Research Topics
Genomes and GenesSpecies | Nancy VazquezSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Structural variants of IFNα preferentially promote antiviral functionsNancy Vazquez
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
Blood 118:2567-77. 2011..Defining IFN structure and function relative to APOBEC and other antiviral genes may enable design of novel IFN-related molecules preserving beneficial antiviral roles while minimizing negative effects...
Modulation of innate host factors by Mycobacterium avium complex in human macrophages includes interleukin 17Nancy Vazquez
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892 4352, USA
J Infect Dis 206:1206-17. 2012..Our study examines the ability of MAC to regulate interleukin 17 (IL-17), a proinflammatory cytokine involved in host cell recruitment...
Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulationNancy Vazquez
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Virol 79:4479-91. 2005..These data implicate p21 as a pivotal macrophage facilitator of the viral life cycle. Moreover, regulators of p21, such as CDDO, may provide an interventional approach to modulate HIV-1 replication...
Mycobacterium avium-induced SOCS contributes to resistance to IFN-gamma-mediated mycobactericidal activity in human macrophagesNancy Vazquez
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892 4352, USA
J Leukoc Biol 80:1136-44. 2006..Our data provide new insights into the manipulation of the host response by this opportunistic pathogen and the potential for modulating SOCS to influence the outcome of M. avium infection in immunocompromised hosts...
Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferonTeresa Greenwell-Wild
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
Blood 114:1864-74. 2009..In addition to macrophages, the IL-27-IFN-alpha connection is operative in CD4(+) T cells, consistent with an IFN-alpha-dependent pathway underlying host cell defense to HIV...
HIV accomplices and adversaries in macrophage infectionSharon M Wahl
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Rm 320, 30 Convent Dr, MSC 4352, Bethesda, MD 20892 4352, USA
J Leukoc Biol 80:973-83. 2006..These and other manipulatable pathways may give the macrophage a fighting chance in its battle against the virus...
Viral and host cofactors facilitate HIV-1 replication in macrophagesSharon M Wahl
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, MD 20892 4352, USA
J Leukoc Biol 74:726-35. 2003..Inroads into understanding how HIV-1 co-opts host factors to generate a permissive environment for viral replication and transmission to new viral hosts may provide opportunities for targeted interruption of this lethal process...
Regulation of the tonsil cytokine milieu favors HIV susceptibilityNiki M Moutsopoulos
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Dr, MSC 4352, Bethesda, MD 20892, USA
J Leukoc Biol 80:1145-55. 2006..These and other local environmental factors may render tonsil cells increasingly susceptible to HIV infection...
Mycobacterium avium infection and modulation of human macrophage gene expressionTeresa Greenwell-Wild
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 169:6286-97. 2002....
Regulatory T cells and transcription factors: gatekeepers in allergic inflammationSharon M Wahl
Building 30, Room 320, 30 Convent Drive, MSC 4352, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4352, USA
Curr Opin Immunol 16:768-74. 2004..Continued unraveling of the pathways underlying the development of deleterious immune responses and their control will guide new avenues of investigation and intervention...
