T B Usdin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Emerging functions for tuberoinfundibular peptide of 39 residues
    Ted B Usdin
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, MD 20892 4094, USA
    Trends Endocrinol Metab 14:14-9. 2003
  2. ncbi request reprint New members of the parathyroid hormone/parathyroid hormone receptor family: the parathyroid hormone 2 receptor and tuberoinfundibular peptide of 39 residues
    T B Usdin
    Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892 4094, USA
    Front Neuroendocrinol 21:349-83. 2000
  3. ncbi request reprint TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus
    T B Usdin
    Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Building 36 Room 3D06, 36 Convent Drive MSC4094, Bethesda, Maryland 20892 4094, USA
    Nat Neurosci 2:941-3. 1999
  4. ncbi request reprint Distribution of the parathyroid hormone 2 receptor in rat: immunolocalization reveals expression by several endocrine cells
    T B Usdin
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4094, USA
    Endocrinology 140:3363-71. 1999
  5. ncbi request reprint Evidence for a parathyroid hormone-2 receptor selective ligand in the hypothalamus
    T B Usdin
    National Institute of Mental Health, Bethesda MD 20892, USA
    Endocrinology 138:831-4. 1997
  6. ncbi request reprint The parathyroid hormone 2 (PTH2) receptor
    T B Usdin
    Laboratory of Genetics, National Institute of Mental Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, Maryland 20892 4094, USA
    Receptors Channels 8:211-8. 2002
  7. ncbi request reprint Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat
    T B Usdin
    Laboratory of Cell Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 137:4285-97. 1996
  8. ncbi request reprint Tuberoinfundibular peptide (7-39) [TIP(7-39)], a novel, selective, high-affinity antagonist for the parathyroid hormone-1 receptor with no detectable agonist activity
    S R Hoare
    Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland, USA
    J Pharmacol Exp Ther 295:761-70. 2000
  9. ncbi request reprint Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity
    S R Hoare
    Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:27274-83. 2000
  10. ncbi request reprint Forebrain projections of tuberoinfundibular peptide of 39 residues (TIP39)-containing subparafascicular neurons
    J Wang
    Laboratory of Genetics, National Institute of Mental Health, Building 35, Room 1B215, 35 Convent Drive, Bethesda, MD 20892 3728, USA
    Neuroscience 138:1245-63. 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Emerging functions for tuberoinfundibular peptide of 39 residues
    Ted B Usdin
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, MD 20892 4094, USA
    Trends Endocrinol Metab 14:14-9. 2003
    ..Injection of TIP39, and sequestration of endogenous TIP39 by intrathecal injection of an antibody to TIP39, have provided evidence that it is involved in some aspects of pain sensitivity. Thus, TIP39 might be a new neuromodulator...
  2. ncbi request reprint New members of the parathyroid hormone/parathyroid hormone receptor family: the parathyroid hormone 2 receptor and tuberoinfundibular peptide of 39 residues
    T B Usdin
    Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892 4094, USA
    Front Neuroendocrinol 21:349-83. 2000
    ..Thus TIP39 and PTH2 receptor-influenced functions may range from pituitary and pancreatic hormone release to pain perception. A third PTH-recognizing receptor has been found in zebrafish...
  3. ncbi request reprint TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus
    T B Usdin
    Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Building 36 Room 3D06, 36 Convent Drive MSC4094, Bethesda, Maryland 20892 4094, USA
    Nat Neurosci 2:941-3. 1999
  4. ncbi request reprint Distribution of the parathyroid hormone 2 receptor in rat: immunolocalization reveals expression by several endocrine cells
    T B Usdin
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4094, USA
    Endocrinology 140:3363-71. 1999
    ..These data suggest a broad role for the PTH2 receptor, especially within the endocrine system, and provide a basis for experimental exploration of its physiology...
  5. ncbi request reprint Evidence for a parathyroid hormone-2 receptor selective ligand in the hypothalamus
    T B Usdin
    National Institute of Mental Health, Bethesda MD 20892, USA
    Endocrinology 138:831-4. 1997
    ..These data provide evidence for a biologically active peptide, which may be related to PTH, and which is a potential new neurotransmitter or hormone...
