M P Waalkes

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Minimal influence of metallothionein over-expression on nickel carcinogenesis in mice
    Michael P Waalkes
    Laboratory of Comparative Carcinogenesis, Inorganic Carcinogenesis Section, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Lett 153:357-64. 2004
  2. pmc Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, North Carolina27709, USA
    Cancer Res 68:8278-85. 2008
  3. pmc Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses
    Michael P Waalkes
    Inorganic Toxicology Group, National Toxicology Program Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, 111 Alexander Drive, MD E1 07, P O Box 12233, Research Triangle Park, NC, 27709, USA
    Arch Toxicol 88:1619-29. 2014
  4. pmc Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase
    Lamia Benbrahim-Tallaa
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1454-9. 2007
  5. pmc Mechanisms of acquired androgen independence during arsenic-induced malignant transformation of human prostate epithelial cells
    Lamia Benbrahim-Tallaa
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:243-7. 2007
  6. pmc Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype
    Erik J Tokar
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:108-15. 2010
  7. pmc Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells
    Wei Qu
    Inorganic Toxicology Group, National Toxicology Program Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:1265-71. 2012
  8. pmc Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1101-6. 2007
  9. pmc Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype
    Yuanyuan Xu
    National Toxicology Program Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:865-71. 2012
  10. pmc Early-life arsenic exposure: methylation capacity and beyond
    Michael P Waalkes
    Environ Health Perspect 116:A104. 2008

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Minimal influence of metallothionein over-expression on nickel carcinogenesis in mice
    Michael P Waalkes
    Laboratory of Comparative Carcinogenesis, Inorganic Carcinogenesis Section, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Lett 153:357-64. 2004
    ..A nickel dose-related trend for increased lung tumors occurred in MT-transgenic mice but not in WT mice. Thus, the over-expression of MT did not significantly mitigate the carcinogenic response to nickel...
  2. pmc Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, North Carolina27709, USA
    Cancer Res 68:8278-85. 2008
    ....
  3. pmc Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses
    Michael P Waalkes
    Inorganic Toxicology Group, National Toxicology Program Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, 111 Alexander Drive, MD E1 07, P O Box 12233, Research Triangle Park, NC, 27709, USA
    Arch Toxicol 88:1619-29. 2014
    ..05) in lung adenoma (25 %) in the 50-ppb group compared to control (11 %) occurred in female offspring. Thus, in CD1 mice whole-life arsenic exposure induced lung tumors at human-relevant doses (i.e., 50 and 500 ppb). ..
  4. pmc Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase
    Lamia Benbrahim-Tallaa
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1454-9. 2007
    ..The typical pattern appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1, inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or 3b causes gene-specific hypermethylation...
  5. pmc Mechanisms of acquired androgen independence during arsenic-induced malignant transformation of human prostate epithelial cells
    Lamia Benbrahim-Tallaa
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:243-7. 2007
    ..Prostate cancer progression often occurs with overexpression of growth factors and receptors, many of which engage the Ras/mitogen-activated protein MAP kinase (MAPK) pathway...
  6. pmc Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype
    Erik J Tokar
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:108-15. 2010
    ..However, proof of emergence of CSCs induced by arsenic in a stem cell population is not available...
  7. pmc Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells
    Wei Qu
    Inorganic Toxicology Group, National Toxicology Program Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:1265-71. 2012
    ..Cancer may be a stem cell (SC)-based disease involving formation of cancer SCs (CSCs) potentially arising from transformation of normal SCs. Cadmium has been linked to human pancreatic cancer...
  8. pmc Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1101-6. 2007
    ..Because metallothionein (MT) is a metal-binding protein that protects against metal intoxication, it could be a biomarker for individual sensitivity to metal toxicity...
  9. pmc Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype
    Yuanyuan Xu
    National Toxicology Program Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:865-71. 2012
    ..Malignant cells release extracellular factors, modifying tumor behavior. Inorganic arsenic, a human carcinogen, is associated with an overproduction of CSCs in various model systems of carcinogenesis...
