Research Topics
Species | Meena VythilingamSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Neural response to self- and other referential praise and criticism in generalized social phobiaKarina Blair
Mood and Anxiety Program, National Institute of Mental Health, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
Arch Gen Psychiatry 65:1176-84. 2008..However, studies have not examined the neural response in GSP to another equally important class of social stimuli, the communication of praise or criticism...
Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorderMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, MAP, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
Psychiatry Res 139:89-99. 2005....- Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorderMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
Neuropsychopharmacology 31:182-8. 2006..Patients with PTSD had increased glucocorticoid sensitivity in the focal brain regions mediating trace eyeblink conditioning... - Psychotic depression and mortalityMeena Vythilingam
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Am J Psychiatry 160:574-6. 2003..The authors hypothesized that patients with psychotic depression would have higher mortality rates than patients with nonpsychotic depression... - Reward circuitry in resilience to severe trauma: an fMRI investigation of resilient special forces soldiersMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD, 20892, USA
Psychiatry Res 172:75-7. 2009..Findings in this group of resilient individuals revealed unique patterns of activation during expectation of reward in the subgenual prefrontal cortex and nucleus accumbens area, regions pivotal to reward processes... - Childhood trauma associated with smaller hippocampal volume in women with major depressionMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
Am J Psychiatry 159:2072-80. 2002..In this study, the volumes of the hippocampus and of control brain regions were measured in depressed women with and without childhood abuse and in healthy nonabused comparison subjects... - Capitol hill staff workers' experiences of bioterrorism: qualitative findings from focus groupsCarol S North
Department of Psychiatry, School of Medicine, Washington University, St Louis, Missouri, USA
J Trauma Stress 18:79-88. 2005..Nonadherence to antibiotic prophylaxis is of immediate concern for response to future bioterrorist events as well as infectious disease epidemics. Other topics that warrant attention are social support and mental health interventions... - Association between level of emotional intelligence and severity of anxiety in generalized social phobiaMadeline Jacobs
Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD, United States
J Anxiety Disord 22:1487-95. 2008..These results suggest that EI may index emotional processing systems that mitigate the impact of systems causally implicated in GSP... - Deficits in verbal declarative memory function in women with childhood sexual abuse-related posttraumatic stress disorderJ Douglas Bremner
Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
J Nerv Ment Dis 192:643-9. 2004..These findings suggest that early abuse with PTSD is associated with deficits in verbal declarative memory, and that these effects are not related to the nonspecific effects of childhood abuse... - Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle studyChristian Grillon
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
Biol Psychiatry 69:549-55. 2011..The current study examines these effects, as instantiated with short- and long-duration threats... - Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorderChristian Grillon
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
Biol Psychiatry 66:47-53. 2009..This study tested the hypothesis that elevated anxious reactivity, specifically for unpredictable aversive events, is a psychophysiological correlate of PTSD... - Effects of yohimbine and hydrocortisone on panic symptoms, autonomic responses, and attention to threat in healthy adultsRoma A Vasa
Department of Psychiatry, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21211, USA
Psychopharmacology (Berl) 204:445-55. 2009..Few studies examine how these two neurochemical systems interact to influence anxiety and attention in humans... - Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatmentMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892-2670, USA
Biol Psychiatry 56:101-12. 2004..Treatment with antidepressants significantly improved memory and depression but did not alter hippocampal volume, suggesting that antidepressants may improve hippocampal function in the absence of detectable structural changes... - The psychobiology of depression and resilience to stress: implications for prevention and treatmentSteven M Southwick
Yale University School of Medicine, National Center for Post Traumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