  6. ncbi request reprint The parathyroid hormone 2 (PTH2) receptor
    T B Usdin
    Laboratory of Genetics, National Institute of Mental Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, Maryland 20892 4094, USA
    Receptors Channels 8:211-8. 2002
    ..Functional hypotheses based on the receptor's distribution are being tested. Recent data support involvement in hypothalamic releasing-factor secretion and pain...
  7. ncbi request reprint Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat
    T B Usdin
    Laboratory of Cell Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 137:4285-97. 1996
    ..A small number of cells associated with the vascular pole of renal glomeruli express the receptor. These data suggest that the PTH2 receptor may be responsible for PTH effects in a number of physiological systems...
  8. ncbi request reprint Tuberoinfundibular peptide (7-39) [TIP(7-39)], a novel, selective, high-affinity antagonist for the parathyroid hormone-1 receptor with no detectable agonist activity
    S R Hoare
    Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland, USA
    J Pharmacol Exp Ther 295:761-70. 2000
    ....
  9. ncbi request reprint Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity
    S R Hoare
    Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:27274-83. 2000
    ..As a result, TIP-(7-39) is a highly potent, selective antagonist for the PTH1 receptor...
  10. ncbi request reprint Forebrain projections of tuberoinfundibular peptide of 39 residues (TIP39)-containing subparafascicular neurons
    J Wang
    Laboratory of Genetics, National Institute of Mental Health, Building 35, Room 1B215, 35 Convent Drive, Bethesda, MD 20892 3728, USA
    Neuroscience 138:1245-63. 2006
    ..Our data provide an anatomical basis for the potential involvement of rostral subparafascicular neurons in limbic and autonomic regulation, with TIP39 cells being major subparafascicular output neurons projecting to forebrain regions...
  11. ncbi request reprint Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
    T B Usdin
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892
    Endocrinology 133:2861-70. 1993
    ..This suggests that a novel peptide may be present in the brain...
  12. ncbi request reprint Comparison of rat and human parathyroid hormone 2 (PTH2) receptor activation: PTH is a low potency partial agonist at the rat PTH2 receptor
    S R Hoare
    Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892 4094, USA
    Endocrinology 140:4419-25. 1999
    ..A peptide homologous to an activity detected in a bovine hypothalamic extract is a good candidate for the endogenous PTH2 receptor ligand...
  13. ncbi request reprint Regions in rat and human parathyroid hormone (PTH) 2 receptors controlling receptor interaction with PTH and with antagonist ligands
    C P Goold
    Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland, USA
    J Pharmacol Exp Ther 299:678-90. 2001
    ..These insights should contribute to the development of a high-affinity PTH2 receptor antagonist, for investigating the receptor's physiological role...
  14. ncbi request reprint Evaluating the signal transduction mechanism of the parathyroid hormone 1 receptor. Effect of receptor-G-protein interaction on the ligand binding mechanism and receptor conformation
    S R Hoare
    Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892-4092, USA
    J Biol Chem 276:7741-53. 2001
    ..The results extend the two-site model to take into account R and RG conformations and suggest a model for differences of receptor conformation between these states...
  15. ncbi request reprint Molecular mechanisms of ligand recognition by parathyroid hormone 1 (PTH1) and PTH2 receptors
    S R Hoare
    Laboratory of Genetics, NIMH, Buidling 36 Rm 3D06, 36 Convent Drive MSC4090, Bethesda, MD 20892 4094, USA
    Curr Pharm Des 7:689-713. 2001
    ..This finding suggests that it might be possible to design low molecular-weight PTH1 receptor agonists, which could be bone anabolic agents and used for the treatment of osteoporosis...
  16. ncbi request reprint Neurons containing tuberoinfundibular peptide of 39 residues project to limbic, endocrine, auditory and spinal areas in rat
    A Dobolyi
    Laboratory of Genetics, National Institute of Mental Health, 36 Convent Drive, MSC4094, Building 36, Room 3D06, Bethesda, MD 20892 4094, USA
    Neuroscience 122:1093-105. 2003
    ....
