Research Topics
Genomes and Genes | Carter Van WaesSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neckClint T Allen
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 10 Center Drive, CRC 4 2732, Bethesda, Maryland 20892, USA
Head Neck 29:959-71. 2007..Understanding the molecular alterations leading to aberrant NF-kappaB activation in HNSCC may direct investigators to novel therapeutic targets...- Nuclear factor-kappaB-related serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinomaClint Allen
Tumor Biology Section, Head and Neck Surgery Branch, National Institute of Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 13:3182-90. 2007..Longitudinal changes in these serum factors could be early biomarkers of treatment response and survival... 
Targeting NF-κB in mouse models of lung adenocarcinomaCarter Van Waes
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Cancer Discov 1:200-2. 2011..Xue et al. demonstrate response and increased survival but development of acquired resistance to proteasome and inhibitor-κB kinase inhibitors targeting NF-κB activation in adenocarcinomas of Kras-activated, p53-deficient mice...- Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinomaCarter Van Waes
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 13:4956-9. 2007 - Head and neck squamous cell carcinoma in patients with Fanconi anemiaCarter Van Waes
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892-1462, USA
Arch Otolaryngol Head Neck Surg 131:640-1. 2005 - Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinomaCarter Van Waes
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
Int J Radiat Oncol Biol Phys 63:1400-12. 2005.... - Nuclear factor-kappaB in development, prevention, and therapy of cancerCarter Van Waes
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders and Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Clin Cancer Res 13:1076-82. 2007..Newer agents targeting the proteasome, inhibitor-kappaB kinase, and other upstream kinases involved in NF-kappaB activation have shown anticancer activity in clinical or preclinical studies... 
A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomasTin Lap Lee
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1419, USA
Int J Cancer 122:1987-98. 2008..Inhibition of signal activation of both NF-kappaB and STAT3 together with reexpression of p53 could be the most effective strategy to restore BAX/BCL-XL regulation and for cytotoxic therapy of HNSCC...- Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancerCarter Van Waes
Head and Neck Surgery Branch, National Institute of Deafness and Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Int J Radiat Oncol Biol Phys 77:447-54. 2010.... - CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsulesMatthew S Brown
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892 1419, USA
Clin Cancer Res 16:2295-307. 2010.... - TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancerHai Lu
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA
Cancer Res 71:6867-77. 2011.... - Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-kappaB and activator protein-1 related mechanismsZhong Chen
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, 10 5D55, MSC 1419, Bethesda, MD 20892 1419, USA
Mol Cancer Ther 7:1949-60. 2008..These findings revealed molecular mechanisms of bortezomib sensitivity and resistance, which are under development as biomarkers for clinical trials in patients with HNSCC... - ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammationXinping Yang
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA
Cancer Res 71:3688-700. 2011..Our study reveals ΔNp63 as a master transcription factor that, in coordination with NF-κB/Rels, orchestrates a broad gene program promoting epidermal hyperplasia, inflammation, and the malignant phenotype of HNSCC... - Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancerFrancisco G Pernas
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 15:2361-72. 2009..To investigate the underlying molecular mechanism, the proteomic signatures and responses of EGFR and downstream signals have been studied in a panel of HNSCC cell lines and tumor specimens pre- and post-gefitinib treatment... - A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 statusTin Lap Lee
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892 1419, USA
Clin Cancer Res 13:5680-91. 2007.... - Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinomaBrian Worden
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892-1419, USA
Cancer Res 65:7071-80. 2005.... - cDNA microarray and bioinformatic analysis of nuclear factor-kappaB related genes in squamous cell carcinomaZhong Chen