  10. pmc Early-life arsenic exposure: methylation capacity and beyond
    Michael P Waalkes
    Environ Health Perspect 116:A104. 2008
  11. pmc Inorganic arsenic and human prostate cancer
    Lamia Benbrahim-Tallaa
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, NIH DHHS, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:158-64. 2008
    ..We critically evaluated the etiologic role of inorganic arsenic in human prostate cancer...
  12. pmc Cadmium malignantly transforms normal human breast epithelial cells into a basal-like phenotype
    Lamia Benbrahim-Tallaa
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute NCI at National Institute of Environmental Health Sciences NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:1847-52. 2009
    ..Thus, we studied the effects of chronic exposure to cadmium on the normal human breast epithelial cell line MCF-10A, which is ER-negative but can convert to ER-positive during malignant transformation...
  13. pmc Recruitment of normal stem cells to an oncogenic phenotype by noncontiguous carcinogen-transformed epithelia depends on the transforming carcinogen
    Yuanyuan Xu
    National Toxicology Program Laboratory, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 121:944-50. 2013
    ..We have found that a normal stem cell (NSC) line from human prostate (WPE-stem) is recruited into CSC-like cells by nearby, but noncontiguous, arsenic-transformed isogenic malignant epithelial cells (MECs)...
  14. pmc Acquisition of apoptotic resistance in cadmium-transformed human prostate epithelial cells: Bcl-2 overexpression blocks the activation of JNK signal transduction pathway
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, NC 27709, USA
    Environ Health Perspect 115:1094-100. 2007
    ....
  15. pmc Transplacental arsenic carcinogenesis in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 222:271-80. 2007
    ..Transplacental carcinogenesis clearly occurs with other agents in humans and investigating a potential transplacental component of the human carcinogenic response to arsenic should be a research priority...
  16. ncbi request reprint Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 215:295-305. 2006
    ..In utero arsenic also initiated urinary bladder tumor formation when followed by postnatal TAM and uroepithelial proliferative lesions when followed by TAM or DES...
  17. ncbi request reprint Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 186:7-17. 2003
    ..The development of this rodent model of inorganic arsenic carcinogenesis has important implications in defining the mechanism of action for this common environmental carcinogen...
  18. ncbi request reprint Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: role of inclusion body formation
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27703, USA
    Cancer Res 64:7766-72. 2004
    ..Poor production of metallothionein may predispose human populations to lead carcinogenicity...
  19. ncbi request reprint Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, PO Box 12233, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Cancer Res 66:1337-45. 2006
    ..Thus, arsenic acts with estrogens to enhance production of female mouse urogenital cancers...
  20. ncbi request reprint Metallothionein-I/II double knockout mice are no more sensitive to the carcinogenic effects of nickel subsulfide than wild-type mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Int J Toxicol 24:215-20. 2005
    ..Overall, MT-null mice appear no more sensitive to the carcinogenic effects of nickel than WT mice. Thus, poor MT production does not appear to be a predisposing factor for nickel carcinogenesis...
  21. ncbi request reprint Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 198:377-84. 2004
    ..The development of these animal models should advance our understanding of the mechanisms of inorganic arsenic carcinogenesis...
  22. ncbi request reprint Mechanisms underlying arsenic carcinogenesis: hypersensitivity of mice exposed to inorganic arsenic during gestation
    Michael P Waalkes
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, 111 Alexander Drive, P O Box 12233, MD F0 09, Research Triangle Park, NC 27709, USA
    Toxicology 198:31-8. 2004
    ..In addition, it appears gestational arsenic can act as a tumor initiator in the female mouse liver, inducing liver lesions that can be promoted by TPA...
