Ted B Usdin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Tuberoinfundibular Peptide of 39 residues is required for germ cell development
    Ted B Usdin
    National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 149:4292-300. 2008
  2. pmc Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues
    Eugene L Dimitrov
    Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:13156-61. 2013
  3. pmc Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation
    Eugene L Dimitrov
    Section on Fundamental Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:18166-79. 2011
  4. ncbi request reprint Emerging functions for tuberoinfundibular peptide of 39 residues
    Ted B Usdin
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, MD 20892 4094, USA
    Trends Endocrinol Metab 14:14-9. 2003
  5. pmc Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception
    Eugene L Dimitrov
    Section on Fundamental Neuroscience, National Institute of Mental Health, 35 Convent Drive, Room 1B 213, Bethesda, MD 20892, USA
    Exp Neurol 226:68-83. 2010
  6. doi request reprint Forebrain GABAergic projections to locus coeruleus in mouse
    Eugene L Dimitrov
    Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Comp Neurol 521:2373-97. 2013
  7. pmc Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brain
    Catherine A Faber
    Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 4094, USA
    J Comp Neurol 502:563-83. 2007
  8. pmc Development of a rat parathyroid hormone 2 receptor antagonist
    Jonathan Kuo
    National Institute of Mental Health, Laboratory of Genetics, Building 35, Room 1B 415, Convent Drive, MSC 3728, Bethesda, MD 20892, USA
    Peptides 28:887-92. 2007
  9. pmc Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
    Robert L Strausberg
    National Cancer Institute, Bethessda, MD 20892 2580, USA
    Proc Natl Acad Sci U S A 99:16899-903. 2002
  10. ncbi request reprint Tuberoinfundibular peptide of 39 residues decreases pain-related affective behavior
    Christopher J LaBuda
    Laboratory of Genetics, National Institute of Mental Health, Bldg 36 Rm 3D06, 36 Convent Dr MSC 4094, Bethesda, MD 20892 4094, USA
    Neuroreport 15:1779-82. 2004

