Research Topics
| Ted B UsdinSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Tuberoinfundibular Peptide of 39 residues is required for germ cell developmentTed B Usdin
National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
Endocrinology 149:4292-300. 2008..These results show that TIP39 is essential for germ cell development and suggest that it may act as an autocrine or paracrine agent within the gonads...- Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulationEugene L Dimitrov
Section on Fundamental Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 31:18166-79. 2011..This excitatory mechanism of heat production appears to be activated on demand, during cold exposure, and parallels the tonic inhibitory GABAergic control of body temperature... - Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociceptionEugene L Dimitrov
Section on Fundamental Neuroscience, National Institute of Mental Health, 35 Convent Drive, Room 1B 213, Bethesda, MD 20892, USA
Exp Neurol 226:68-83. 2010..We infer a new central mechanism for endocannabinoid regulation, via TIP39 acting on the PTH2R in discrete brain regions... 
Emerging functions for tuberoinfundibular peptide of 39 residuesTed B Usdin
Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, MD 20892 4094, USA
Trends Endocrinol Metab 14:14-9. 2003..Injection of TIP39, and sequestration of endogenous TIP39 by intrathecal injection of an antibody to TIP39, have provided evidence that it is involved in some aspects of pain sensitivity. Thus, TIP39 might be a new neuromodulator...- Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brainCatherine A Faber
Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 4094, USA
J Comp Neurol 502:563-83. 2007..Published 2007 Wiley-Liss, Inc... - Development of a rat parathyroid hormone 2 receptor antagonistJonathan Kuo
National Institute of Mental Health, Laboratory of Genetics, Building 35, Room 1B 415, Convent Drive, MSC 3728, Bethesda, MD 20892, USA
Peptides 28:887-92. 2007..This ligand should be useful for in vivo investigation of PTH2 receptor function... - Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequencesRobert L Strausberg
National Cancer Institute, Bethessda, MD 20892 2580, USA
Proc Natl Acad Sci U S A 99:16899-903. 2002..All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http:mgc.nci.nih.gov)... - Tuberoinfundibular peptide of 39 residues decreases pain-related affective behaviorChristopher J LaBuda
Laboratory of Genetics, National Institute of Mental Health, Bldg. 36/Rm. 3D06, 36 Convent Dr. MSC 4094, Bethesda, MD 20892-4094, USA
Neuroreport 15:1779-82. 2004..c.v. TIP39 were opposite in direction from previously described effects of intrathecal TIP39, this suggests that TIP39 may modulate an affective component of nociception within the brain... - Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7-39)Sam R J Hoare
Unit on Cell Biology, National Institute of Mental Health, Room 3D06, Bld 36, 36 Convent Drive, Bethesda, MD 20892 4092, USA
Peptides 23:989-98. 2002..6 min (92%), and t(1/2)=21 min (8%)). Loss of unlabeled mTIP(7-39) (250 microg/kg i.v.) receptor binding was similar. mTIP(7-39)'s high-affinity should facilitate animal evaluation of effects of PTH1 receptor antagonism... - Tuberoinfundibular peptide of 39 residues produces anxiolytic and antidepressant actionsChristopher J LaBuda
Laboratory of Genetics, National Institute of Mental Health, Bldg. 36/Rm. 3D06, 36 Convent Dr. MSC 4094, Bethesda, MD 20892-4094, USA
Neuroreport 15:881-5. 2004..TIP39 did not change activity in the open field test. These findings point to a previously unknown role of the PTH2-R in the regulation of anxiety and depression... - Evaluation of vector-primed cDNA library production from microgram quantities of total RNAJonathan Kuo
Laboratory of Genetics, National Institute of Mental Health Building 35, Room 1B-215, 35 Convent Drive, Bethesda, MD 20892-3728, USA
Nucleic Acids Res 32:e183. 2004.... 
Forebrain GABAergic projections to locus coeruleus in mouseEugene L Dimitrov
Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892
J Comp Neurol 521:2373-97. 2013..J. Comp. Neurol. 521:2373-2397, 2013. © 2012 Wiley Periodicals, Inc...- Neurons containing tuberoinfundibular peptide of 39 residues are activated following male sexual behaviorJing Wang
Laboratory of Genetics, National Institute of Mental Health, Bethesda, MD 20892-4094, USA
Neuropeptides 40:403-8. 2006..This suggests that TIP39-IR neurons in the mSPFp are part of the afferent circuits that process genital-somatosensory information related to ejaculation, and which contribute to mating and mating-induced changes in reproductive behavior... - Reduced fear memory and anxiety-like behavior in mice lacking formylpeptide receptor 1Ji Liang Gao
Molecular Signalling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N107, NIH, Bethesda, MD 20892, USA
Behav Genet 41:724-33. 2011..The data implicate Fpr1 in modulation of anxiety-like behavior and fear memory by regulating glucocorticoid production... - Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociceptionArpad Dobolyi
Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:1651-6. 2002..Cells in these areas project to the superficial dorsal horn of the spinal cord. Our data suggest that TIP39 released from supraspinal fibers potentiates aspects of nociception within the spinal cord... - The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)Daniela S Gerhard
Genome Res 14:2121-7. 2004..Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline... - Evidence for the expression of parathyroid hormone 2 receptor in the human brainstemAttila G Bagó
Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Histology and Embryology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
Ideggyogy Sz 61:123-6. 2008..Initial functional studies suggest that the PTH2R is involved in the regulation of viscerosensory information processing. As a first step towards clinical applications, herein we describe the presence of the PTH2R in the human brainstem... - Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalizationAlessandro Bisello
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Mol Endocrinol 18:1486-98. 2004.... - Centrally administered tuberoinfundibular peptide of 39 residues inhibits arginine vasopressin release in conscious ratsYoshihisa Sugimura
Department of Internal Medicine, Graduate School of Medicine, Nagoya University, Nagoya, Aichi 466-8550, Japan
Endocrinology 144:2791-6. 2003..These results suggest that central TIP39 plays an inhibitory role in the osmoregulation and baroregulation of AVP release and that intrinsic opioid systems are involved in its mechanism...