Meena Vythilingam

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Neural response to self- and other referential praise and criticism in generalized social phobia
    Karina Blair
    Mood and Anxiety Program, National Institute of Mental Health, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 65:1176-84. 2008
  2. ncbi request reprint Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, MAP, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
    Psychiatry Res 139:89-99. 2005
  3. ncbi request reprint Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorder
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Neuropsychopharmacology 31:182-8. 2006
  4. ncbi request reprint Psychotic depression and mortality
    Meena Vythilingam
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 160:574-6. 2003
  5. pmc Reward circuitry in resilience to severe trauma: an fMRI investigation of resilient special forces soldiers
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD, 20892, USA
    Psychiatry Res 172:75-7. 2009
  6. pmc Childhood trauma associated with smaller hippocampal volume in women with major depression
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 159:2072-80. 2002
  7. ncbi request reprint Capitol hill staff workers' experiences of bioterrorism: qualitative findings from focus groups
    Carol S North
    Department of Psychiatry, School of Medicine, Washington University, St Louis, Missouri, USA
    J Trauma Stress 18:79-88. 2005
  8. pmc Association between level of emotional intelligence and severity of anxiety in generalized social phobia
    Madeline Jacobs
    Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD, United States
    J Anxiety Disord 22:1487-95. 2008
  9. ncbi request reprint Deficits in verbal declarative memory function in women with childhood sexual abuse-related posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
    J Nerv Ment Dis 192:643-9. 2004
  10. pmc Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle study
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 69:549-55. 2011

Detail Information

Publications43

  1. pmc Neural response to self- and other referential praise and criticism in generalized social phobia
    Karina Blair
    Mood and Anxiety Program, National Institute of Mental Health, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 65:1176-84. 2008
    ..However, studies have not examined the neural response in GSP to another equally important class of social stimuli, the communication of praise or criticism...
  2. ncbi request reprint Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, MAP, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
    Psychiatry Res 139:89-99. 2005
    ....
  3. ncbi request reprint Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorder
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Neuropsychopharmacology 31:182-8. 2006
    ..Patients with PTSD had increased glucocorticoid sensitivity in the focal brain regions mediating trace eyeblink conditioning...
  4. ncbi request reprint Psychotic depression and mortality
    Meena Vythilingam
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 160:574-6. 2003
    ..The authors hypothesized that patients with psychotic depression would have higher mortality rates than patients with nonpsychotic depression...
  5. pmc Reward circuitry in resilience to severe trauma: an fMRI investigation of resilient special forces soldiers
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD, 20892, USA
    Psychiatry Res 172:75-7. 2009
    ..Findings in this group of resilient individuals revealed unique patterns of activation during expectation of reward in the subgenual prefrontal cortex and nucleus accumbens area, regions pivotal to reward processes...
  6. pmc Childhood trauma associated with smaller hippocampal volume in women with major depression
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 159:2072-80. 2002
    ..In this study, the volumes of the hippocampus and of control brain regions were measured in depressed women with and without childhood abuse and in healthy nonabused comparison subjects...
  7. ncbi request reprint Capitol hill staff workers' experiences of bioterrorism: qualitative findings from focus groups
    Carol S North
    Department of Psychiatry, School of Medicine, Washington University, St Louis, Missouri, USA
    J Trauma Stress 18:79-88. 2005
    ..Nonadherence to antibiotic prophylaxis is of immediate concern for response to future bioterrorist events as well as infectious disease epidemics. Other topics that warrant attention are social support and mental health interventions...
  8. pmc Association between level of emotional intelligence and severity of anxiety in generalized social phobia
    Madeline Jacobs
    Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD, United States
    J Anxiety Disord 22:1487-95. 2008
    ..These results suggest that EI may index emotional processing systems that mitigate the impact of systems causally implicated in GSP...
  9. ncbi request reprint Deficits in verbal declarative memory function in women with childhood sexual abuse-related posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
    J Nerv Ment Dis 192:643-9. 2004
    ..These findings suggest that early abuse with PTSD is associated with deficits in verbal declarative memory, and that these effects are not related to the nonspecific effects of childhood abuse...
  10. pmc Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle study
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 69:549-55. 2011
    ..The current study examines these effects, as instantiated with short- and long-duration threats...
  11. pmc Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 66:47-53. 2009
    ..This study tested the hypothesis that elevated anxious reactivity, specifically for unpredictable aversive events, is a psychophysiological correlate of PTSD...
  12. pmc Effects of yohimbine and hydrocortisone on panic symptoms, autonomic responses, and attention to threat in healthy adults
    Roma A Vasa
    Department of Psychiatry, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21211, USA
    Psychopharmacology (Berl) 204:445-55. 2009
    ..Few studies examine how these two neurochemical systems interact to influence anxiety and attention in humans...
