Research Topics
Species | R ViscontiSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activityR Visconti
Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
Blood 96:1844-52. 2000..Blood. 2000;96:1844-1852)..
The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokinesM Gadina
Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 275:26959-66. 2000..Therefore, up-regulation and activation of Gab2 may be important in linking the IL-2 receptor to activation of MAPK and may be an important means of achieving specificity in cytokine signaling...
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulationR A Ortmann
Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Arthritis Res 2:16-32. 2000..It is hoped that further elucidation of cytokine signaling through these pathways will not only allow for a better comprehension of the etiopathogenesis of rheumatologic illnesses, but may also direct future treatment options...
Jaks and stats as therapeutic targetsJ J O'Shea
National Institutes of Health, Bethesda, MD 20892 1820, USA
Ann Rheum Dis 59:i115-8. 2000..The possibility that these molecules could be targeted to produce novel immunosuppressive compounds is considered in this review...
Ret-mediated mitogenesis requires Src kinase activityR M Melillo
Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita di Napoli Federico II, Naples, Italy
Cancer Res 59:1120-6. 1999..These experiments demonstrate that activated Ret is able to bind and stimulate c-Src kinase and that Src activation is essential for the mitogenic activity of Ret...
Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2BD Salvatore
Centro di Endocrinologia ed Oncologia Sperimentale del CNR, , Italy
Cancer Res 61:1426-31. 2001..The more efficient triggering of these pathways may account for the difference between MEN2A and MEN2B syndromes...
The RFG oligomerization domain mediates kinase activation and re-localization of the RET/PTC3 oncoprotein to the plasma membraneC Monaco
Centro di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, , , Via S. Pansini 5, 80131 Naples, Italy
Oncogene 20:599-608. 2001....