  23. ncbi request reprint Cadmium carcinogenesis
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Triangle Park, NC 27706, USA
    Mutat Res 533:107-20. 2003
    ..Most studies indicate cadmium is poorly mutagenic and probably acts through indirect or epigenetic mechanisms, potentially including aberrant activation of oncogenes and suppression of apoptosis...
  24. ncbi request reprint Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 96:466-74. 2004
    ....
  25. ncbi request reprint Hypersusceptibility to cisplatin carcinogenicity in metallothionein-I/II double knockout mice: production of hepatocellular carcinoma at clinically relevant doses
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Cancer 119:28-32. 2006
    ..Our results indicate that MT-null mice are hypersusceptible to the hepatocarcinogenic effects of cisplatin, and poor MT expression may be a predisposing factor for cisplatin-induced secondary tumors after chemotherapy...
  26. ncbi request reprint Carcinogenic effects of cadmium in the noble (NBL/Cr) rat: induction of pituitary, testicular, and injection site tumors and intraepithelial proliferative lesions of the dorsolateral prostate
    M P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 52:154-61. 1999
    ..These results show that cadmium induces proliferative lesions in the dorsolateral prostate of the Noble rat, a model having a presumed relevance to human prostate cancers...
  27. ncbi request reprint Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 25:133-41. 2004
    ..Skin tumors were not initiated by arsenic in mouse fetuses possibly indicating tissue-specific mechanisms of action. This study indicates that gestation is a period of high sensitivity to arsenic carcinogenesis...
  28. ncbi request reprint Cadmium carcinogenesis in review
    M P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27706, USA
    J Inorg Biochem 79:241-4. 2000
    ..Cadmium is poorly mutagenic and probably acts through indirect mechanisms, although the precise mechanisms remain unknown...
  29. ncbi request reprint Purine nucleoside phosphorylase: a fortuitous cytosolic arsenate reductase?
    Michael P Waalkes
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, 111 Alexander Drive, Research Triangle Park, North Carolina, 27709, USA
    Toxicol Sci 70:1-3. 2002
  30. ncbi request reprint Induction of proliferative lesions of the uterus, testes, and liver in swiss mice given repeated injections of sodium arsenate: possible estrogenic mode of action
    M P Waalkes
    Inorganic Carcinogenesis Section, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 166:24-35. 2000
    ..Estrogen treatment has been associated with proliferative lesions and tumors of the uterus, female liver, and testes in other studies, supporting a hypothesis that arsenate might somehow act through an estrogenic mode of action...
  31. ncbi request reprint Cadmium-induced inhibition of the growth and metastasis of human lung carcinoma xenografts: role of apoptosis
    M P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:65-70. 1999
    ..These studies show cadmium can effectively reduce growth and progression of human lung carcinoma xenografts in a fashion that is probably independent of apoptosis...
  32. ncbi request reprint Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation
    H Chen
    Laboratory of Comparative Carcinogenesis, National Cancer Institute (NCI) at National Institute of Environmental Health Sciences (NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 175:260-8. 2001
    ..These correlations provide convincing evidence c-myc overexpression is mechanistically important in arsenic-induced malignant transformation in this model system...
  33. ncbi request reprint Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice
    J Liu
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicology 147:157-66. 2000
    ..In conclusion, this study indicates that As may potentiate Cd nephrotoxicity during the long-term, combined exposure, and that intracellular MT plays a role in decreasing the nephropathy of combined exposure to Cd and As...
  34. ncbi request reprint Stress-related gene expression in mice treated with inorganic arsenicals
    J Liu
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute for Environmental Health Sciences, Mail Drop F0 09, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 61:314-20. 2001
    ..In summary, this study profiled the gene expression pattern in mice treated with inorganic arsenicals, which adds to our understanding of acute arsenic poisoning and toxicity...
  35. ncbi request reprint Comparison of inflammatory lung responses in Wistar rats and C57 and DBA mice following acute exposure to cadmium oxide fumes
    I M McKenna
    Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Toxicol Appl Pharmacol 146:196-206. 1997
    ..An extrapolation of this conclusion is that genetic variations in the human population may determine individual sensitivity differences to inhaled Cd...