  13. ncbi request reprint Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 56:101-12. 2004
    ..However, the relationships between depression, hippocampal structure and function, and cortisol levels are unclear and the effects of antidepressant treatment on the measures are not well studied...
  14. ncbi request reprint The psychobiology of depression and resilience to stress: implications for prevention and treatment
    Steven M Southwick
    Yale University School of Medicine, National Center for Post Traumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Annu Rev Clin Psychol 1:255-91. 2005
    ....
  15. ncbi request reprint The neuroendocrinology of posttraumatic stress disorder: new directions
    Ann M Rasmusson
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    CNS Spectr 8:651-6, 665-7. 2003
    ....
  16. pmc Common regions of dorsal anterior cingulate and prefrontal-parietal cortices provide attentional control of distracters varying in emotionality and visibility
    Qian Luo
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 300C, MSC 2670, Bethesda, MD 20892 2670, USA
    Neuroimage 38:631-9. 2007
    ..Moreover, a conjunction analysis indicated considerable overlap in the regions of prefrontal, parietal cortex and anterior cingulate cortex responding to distracters of increased emotionality and visibility...
  17. ncbi request reprint Assessment of the hypothalamic-pituitary-adrenal axis over a 24-hour diurnal period and in response to neuroendocrine challenges in women with and without childhood sexual abuse and posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 54:710-8. 2003
    ..We performed a comprehensive assessment of the HPA axis in women with and without a history of early childhood sexual abuse and posttraumatic stress disorder (PTSD)...
  18. ncbi request reprint Sex differences in diencephalon serotonin transporter availability in major depression
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine and West Haven VA Connecticut Health Care System, CT 06516, USA
    Biol Psychiatry 59:40-7. 2006
    ..The present study evaluated if previous findings that demonstrated decreased 5-hydroxytryptamine (5-HT) transporter availability in depressed patients would be confirmed in a larger sample and also evaluated sex differences...
  19. pmc Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders
    Karina Blair
    Mood and Anxiety Program, NIMH, NIH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 165:1193-202. 2008
    ..Functional magnetic resonance imaging assessed the neural response to facial expressions in generalized social phobia and generalized anxiety disorder...
  20. ncbi request reprint Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy
    Omer Bonne
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
    Neurosci Biobehav Rev 28:65-94. 2004
    ..The implications of this model for the discovery of novel pharmacological approaches to the treatment of severe psychological distress are discussed...
  21. pmc Habenula volume in post-traumatic stress disorder measured with high-resolution MRI
    Jonathan B Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH, Bethesda, MD, USA
    Biol Mood Anxiety Disord 1:7. 2011
    ..abstract:..
  22. ncbi request reprint No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
    Omer Bonne
    Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 162:383-5. 2005
    ..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)...
  23. doi request reprint Sustained elevation of serum interleukin-6 and relative insensitivity to hydrocortisone differentiates posttraumatic stress disorder with and without depression
    Jessica Gill
    National Institutes of Nursing Research, Bethesda, Maryland, USA
    Biol Psychiatry 68:999-1006. 2010
    ..However, IL-6 levels are not consistently elevated in either PTSD or MDD. Although PTSD is associated with supersensitivity to glucocorticoids; prior studies have not evaluated the effect of comorbid MDD...
  24. pmc Response options and expectations of reward in decision-making: the differential roles of dorsal and rostral anterior cingulate cortex
    Abigail A Marsh
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, MSC 2670, Bethesda, MD 20892, USA
    Neuroimage 35:979-88. 2007
    ..The current results suggest functional specificity with respect to the roles of dACC/dmFC and rACC/mPFC in decision-making...
  25. ncbi request reprint The impact of affect and frequency on lexical decision: the role of the amygdala and inferior frontal cortex
    Marina Nakic
    Unit on Affective Cognitive Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuroimage 31:1752-61. 2006
    ....
  26. pmc Regional brain metabolic correlates of alpha-methylparatyrosine-induced depressive symptoms: implications for the neural circuitry of depression
    J Douglas Bremner
    Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    JAMA 289:3125-34. 2003
    ....
  27. ncbi request reprint Choosing the lesser of two evils, the better of two goods: specifying the roles of ventromedial prefrontal cortex and dorsal anterior cingulate in object choice
    Karina Blair
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 2670, USA
    J Neurosci 26:11379-86. 2006
    ..These data are interpreted with reference to models of ACd and vmPFC functioning...
  28. ncbi request reprint Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
    Biol Psychiatry 54:744-50. 2003
    ..Using automated multivoxel two-dimensional CSI (1)H-MRS techniques, we tested the hypothesis that patients with MDD have focal neuronal and membrane abnormalities localized in the subcortical region...
