Charles Vinson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint SREBP-1 dimerization specificity maps to both the helix-loop-helix and leucine zipper domains: use of a dominant negative
    Vikas Rishi
    Laboratory of Metabolism, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:11863-74. 2004
  2. ncbi request reprint Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha
    Connie Cheung
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 64:3849-54. 2004
  3. ncbi request reprint A rationally designed small molecule that inhibits the HIF-1alpha-ARNT heterodimer from binding to DNA in vivo
    Charles Vinson
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci STKE 2005:pe23. 2005
  4. pmc Combinatorial recruitment of CREB, C/EBPβ and c-Jun determines activation of promoters upon keratinocyte differentiation
    Julian M Rozenberg
    Department of Pathology and Lab Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e78179. 2013
  5. pmc Classification of human B-ZIP proteins based on dimerization properties
    Charles Vinson
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:6321-35. 2002
  6. ncbi request reprint Deciphering B-ZIP transcription factor interactions in vitro and in vivo
    Charles Vinson
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1759:4-12. 2006
  7. pmc CpG methylation of half-CRE sequences creates C/EBPalpha binding sites that activate some tissue-specific genes
    Vikas Rishi
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:20311-6. 2010
  8. doi request reprint Inhibition of CREB function in mouse epidermis reduces papilloma formation
    Julian Rozenberg
    Laboratory of Metabolism, National Cancer Institute, NIH, 37 Convent Drive, Room 2D24, Bethesda, MD 20892, USA
    Mol Cancer Res 7:654-64. 2009
  9. pmc Contribution of nucleosome binding preferences and co-occurring DNA sequences to transcription factor binding
    Ximiao He
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Genomics 14:428. 2013
  10. pmc P6981, an arylstibonic acid, is a novel low nanomolar inhibitor of cAMP response element-binding protein binding to DNA
    Jianfei Zhao
    Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Pharmacol 82:814-23. 2012

Detail Information

Publications84

  1. ncbi request reprint SREBP-1 dimerization specificity maps to both the helix-loop-helix and leucine zipper domains: use of a dominant negative
    Vikas Rishi
    Laboratory of Metabolism, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:11863-74. 2004
    ..Transient co-transfection studies demonstrate that A-SREBP-1 can inhibit the transactivation of SREBP-1 and SREBP-2 but not USF. A-SREBP-1 may be useful in metabolic diseases where SREBP family members are overexpressed...
  2. ncbi request reprint Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha
    Connie Cheung
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 64:3849-54. 2004
    ..The PPARalpha-humanized mice should serve as models for use in drug development and human risk assessment and to determine the mechanism of hepatocarcinogenesis of peroxisome proliferators...
  3. ncbi request reprint A rationally designed small molecule that inhibits the HIF-1alpha-ARNT heterodimer from binding to DNA in vivo
    Charles Vinson
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci STKE 2005:pe23. 2005
    ..To specifically disrupt transcriptional activation, they used a rationally designed small molecule that binds specifically in the minor groove of a DNA sequence that in vivo is bound by a bHLH heterodimer transcription factor...
  4. pmc Combinatorial recruitment of CREB, C/EBPβ and c-Jun determines activation of promoters upon keratinocyte differentiation
    Julian M Rozenberg
    Department of Pathology and Lab Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e78179. 2013
    ..We questioned if specific combinations of CREB, C/EBPβ and c-Jun bound to promoters correlate with RNA polymerase II binding, mRNA transcript levels and methylation of promoters in proliferating and differentiating keratinocytes...
  5. pmc Classification of human B-ZIP proteins based on dimerization properties
    Charles Vinson
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:6321-35. 2002
  6. ncbi request reprint Deciphering B-ZIP transcription factor interactions in vitro and in vivo
    Charles Vinson
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1759:4-12. 2006
    ..This review will focus on the dimerization specificity of coiled-coil proteins, particularly the human B-ZIP transcription family that consists of 53 proteins that use the leucine zipper coiled-coil as a dimerization motif...
  7. pmc CpG methylation of half-CRE sequences creates C/EBPalpha binding sites that activate some tissue-specific genes
    Vikas Rishi
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:20311-6. 2010
    ..These data identify a new function for methyl CpGs: producing DNA binding sites at half-CRE and half-C/EBP sequences for C/EBPα that are needed to activate tissue-specific genes...
