009
    ..The impact of loop electrosurgical excision procedure (LEEP) treatment for cervical precancerous lesions on subsequent acquisition of new human papillomavirus (HPV) infections is not well described...
  74. ncbi request reprint Bias in intervention studies that enroll patients from high-risk clinics
    Sholom Wacholder
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 96:1204-7. 2004
    ....
  75. doi request reprint Improved genetic association tests for an ordinal outcome representing the disease progression process
    Hong Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892, USA
    Genet Epidemiol 35:499-505. 2011
    ..As a demonstration, we applied the considered tests to a genetic association study of cervical cancer...
  76. pmc Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Am J Hum Genet 79:1002-16. 2006
    ....
  77. ncbi request reprint PCR testing of pooled longitudinally collected cervical specimens of women to increase the efficiency of studying human papillomavirus infection
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7074, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:256-60. 2005
    ..7-91.4%), respectively. We conclude that pooling specimens and testing by PCR may be useful for discriminating HPV DNA-positive from completely negative specimen sets in women who are likely to have been HPV DNA-negative.>..
  78. ncbi request reprint Absolute risk of a subsequent abnormal pap among oncogenic human papillomavirus DNA-positive, cytologically negative women
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Cancer 95:2145-51. 2002
    ..The absolute risk of a subsequent abnormal Pap test for these women is uncertain. Therefore, the proper counseling and clinical management of these women is also uncertain...
  79. pmc Human papillomavirus genotype specificity of hybrid capture 2
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5030, EPS MSC 7234, Bethesda, MD 20892 7234, USA
    J Clin Microbiol 46:2595-604. 2008
    ..In conclusion, hc2 cross-reacts with certain untargeted, noncarcinogenic HPV genotypes that are phylogenetically related to the targeted genotypes, but the degree of cross-reactivity may be less than previously reported...
  80. pmc Population substructure and control selection in genome-wide association studies
    Kai Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 3:e2551. 2008
    ..A study using suboptimal controls can have acceptable type I error when an effective strategy for the correction of PS is employed...
  81. pmc Assessment of human papillomavirus in lung tumor tissue
    Jill Koshiol
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7248, USA
    J Natl Cancer Inst 103:501-7. 2011
    ..Lung cancer kills more than 1 million people worldwide each year. Whereas several human papillomavirus (HPV)-associated cancers have been identified, the role of HPV in lung carcinogenesis remains controversial...
  82. pmc Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Int J Cancer 125:2151-8. 2009
    ..The potential range of HPV genotype attribution is wide at the disease categories <CIN2 to CIN3. Genotyping from cervical lesions and analyzing viral oncogene expression can improve estimates of HPV genotype attribution...
  83. doi request reprint Seroprevalence and correlates of human papillomavirus 16/18 seropositivity among young women in Costa Rica
    Sarah Coseo
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS, Room 7079, Rockville, MD 20852, USA
    Sex Transm Dis 37:706-14. 2010
    ..We investigated HPV16 and 18 seroepidemiology among young, unvaccinated women aged between 18 and 25...
  84. doi request reprint Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations
    Elizabeth M Azzato
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland 20852, USA
    Pharmacogenet Genomics 20:58-63. 2010
    ....
  85. ncbi request reprint Gynecologic surgeries and risk of ovarian cancer in women with BRCA1 and BRCA2 Ashkenazi founder mutations: an Israeli population-based case-control study
    Joni L Rutter
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7246, USA
    J Natl Cancer Inst 95:1072-8. 2003
    ..We assessed the level and persistence of reduction of ovarian (including peritoneal) cancer risk after gynecologic surgeries for women who carry BRCA1/2 mutations but were not selected from high-risk clinics...
  86. pmc Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
    PLoS ONE 3:e1651. 2008
    ..Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure...
  87. ncbi request reprint Joint effect of genes and environment distorted by selection biases: implications for hospital-based case-control studies
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7244, USA
    Cancer Epidemiol Biomarkers Prev 11:885-9. 2002
    ..This formulation extends to the general problem of distortion of joint effects from selection biases or confounding...