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Methods Mol Biol 383:81-99. 2007.... - Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancerClint Allen
Tumor Biology Section, Head and Neck Surgery Branch, National Institute of Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA
Clin Cancer Res 14:4175-85. 2008..However, limited clinical activity of bortezomib has been observed in many epithelial malignancies, suggesting this could result from incomplete inhibition of NF-kappaB/RELs or other prosurvival signal pathways... - Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancerPattatheyil Arun
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892 0001, USA
Clin Cancer Res 15:5974-84. 2009..Here, we investigated the prevalence and function of p65-Ser276 phosphorylation by protein kinase A (PKA) in the malignant phenotype and gene transactivation, and studied p65-Ser276 as a potential target for therapy... - Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancerJay Friedman
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Clin Cancer Res 13:6568-78. 2007.... - Attenuated transforming growth factor beta signaling promotes nuclear factor-kappaB activation in head and neck cancerJonah Cohen
Howard Hughes Medical Institute NIH Research Scholars Program, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA
Cancer Res 69:3415-24. 2009..Together, these findings elucidate a regulatory framework in which attenuated TGFbeta signaling promotes NF-kappaB activation and squamous epithelial malignancy in the setting of altered TP53 status... - Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101Jianming Duan
National Institute on Deafness and Other Communication Disorders, NIH, CRC Building 10, Room 4 2732, 10 Center Drive, Bethesda, MD 20892, USA
Mol Cancer Ther 6:37-50. 2007..The combination of HDI and proteasome inhibitor produced increased antitumor activity. Low starting dosages for clinical studies combining HDIs with proteasome inhibitors and IV fluid support may be warranted... - Systems biology-defined NF-kappaB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 statusBin Yan
Head and Neck Surgery Branch, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA
Genome Biol 9:R53. 2008..However, how NF-kappaB acts as a key regulatory node to modulate global gene expression, and contributes to the malignant heterogeneity of head and neck cancer, is not well understood... - Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccineTakashi Hirano
Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA
Immunol Lett 107:131-9. 2006..These kinetic antibody patterns and cellular responses may provide useful information regarding to effective mucosal vaccines against NTHi infections... - A pilot study of longitudinal serum cytokine and angiogenesis factor levels as markers of therapeutic response and survival in patients with head and neck squamous cell carcinomaColleen H Druzgal
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg. 10 CRC, Rm 4-2732, 10 Center Drive, Bethesda, MD 20892, USA
Head Neck 27:771-84. 2005..HGF, IL-6, IL-8, and VEGF merit investigation as markers of response, survival, and recurrence in larger prospective studies... - High incidence of oral dysesthesias on a trial of gefitinib, Paclitaxel, and concurrent external beam radiation for locally advanced head and neck cancersHadley Sharp
Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
Am J Clin Oncol 31:557-60. 2008.... - The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growthKathryn E King
Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Cancer Res 68:5122-31. 2008..This is the first report indicating that high levels of DeltaNp63alpha interact with activated c-Rel in keratinocytes and SCC, thereby promoting uncontrolled proliferation, a key alteration in the pathogenesis of cancers... - Dynamic effect of bortezomib on nuclear factor-kappaB activity and gene expression in tumor cellsMyong Hee Sung
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Room B602, Bldg 41, 41 Library Dr, Bethesda, MD 20892, USA
Mol Pharmacol 74:1215-22. 2008.... - Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cellsMing Yu
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders/NIH, 10 Center Drive, Bethesda, MD 20892, USA
Cancer Res 66:6722-31. 2006.... - Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomasTin Lap Lee
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, 10 5D55, MSC 1419, Bethesda, MD 20892 1419, USA
Mol Cancer Ther 5:8-19. 2006..Identifying the potential factors and the regulatory pathways in STAT3 activation has important implications for the development and selection of molecularly targeted therapy in HNSCC... - Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-kappaB and other signal transcription factors in head and neck squamous cell carcinomaBin Yan