Annu Rev Clin Psychol 1:255-91. 2005.... - The neuroendocrinology of posttraumatic stress disorder: new directionsAnn M Rasmusson
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
CNS Spectr 8:651-6, 665-7. 2003.... - Common regions of dorsal anterior cingulate and prefrontal-parietal cortices provide attentional control of distracters varying in emotionality and visibilityQian Luo
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 300C, MSC 2670, Bethesda, MD 20892 2670, USA
Neuroimage 38:631-9. 2007..Moreover, a conjunction analysis indicated considerable overlap in the regions of prefrontal, parietal cortex and anterior cingulate cortex responding to distracters of increased emotionality and visibility... - Assessment of the hypothalamic-pituitary-adrenal axis over a 24-hour diurnal period and in response to neuroendocrine challenges in women with and without childhood sexual abuse and posttraumatic stress disorderJ Douglas Bremner
Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia, USA
Biol Psychiatry 54:710-8. 2003.... - Sex differences in diencephalon serotonin transporter availability in major depressionJulie K Staley
Department of Psychiatry, Yale University School of Medicine and West Haven VA Connecticut Health Care System, CT 06516, USA
Biol Psychiatry 59:40-7. 2006..The present study evaluated if previous findings that demonstrated decreased 5-hydroxytryptamine (5-HT) transporter availability in depressed patients would be confirmed in a larger sample and also evaluated sex differences... - Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disordersKarina Blair
Mood and Anxiety Program, NIMH, NIH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
Am J Psychiatry 165:1193-202. 2008..Functional magnetic resonance imaging assessed the neural response to facial expressions in generalized social phobia and generalized anxiety disorder... - Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapyOmer Bonne
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
Neurosci Biobehav Rev 28:65-94. 2004..The implications of this model for the discovery of novel pharmacological approaches to the treatment of severe psychological distress are discussed... - Habenula volume in post-traumatic stress disorder measured with high-resolution MRIJonathan B Savitz
Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH, Bethesda, MD, USA
Biol Mood Anxiety Disord 1:7. 2011..abstract:.. - No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorderOmer Bonne
Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
Am J Psychiatry 162:383-5. 2005..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)... 
Sustained elevation of serum interleukin-6 and relative insensitivity to hydrocortisone differentiates posttraumatic stress disorder with and without depressionJessica Gill
National Institutes of Nursing Research, Bethesda, Maryland, USA
Biol Psychiatry 68:999-1006. 2010..However, IL-6 levels are not consistently elevated in either PTSD or MDD. Although PTSD is associated with supersensitivity to glucocorticoids; prior studies have not evaluated the effect of comorbid MDD...- Response options and expectations of reward in decision-making: the differential roles of dorsal and rostral anterior cingulate cortexAbigail A Marsh
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, MSC 2670, Bethesda, MD 20892, USA
Neuroimage 35:979-88. 2007..The current results suggest functional specificity with respect to the roles of dACC/dmFC and rACC/mPFC in decision-making... - The impact of affect and frequency on lexical decision: the role of the amygdala and inferior frontal cortexMarina Nakic
Unit on Affective Cognitive Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuroimage 31:1752-61. 2006.... - Regional brain metabolic correlates of alpha-methylparatyrosine-induced depressive symptoms: implications for the neural circuitry of depressionJ Douglas Bremner
Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
JAMA 289:3125-34. 2003.... - Choosing the lesser of two evils, the better of two goods: specifying the roles of ventromedial prefrontal cortex and dorsal anterior cingulate in object choiceKarina Blair
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 2670, USA
J Neurosci 26:11379-86. 2006..These data are interpreted with reference to models of ACd and vmPFC functioning... - Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy studyMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
Biol Psychiatry 54:744-50. 2003..Our results are consistent with prior magnetic resonance imaging, positron emission tomography, and postmortem reports of focal and lateralized abnormalities of the basal ganglia in MDD... - A selective neurokinin-1 receptor antagonist in chronic PTSD: a randomized, double-blind, placebo-controlled, proof-of-concept trialSanjay J Mathew
Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