  8. doi request reprint Inhibition of CREB function in mouse epidermis reduces papilloma formation
    Julian Rozenberg
    Laboratory of Metabolism, National Cancer Institute, NIH, 37 Convent Drive, Room 2D24, Bethesda, MD 20892, USA
    Mol Cancer Res 7:654-64. 2009
    ..These results suggest that inhibiting CREB function is a valuable cancer prevention strategy...
  9. pmc Contribution of nucleosome binding preferences and co-occurring DNA sequences to transcription factor binding
    Ximiao He
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Genomics 14:428. 2013
    ..Recent studies in vertebrates show that many TFs preferentially bind to genomic regions that are well bound by nucleosomes in vitro. Co-occurring secondary motifs sometimes correlated with functional TFBS...
  10. pmc P6981, an arylstibonic acid, is a novel low nanomolar inhibitor of cAMP response element-binding protein binding to DNA
    Jianfei Zhao
    Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Pharmacol 82:814-23. 2012
    ..These experiments suggest that antimony containing arylstibonic acids are promising leads for suppression of DNA binding activities of B-ZIP and B-HLH-ZIP transcription factors...
  11. ncbi request reprint A heterodimerizing leucine zipper coiled coil system for examining the specificity of a position interactions: amino acids I, V, L, N, A, and K
    Asha Acharya
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 41:14122-31. 2002
    ....
  12. doi request reprint The arylstibonic acid compound NSC13746 disrupts B-ZIP binding to DNA in living cells
    Sarah L Heyerdahl
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Cell Biol 89:564-73. 2010
    ..These studies suggest that arylstibonic acid compounds or other small molecules capable of inhibiting B-ZIP DNA binding could be valuable anticancer agents...
  13. ncbi request reprint Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
    Oksana Gavrilova
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:34268-76. 2003
    ..Thus, liver PPAR gamma regulates triglyceride homeostasis, contributing to hepatic steatosis, but protecting other tissues from triglyceride accumulation and insulin resistance...
  14. ncbi request reprint Dominant-negative mutants of helix-loop-helix proteins: transcriptional inhibition
    Vikas Rishi
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bldg 37, Rm 2D24, Bethesda, Maryland 20892, USA
    Methods Enzymol 370:454-66. 2003
  15. pmc All and only CpG containing sequences are enriched in promoters abundantly bound by RNA polymerase II in multiple tissues
    Julian M Rozenberg
    Laboratory of Metabolism, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Genomics 9:67. 2008
    ..Although the promoters of these genes are known to contain CpG islands, the specific DNA sequences that are associated with high RNAP binding to housekeeping promoters has not been described...
  16. ncbi request reprint Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice. Role of triglyceride clearance
    Carlo Colombo
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:3992-9. 2003
    ..Thus, it is likely that increased triglyceride clearance in B6, as compared with FVB, mice contributes to the strain differences in insulin resistance and lipid metabolism...
  17. ncbi request reprint A high-throughput fluorescence-anisotropy screen that identifies small molecule inhibitors of the DNA binding of B-ZIP transcription factors
    Vikas Rishi
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Anal Biochem 340:259-71. 2005
    ..These experiments suggest that the DNA binding of B-ZIP transcription factors is a potential target for clinical intervention...
  18. ncbi request reprint Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional status
    Ana Anzulovich
    Unit on Temporal Gene Expression, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 47:2690-700. 2006
    ..This mechanism would permit a rapid adjustment in the sequence of key aspects of the absorptive and postabsorptive phases in the liver...
  19. pmc Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy
    Raghunath Chatterjee
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, Maryland 20892, USA
    J Mol Endocrinol 46:175-92. 2011
    ..These results demonstrate that the C/EBP family is essential for adipose tissue development during the early postnatal period, the regulation of glucose and lipid homeostasis in adults, and the suppression of the muscle lineage...
  20. pmc FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo
    Taketomo Kido
    Laboratory or Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 300:L441-52. 2011
    ....