  17. pmc Maternal absence of the parathyroid hormone 2 receptor affects postnatal pup development
    L Coutellier
    Section on Fundamental Neuroscience, National Institute of Mental Health National Institutes of Health, Bethesda, MD, USA
    J Neuroendocrinol 23:612-9. 2011
    ..Taken together, our findings suggest the involvement of the TIP39/PTH2-R system in the pathways involved in the successful development of the pups...
  18. pmc Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues
    D B Fegley
    National Institute of Mental Health National Institutes of Health, Bethesda, MD, USA
    Genes Brain Behav 7:933-42. 2008
    ..Current data support the hypothesis that TIP39 modulates anxiety-related behaviors following environmental provocation...
  19. ncbi request reprint Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization
    T B Usdin
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892 4090, USA
    Genomics 37:140-1. 1996
  20. ncbi request reprint Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors
    J A Clark
    Section on Genetics, National Institute of Mental Health, Bethesda, Maryland 20892 4090, USA
    Mol Endocrinol 12:193-206. 1998
    ..These data suggest that the amino terminus and third extracellular loop of the PTH2 and PTH/PTHrP receptors interact similarly with PTH, and that both domains contribute to differential interaction with PTHrP...
  21. ncbi request reprint Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions
    T B Usdin
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892
    Endocrinology 135:2662-80. 1994
    ..In the CNS VIP2 receptor mRNA is exclusively present in areas associated with neuroendocrine function, including several hypothalamic nuclei. In the periphery, it is also present in the pituitary and in pancreatic islets...
  22. ncbi request reprint Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus
    J D Erickson
    Section on Molecular Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892
    J Biol Chem 269:21929-32. 1994
    ....
  23. ncbi request reprint Afferent connections of the subparafascicular area in rat
    J Wang
    Laboratory of Genetics, National Institute of Mental Health, 35 Convent Drive, Bethesda, MD 20892 3728, USA
    Neuroscience 138:197-220. 2006
    ..Overall, the afferent connections of the subparafascicular nucleus and area suggest its involvement in central reproductive, visceral, nociceptive, and auditory regulation...
  24. pmc TIP39 modulates effects of novelty-induced arousal on memory
    L Coutellier
    Section on Fundamental Neuroscience, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20892, USA
    Genes Brain Behav 10:90-9. 2011
    ..Collectively, these results suggest that the TIP39/PTH2-R system modulates the effects of novelty exposure on memory performance, potentially by acting on noradrenergic signaling...
  25. ncbi request reprint Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor
    T B Usdin
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892 4090, USA
    J Biol Chem 270:15455-8. 1995
    ..The PTH2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution. It is activated by PTH and not by PTHrP and is particularly abundant in the brain and pancreas...
  26. pmc Cloning of the cocaine-sensitive bovine dopamine transporter
    T B Usdin
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 88:11168-71. 1991
    ..3H]Dopamine accumulation in tissue culture cells transfected with the cDNA was inhibited by amphetamine, cocaine, and specific inhibitors of dopamine transport, including GBR12909...
  27. pmc Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brain
    Catherine A Faber
    Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 4094, USA
    J Comp Neurol 502:563-83. 2007
    ..Published 2007 Wiley-Liss, Inc...
  28. pmc Development of a rat parathyroid hormone 2 receptor antagonist
    Jonathan Kuo
    National Institute of Mental Health, Laboratory of Genetics, Building 35, Room 1B 415, Convent Drive, MSC 3728, Bethesda, MD 20892, USA
    Peptides 28:887-92. 2007
    ..This ligand should be useful for in vivo investigation of PTH2 receptor function...
  29. pmc Tuberoinfundibular Peptide of 39 residues is required for germ cell development
    Ted B Usdin
    National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 149:4292-300. 2008
    ..These results show that TIP39 is essential for germ cell development and suggest that it may act as an autocrine or paracrine agent within the gonads...
