D Bruce Vaupel
Affiliation: National Institutes of Health
- Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomographyD Bruce Vaupel
NIDA IRP, Neuroimaging Research Branch, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
J Pharmacol Exp Ther 312:355-65. 2005..v.) to elevate blood pressure and heart rate by 10% in humans and should elicit no clinically significant effects and have acceptable dosimetry...
- Quantification of alpha4beta2* nicotinic receptors in the rat brain with microPET and 2-[18F]F-A-85380D Bruce Vaupel
Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Neuroimage 34:1352-62. 2007....
- NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluationSvetlana I Chefer
Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Department of Health and Human Services, Baltimore, Maryland, USA
J Neurochem 104:306-15. 2008..These results suggest that [(18)F]NIDA522131 is a promising positron emission tomography radioligand for studying extrathalamic nAChR in humans...
- Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380Alexey G Mukhin
National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
J Nucl Med 49:1628-35. 2008..Quantitative PET imaging of nAChRs in humans has recently been reported using the alpha4beta2* subtype-specific radioligand 2-(18)F-FA-85380 (2FA)...
- Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F]F-A85380Alane S Kimes
Neuroimaging Research Branch, NIDA IRP NIH DHHS, Baltimore, MD 21224, USA
Neuroimage 39:717-27. 2008..The results of repeated PET studies with 2FA showed a high reproducibility of V(T) measurements. We conclude that B/I methodology will be useful for clinical and research studies of brain nAChRs...
- Acute nicotine-induced tachyphylaxis is differentially manifest in the limbic systemYantao Zuo
Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
Neuropsychopharmacology 36:2498-512. 2011..These data provide pharmacodynamic insight into the regional heterogeneity of nicotine tachyphylaxis development, which may be relevant to behavioral and neurobiological mechanisms associated with repeated tobacco consumption...
- Evaluation of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-methyl-2-(S)-pyrrolidinylmethoxy)pyridine and its analogues as PET radioligands for imaging nicotinic acetylcholine receptorsLaVerne Brown
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Neurochem 91:600-12. 2004..Taken together, these results suggest that [(11)C]Me-p-PVC is a promising PET radioligand for studying nAChR occupancy by endogenous and exogenous ligands in the brain in vivo...
- Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomographyPeter G Willis
Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
J Med Chem 48:5813-22. 2005..A pretreatement study for the other enantiomer found no displaceable radioactivity in the same group of mice; this result suggested the enantiomer was inactive...
- fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration historyHanbing Lu
Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Neuroimage 62:1857-66. 2012....
- Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPETMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 0135, USA
Eur J Nucl Med Mol Imaging 30:1620-9. 2003..These results demonstrate the feasibility of quantifying high-affinity type nAChRs using [123I]5-I-A-85380 in humans and support the use of VT' measured by bolus studies...
- When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptorTSUNG PING SU
Cellular Pathobiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Sci Signal 2:pe12. 2009..Thus, it is possible that the psychedelic action of DMT might be mediated in part through sigma-1 receptors. Here, we present a hypothetical signaling scheme that might be triggered by the binding of DMT to sigma-1 receptors...
- 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humansAlane S Kimes
NIDA Intramural Research Program Baltimore, Maryland 21224, USA
FASEB J 17:1331-3. 2003..180 +/- 30 mSv/MBq or 0.7 rem/mCi with a 2.4 h void interval) suggests that multiple studies could be performed in a single subject. The results predict that quantitative PET imaging of nAChRs in human brain with 2-[18F]FA is feasible...
- Temporary disruption of the rat blood-brain barrier with a monoclonal antibody: a novel method for dynamic manganese-enhanced MRIHanbing Lu
Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, 251 Bayview Blvd, Suite 200, Rm 7A711, Baltimore, MD 21224, USA
Neuroimage 50:7-14. 2010....
- Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjectsMasahiro Fujita
Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, VA Connecticut 116A2, West Haven 06516, USA
Eur J Nucl Med Mol Imaging 29:183-90. 2002..These results suggest that [123I]5-I-A-85380 is a promising SPET agent to image alpha4beta2 nAChRs in humans, with acceptable dosimetry and high brain uptake...