  21. ncbi request reprint Activator protein-1 activity regulates epithelial tumor cell identity
    Michael J Gerdes
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA
    Cancer Res 66:7578-88. 2006
    ..Thus, AP-1 activity regulates tumor cell lineage and is essential to maintain the squamous tumor cell identity...
  22. pmc B-ZIP proteins encoded by the Drosophila genome: evaluation of potential dimerization partners
    Jan Fassler
    Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20814, USA
    Genome Res 12:1190-200. 2002
    ..Thus, we propose that the presence of polar amino acids in novel positions of the 'a' position of Drosophila B-ZIP proteins has led to leucine zippers that homodimerize rather than heterodimerize...
  23. ncbi request reprint Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation
    Nomeli P Nunez
    Laboratories of Biosystems and Cancer, Metabolism, Human Carcinogenesis and Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:5469-76. 2006
    ..We postulate that insulin resistance and inflammation are responsible for the positive correlation with cancer observed in A-ZIP/F-1 mice...
  24. ncbi request reprint Experimental identification of homodimerizing B-ZIP families in Homo sapiens
    Asha Acharya
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bldg 37, Rm 3128, Bethesda, MD 20892, USA
    J Struct Biol 155:130-9. 2006
    ..These A-ZIP reagents may be of value in biological systems to inhibit the DNA binding and transcriptional potential of specific B-ZIP families...
  25. pmc Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPα and CREB proteins
    Raghunath Chatterjee
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    G3 (Bethesda) 2:1243-56. 2012
    ....
  26. ncbi request reprint Inhibition of CCAAT/enhancer binding protein family DNA binding in mouse epidermis prevents and regresses papillomas
    Won Jun Oh
    Laboratory of Metabolism, National Cancer Institute, Center for Cancer Research NIH, Bethesda, MD 20892, USA
    Cancer Res 67:1867-76. 2007
    ..These results implicate DNA binding of C/EBP family members as a potential molecular therapeutic target...
  27. pmc C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements
    Lars Grøntved
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    EMBO J 32:1568-83. 2013
    ..We suggest that selective targeting of GR in other tissues is likely mediated by the combined action of cell-specific priming proteins and chromatin remodellers...
  28. ncbi request reprint Stability of 100 homo and heterotypic coiled-coil a-a' pairs for ten amino acids (A, L, I, V, N, K, S, T, E, and R)
    Asha Acharya
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 45:11324-32. 2006
    ..In contrast, the a-a' pairs containing charged amino acids (K, R, and E) show the least range in coupling energies and promiscuously encourage heterodimerization...
  29. ncbi request reprint Histological and proteomic analysis of reversible H-RasV12G expression in transgenic mouse skin
    Won Jun Oh
    Laboratory of Metabolism, National Cancer Institute, Centre for Cancer Research, National Institutes of Health, Building 37, Room 3128, Bethesda, MD 20892, USA
    Carcinogenesis 28:2244-52. 2007
    ..These results from skin and primary keratinocytes are organized to reflect the molecular events that cause the histological changes observed. These proteomic changes identify markers that may mediate the oncogenic addiction paradigm...
  30. doi request reprint 12 Arylstibonic acids that inhibit the DNA binding of five B-ZIP dimers
    Vikas Rishi
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, MD 20892, USA
    J Struct Biol 170:216-25. 2010
    ..These experiments suggest that arylstibonic acids are promising leads for inhibiting the DNA binding of a group of B-ZIP proteins in cells...
  31. pmc CpG methylation recruits sequence specific transcription factors essential for tissue specific gene expression
    Raghunath Chatterjee
    Laboratory of Metabolism, NCI, NIH, USA
    Biochim Biophys Acta 1819:763-70. 2012
    ..We also discuss how aberrant CG methylation can lead to cancer. This article is part of a Special Issue entitled: Chromatin in time and space...
  32. pmc CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression
    Takeshi Tomita
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 283:25617-27. 2008
    ....
  33. pmc CG methylation
    Charles Vinson
    Laboratory of Metabolism, NCI, NIH, Bethesda, MD 20892, USA
    Epigenomics 4:655-63. 2012
    ..In this review, our growing understanding of the consequences of CG methylation will be surveyed...