  30. pmc Evaluation of vector-primed cDNA library production from microgram quantities of total RNA
    Jonathan Kuo
    Laboratory of Genetics, National Institute of Mental Health Building 35, Room 1B 215, 35 Convent Drive, Bethesda, MD 20892 3728, USA
    Nucleic Acids Res 32:e183. 2004
    ....
  31. pmc The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
    Daniela S Gerhard
    Genome Res 14:2121-7. 2004
    ..Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline...
  32. ncbi request reprint Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7-39)
    Sam R J Hoare
    Unit on Cell Biology, National Institute of Mental Health, Room 3D06, Bld 36, 36 Convent Drive, Bethesda, MD 20892 4092, USA
    Peptides 23:989-98. 2002
    ..6 min (92%), and t(1/2)=21 min (8%)). Loss of unlabeled mTIP(7-39) (250 microg/kg i.v.) receptor binding was similar. mTIP(7-39)'s high-affinity should facilitate animal evaluation of effects of PTH1 receptor antagonism...
  33. pmc Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
    Robert L Strausberg
    National Cancer Institute, Bethessda, MD 20892 2580, USA
    Proc Natl Acad Sci U S A 99:16899-903. 2002
    ..All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http:mgc.nci.nih.gov)...
  34. pmc Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception
    Arpad Dobolyi
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:1651-6. 2002
    ..Cells in these areas project to the superficial dorsal horn of the spinal cord. Our data suggest that TIP39 released from supraspinal fibers potentiates aspects of nociception within the spinal cord...
  35. ncbi request reprint Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization
    Alessandro Bisello
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 18:1486-98. 2004
    ....
  36. ncbi request reprint Tuberoinfundibular peptide of 39 residues produces anxiolytic and antidepressant actions
    Christopher J LaBuda
    Laboratory of Genetics, National Institute of Mental Health, Bldg 36 Rm 3D06, 36 Convent Dr MSC 4094, Bethesda, MD 20892 4094, USA
    Neuroreport 15:881-5. 2004
    ..TIP39 did not change activity in the open field test. These findings point to a previously unknown role of the PTH2-R in the regulation of anxiety and depression...
  37. ncbi request reprint Centrally administered tuberoinfundibular peptide of 39 residues inhibits arginine vasopressin release in conscious rats
    Yoshihisa Sugimura
    Department of Internal Medicine, Graduate School of Medicine, Nagoya University, Nagoya, Aichi 466 8550, Japan
    Endocrinology 144:2791-6. 2003
    ..These results suggest that central TIP39 plays an inhibitory role in the osmoregulation and baroregulation of AVP release and that intrinsic opioid systems are involved in its mechanism...
  38. ncbi request reprint Neurons containing tuberoinfundibular peptide of 39 residues are activated following male sexual behavior
    Jing Wang
    Laboratory of Genetics, National Institute of Mental Health, Bethesda, MD 20892 4094, USA
    Neuropeptides 40:403-8. 2006
    ..This suggests that TIP39-IR neurons in the mSPFp are part of the afferent circuits that process genital-somatosensory information related to ejaculation, and which contribute to mating and mating-induced changes in reproductive behavior...
  39. ncbi request reprint Tuberoinfundibular peptide of 39 residues decreases pain-related affective behavior
    Christopher J LaBuda
    Laboratory of Genetics, National Institute of Mental Health, Bldg 36 Rm 3D06, 36 Convent Dr MSC 4094, Bethesda, MD 20892 4094, USA
    Neuroreport 15:1779-82. 2004
    ..c.v. TIP39 were opposite in direction from previously described effects of intrathecal TIP39, this suggests that TIP39 may modulate an affective component of nociception within the brain...
  40. pmc Evidence for the expression of parathyroid hormone 2 receptor in the human brainstem
    Attila G Bagó
    Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Histology and Embryology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
    Ideggyogy Sz 61:123-6. 2008
    ..Initial functional studies suggest that the PTH2R is involved in the regulation of viscerosensory information processing. As a first step towards clinical applications, herein we describe the presence of the PTH2R in the human brainstem...