  36. ncbi request reprint Genetic events associated with arsenic-induced malignant transformation: applications of cDNA microarray technology
    H Chen
    Laboratory of Comparative Carcinogenesis, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 30:79-87. 2001
    ..Mol. Carcinog. 30:79-87, 2001. Published 2001 Wiley-Liss, Inc...
  37. ncbi request reprint Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis
    Hua Chen
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Carcinogenesis 25:1779-86. 2004
    ....
  38. pmc The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Lett 256:238-45. 2007
    ..The role of NO in reducing the hepatotoxicity of arsenical chemotherapeutics in vivo deserves additional study...
  39. pmc Requirement of arsenic biomethylation for oxidative DNA damage
    Chikara Kojima
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 101:1670-81. 2009
    ..We assessed the role of arsenic biomethylation in oxidative DNA damage (ODD) using a recently developed immuno-spin trapping method...
  40. ncbi request reprint Cadmium-induced malignant transformation of human prostate epithelial cells
    W E Achanzar
    Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 61:455-8. 2001
    ..Cadmium-induced malignant transformation of human prostate epithelial cells strongly fortifies the evidence for a potential role of cadmium in prostate cancer...
  41. ncbi request reprint Lead effects on protamine-DNA binding
    B Quintanilla-Vega
    National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Am J Ind Med 38:324-9. 2000
    ..The mobility shift assay showed that lead interaction with HP2 caused a dose-dependent decrease on HP2 binding to DNA, suggesting that lead may alter chromatin stability...
  42. ncbi request reprint Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals
    J Liu
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F0 09, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 55:460-7. 2000
    ....
  43. ncbi request reprint Renal tubular tumors and atypical hyperplasias in B6C3F1 mice exposed to lead acetate during gestation and lactation occur with minimal chronic nephropathy
    M P Waalkes
    Inorganic Carcinogenesis Section, Science Applications International Corporation Frederick, National Cancer Institute, Maryland 21702 1201, USA
    Cancer Res 55:5265-71. 1995
    ..Thus, short-term lead exposure during the gestational/lactational period has carcinogenic potential in the mouse kidney...
  44. ncbi request reprint Anticarcinogenic effects of cadmium in B6C3F1 mouse liver and lung
    M P Waalkes
    Inorganic Carcinogenesis Section, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201
    Toxicol Appl Pharmacol 110:327-35. 1991
    ..The possibility exists that cadmium has a specific toxicity toward previously initiated cells within liver and lung...
  45. ncbi request reprint Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic
    J Liu
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 60:302-9. 2001
    ..Thus, acquired tolerance to arsenic is associated with increased expression GST-Pi, Mrp1/Mrp2 and P-glycoprotein, which function together to reduce cellular arsenic accumulation...
  46. pmc Impact of life stage and duration of exposure on arsenic-induced proliferative lesions and neoplasia in C3H mice
    Gene J Ahlborn
    United States Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA
    Toxicology 262:106-13. 2009
    ..The paradoxical nature of these effects may be related to altered lipid metabolism, the effective dose in each target organ, and/or the shorter one-year observational period...
  47. pmc Global gene expression associated with hepatocarcinogenesis in adult male mice induced by in utero arsenic exposure
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 114:404-11. 2006
    ..These novel findings are in agreement with the biology and histology of arsenic-induced HCC, thereby indicating that multiple genetic events are associated with transplacental arsenic hepatocarcinogenesis...
  48. pmc Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic
    Yaxiong Xie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC 27709, United States
    Toxicology 236:7-15. 2007
    ..Thus, transplacental exposure to arsenic at a hepatocarcinogenic dose induces alterations in DNA methylation and a complex set of aberrant gene expressions in the newborn liver, a target of arsenic carcinogenesis...
