R S Vasan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Site 2, Framingham, MA 01702 5803, USA
    JAMA 289:1251-7. 2003
  2. ncbi request reprint Doppler transmitral flow indexes and risk of atrial fibrillation (the Framingham Heart Study)
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Am J Cardiol 91:1079-83. 2003
  3. ncbi request reprint Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Circulation 107:1486-91. 2003
  4. ncbi request reprint Relations of serum aldosterone to cardiac structure: gender-related differences in the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Bethesda, MD, USA
    Hypertension 43:957-62. 2004
  5. ncbi request reprint Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    JAMA 288:1252-9. 2002
  6. ncbi request reprint Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study, 5 Thurber St, Framingham, MA 01702, USA
    JAMA 287:1003-10. 2002
  7. ncbi request reprint Impact of high-normal blood pressure on the risk of cardiovascular disease
    R S Vasan
    Framingham Heart Study, Mass 01702, USA
    N Engl J Med 345:1291-7. 2001
  8. ncbi request reprint Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 105:48-53. 2002
  9. ncbi request reprint Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study
    R S Vasan
    From the National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Lancet 358:1682-6. 2001
  10. ncbi request reprint Risk factors for heart failure
    Satish Kenchaiah
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Med Clin North Am 88:1145-72. 2004

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Site 2, Framingham, MA 01702 5803, USA
    JAMA 289:1251-7. 2003
    ..Elevated plasma homocysteine levels are associated with increased risk of vascular disease. It is unclear whether elevated homocysteine levels are a risk factor for congestive heart failure (CHF)...
  2. ncbi request reprint Doppler transmitral flow indexes and risk of atrial fibrillation (the Framingham Heart Study)
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Am J Cardiol 91:1079-83. 2003
    ..Thus, in our elderly community-based sample, increased VTI E/A and a low atrial filling fraction were markers of increased risk of AF, suggesting that altered atrial filling may antedate AF...
  3. ncbi request reprint Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Circulation 107:1486-91. 2003
    ..It is unclear whether cytokine levels can predict the incidence of CHF in asymptomatic individuals...
  4. ncbi request reprint Relations of serum aldosterone to cardiac structure: gender-related differences in the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Bethesda, MD, USA
    Hypertension 43:957-62. 2004
    ..Additional investigations are warranted to confirm these findings...
  5. ncbi request reprint Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    JAMA 288:1252-9. 2002
    ..Prior studies were limited by small sample sizes and selection bias and none compared the diagnostic performance of these peptides in men and women...
  6. ncbi request reprint Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study, 5 Thurber St, Framingham, MA 01702, USA
    JAMA 287:1003-10. 2002
    ..The long-term risk for developing hypertension is best described by the lifetime risk statistic. The lifetime risk for hypertension and trends in this risk over time are unknown...
  7. ncbi request reprint Impact of high-normal blood pressure on the risk of cardiovascular disease
    R S Vasan
    Framingham Heart Study, Mass 01702, USA
    N Engl J Med 345:1291-7. 2001
    ..Information is limited regarding the absolute and relative risk of cardiovascular disease in persons with high-normal blood pressure (systolic pressure of 130 to 139 mm Hg, diastolic pressure of 85 to 89 mm Hg, or both)...
  8. ncbi request reprint Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 105:48-53. 2002
    ..It is unclear whether time-averaged past BP measures incrementally improve CVD risk assessment...
  9. ncbi request reprint Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study
    R S Vasan
    From the National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Lancet 358:1682-6. 2001
    ..We aimed to establish the best frequency of BP screening by assessing the rates and determinants of progression to hypertension...
  10. ncbi request reprint Risk factors for heart failure
    Satish Kenchaiah
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Med Clin North Am 88:1145-72. 2004
    ....
  11. pmc Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium
    George Thanassoulis
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Am Coll Cardiol 55:2491-8. 2010
    ..To determine the association of long-term exposure to atherosclerosis risk factors with valvular calcification...
  12. pmc Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Am J Kidney Dis 52:39-48. 2008
    ..Prior research yielded conflicting results about the magnitude of the association between body mass index (BMI) and chronic kidney disease (CKD)...
  13. ncbi request reprint Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
    ..Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP...
  14. ncbi request reprint Natural history of asymptomatic left ventricular systolic dysfunction in the community
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 108:977-82. 2003
    ..We sought to characterize the natural history of ALVD, by studying unselected individuals with this condition in the community...
  15. ncbi request reprint Mitral annular calcification is a predictor for incident atrial fibrillation
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, MA 01702 5827, USA
    Atherosclerosis 173:291-4. 2004
    ..Mitral annular calcification (MAC) has been associated with adverse cardiovascular disease outcomes and stroke in longitudinal and community-based cohorts. Prospective data are limited on its association with atrial fibrillation (AF)...