  34. pmc Direct measurement of association and dissociation rates of DNA binding in live cells by fluorescence correlation spectroscopy
    Ariel Michelman-Ribeiro
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Biophys J 97:337-46. 2009
    ..In sum, we provide a straightforward approach to directly measure binding rates from FCS data...
  35. pmc Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse
    Shioko Kimura
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cancer 11:90. 2012
    ..Since multiple C/EBPs are expressed in lung, the combinatorial expression of these C/EBPs on lung carcinogenesis is not known...
  36. pmc Comparative genomics of Drosophila and human core promoters
    Peter C FitzGerald
    Genome Analysis Unit, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genome Biol 7:R53. 2006
    ..We compare these results with those obtained for human promoters...
  37. doi request reprint Ubiquitin tagged dominant negative induces degradation of B-ZIP proteins
    Eric Rios-Doria
    Building 37, Room 3128, Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 424:624-8. 2012
    ..These ubiquitin tagged A-ZIP dominant negatives may be more active in vivo because their endogenous heterodimerization partners are degraded more efficiently. This may be a general strategy to identify protein interaction partners...
  38. pmc Capacity for resolution of Ras-MAPK-initiated early pathogenic myocardial hypertrophy modeled in mice
    Bih Rong Wei
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Comp Med 61:109-18. 2011
    ..The model we present provides a means to further explore the underlying mechanisms governing cell-cycle capacity in cardiomyocytes, as well as progression and regression of pathogenic cardiomyocyte hypertrophy...
  39. ncbi request reprint Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways
    Christophe Cataisson
    Laboratories of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    J Immunol 171:2703-13. 2003
    ....
  40. pmc Magnesium is required for specific DNA binding of the CREB B-ZIP domain
    Jonathan R Moll
    Building 37, Room 4D06, Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 30:1240-6. 2002
    ....
  41. ncbi request reprint Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy
    Carlo Colombo
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 51:2727-33. 2002
    ..Taken together, these results suggest that sequestration of triglycerides into fat may not be enough to restore a nondiabetic phenotype and that leptin deficiency plays a major role in causing the metabolic complications of lipoatrophy...
  42. ncbi request reprint A calcium-initiated signaling pathway propagated through calcineurin and cAMP response element-binding protein activates proenkephalin gene transcription after depolarization
    Sung Ho Hahm
    Building 36, Room 2A 11, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892
    Mol Pharmacol 64:1503-11. 2003
    ....
  43. ncbi request reprint A search for candidate genes for lipodystrophy, obesity and diabetes via gene expression analysis of A-ZIP/F-1 mice
    Alain A Mir
    Laboratory of Metabolism, National Institutes of Health, Baltimore, MD 21224, USA
    Genomics 81:378-90. 2003
    ..These genes include a cluster of 3 S100A genes on chromosome 1 and SLPI1 on chromosome 20...
  44. ncbi request reprint Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation
    Ben Zion Katz
    Craniofacial Developmental Biology and Regeneration Branch, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Biochim Biophys Acta 1592:141-52. 2002
    ..This study identifies a proximity mechanism for regulating the initiation of FAK-mediated biochemical signaling...
  45. ncbi request reprint Adenoviral delivery of A-FOS, an AP-1 dominant negative, selectively inhibits drug resistance in two human cancer cell lines
    Maria Bonovich
    Laboratory of Metabolism, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Gene Ther 9:62-70. 2002
    ....
  46. pmc Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding
    Simon C Biddie
    Laboratory of Receptor Biology and Gene Expression, B602, Building 41, 41 Library Drive, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 43:145-55. 2011
    ..We propose a model in which the basal occupancy of transcription factors acts to prime chromatin and direct inducible transcription factors to select regions in the genome...
  47. doi request reprint Transcription factor binding sites and other features in human and Drosophila proximal promoters
    Charles Vinson
    Laboratory of Metabolism, NCI, NIH, Bethesda, MD, 20892, USA
    Subcell Biochem 52:205-22. 2011
    ..Thus, fundamental differences have arisen as promoters evolved in metazoans...
  48. ncbi request reprint Carboxylation of cytosine (5caC) in the CG dinucleotide in the E-box motif (CGCAG|GTG) increases binding of the Tcf3|Ascl1 helix-loop-helix heterodimer 10-fold
    Jaya Prakash Golla
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Room 3128, Building 37, Bethesda, MD 20892, United States
    Biochem Biophys Res Commun 449:248-55. 2014
    ..These results highlight a potential function of the oxidative products of 5mC, changing the DNA binding of sequence-specific transcription factors. ..