  49. pmc Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure
    Jun Shen
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 95:313-20. 2007
    ..These data provide evidence that arsenic-induced aberrant ER signaling could disrupt early life stage genetic programing in the lung leading eventually to lung tumor formation much later in adulthood...
  50. pmc Potential role of alpha-synuclein and metallothionein in lead-induced inclusion body formation
    Peijun Zuo
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 111:100-8. 2009
    ..In WT mice after chronic Pb exposure Scna was localized in renal cells containing forming IBs, whereas MT-null mice did not form IBs. Thus, Scna could be component of Pb-induced IBs and, with MT, may play a role in IBs formation...
  51. pmc Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice
    Yaxiong Xie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 112:1255-63. 2004
    ..These effects may play a role in arsenic-induced hepatotoxicity and carcinogenesis and may be of particular toxicologic relevance...
  52. ncbi request reprint Gene array analysis of the hepatic response to endotoxin in glutathione peroxidase-deficient mice
    Chengxiu Li
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Lett 144:397-406. 2003
    ..Thus, only a combination of gene array analysis with functional studies allows valid conclusions regarding mechanisms of cell injury...
  53. ncbi request reprint Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation
    M Takiguchi
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, 111 Alexander Drive, P.O. Box 12233, MD F0-09, Research Triangle Park, NC 27709, USA
    Toxicology 165:13-25. 2001
    ..This decrease of cellular cadmium accumulation appears to be related to events that require protein synthesis and may be due to activation of the genes associated with zinc efflux...
  54. ncbi request reprint Mechanisms of arsenic-induced cross-tolerance to nickel cytotoxicity, genotoxicity, and apoptosis in rat liver epithelial cells
    W Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 63:189-95. 2001
    ....
  55. pmc Isolation and partial characterization of the low-molecular-mass zinc/cadmium-binding protein from the testes of the patas monkey (Erythrocebus patas). Distinction from metallothionein
    M P Waalkes
    Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, MD 21701
    Biochem J 256:131-7. 1988
    ....
  56. ncbi request reprint Immunohistochemical evidence of high concentrations of metallothionein in pancreatic hepatocytes induced by cadmium in rats
    M P Waalkes
    Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, Maryland 21702 1201
    Toxicol Pathol 20:323-6. 1992
    ..Surrounding normal pancreatic islet and acinar cells were not immunoreactive. Thus, metallothionein is expressed actively in cells transdifferentiated to hepatocytes by cadmium within the pancreas...
  57. ncbi request reprint Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Cancer Ther 3:709-14. 2004
    ....
  58. ncbi request reprint Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide
    Jingbo Pi
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Exp Cell Res 290:234-45. 2003
    ..Taken together, these data clearly show that arsenic increases Nrf2 expression and activity at multiple levels and that H(2)O(2) is one of the mediators of this process...
  59. ncbi request reprint Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice
    Yaxiong Xie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Cell Biochem 255:11-8. 2004
    ..In summary, this study shows that chronic arsenic toxicity, including liver pathology and oxidative stress, is enhanced in mdr1a/1b(-/-) mice, possibly due to enhanced accumulation of arsenic as a result of transport system deficiency...
  60. ncbi request reprint The nitric oxide donor, O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), protects against cadmium-induced hepatotoxicity in mice
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Instititue of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 310:18-24. 2004
    ..This protection is not mediated through altered distribution of Cd but may be related to reduced hepatic inflammation, reduced acute phase responses, and the suppression of cell-death-related components...
  61. ncbi request reprint Genomic analysis of the rat lung following elemental mercury vapor exposure
    Jie Liu
    Inorganic Carcinogenesis Section, NCI at NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:174-81. 2003
    ..In summary, genomic analysis revealed an array of gene alterations in response to Hg0 vapor exposure, which could be important for the development of pulmonary adaptation to Hg during Hg0 vapor inhalation...