  16. pmc Altered blood pressure progression in the community and its relation to clinical events
    Erik Ingelsson
    Framingham Heart Study, 73 Mount Wayte Ave, Ste 2, Framingham, MA 01702 5803, USA
    Arch Intern Med 168:1450-7. 2008
    ..Long-term blood pressure (BP) progression and its importance as a predictor of clinical outcome have not been well characterized across different periods...
  17. ncbi request reprint Association of parental heart failure with risk of heart failure in offspring
    Douglas S Lee
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, Mass, USA
    N Engl J Med 355:138-47. 2006
    ..The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting...
  18. ncbi request reprint Plasma natriuretic peptide levels and the risk of cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    N Engl J Med 350:655-63. 2004
    ..The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established...
  19. pmc Aortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study
    Carolyn S P Lam
    Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 122:884-90. 2010
    ..Aortic root remodeling in adulthood is known to be associated with cardiovascular outcomes. However, there is a lack of longitudinal data defining the clinical correlates of aortic root remodeling over the adult life course...
  20. pmc Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 58:134-7. 2009
    ..Parental obesity is a risk factor for offspring obesity. It is unclear whether parental obesity also confers risk for obesity-associated conditions (e.g., a proinflammatory or prothrombotic state) in the absence of offspring obesity...
  21. pmc Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA, USA
    Circulation 119:37-43. 2009
    ..Knowledge about the pathophysiological processes that determine arterial stiffness may help guide therapeutic approaches...
  22. pmc Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study
    Renate Schnabel
    The NHLBI s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Atherosclerosis 204:601-7. 2009
    ..Higher circulating Lp-PLA(2) predicts cardiovascular disease risk, but sources of inter-individual variability are incompletely understood...
  23. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  24. ncbi request reprint Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community
    Ravi Dhingra
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803, USA
    Circulation 116:480-8. 2007
    ..Consumption of soft drinks has been linked to obesity in children and adolescents, but it is unclear whether it increases metabolic risk in middle-aged individuals...
  25. ncbi request reprint Increasing trends in incidence of overweight and obesity over 5 decades
    Nisha I Parikh
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Am J Med 120:242-50. 2007
    ..We evaluated trends in the incidence of overweight and obesity over the past 50 years...
  26. ncbi request reprint Association of aortic valve calcium detected by electron beam computed tomography with echocardiographic aortic valve disease and with calcium deposits in the coronary arteries and thoracic aorta
    Craig R Walsh
    National Heart, Lung and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702, USA
    Am J Cardiol 93:421-5. 2004
    ..EBCT AV calcium was associated with calcium deposits in the coronary arteries and the thoracic aorta, but these associations were confounded by age and risk factors...
  27. pmc Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring
    Wolfgang Lieb
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 52:381-6. 2008
    ..In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk...
  28. ncbi request reprint Relative importance of borderline and elevated levels of coronary heart disease risk factors
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 142:393-402. 2005
    ..Clinical trials indicate that a sizable proportion of adults have multiple borderline coronary risk factors and may benefit from treatment...
  29. pmc Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702 5827, USA
    JAMA 302:168-78. 2009
    ..Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease...
  30. doi request reprint Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study
    Yamini S Levitzky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    J Am Coll Cardiol 51:264-70. 2008
    ..We sought to determine whether impaired fasting glucose (IFG) predicts cardiovascular disease (CVD) events...
  31. ncbi request reprint A risk score for predicting near-term incidence of hypertension: the Framingham Heart Study
    Nisha I Parikh
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 148:102-10. 2008
    ..Risk stratification may facilitate cost-effective approaches to management...
  32. pmc Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection
    Renate Schnabel
    National Heart Lung and Blood Institute Framingham Study, Framingham, Mass, USA
    Hypertension 51:1651-7. 2008
    ..Additional studies are needed to determine whether variation in inflammatory marker genes is associated with tonometry measures...
  33. pmc Prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat depots in the Framingham heart study
    George Thanassoulis
    National Institutes of Health National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, MA, Boston, USA
    Circ Cardiovasc Imaging 3:559-66. 2010
    ..We sought to determine the prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat deposits...
  34. pmc Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality
    Wolfgang Lieb
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Arterioscler Thromb Vasc Biol 30:1849-54. 2010
    ..Experimental evidence identified the osteoprotegerin (OPG)/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand (RANKL) pathway as a candidate system modulating vascular remodeling and cardiovascular disease (CVD)...