  49. ncbi request reprint Comparative validation of the D. melanogaster modENCODE transcriptome annotation
    Zhen Xia Chen
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 24:1209-23. 2014
    ..We report that the vast majority of elements in the annotation are evolutionarily conserved, indicating that the annotation will be an important springboard for functional genetic testing by the Drosophila community. ..
  50. pmc Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel
    Rui Gao
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    DNA Repair (Amst) 13:1-9. 2014
    ..It also reveals two TDP1 knockout lung cancer cell lines for further TDP1 functional analyses. ..
  51. pmc Clustering of DNA sequences in human promoters
    Peter C FitzGerald
    Genome Analysis Unit, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 14:1562-74. 2004
    ..g., ribosomal genes). In contrast, TATA is more abundant in the promoters of tissue-specific genes. This analysis identified eight DNA sequences in 5082 promoters that we suggest are important for regulating gene expression...
  52. pmc Predisposition to cancer caused by genetic and functional defects of mammalian Atad5
    Daphne W Bell
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 7:e1002245. 2011
    ..Taken together, our findings indicate that loss-of-function mutations in mammalian Atad5 are sufficient to cause genomic instability and tumorigenesis...
  53. ncbi request reprint WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice
    Chieh J Chou
    Diabetes Branch, NIDDK and the Metabolism Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:24484-9. 2002
    ....
  54. pmc The biology of tobacco and nicotine: bench to bedside
    Phillip A Dennis
    Cancer Therapeutics Branch, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20889, USA
    Cancer Epidemiol Biomarkers Prev 14:764-7. 2005
    ..Importantly, new opportunities to use molecular biology to identify and abrogate tobacco-mediated carcinogenesis and to identify high-risk individuals were recognized...
  55. ncbi request reprint Adipose tissue: a vital in vivo role in mammary gland development but not differentiation
    Christine Couldrey
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 29896, USA
    Dev Dyn 223:459-68. 2002
    ..The rudimentary epithelial anlage, however, contain mammary stem cells, which are fully capable of alveolar differentiation...
  56. ncbi request reprint The IGF2 receptor is a USF2-specific target in nontumorigenic mammary epithelial cells but not in breast cancer cells
    Marilyn N Szentirmay
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:37231-40. 2003
    ..IGF2R promoter-driven expression was USF-independent in both MCF-7 and MDA-MB-231 breast cancer cell lines, suggesting that a defect in USF function may contribute to down-regulation of IGF2R expression in cancer cells...
  57. ncbi request reprint Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons
    Wen G Chen
    Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:2572-81. 2003
    ..These results suggest a new function for the USFs in the regulation of activity-dependent transcription in neurons...
  58. ncbi request reprint Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein beta gene during adipogenesis
    Jiang Wen Zhang
    Department of Biological Chemistry and Biochemistry, Cellular and Molecular Biology Program, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 279:4471-8. 2004
    ..The low level of expression of C/EBPbeta and differentiation in CREB(-/-) MEFs appears to be due to up-regulation of other CREB protein family members, i.e. ATF1 and CREM...
  59. ncbi request reprint CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: involvement of NF-kappa B, AP-1, and C/EBP
    Mekhine Baccam
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 170:3099-108. 2003
    ..Furthermore, CD40 stimulation led to phosphorylation of c-Jun on its activation domain, implicating CD40-mediated Jun kinase activation in the transcriptional regulation of IL-6 production...
  60. ncbi request reprint Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase
    Inge Bauer
    Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, D 66421 Homburg, Germany
    Arch Biochem Biophys 438:36-52. 2005
    ..The fact that Egr-1 promoter/reporter gene transcription is upregulated by a constitutively active CREB mutant indicates that the CRE couples other signaling cascades via CREB to the Egr-1 gene...