  62. ncbi request reprint Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation
    Masufumi Takiguchi
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Exp Cell Res 286:355-65. 2003
    ..These results indicate that, while cadmium is an effective inhibitor of DNA MeTase and initially induces DNA hypomethylation, prolonged exposure results in DNA hypermethylation and enhanced DNA MeTase activity...
  63. ncbi request reprint Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation
    Lamia Benbrahim-Tallaa
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, MD F0 09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 206:288-98. 2005
    ..However, overexpression of K-ras occurred without mutations and through a mechanism other than promoter region hypomethylation...
  64. pmc V-PROLI/NO, a nitric oxide donor prodrug, protects liver cells from arsenic-induced toxicity
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Sci 100:382-8. 2009
    ....
  65. pmc The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 160:1047-56. 2002
    ..This study reveals important roles for MT in chronic lead toxicity, lead accumulation, and inclusion body formation...
  66. ncbi request reprint Cadmium-induced malignant transformation in rat liver cells: role of aberrant oncogene expression and minimal role of oxidative stress
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Cancer 114:346-55. 2005
    ....
  67. pmc Liver is a target of arsenic carcinogenesis
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 105:24-32. 2008
    ..Some of these mechanisms may be liver specific/selective. Overall, accumulating evidence clearly indicates that the liver could be an important target of arsenic carcinogenesis...
  68. ncbi request reprint Nitric oxide induces metallothionein (MT) gene expression apparently by displacing zinc bound to MT
    K Katakai
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research, Mail Drop F0-09, 111 Alexander Drive, 27709, Research Triangle Park, NC, USA
    Toxicol Lett 119:103-8. 2001
    ....
  69. ncbi request reprint Differential effects between maotai and ethanol on hepatic gene expression in mice: Possible role of metallothionein and heme oxygenase-1 induction by maotai
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina, USA
    Exp Biol Med (Maywood) 231:1535-41. 2006
    ..The dramatic induction of metallothionein and heme oxygenase-1 with Maotai could be important adaptive responses to reduce alcoholic liver injury...
  70. pmc Cadmium-induced toxicity in rat primary mid-brain neuroglia cultures: role of oxidative stress from microglia
    Zhengqin Yang
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 98:488-94. 2007
    ..In conclusion, Cd is toxic to neuron-glia cultures, and the oxidative stress from microglia may play important roles in Cd-induced damage to dopaminergic neurons...
  71. pmc Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells
    Jean Francois Coppin
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 283:19342-50. 2008
    ....
  72. pmc Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis
    Yang Sun
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Reasearch Triangle Park, NC 27709, USA
    Toxicology 262:162-70. 2009
    ....
  73. ncbi request reprint Acquisition of apoptotic resistance in cadmium-induced malignant transformation: specific perturbation of JNK signal transduction pathway and associated metallothionein overexpression
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 45:561-71. 2006
    ..The acquisition of apoptotic resistance may play an important role in cadmium carcinogenesis by contributing to both tumor initiation and malignant progression...
  74. ncbi request reprint Metallothionein is a potential negative regulator of apoptosis
    Ryuya Shimoda
    National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 73:294-300. 2003
    ..965). These suggest that MT may play a role in regulating apoptosis and that modulating MT expression may provide a strategy for altering cellular resistance to chemotherapeutic compounds...
  75. doi request reprint Arsenic exposure in utero and nonepidermal proliferative response in adulthood in Tg.AC mice
    Erik J Tokar
    National Cancer Institute at NIEHS, Research Triangle Park, NC 27709, USA
    Int J Toxicol 29:291-6. 2010
    ..Thus, arsenic in utero rapidly induces ACAs and uterine and UB preneoplasias in Tg.AC mice, showing transplacental carcinogenic potential in yet another strain of mice...
  76. pmc Changes in hepatic gene expression in response to hepatoprotective levels of zinc
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC
    Liver Int 29:1222-9. 2009
    ..Zinc (Zn) administration at non-toxic doses protects against the hepatotoxicity produced by many agents, but the underlying mechanisms remain elusive...