Eur Neuropsychopharmacol 21:221-9. 2011..The selective NK(1)R antagonist GR205171 had fewer adverse effects but was not significantly superior to placebo in the short-term treatment of chronic PTSD. (ClinicalTrials.gov Identifier: NCT 00211861, NCT 00383786)... - Low cortisol, high DHEA, and high levels of stimulated TNF-alpha, and IL-6 in women with PTSDJessica Gill
National Institute of Nursing Research, National Institutes of Health, Bethesda, MD 20892 1506, USA
J Trauma Stress 21:530-9. 2008..These findings suggest dysregulated HPA axis and immune function in women with PTSD, and that comorbid depression may contribute to these abnormalities... - Concerns of Capitol Hill staff workers after bioterrorism: focus group discussions of authorities' responseCarol S North
School of Medicine, Department of Psychiatry, Washington University, St. Louis, Missouri 63110, USA
J Nerv Ment Dis 193:523-7. 2005..This suggests focus on risk communication in developing interventions, but more systematic investigation is needed... - Effects of dexamethasone on declarative memory function in posttraumatic stress disorderJ Douglas Bremner
Departments of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta 30306 GA, USA
Psychiatry Res 129:1-10. 2004.... - Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuseJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia 30306, USA
Biol Psychiatry 53:879-89. 2003.... - Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorderEric Vermetten
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
Biol Psychiatry 54:693-702. 2003..6% increase in mean hippocampal volume. CONCLUSIONS: These findings suggest that long-term treatment with paroxetine is associated with improvement of verbal declarative memory deficits and an increase in hippocampal volume in PTSD... - Neural correlates of the classic color and emotional stroop in women with abuse-related posttraumatic stress disorderJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
Biol Psychiatry 55:612-20. 2004..CONCLUSIONS: These findings add further evidence for dysfunction of a network of brain regions, including anterior cingulate and visual and parietal cortex, in abuse-related PTSD... - Effects of glucocorticoids on declarative memory function in major depressionJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 126 Briarcliff Road, Atlanta, GA 30306, USA
Biol Psychiatry 55:811-5. 2004.... - Reduced posterior hippocampal volume in posttraumatic stress disorderOmer Bonne
Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
J Clin Psychiatry 69:1087-91. 2008..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure... - Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depressionJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, and Atlanta VA Medical Center, Decatur, GA, USA
Am J Psychiatry 161:637-45. 2004..The purpose of the present study was to assess hippocampal and prefrontal functioning during performance of a verbal declarative memory task in subjects with midlife major depression... - Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorderJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
Psychol Med 35:791-806. 2005..No studies have examined neural correlates of fear conditioning and extinction in patients with post-traumatic stress disorder (PTSD)... - Alterations in stress reactivity after long-term treatment with paroxetine in women with posttraumatic stress disorderEric Vermetten
Rudolf Magnus Institute of Neurosciences, Department Psychiatry, University Medical Center, Int mailbox B01206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Ann N Y Acad Sci 1071:184-202. 2006..These results suggest that successful treatment with SSRI in chronic PTSD is associated with a trend for a decrease in baseline diurnal cortisol and with reduced cortisol reactivity to stress... - Effects of antidepressant treatment on neural correlates of emotional and neutral declarative verbal memory in depressionJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States
J Affect Disord 101:99-111. 2007..The purpose of this study was to examine the effects of treatment with antidepressants on verbal declarative memory in patients with depression... - Reduced volume of orbitofrontal cortex in major depressionJ Douglas Bremner
Atlanta VA Medical Center, Decatur, Georgia, USA
Biol Psychiatry 51:273-9. 2002..The findings were significant after statistically controlling for brain size. CONCLUSIONS: These findings are consistent with smaller orbitofrontal cortical volume in depression... - MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorderJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory Clinical Neuroscience Research Unit, Emory University School of Medicine, 1256 Briarcliff Road, Atlanta, GA 30306, USA
Am J Psychiatry 160:924-32. 2003..The purpose of this study was to measure both hippocampal structure and function in women with and without early childhood sexual abuse and the diagnosis of posttraumatic stress disorder (PTSD)...