  88. ncbi request reprint Genetic variations in CC chemokine receptors and hypertension
    Mingdong Zhang
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Rm 7082, MSC 7234, Rockville, MD 20852, USA
    Am J Hypertens 19:67-72. 2006
    ..The present study was carried out to verify these associations...
  89. ncbi request reprint Interpreting epidemiologic research: lessons from studies of childhood cancer
    Martha S Linet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7238, USA
    Pediatrics 112:218-32. 2003
  90. ncbi request reprint Quantifying epidemiologic risk factors using non-parametric regression: model selection remains the greatest challenge
    Philip S Rosenberg
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Biostatistics Branch, 6120 Executive Boulevard, EPS 7006, Rockville, MD 20852, USA
    Stat Med 22:3369-81. 2003
    ..Nonetheless, the semi-parametric approach appears to be a practical advance...
  91. ncbi request reprint One gene and one outcome? No way
    Stephen Chanock
    Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Trends Mol Med 8:266-9. 2002
    ..The challenge lies in sorting through the information and developing effective strategies to advance molecular diagnostics...
  92. ncbi request reprint The HER2 I655V polymorphism and breast cancer risk in Ashkenazim
    Joni L Rutter
    Laboratory of Population Genetics, Center for Cancer Research, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Epidemiology 14:694-700. 2003
    ..CONCLUSION These analyses suggest that the HER2 valine allele might be associated with increased risk of breast cancer, especially in young women and in women with a family history of the disease...
  93. ncbi request reprint Adjustment for competing risk in kin-cohort estimation
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Genet Epidemiol 25:303-13. 2003
    ..We also evaluate the performance of the proposed estimation method, based on simulated data that were generated following the setup of the Washington Ashkenazi Study...
  94. ncbi request reprint A prospective study of high-grade cervical neoplasia risk among human papillomavirus-infected women
    Philip E Castle
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD 20892, USA
    J Natl Cancer Inst 94:1406-14. 2002
    ..However, these potential risk factors have not been adequately studied in prospective studies...
  95. pmc Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Cancer Epidemiol Biomarkers Prev 19:1349-55. 2010
    ..2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7))...
  96. ncbi request reprint Assessing the probability that a positive report is false: an approach for molecular epidemiology studies
    Sholom Wacholder
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 96:434-42. 2004
    ..An FPRP-based criterion for deciding whether to call a finding noteworthy formalizes the process already used informally by investigators--that is, tempering enthusiasm for remarkable study findings with considerations of plausibility...
  97. pmc Lower risk of lung cancer after multiple pneumonia diagnoses
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7248, Bethesda, MD 20892 7248, USA
    Cancer Epidemiol Biomarkers Prev 19:716-21. 2010
    ..Although pneumonia has been suggested as a risk factor for lung cancer, previous studies have not evaluated the influence of number of pneumonia diagnoses in relation to lung cancer risk...
  98. ncbi request reprint Interobserver agreement in the evaluation of digitized cervical images
    Jose Jeronimo
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Obstet Gynecol 110:833-40. 2007
    ..To estimate the agreement among multiple expert colposcopists evaluating high-resolution digitized cervigrams taken from patients with a variety of human papillomavirus (HPV) infection states and previous cervigram interpretations...
  99. ncbi request reprint Effect of human papillomavirus 16/18 L1 viruslike particle vaccine among young women with preexisting infection: a randomized trial
    Allan Hildesheim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    JAMA 298:743-53. 2007
    ..Viruslike particle human papillomavirus (HPV) vaccines were designed to prevent HPV infection and development of cervical precancers and cancer. Women with oncogenic HPV infections might consider vaccination as therapy...
  100. ncbi request reprint Maternal sensitivity concerning aetiological research into childhood cancer: results of preliminary focus groups
    Martha S Linet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Baethesda, MD 20892 7238, USA
    Paediatr Perinat Epidemiol 21:169-78. 2007
    ..We conclude that the focus group approach can contribute to a broad strategy for improving questionnaires and methods for conducting paediatric cancer epidemiological research...
  101. ncbi request reprint Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Lancet Oncol 7:27-38. 2006
    ..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)...