  35. pmc Relations of biomarkers representing distinct biological pathways to left ventricular geometry
    Raghava S Velagaleti
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 118:2252-8, 5p following 2258. 2008
    ..Several biological pathways are activated concomitantly during left ventricular (LV) remodeling. However, the relative contribution of circulating biomarkers representing these distinct pathways to LV geometry is unclear...
  36. pmc Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 120:1195-202. 2009
    ..Left ventricular (LV) mass is a biomarker of long-standing exposure to cardiovascular disease risk factors. We hypothesized that LTL is related inversely to LV mass...
  37. pmc Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 119:1203-10. 2009
    ..We hypothesized that this paradox is due partly to the advent of increasingly sensitive biomarkers for AMI diagnosis...
  38. pmc Relation of multiple inflammatory biomarkers to incident atrial fibrillation
    Renate B Schnabel
    National Heart Lung Blood Institute Framingham Study, Framingham, MA, USA
    Am J Cardiol 104:92-6. 2009
    ..18, 95% confidence interval 0.98 to 1.43, p = 0.09). In conclusion, circulating osteoprotegerin concentration was significantly associated with incident AF in our community-based sample, possibly mediated by interim cardiovascular events...
  39. pmc Abdominal subcutaneous adipose tissue: a protective fat depot?
    Stacy A Porter
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 32:1068-75. 2009
    ..Obesity is associated with increased metabolic and cardiovascular risk. The ectopic fat hypothesis suggests that subcutaneous fat may be protective, but this theory has yet to be fully explored...
  40. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  41. ncbi request reprint Serum aldosterone and the incidence of hypertension in nonhypertensive persons
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, Mass 01702 5827, USA
    N Engl J Med 351:33-41. 2004
    ..Primary hyperaldosteronism is a well-recognized cause of secondary hypertension. It is unknown whether serum aldosterone levels within the physiologic range influence the risk of hypertension...
  42. ncbi request reprint Assessment of cardiovascular risk and choice of antihypertensive therapy
    William B Kannel
    Boston University School of Medicine, 73 Mt Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    Curr Hypertens Rep 6:346-51. 2004
    ..They require weight control and exercise, as well as specific choices of antihypertensive agents...
  43. ncbi request reprint Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community
    Sekar Kathiresan
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Circulation 112:1419-27. 2005
    ..Sequence variants at the endothelial nitric oxide synthase (NOS3) locus have been associated with endothelial function measures, but replication has been limited...
  44. ncbi request reprint Cross-sectional correlates of serum heat shock protein 70 in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Hypertens 19:227-31; discussion 232-3. 2006
    ..It is unclear whether circulating heat shock protein 70 (HSP70) levels are related to CVD risk factors, echocardiographic indexes of left ventricular (LV) remodeling, and prevalent CVD in the population...
  45. ncbi request reprint Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Circulation 107:2920-5. 2003
    ..Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of these conditions on mortality...
  46. ncbi request reprint Impact of obesity on the risk of heart failure and survival after the onset of heart failure
    Satish Kenchaiah
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Med Clin North Am 88:1273-94. 2004
    ....
  47. ncbi request reprint Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: the Framingham Heart Study
    Daniel Levy
    NHLBI Framingham Heart Study, Framingham, Mass, USA
    Circulation 115:3079-85. 2007
    ..Little is known about the relations of natriuretic peptides and homocysteine to arterial wall stiffness in the community...
  48. ncbi request reprint Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study
    Erik Ingelsson
    Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5803, USA
    Circulation 116:984-92. 2007
    ..We evaluated the relative contributions of circulating biomarkers representing distinct biological pathways to the incidence of MetS and to longitudinal changes of its constituent risk factors...
  49. ncbi request reprint Impact of age and sex on plasma natriuretic peptide levels in healthy adults
    Thomas J Wang
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Massachusetts 01702, USA
    Am J Cardiol 90:254-8. 2002
    ..The reference limits derived from this large, healthy community-based sample will aid in the identification of elevated natriuretic peptide levels in clinical practice...
  50. ncbi request reprint Heritability and genetic linkage of plasma natriuretic peptide levels
    Thomas J Wang
    Framingham Heart Study, MA 01702 5827, USA
    Circulation 108:13-6. 2003
    ..It is unknown to what extent genetic factors contribute to variation in plasma natriuretic peptide levels...
  51. pmc Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 59:242-8. 2010
    ..Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear...
  52. pmc Longitudinal tracking of left atrial diameter over the adult life course: Clinical correlates in the community
    David D McManus
    Framingham Heart Study, MA 01702 5803, USA
    Circulation 121:667-74. 2010
    ..Increased left atrial diameter (LAD) is associated with elevated risk of atrial fibrillation (AF) and cardiovascular disease. Information is limited regarding the short- or long-term correlates of LAD...