  61. pmc Dimerization specificity of all 67 B-ZIP motifs in Arabidopsis thaliana: a comparison to Homo sapiens B-ZIP motifs
    Christopher D Deppmann
    Department of Neuroscience, Johns Hopkins Medical School, Baltimore, MD, USA
    Nucleic Acids Res 32:3435-45. 2004
    ..It appears that A.thaliana define many families of homodimerizing B-ZIP proteins by having long leucine zippers with asparagine judiciously placed in the a position of different heptads...
  62. pmc Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality
    Sheng Zhong Duan
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Clin Invest 117:812-22. 2007
    ..Surprisingly, genetic loss of PPARgamma function, like activation by agonists, lowered blood pressure, likely through a mechanism involving increased vascular relaxation...
  63. ncbi request reprint Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite
    Pengfei Gong
    Department of Molecular Genetics, Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Arch Biochem Biophys 405:265-74. 2002
    ..Together, these results implicate multiple basic-leucine zipper transcription factors in ho-1 gene activation by arsenite...
  64. ncbi request reprint Role of basic region leucine zipper transcription factors cyclic AMP response element binding protein (CREB), CREB2, activating transcription factor 2 and CAAT/enhancer binding protein alpha in cyclic AMP response element-mediated transcription
    Gerald Thiel
    Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Homburg, Germany
    J Neurochem 92:321-36. 2005
    ..Rather, CREB and ATF2 compete for binding to the CRE, and are independently able to up-regulate transcription of genes containing CRE motifs in their regulatory regions...
  65. ncbi request reprint Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors
    Jude Al Sarraj
    Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Homburg, Germany
    J Cell Biochem 96:1003-20. 2005
    ..Hence, enzymatic reactions that require tetrahydrobiopterin as cofactor are therefore indirectly controlled by signaling cascades involving the signal-responsive transcription factors CREB, c-Jun, and ATF2...
  66. pmc 5'UTR of the neurogenic bHLH Nex1/MATH-2/NeuroD6 gene is regulated by two distinct promoters through CRE and C/EBP binding sites
    Martine Uittenbogaard
    Department of Anatomy and Cell Biology, George Washington University Medical Center, Washington, DC, USA
    J Neurosci Res 85:1-18. 2007
    ..The fact that Nex1 is a target gene of C/EBPbeta provides new insight into the C/EBP transcriptional cascade known to promote neurogenesis, while repressing gliogenesis...
  67. ncbi request reprint BATF transgenic mice reveal a role for activator protein-1 in NKT cell development
    Kristi L Williams
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 170:2417-26. 2003
    ....
  68. ncbi request reprint Content and activity of cAMP response element-binding protein regulate platelet-derived growth factor receptor-alpha content in vascular smooth muscles
    Peter A Watson
    Denver Research Institute, Denver Veterans Affairs Medical Center, University of Colorado Health Sciences Center, 1055 Clermont Street, Denver, CO 80220, USA
    Endocrinology 143:2922-9. 2002
    ..Thus, both in vitro and in vivo loss of CREB content and activity and subsequent accumulation of PDGFRalpha may contribute to SMC activation during diabetes...
  69. ncbi request reprint Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP
    Jude Al Sarraj
    Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, D 66421 Homburg, Germany
    Biol Chem 386:873-9. 2005
    ..These data indicate that CHOP functions as a shut-off-device for nutrient deprivation-induced gene transcription...
  70. ncbi request reprint The obesity-cancer link: lessons learned from a fatless mouse
    Stephen D Hursting
    Division of Nutritional Sciences, University of Texas, Austin, Texas, USA
    Cancer Res 67:2391-3. 2007
    ..We postulate that the pathways associated with insulin resistance and inflammation, rather than adipocyte-derived factors, may represent key prevention and therapeutic targets for disrupting the obesity-cancer link...
  71. ncbi request reprint Up-regulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Ets-like protein-1 (Elk-1) and Egr-1
    Luisa Stefano
    Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Homburg, Germany
    J Neurochem 97:92-104. 2006
    ....
  72. ncbi request reprint Glucose-induced lipogenesis in pancreatic beta-cells is dependent on SREBP-1
    Maria B Sandberg
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense
    Mol Cell Endocrinol 240:94-106. 2005
    ..Thus, we demonstrate for the first time that SREBP activity is necessary for full glucose induction of de novo fatty acid synthesis in pancreatic beta-cells...