Collaborators

Detail Information

Publications20

  1. pmc Tuberoinfundibular Peptide of 39 residues is required for germ cell development
    Ted B Usdin
    National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 149:4292-300. 2008
    ..These results show that TIP39 is essential for germ cell development and suggest that it may act as an autocrine or paracrine agent within the gonads...
  2. pmc Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues
    Eugene L Dimitrov
    Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:13156-61. 2013
    ..TIP39's normal role may be to inhibit release of hypoalgesic amounts of norepinephrine during chronic pain. The neuropeptide may help maintain central sensitization, which could serve to enhance guarding behavior. ..
  3. pmc Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation
    Eugene L Dimitrov
    Section on Fundamental Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:18166-79. 2011
    ..This excitatory mechanism of heat production appears to be activated on demand, during cold exposure, and parallels the tonic inhibitory GABAergic control of body temperature...
  4. ncbi request reprint Emerging functions for tuberoinfundibular peptide of 39 residues
    Ted B Usdin
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, MD 20892 4094, USA
    Trends Endocrinol Metab 14:14-9. 2003
    ..Injection of TIP39, and sequestration of endogenous TIP39 by intrathecal injection of an antibody to TIP39, have provided evidence that it is involved in some aspects of pain sensitivity. Thus, TIP39 might be a new neuromodulator...
  5. pmc Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception
    Eugene L Dimitrov
    Section on Fundamental Neuroscience, National Institute of Mental Health, 35 Convent Drive, Room 1B 213, Bethesda, MD 20892, USA
    Exp Neurol 226:68-83. 2010
    ..We infer a new central mechanism for endocannabinoid regulation, via TIP39 acting on the PTH2R in discrete brain regions...
  6. doi request reprint Forebrain GABAergic projections to locus coeruleus in mouse
    Eugene L Dimitrov
    Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Comp Neurol 521:2373-97. 2013
    ..This description of GABAergic projections from the CAmy and PLH to the LC clarifies important forebrain sources of inhibitory control of central nervous system noradrenergic activity...
  7. pmc Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brain
    Catherine A Faber
    Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 4094, USA
    J Comp Neurol 502:563-83. 2007
    ..Published 2007 Wiley-Liss, Inc...
  8. pmc Development of a rat parathyroid hormone 2 receptor antagonist
    Jonathan Kuo
    National Institute of Mental Health, Laboratory of Genetics, Building 35, Room 1B 415, Convent Drive, MSC 3728, Bethesda, MD 20892, USA
    Peptides 28:887-92. 2007
    ..This ligand should be useful for in vivo investigation of PTH2 receptor function...
  9. pmc Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
    Robert L Strausberg
    National Cancer Institute, Bethessda, MD 20892 2580, USA
    Proc Natl Acad Sci U S A 99:16899-903. 2002
    ..All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http:mgc.nci.nih.gov)...
  10. ncbi request reprint Tuberoinfundibular peptide of 39 residues decreases pain-related affective behavior
    Christopher J LaBuda
    Laboratory of Genetics, National Institute of Mental Health, Bldg 36 Rm 3D06, 36 Convent Dr MSC 4094, Bethesda, MD 20892 4094, USA
    Neuroreport 15:1779-82. 2004
    ..c.v. TIP39 were opposite in direction from previously described effects of intrathecal TIP39, this suggests that TIP39 may modulate an affective component of nociception within the brain...
  11. ncbi request reprint Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7-39)
    Sam R J Hoare
    Unit on Cell Biology, National Institute of Mental Health, Room 3D06, Bld 36, 36 Convent Drive, Bethesda, MD 20892 4092, USA
    Peptides 23:989-98. 2002
    ..6 min (92%), and t(1/2)=21 min (8%)). Loss of unlabeled mTIP(7-39) (250 microg/kg i.v.) receptor binding was similar. mTIP(7-39)'s high-affinity should facilitate animal evaluation of effects of PTH1 receptor antagonism...
  12. pmc Evaluation of vector-primed cDNA library production from microgram quantities of total RNA
    Jonathan Kuo
    Laboratory of Genetics, National Institute of Mental Health Building 35, Room 1B 215, 35 Convent Drive, Bethesda, MD 20892 3728, USA
    Nucleic Acids Res 32:e183. 2004
    ....
  13. ncbi request reprint Tuberoinfundibular peptide of 39 residues produces anxiolytic and antidepressant actions
    Christopher J LaBuda
    Laboratory of Genetics, National Institute of Mental Health, Bldg 36 Rm 3D06, 36 Convent Dr MSC 4094, Bethesda, MD 20892 4094, USA
    Neuroreport 15:881-5. 2004
    ..TIP39 did not change activity in the open field test. These findings point to a previously unknown role of the PTH2-R in the regulation of anxiety and depression...
  14. pmc Reduced fear memory and anxiety-like behavior in mice lacking formylpeptide receptor 1
    Ji Liang Gao
    Molecular Signalling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N107, NIH, Bethesda, MD 20892, USA
    Behav Genet 41:724-33. 2011
    ..The data implicate Fpr1 in modulation of anxiety-like behavior and fear memory by regulating glucocorticoid production...
  15. ncbi request reprint Neurons containing tuberoinfundibular peptide of 39 residues are activated following male sexual behavior
    Jing Wang
    Laboratory of Genetics, National Institute of Mental Health, Bethesda, MD 20892 4094, USA
    Neuropeptides 40:403-8. 2006
    ..This suggests that TIP39-IR neurons in the mSPFp are part of the afferent circuits that process genital-somatosensory information related to ejaculation, and which contribute to mating and mating-induced changes in reproductive behavior...
  16. pmc Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception
    Arpad Dobolyi
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:1651-6. 2002
    ..Cells in these areas project to the superficial dorsal horn of the spinal cord. Our data suggest that TIP39 released from supraspinal fibers potentiates aspects of nociception within the spinal cord...
  17. pmc The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
    Daniela S Gerhard
    Genome Res 14:2121-7. 2004
    ..Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline...
  18. pmc Evidence for the expression of parathyroid hormone 2 receptor in the human brainstem
    Attila G Bagó
    Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Histology and Embryology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
    Ideggyogy Sz 61:123-6. 2008
    ..Initial functional studies suggest that the PTH2R is involved in the regulation of viscerosensory information processing. As a first step towards clinical applications, herein we describe the presence of the PTH2R in the human brainstem...
  19. ncbi request reprint Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization
    Alessandro Bisello
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 18:1486-98. 2004
    ....
  20. ncbi request reprint Centrally administered tuberoinfundibular peptide of 39 residues inhibits arginine vasopressin release in conscious rats
    Yoshihisa Sugimura
    Department of Internal Medicine, Graduate School of Medicine, Nagoya University, Nagoya, Aichi 466 8550, Japan
    Endocrinology 144:2791-6. 2003
    ..These results suggest that central TIP39 plays an inhibitory role in the osmoregulation and baroregulation of AVP release and that intrinsic opioid systems are involved in its mechanism...