  77. ncbi request reprint Cadmium at a non-toxic dose alters gene expression in mouse testes
    Tong Zhou
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Lett 154:191-200. 2004
    ..These results indicate that changes in gene expression occur well before overt effects of Cd-induced testicular toxicity and carcinogenicity are apparent...
  78. ncbi request reprint Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance
    Y Y He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Oncogene 25:3680-8. 2006
    ..Further comparisons between the transformed ULTH and control cells should lead to a better understanding of the mechanism of UVA carcinogenesis and may help identify biomarkers for UVA-induced skin malignancies...
  79. pmc Early life inorganic lead exposure induces testicular teratoma and renal and urinary bladder preneoplasia in adult metallothionein-knockout mice but not in wild type mice
    Erik J Tokar
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicology 276:5-10. 2010
    ..Thus, MT deficiency made mice more sensitive to early life Pb exposure with regard to testes tumors, and renal and urinary bladder preneoplastic lesions...
  80. pmc Arsenic-induced aberrant gene expression in fetal mouse primary liver-cell cultures
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina, USA
    Ann N Y Acad Sci 1140:368-75. 2008
    ....
  81. pmc Mineral arsenicals in traditional medicines: orpiment, realgar, and arsenolite
    Jie Liu
    Inorganic Carcinogenesis Section, NCI at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 326:363-8. 2008
    ..Arsenic speciation, bioavailability, and toxicity/benefit should be considered in evaluation of mineral arsenical-containing traditional medicines...
  82. pmc Cadmium-induced cancers in animals and in humans
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27514, USA
    Int J Occup Environ Health 13:202-12. 2007
    ..Available information about the carcinogenicity of cadmium and cadmium compounds is reviewed, evaluated, and discussed...
  83. ncbi request reprint Nitric oxide and chemically induced hepatotoxicity: beneficial effects of the liver-selective nitric oxide donor, V-PYRRO/NO
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicology 208:289-97. 2005
    ....
  84. ncbi request reprint Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Int J Cancer 116:20-6. 2005
    ..The observation that As-TL cells show no lessening of UV-induced genotoxicity supports this possibility...
  85. ncbi request reprint Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 213:216-23. 2006
    ....
  86. ncbi request reprint Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas
    Renata Kowara
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Mol Cell Biochem 255:195-202. 2004
    ..Overall, the decline of Fhit in cells or tissues malignantly transformed by nickel may indicate possible involvement of this effect in the mechanisms of nickel carcinogenesis...
  87. pmc Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC, USA
    Genomics 94:32-8. 2009
    ..Confocal analysis confirmed key gene changes at the protein levels. Thus, multiple molecular events are associated with JS-K effects in killing HL-60, which could be molecular targets for this novel anticancer NO prodrug...
  88. ncbi request reprint Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 216:407-15. 2006
    ..Overall, an intricate variety of gene expression changes occur in arsenic-induced malignant transformation of liver cells including oncogene activation and alterations in expression of genes critical to growth regulation...
  89. pmc Transplacental exposure to inorganic arsenic at a hepatocarcinogenic dose induces fetal gene expression changes in mice indicative of aberrant estrogen signaling and disrupted steroid metabolism
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 220:284-91. 2007
    ..These alterations could disrupt genetic programming at the very early life stage, which could impact tumor formation much later in adulthood...
  90. ncbi request reprint Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice
    Jie Liu
    Laboratory of Comparative Carcinogenesis, Mail Drop F0 09, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 32:525-35. 2002
    ..Thus, the mechanism of acute cadmium toxicity involves multiple facets including oxidative damage and aberrant gene expression, and absence of MT exacerbates Cd-induced aberrant gene expression...
