D Bruce Vaupel

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography
    D Bruce Vaupel
    NIDA IRP, Neuroimaging Research Branch, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 312:355-65. 2005
  2. pmc Quantification of alpha4beta2* nicotinic receptors in the rat brain with microPET and 2-[18F]F-A-85380
    D Bruce Vaupel
    Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuroimage 34:1352-62. 2007
  3. ncbi request reprint NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluation
    Svetlana I Chefer
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    J Neurochem 104:306-15. 2008
  4. pmc Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380
    Alexey G Mukhin
    National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    J Nucl Med 49:1628-35. 2008
  5. pmc Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F]F-A85380
    Alane S Kimes
    Neuroimaging Research Branch, NIDA IRP NIH DHHS, Baltimore, MD 21224, USA
    Neuroimage 39:717-27. 2008
  6. pmc Acute nicotine-induced tachyphylaxis is differentially manifest in the limbic system
    Yantao Zuo
    Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
    Neuropsychopharmacology 36:2498-512. 2011
  7. ncbi request reprint Evaluation of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-methyl-2-(S)-pyrrolidinylmethoxy)pyridine and its analogues as PET radioligands for imaging nicotinic acetylcholine receptors
    LaVerne Brown
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Neurochem 91:600-12. 2004
  8. ncbi request reprint Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography
    Peter G Willis
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 48:5813-22. 2005
  9. doi request reprint fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration history
    Hanbing Lu
    Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuroimage 62:1857-66. 2012
  10. ncbi request reprint Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 0135, USA
    Eur J Nucl Med Mol Imaging 30:1620-9. 2003

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography
    D Bruce Vaupel
    NIDA IRP, Neuroimaging Research Branch, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 312:355-65. 2005
    ..v.) to elevate blood pressure and heart rate by 10% in humans and should elicit no clinically significant effects and have acceptable dosimetry...
  2. pmc Quantification of alpha4beta2* nicotinic receptors in the rat brain with microPET and 2-[18F]F-A-85380
    D Bruce Vaupel
    Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuroimage 34:1352-62. 2007
    ....
  3. ncbi request reprint NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluation
    Svetlana I Chefer
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    J Neurochem 104:306-15. 2008
    ..These results suggest that [(18)F]NIDA522131 is a promising positron emission tomography radioligand for studying extrathalamic nAChR in humans...
  4. pmc Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380
    Alexey G Mukhin
    National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    J Nucl Med 49:1628-35. 2008
    ..Quantitative PET imaging of nAChRs in humans has recently been reported using the alpha4beta2* subtype-specific radioligand 2-(18)F-FA-85380 (2FA)...
  5. pmc Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F]F-A85380
    Alane S Kimes
    Neuroimaging Research Branch, NIDA IRP NIH DHHS, Baltimore, MD 21224, USA
    Neuroimage 39:717-27. 2008
    ..The results of repeated PET studies with 2FA showed a high reproducibility of V(T) measurements. We conclude that B/I methodology will be useful for clinical and research studies of brain nAChRs...
  6. pmc Acute nicotine-induced tachyphylaxis is differentially manifest in the limbic system
    Yantao Zuo
    Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
    Neuropsychopharmacology 36:2498-512. 2011
    ..These data provide pharmacodynamic insight into the regional heterogeneity of nicotine tachyphylaxis development, which may be relevant to behavioral and neurobiological mechanisms associated with repeated tobacco consumption...
  7. ncbi request reprint Evaluation of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-methyl-2-(S)-pyrrolidinylmethoxy)pyridine and its analogues as PET radioligands for imaging nicotinic acetylcholine receptors
    LaVerne Brown
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Neurochem 91:600-12. 2004
    ..Taken together, these results suggest that [(11)C]Me-p-PVC is a promising PET radioligand for studying nAChR occupancy by endogenous and exogenous ligands in the brain in vivo...
  8. ncbi request reprint Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography
    Peter G Willis
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 48:5813-22. 2005
    ..A pretreatement study for the other enantiomer found no displaceable radioactivity in the same group of mice; this result suggested the enantiomer was inactive...
  9. doi request reprint fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration history
    Hanbing Lu
    Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuroimage 62:1857-66. 2012
    ....
  10. ncbi request reprint Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 0135, USA
    Eur J Nucl Med Mol Imaging 30:1620-9. 2003
    ..These results demonstrate the feasibility of quantifying high-affinity type nAChRs using [123I]5-I-A-85380 in humans and support the use of VT' measured by bolus studies...
  11. pmc When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor
    TSUNG PING SU
    Cellular Pathobiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Sci Signal 2:pe12. 2009
    ..Thus, it is possible that the psychedelic action of DMT might be mediated in part through sigma-1 receptors. Here, we present a hypothetical signaling scheme that might be triggered by the binding of DMT to sigma-1 receptors...
  12. ncbi request reprint 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans
    Alane S Kimes
    NIDA Intramural Research Program Baltimore, Maryland 21224, USA
    FASEB J 17:1331-3. 2003
    ..180 +/- 30 mSv/MBq or 0.7 rem/mCi with a 2.4 h void interval) suggests that multiple studies could be performed in a single subject. The results predict that quantitative PET imaging of nAChRs in human brain with 2-[18F]FA is feasible...
  13. pmc Temporary disruption of the rat blood-brain barrier with a monoclonal antibody: a novel method for dynamic manganese-enhanced MRI
    Hanbing Lu
    Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, 251 Bayview Blvd, Suite 200, Rm 7A711, Baltimore, MD 21224, USA
    Neuroimage 50:7-14. 2010
    ....
  14. ncbi request reprint Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects
    Masahiro Fujita
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, VA Connecticut 116A2, West Haven 06516, USA
    Eur J Nucl Med Mol Imaging 29:183-90. 2002
    ..These results suggest that [123I]5-I-A-85380 is a promising SPET agent to image alpha4beta2 nAChRs in humans, with acceptable dosimetry and high brain uptake...