  29. pmc A selective neurokinin-1 receptor antagonist in chronic PTSD: a randomized, double-blind, placebo-controlled, proof-of-concept trial
    Sanjay J Mathew
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Eur Neuropsychopharmacol 21:221-9. 2011
    ..The selective NK(1)R antagonist GR205171 had fewer adverse effects but was not significantly superior to placebo in the short-term treatment of chronic PTSD. (ClinicalTrials.gov Identifier: NCT 00211861, NCT 00383786)...
  30. pmc Low cortisol, high DHEA, and high levels of stimulated TNF-alpha, and IL-6 in women with PTSD
    Jessica Gill
    National Institute of Nursing Research, National Institutes of Health, Bethesda, MD 20892 1506, USA
    J Trauma Stress 21:530-9. 2008
    ..These findings suggest dysregulated HPA axis and immune function in women with PTSD, and that comorbid depression may contribute to these abnormalities...
  31. ncbi request reprint Concerns of Capitol Hill staff workers after bioterrorism: focus group discussions of authorities' response
    Carol S North
    School of Medicine, Department of Psychiatry, Washington University, St Louis, Missouri 63110, USA
    J Nerv Ment Dis 193:523-7. 2005
    ..This suggests focus on risk communication in developing interventions, but more systematic investigation is needed...
  32. ncbi request reprint Effects of dexamethasone on declarative memory function in posttraumatic stress disorder
    J Douglas Bremner
    Departments of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta 30306 GA, USA
    Psychiatry Res 129:1-10. 2004
    ....
  33. ncbi request reprint Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia 30306, USA
    Biol Psychiatry 53:879-89. 2003
    ..The purpose of this study was to assess neural correlates of emotionally valenced declarative memory in women with early childhood sexual abuse and PTSD...
  34. pmc Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder
    Eric Vermetten
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 54:693-702. 2003
    ..This study assessed the effects of long-term treatment with paroxetine on hippocampal volume and declarative memory performance in PTSD...
  35. ncbi request reprint Neural correlates of the classic color and emotional stroop in women with abuse-related posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 55:612-20. 2004
    ..Dysfunction of the anterior cingulate/medial prefrontal cortex has been implicated in posttraumatic stress disorder (PTSD). The purpose of this study was to use the Stroop task as a probe of anterior cingulate function in PTSD...
  36. ncbi request reprint Effects of glucocorticoids on declarative memory function in major depression
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 126 Briarcliff Road, Atlanta, GA 30306, USA
    Biol Psychiatry 55:811-5. 2004
    ..The purpose of this study was to assess the effects of the glucocorticoid, dexamethasone, on verbal declarative memory function in patients with untreated unipolar major depressive disorder (MDD)...
  37. pmc Reduced posterior hippocampal volume in posttraumatic stress disorder
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Psychiatry 69:1087-91. 2008
    ..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure...
  38. ncbi request reprint Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depression
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, and Atlanta VA Medical Center, Decatur, GA, USA
    Am J Psychiatry 161:637-45. 2004
    ..The purpose of the present study was to assess hippocampal and prefrontal functioning during performance of a verbal declarative memory task in subjects with midlife major depression...
  39. pmc Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    Psychol Med 35:791-806. 2005
    ..No studies have examined neural correlates of fear conditioning and extinction in patients with post-traumatic stress disorder (PTSD)...
  40. pmc Alterations in stress reactivity after long-term treatment with paroxetine in women with posttraumatic stress disorder
    Eric Vermetten
    Rudolf Magnus Institute of Neurosciences, Department Psychiatry, University Medical Center, Int mailbox B01206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Ann N Y Acad Sci 1071:184-202. 2006
    ..These results suggest that successful treatment with SSRI in chronic PTSD is associated with a trend for a decrease in baseline diurnal cortisol and with reduced cortisol reactivity to stress...
  41. pmc Effects of antidepressant treatment on neural correlates of emotional and neutral declarative verbal memory in depression
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States
    J Affect Disord 101:99-111. 2007
    ..The purpose of this study was to examine the effects of treatment with antidepressants on verbal declarative memory in patients with depression...
  42. ncbi request reprint Reduced volume of orbitofrontal cortex in major depression
    J Douglas Bremner
    Atlanta VA Medical Center, Decatur, Georgia, USA
    Biol Psychiatry 51:273-9. 2002
    ..The purpose of this study was to measure volume of orbitofrontal cortex and other frontal cortical subregions in patients with major depression...
  43. ncbi request reprint MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Clinical Neuroscience Research Unit, Emory University School of Medicine, 1256 Briarcliff Road, Atlanta, GA 30306, USA
    Am J Psychiatry 160:924-32. 2003
    ..The purpose of this study was to measure both hippocampal structure and function in women with and without early childhood sexual abuse and the diagnosis of posttraumatic stress disorder (PTSD)...