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Center Drive, Bethesda, Maryland 20892, USA
Genome Biol 8:R78. 2007..However, the molecular expression signatures and transcriptional regulatory controls that underlie the heterogeneity in HNSCCs are not well defined... - 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinomaJustin L Ricker
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Clin Cancer Res 10:8665-73. 2004..CONCLUSIONS: These results provide support for the use of 2ME2 in combination with paclitaxel for the treatment of recurrent or advanced head and neck squamous cell carcinoma... - Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunctionBruce J Baum
Molecular Physiology and Therapeutics Branch, and Neurobiology and Pain Therapeutics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:19403-7. 2012..AdhAQP1 vector delivery to a single parotid gland was safe and transfer of the hAQP1 cDNA increased parotid flow and relieved symptoms in a subset of subjects... - Current and potential inflammation targeted therapies in head and neck cancerFrederick Wang
Howard Hughes Medical Institute, National Institutes of Health Research Scholars Program, 1 Cloister Ct, Bethesda, MD 20814, USA
Curr Opin Pharmacol 9:389-95. 2009..This review provides an update on recent advances in the understanding of the mechanisms driving cancer-related inflammation in HNSCC and on molecular targeted therapies under preclinical and clinical investigation... - Pulsed high-intensity focused ultrasound enhances apoptosis and growth inhibition of squamous cell carcinoma xenografts with proteasome inhibitor bortezomibJason A Poff
Diagnostic Radiology Department, Clinical Center and Head and Neck Surgery Branch, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Radiology 248:485-91. 2008..To investigate whether combining pulsed high-intensity focused ultrasound (HIFU) with the chemotherapeutic drug bortezomib could improve antitumor activity against murine squamous cell carcinoma (SCC) tumors... - Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancerDeborah Citrin
Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Int J Radiat Oncol Biol Phys 74:1040-6. 2009..To report the long-term outcomes and toxicity of a regimen of infusion paclitaxel delivered concurrently with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck... - Nuclear factor-KappaB as a common target and activator of oncogenes in head and neck squamous cell carcinomaAngela A Chang
National Institutes of Health Clinical Research Training Program, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
Adv Otorhinolaryngol 62:92-102. 2005..Because of its important role, activation of nuclear factor-KappaB by the proteasome and other signal molecules may provide targets for molecular therapy of squamous cell carcinoma and other cancers... - NF-kappaB in carcinoma therapy and preventionMatthew Brown
National Institute on Deafness and Other Communication Disorders, Head and Neck Surgery Branch, Bethesda, MD 20892, USA
Expert Opin Ther Targets 12:1109-22. 2008..NF-kappaB includes a family of signal-activated transcription factors that normally regulate responses to injury and infection but which are aberrantly activated in many carcinomas... - Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinomaAmy Loercher
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20832-0001, USA
Cancer Res 64:6511-23. 2004..These results provide evidence that NF-kappaB is an important modulator of gene expression programs that contribute to the malignant phenotype of SCC... - EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapyChristian Freudlsperger
National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Head and Neck Surgery Branch, Bethesda, MD 20892, USA
Expert Opin Ther Targets 15:63-74. 2011..This pathway plays a central role in numerous cellular processes including metabolism, cell growth, apoptosis, survival and differentiation, which ultimately contributes to HNSCC progression... - Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma linesCaren C Bancroft
Tumor Biology Section, Head and Neck Surgery Branch, The National Institute on Deafness and Other Communication Disorders, The National Institutes of Health, Bethesda, MD 20892, USA
Int J Cancer 99:538-48. 2002..We conclude that antagonists of EGFR, PI3K and MEK signal pathways have inhibitory activity against EGFR-induced NF-kappaB and AP-1 activation, IL-8 and VEGF expression and growth by HNSCC. Published 2002 Wiley-Liss, Inc... - Dyskeratosis congenita: the first NIH clinical research workshopSharon A Savage
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA
Pediatr Blood Cancer 53:520-3. 2009..dcoutreach.com/). Ongoing, open collaboration between the clinical, scientific, and family communities is required for continued improvement in our understanding of DC and the clinical consequences of telomeric defects... - Randomized, double-blind, placebo-controlled phase IIb trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakiaJames L Mulshine
Intervention Section, Cell and Cancer Biology Branch, Department of Pathology and Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1906, USA
Clin Cancer Res 10:1565-73. 2004..This trial evaluated if a topically delivered oral rinse containing ketorolac was as safe as and more effective than oral rinse alone in reducing the area of oral leukoplakia... - Carcinoembryonic antigen as a target for specific antitumor immunotherapy of head and neck cancerErik S Kass
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892-1750, USA
Cancer Res 62:5049-57. 2002..These results suggest that CEA may be considered as a possible target for specific vaccine-mediated immunotherapy against HNCs... - Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering and metastasis in response to hepatocyte growth factorGang Dong
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 10/5D55, MSC-1419, Bethesda, MD 20892-1419, USA
Oncogene 23:6199-208. 2004.... - Phase I study of a lipooligosaccharide-based conjugate vaccine against nontypeable Haemophilus influenzaeXin Xing Gu
National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rockville, MD 20850, USA
Vaccine 21:2107-14. 2003..The LOS-TT conjugate is well tolerant in adults and a Phase II evaluation of the conjugate in children is planned... - The biology of tobacco and nicotine: bench to bedsidePhillip A Dennis
Cancer Therapeutics Branch, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20889, USA
Cancer Epidemiol Biomarkers Prev 14:764-7. 2005..Importantly, new opportunities to use molecular biology to identify and abrogate tobacco-mediated carcinogenesis and to identify high-risk individuals were recognized... - Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancersReza Ehsanian
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Cell Commun Signal 9:13. 2011..In particular, quinacrine's role on the NF-κB, p53, and AKT pathways are summarized... - Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunctionBruce J Baum
Gene Therapy and Therapeutics Branch, Bethesda, MD 20892 1190, USA
Biochim Biophys Acta 1758:1071-7. 2006..Based on these results, we are developing a clinical trial to test if the hAQP1 cDNA transfer strategy will be clinically effective in restoring salivary flow in patients with IR-induced parotid hypofunction... - Antitumor effect of secreted Flt3-ligand can act at distant tumor sites in a murine model of head and neck cancerJian Dong
Department of Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, Ohio 45267-0521, USA
Cancer Gene Ther 10:96-104. 2003..Furthermore, the combination of local Flt3-L and HSVTK production, together with GCV administration, does not enhance the distant bystander effect produced by Flt3-L alone... - Cytokines IL-1 alpha, IL-6, and GM-CSF constitutively secreted by oral squamous carcinoma induce down-regulation of CD80 costimulatory molecule expression: restoration by interferon gammaGiovana R Thomas
Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Papanicolau Building, 1550 NW 10th Avenue, Room 214, Miami, FL 33136, USA
Cancer Immunol Immunother 53:33-40. 2004..These data provide evidence for a novel mechanism of cytokine-mediated down-modulation of CD80 during malignant progression of HNSCC that can be restored by IFN-gamma... - Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapyJun Wang
Department of Otolaryngology, University of Pittsburgh Medical School, Pittsburgh, PA, USA
J Natl Cancer Inst 100:502-12. 2008..Constitutive prosurvival signaling by the phosphoinositide-3 kinase/Akt pathway has been observed in SCCHN cells independent of epidermal growth factor receptor (EGFR) signaling... - Assessment of gene expression in head and neck carcinoma using laser capture microdissection and real-time reverse transcription polymerase chain reactionPramit S Malhotra
Department of Otolaryngology-Head and Neck Surgery, University of Minnesota Hospitals, Minneapolis, Minnesota, USA
Laryngoscope 114:2123-8. 2004..The combination of LCM and real-time RT-PCR appears particularly efficacious for studying HNSCC molecular pathogenesis and identifying tissue-specific biomarkers... - Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia miceQing Shuo Zhang
Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97239, USA
Cancer Res 68:1601-8. 2008..The reduction in oxidative DNA damage in tempol-treated FA fibroblasts and mice suggests that its tumor-delaying function may be attributed to its antioxidant activity...