Melanie S Vacchio

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8 T cells
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:19-26. 2003
  2. ncbi request reprint A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA
    Eur J Immunol 35:418-27. 2005
  3. ncbi request reprint Fetal expression of Fas ligand is necessary and sufficient for induction of CD8 T cell tolerance to the fetal antigen H-Y during pregnancy
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
    J Immunol 174:4657-61. 2005
  4. pmc ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:6323-8. 2007
  5. ncbi request reprint T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form
    Meifen Zhang
    National Eye Institute and National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:3954-62. 2003
  6. ncbi request reprint Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha
    Denis Franchimont
    Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:2212-8. 2002

Collaborators

Detail Information

Publications6

  1. pmc CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8 T cells
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:19-26. 2003
    ....
  2. ncbi request reprint A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA
    Eur J Immunol 35:418-27. 2005
    ..Together these findings demonstrate a novel negative regulatory role for CD28 in inhibiting differentiation of SP thymocytes, probably through inhibition of thymic selection...
  3. ncbi request reprint Fetal expression of Fas ligand is necessary and sufficient for induction of CD8 T cell tolerance to the fetal antigen H-Y during pregnancy
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
    J Immunol 174:4657-61. 2005
    ..Fas interaction with fetal FasL is thus critical for both deletion and hyporesponsiveness of H-Y-reactive CD8+ T cells during pregnancy...
  4. pmc ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:6323-8. 2007
    ....
  5. ncbi request reprint T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form
    Meifen Zhang
    National Eye Institute and National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:3954-62. 2003
    ....
  6. ncbi request reprint Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha
    Denis Franchimont
    Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:2212-8. 2002
    ..These observations provide a mechanism by which glucocorticoids may have a positive influence on T cell survival and function...