  91. ncbi request reprint Effect of mercury vapor exposure on metallothionein and glutathione s-transferase gene expression in the kidney of nonpregnant, pregnant, and neonatal rats
    Eduardo Brambila
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Toxicol Environ Health A 65:1273-88. 2002
    ..Activation of these genes could be part of a defensive response directed at decreasing renal mercury toxicity, and may help divert the metal away from the fetus...
  92. ncbi request reprint Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Sci 77:249-57. 2004
    ..Some of these aberrantly expressed genes could play a role in the development of arsenic-induced tumors, at least in the liver...
  93. ncbi request reprint Expression of metallothionein protein in the lungs of Wistar rats and C57 and DBA mice exposed to cadmium oxide fumes
    I M McKenna
    Laboratory of Comparative Carcinogenesis, National Cancer Institute, USA
    Toxicol Appl Pharmacol 153:169-78. 1998
    ..Thus intraspecies genetic variability in pulmonary MT may influence the susceptibility of rats or mice to lung carcinogenesis induced by inhalation of Cd compounds...
  94. ncbi request reprint Lead interaction with human protamine (HP2) as a mechanism of male reproductive toxicity
    B Quintanilla-Vega
    National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Chem Res Toxicol 13:594-600. 2000
    ..Therefore, the ability of lead to decrease the level of HP2-DNA interaction may result in alterations to sperm chromatin condensation, and thus in reduced fertility...
  95. ncbi request reprint Strain differences of cadmium-induced hepatotoxicity in Wistar-Imamichi and Fischer 344 rats: involvement of cadmium accumulation
    Hideaki Shimada
    Faculty of Education, Kumamoto University, 2 40 1, Kurokami, 860 8555, Japan
    Toxicology 203:189-97. 2004
    ..We propose the possibility that Zn transporter plays an important role in the strain difference of Cd toxicity in WI and Fischer rats...
  96. ncbi request reprint Hybridization buffer systems impact the quality of filter array data
    Jie Liu
    Inorganic Carcinogenesis Section, LCC, NCI at NIEHS, 111 Alexander Drive, RTP, NC 27709, USA
    J Pharmacol Toxicol Methods 50:67-71. 2004
    ..A clean hybridization with minimal background is critical for successful microarray analysis and is highly desired. However, clean hybridization alone is not enough; verification is needed...
  97. ncbi request reprint A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits
    Jingbo Pi
    Graduate School Doctoral Program in Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Free Radic Biol Med 35:102-13. 2003
    ..produced from endothelial NOS, such that enhanced free radicals are produced at the expense of NO...
  98. ncbi request reprint Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity
    Kartik Shankar
    Department of Toxicology, School of Pharmacy, College of Health Sciences, The University of Louisiana at Monroe, Louisiana 71209 0495, USA
    FASEB J 17:1748-50. 2003
    ..Gel shift assays revealed higher activation of nuclear factor-kappaB in WT-DB mice after APAP treatment. These findings suggest PPAR-alpha activation as a hepatoprotective adaptive response mediating protection against APAP in diabetes...
  99. ncbi request reprint Expression profiling of human keratinocyte response to ultraviolet A: implications in apoptosis
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 122:533-43. 2004
    ..This initial microarray analysis could advance our understanding of cellular responses to ultraviolet A exposure, and provide a platform from which to further study ultraviolet-A-induced apoptosis and carcinogenesis...
  100. ncbi request reprint Antimetastatic effect of salvicine on human breast cancer MDA-MB-435 orthotopic xenograft is closely related to Rho-dependent pathway
    Jing Yu Lang
    Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Division of Phytochemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China
    Clin Cancer Res 11:3455-64. 2005
    ..In present study, the effect of salvicine against metastasis is evaluated using human breast carcinoma orthotopic metastasis model and its mechanism is further investigated both in animal and cellular levels...
  101. ncbi request reprint Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F0 09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 70:144-51. 2005
    ..Thus, the liver-selective NO donor, V-PYRRO/NO, was partially protective against ANIT-induced liver injury, without affecting ANIT-induced cholestasis and cholestasis-related gene expression...