M P Vawter
Affiliation: National Institutes of Health
- Dysregulation of the neural cell adhesion molecule and neuropsychiatric disordersM P Vawter
National Institute on Drug Abuse IRP NIDA IRP, Addiction Research Center, Section on Development and Plasticity, Baltimore, MD 21224, USA
Eur J Pharmacol 405:385-95. 2000..Synapse stability and plasticity may be part of the molecular neuropathology of these disorders...
- Elevated concentration of N-CAM VASE isoforms in schizophreniaM P Vawter
Cellular Neurobiology Branch, NIDA IRP, Baltimore, MD 21224, USA
J Psychiatr Res 34:25-34. 2000..These results provide further evidence of an abnormality of N-CAM protein in chronic schizophrenia and suggest differences between schizophrenia and affective disorders in regulation of N-CAM...
- The use of microarrays to characterize neuropsychiatric disorders: postmortem studies of substance abuse and schizophreniaE Lehrmann
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
Curr Mol Med 3:437-46. 2003....
- Application of cDNA microarrays to examine gene expression differences in schizophreniaM P Vawter
Section on Plasticity and Development, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
Brain Res Bull 55:641-50. 2001..Identification of patterns of changes in gene expression may lead to a better understanding of the pathophysiology of schizophrenia disorders...
- Assembly and use of a broadly applicable neural cDNA microarrayT Barrett
Transgenic and Knockout Facility Section, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Restor Neurol Neurosci 18:127-35. 2001..This selected set of brain-relevant cDNAs should be widely useful in the analysis of gene expression patterns from brain tissues as well as neural cell lines...
- Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophreniaM P Vawter
Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Mol Psychiatry 7:571-8. 2002..Reductions in synapsin in both patients with schizophrenia (synapsin IIa and IIIa) and bipolar disorder (synapsin Ia, IIa and IIIa) imply that altered or reduced synaptic function in the hippocampus may be involved in these disorders...
- Gene expression profile in early stage of retinoic acid-induced differentiation of human SH-SY5Y neuroblastoma cellsM E Truckenmiller
Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Restor Neurol Neurosci 18:67-80. 2001..We employed a broad human 15K microarray (15,000 genes) and focused Neuroarray (1152 genes) to examine changes in gene expression early in the process of differentiation (6 hr), before morphology or growth changes are observed...
- Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuseE Lehrmann
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
Pharmacogenomics J 3:27-40. 2003..These data suggest that cocaine abuse targets a distinct subset of genes in the dlPFC, resulting in either a state of acute activation in which increased gene expression predominates, or a relatively destimulated, refractory phase...
- A murine dopamine neuron-specific cDNA library and microarray: increased COX1 expression during methamphetamine neurotoxicityT Barrett
Research Resources Branch, Laboratory of Genetics, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224-6825, USA
Neurobiol Dis 8:822-33. 2001..This is the first work to describe a gene expression profile for a neuronal subtype and to identify gene expression changes during methamphetamine neurotoxicity...
- Characterization of human cleaved N-CAM and association with schizophreniaM P Vawter
Development and Plasticity Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Exp Neurol 172:29-46. 2001..Alternatively, the increases in cN-CAM in schizophrenia may be a reflection of a more general abnormality in the regulation of proteolysis or of extracellular matrix stability...
- Region-specific transcriptional response to chronic nicotine in rat brain- Konu O
Department of Pharmacology, University of Tennessee College of Medicine, 874 Union Avenue, Memphis, TN 38163, USA
Brain Res 909:194-203. 2001..Finally, a number of genes, involved in MAPK, phosphatidylinositol, and EGFR signaling pathways, were identified and proposed as possible targets in response to nicotine administration...
- DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profilesS J Evans
Pritzker Consortium for Severe Psychiatric Disorders, San Francisco, CA, USA
Neurobiol Dis 14:240-50. 2003....
- Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disordersM P Vawter
Department of Psychiatry, University of California, Irvine, USA
Mol Psychiatry 11:615, 663-79. 2006..Genes with the least sensitivity to agonal-pH could present a starting point for candidate gene search in neuropsychiatric disorders...
- Dysregulation of the fibroblast growth factor system in major depressionS J Evans
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 101:15506-11. 2004..We also make available the gene-expression profile of all of the other growth factors and growth factor receptors detected in these postmortem samples...
- Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depressionP V Choudary
Center for Neuroscience and Department of Psychiatry and Behavioral Sciences, University of California Davis, 1544 Newton Court, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 102:15653-8. 2005..These findings point to previously undiscovered molecular underpinnings of the pathophysiology of major depression and offer potentially new pharmacological targets for treating depression...
- Coding SNPs included in exon arrays for the study of psychiatric disordersA Sequeira
Mol Psychiatry 13:363-5. 2008