  73. pmc A combined yeast/bacteria two-hybrid system: development and evaluation
    Ilya G Serebriiskii
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Proteomics 4:819-26. 2005
    ..In addition, the modified expression vectors we describe in this report should be useful for any application requiring facile expression of a protein of interest in both yeast and bacteria...
  74. ncbi request reprint Interleukin-1beta and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor alpha in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases
    Inge Bauer
    Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, D 66421 Homburg, Germany
    J Cell Biochem 100:242-55. 2007
    ....
  75. pmc Math6 expression during kidney development and altered expression in a mouse model of glomerulosclerosis
    Michael D Ross
    Department of Medicine and Rammelkamp Center for Education and Research, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Dev Dyn 235:3102-9. 2006
    ..These studies suggest that Math6 may participate in kidney development and may be a permissive factor for podocyte differentiation...
  76. ncbi request reprint Susceptibility to induced and spontaneous carcinogenesis is increased in fatless A-ZIP/F-1 but not in obese ob/ob mice
    Vitaly Ablamunits
    New York Obesity Research Center, St Luke s Roosevelt Hospital Center, New York, New York 10025, USA
    Cancer Res 66:8897-902. 2006
    ..Our data suggest that, in contrast to a well-known correlation between obesity and cancer, the direct effect of adipose tissue may rather be protective...
  77. ncbi request reprint Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy
    Takayoshi Suganami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    FASEB J 19:127-9. 2005
    ..The model presented here will serve as a novel tool to analyze the molecular mechanism underlying not only the progression but also the regression of diabetic nephropathy...
  78. pmc AFos dissociates cardiac myocyte hypertrophy and expression of the pathological gene program
    Mark Y Jeong
    Cardiology Section, Denver Health Medical Center, Denver, Colo 80204, USA
    Circulation 111:1645-51. 2005
    ..Although induction of activator protein-1 (AP-1) transcription factor activity has been observed in cardiac hypertrophy, a direct role for AP-1 in myocardial growth and gene expression remains obscure...
  79. ncbi request reprint Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function
    Kumiko Takemori
    Department of Pathology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Hypertension 49:365-72. 2007
    ....
  80. ncbi request reprint Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways
    Dirk Motzkus
    IPF PharmaCeuticals GmbH, Hannover, Germany
    Chronobiol Int 24:783-92. 2007
    ..The present findings imply that CLOCK/BMAL1-mediated activation of hPER1 by AP1 and E-Box elements is distinct from peripheral transcriptional modulation via cAMP-induced CREB and C/EBP...
  81. ncbi request reprint Resistin is expressed in pancreatic islets
    Alexandra H Minn
    Endocrinology Section, Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    Biochem Biophys Res Commun 310:641-5. 2003
    ..Our results demonstrate that resistin is expressed in islets and up-regulated in insulin resistance and thereby shed new light on the role of resistin in mice and humans...
  82. ncbi request reprint An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis
    Catherine Ménard
    Centre for Neuronal Survival and Brain Tumor Research Centre, Montreal Neurological Institute, Montreal, Canada
    Neuron 36:597-610. 2002
    ..Thus, activation of a MEK-C/EBP pathway enhances neurogenesis and inhibits gliogenesis, thereby providing a mechanism whereby growth factors can selectively bias progenitors to become neurons during development...
  83. ncbi request reprint Role of the Fos family members, c-Fos, Fra-1 and Fra-2, in the regulation of cell motility
    Vadim Tkach
    Protein Laboratory, Institute of Molecular Pathology, School of Medicine, Copenhagen University, DK 2200 Copenhagen, Denmark
    Oncogene 22:5045-54. 2003
    ..Changes in cell motility correlated with the morphological appearance and the degree of contact with the substratum. We conclude that Fos proteins have distinct roles in the regulation of cell motility...
  84. ncbi request reprint Role of CCAAT/enhancer-binding protein, histone acetylation, and coactivator recruitment in the regulation of malic enzyme transcription by thyroid hormone
    Liya Yin
    Department of Biochemistry and Molecular Pharmacology, School of Medicine, P O Box 9142, West Virginia University, Morgantown, 26506 9142, USA
    Mol Cell Endocrinol 245:43-52. 2005
    ....