Rajat Varma

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint TCR triggering by the pMHC complex: valency, affinity, and dynamics
    Rajat Varma
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bethesda, MD 20892, USA
    Sci Signal 1:pe21. 2008
  2. ncbi request reprint The immunological synapse balances T cell receptor signaling and degradation
    Kyeong Hee Lee
    Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA
    Science 302:1218-22. 2003
  3. pmc Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
    Gabriele Campi
    Department of Pathology and the Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York, NY 10016, USA
    J Exp Med 202:1031-6. 2005
  4. pmc T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
    Rajat Varma
    Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Immunity 25:117-27. 2006
  5. ncbi request reprint Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse
    Tasha N Sims
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cell 129:773-85. 2007
  6. ncbi request reprint Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes
    Dimitris Skokos
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10021, USA
    Nat Immunol 8:835-44. 2007
  7. ncbi request reprint Supported planar bilayers for study of the immunological synapse
    Michael L Dustin
    Skirball Institute of Biomolecular Medicine, New York, New York, USA
    Curr Protoc Immunol . 2007

Collaborators

  • Michael L Dustin
  • Tasha N Sims
  • Gabriele Campi
  • Dimitris Skokos
  • Thomas O Cameron
  • Janelle C Waite
  • V Kaye Thomas
  • Kyeong Hee Lee
  • Randall L Lindquist
  • Guy Shakhar
  • Timothy J Soos
  • Michel C Nussenzweig
  • Chris H Wiggins
  • Michael P Sheetz
  • Benjamin Dubin-Thaler
  • Dan R Littman
  • Jake M Hofman
  • Harry S Xenias
  • Toby Starr
  • Tanja Schwickert
  • Andrey S Shaw
  • Subhadip Raychaudhuri
  • Mary Markiewicz
  • Arup K Chakraborty
  • Chun Tu
  • Osami Kanagawa
  • W Richard Burack
  • Aaron R Dinner
  • Paul M Allen
  • Julia Wang
  • Hui Wu

Detail Information

Publications7

  1. doi request reprint TCR triggering by the pMHC complex: valency, affinity, and dynamics
    Rajat Varma
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bethesda, MD 20892, USA
    Sci Signal 1:pe21. 2008
    ..Whether this involves monomeric or multimeric pMHCs may depend on the affinity of the TCR for the pMHC...
  2. ncbi request reprint The immunological synapse balances T cell receptor signaling and degradation
    Kyeong Hee Lee
    Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA
    Science 302:1218-22. 2003
    ..We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals...
  3. pmc Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
    Gabriele Campi
    Department of Pathology and the Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York, NY 10016, USA
    J Exp Med 202:1031-6. 2005
    ..We propose that Src kinase-independent formation of TCR microclusters in response to agonist MHC-peptide provides an actin-dependent scaffold for signal amplification...
  4. pmc T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
    Rajat Varma
    Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Immunity 25:117-27. 2006
    ..Our studies reveal a role for F-actin in TCR signaling beyond microcluster formation...
  5. ncbi request reprint Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse
    Tasha N Sims
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cell 129:773-85. 2007
    ..WASp(-/-) T cells displayed normal IS formation but were unable to reform IS after migration unless PKCtheta was inhibited. Thus, opposing effects of PKCtheta and WASp control IS stability through pSMAC symmetry breaking and reformation...
  6. ncbi request reprint Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes
    Dimitris Skokos
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10021, USA
    Nat Immunol 8:835-44. 2007
    ..The pMHC complexes of lower potency instead induced T cell anergy by a biochemically distinct process that did not affect T cell dynamics...
  7. ncbi request reprint Supported planar bilayers for study of the immunological synapse
    Michael L Dustin
    Skirball Institute of Biomolecular Medicine, New York, New York, USA
    Curr Protoc Immunol . 2007
    ..This provides a more physiological presentation of cell-surface molecules and supports visualization of protein rearrangement on the bilayer by live cells...