  53. pmc Cross-sectional relations of lipid concentrations to left ventricular structural attributes
    Raghava S Velagaleti
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Am J Cardiol 105:1297-9. 2010
    ..In conclusion, these data do not support an independent association between lipid concentrations and left ventricular structure...
  54. ncbi request reprint What is normal blood pressure?
    Michael H Freitag
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    Curr Opin Nephrol Hypertens 12:285-92. 2003
    ..This review examines what constitutes optimal blood pressure...
  55. ncbi request reprint Obesity and the risk of heart failure
    Satish Kenchaiah
    Framingham Heart Study, Framingham, Mass 01702, USA
    N Engl J Med 347:305-13. 2002
    ..Extreme obesity is recognized to be a risk factor for heart failure. It is unclear whether overweight and lesser degrees of obesity also pose a risk...
  56. pmc Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study
    George Thanassoulis
    Framingham Heart Study, Boston University and the National Institutes of Health National Heart, Lung, and Blood Institute, 73 Mt Wayte Ave No 2, Framingham, MA 01702, USA
    Circ Arrhythm Electrophysiol 3:345-50. 2010
    ..We tested the hypothesis that pericardial fat, a unique fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF...
  57. pmc Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study
    Susan Cheng
    The Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 122:570-8. 2010
    ..The heart progressively remodels over the life course, yet longitudinal data characterizing such remodeling in the community are limited...
  58. ncbi request reprint Impact of obesity on plasma natriuretic peptide levels
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 109:594-600. 2004
    ..The natriuretic peptides are important regulators of sodium homeostasis and neurohormonal activation, raising the possibility that obese individuals have an impaired natriuretic peptide response...
  59. pmc Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study
    Wolfgang Lieb
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 119:3085-92. 2009
    ..Information is limited on the longitudinal tracking of left ventricular (LV) mass over the adult life course and the determinants of such change...
  60. ncbi request reprint Multiple biomarkers for the prediction of first major cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA, USA
    N Engl J Med 355:2631-9. 2006
    ..Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events...
  61. ncbi request reprint Screening for ventricular remodeling
    Douglas S Lee
    Framingham Heart Study, MA 01702, USA
    Curr Heart Fail Rep 3:5-13. 2006
    ..Additional studies are warranted to confirm these findings...
  62. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  63. pmc Plasma asymmetric dimethylarginine, L-arginine and left ventricular structure and function in a community-based sample
    Wolfgang Lieb
    Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5803, USA
    Atherosclerosis 204:282-7. 2009
    ..It is unclear if circulating ADMA and L-arginine levels are related to cardiac structure and function in the general population...
  64. ncbi request reprint Low-grade albuminuria and the risks of hypertension and blood pressure progression
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Circulation 111:1370-6. 2005
    ....
  65. ncbi request reprint Obesity and the risk of new-onset atrial fibrillation
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    JAMA 292:2471-7. 2004
    ..Obesity is associated with atrial enlargement and ventricular diastolic dysfunction, both known predictors of atrial fibrillation (AF). However, it is unclear whether obesity is a risk factor for AF...
  66. pmc Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 32:612-6. 2009
    ..We tested the hypothesis that leptin levels are associated with greater risk of CHF, CVD, and mortality in elderly individuals...
  67. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  68. pmc Long-term trends in the incidence of heart failure after myocardial infarction
    Raghava S Velagaleti
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 118:2057-62. 2008
    ....
  69. pmc Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community
    Susan Cheng
    The Framingham Heart Study, 73 Mount Wayte Ave, Ste 2, Framingham, MA 01702 5803, USA
    Circulation 122:1470-7. 2010
    ..However, the relation of exhaled CO to metabolic/vascular risk in the community is unknown...
  70. ncbi request reprint Plasma brain natriuretic peptide levels and blood pressure tracking in the Framingham Heart Study
    Michael H Freitag
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Hypertension 41:978-83. 2003
    ..Additional investigations are warranted to confirm these findings and elucidate the basis for these gender-related differences...
  71. ncbi request reprint Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample
    C S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    Kidney Int 69:2064-9. 2006
    ..Our cross-sectional observations raise the possibility that dietary salt intake may be associated with early renovascular damage...
  72. ncbi request reprint Elevated midlife blood pressure increases stroke risk in elderly persons: the Framingham Study
    S Seshadri
    National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA, USA
    Arch Intern Med 161:2343-50. 2001
    ..CONCLUSIONS: Antecedent BP contributes to the future risk of ischemic stroke. Optimal prevention of late-life stroke will likely require control of midlife BP...
  73. pmc Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: the Framingham Heart Study
    R Haring
    Preventive Medicine and Epidemiology Section, Boston University School of Medicine, Boston, MA, USA
    Int J Androl 35:775-82. 2012
    ....