Takeji Umemura

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Association between SEN virus infection and hepatitis C in Japan
    T Umemura
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    J Infect Dis 184:1246-51. 2001
  2. ncbi request reprint SEN virus: response to interferon alfa and influence on the severity and treatment response of coexistent hepatitis C
    Takeji Umemura
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 35:953-9. 2002
  3. doi request reprint Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients
    Satoru Joshita
    Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Hepatol 53:537-41. 2010
  4. doi request reprint Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Hum Immunol 70:742-6. 2009
  5. doi request reprint Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C
    Takeji Umemura
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Antivir Ther 16:1073-80. 2011
  6. ncbi request reprint Serum fragmented cytokeratin 18 levels reflect the histologic activity score of nonalcoholic fatty liver disease more accurately than serum alanine aminotransferase levels
    Masaru Tsutsui
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Asahi, Matsumoto, Japan
    J Clin Gastroenterol 44:440-7. 2010
  7. doi request reprint Association of autoimmune pancreatitis with cytotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Gastroenterol 103:588-94. 2008
  8. doi request reprint Clinical significance of immunoglobulin G4-associated autoimmune hepatitis
    Takeji Umemura
    Division of Hepatology and Gastroenterology, Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    J Gastroenterol 46:48-55. 2011
  9. doi request reprint Association of serum cytokine levels with treatment response to pegylated interferon and ribavirin therapy in genotype 1 chronic hepatitis C patients
    Suguru Yoneda
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    J Infect Dis 203:1087-95. 2011
  10. ncbi request reprint A genomewide DNA microsatellite association study of Japanese patients with autoimmune hepatitis type 1
    Shuichi Yokosawa
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 45:384-90. 2007

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Association between SEN virus infection and hepatitis C in Japan
    T Umemura
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    J Infect Dis 184:1246-51. 2001
    ..SENV is a common infection that appears to have transmission routes and age-related prevalence that are distinct from those of HCV. No evidence was found that SENV caused hepatitis or worsened the course of hepatitis C...
  2. ncbi request reprint SEN virus: response to interferon alfa and influence on the severity and treatment response of coexistent hepatitis C
    Takeji Umemura
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 35:953-9. 2002
    ..SENV infection had no apparent influence on the severity of HCV-related liver disease or the HCV response to IFN-alpha. SENV was sensitive to IFN-alpha therapy and the majority of patients had a sustained virologic response...
  3. doi request reprint Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients
    Satoru Joshita
    Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Hepatol 53:537-41. 2010
    ....
  4. doi request reprint Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Hum Immunol 70:742-6. 2009
    ..Analysis of allelic frequencies revealed no statistical association with either susceptibility or relapse of AIP. These data indicate that TLR4 polymorphisms do not play an important role in the development of AIP...
  5. doi request reprint Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C
    Takeji Umemura
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Antivir Ther 16:1073-80. 2011
    ..Both IL28B gene polymorphisms and serum levels of interleukin (IL)-10, IL-12p40 and IL-18 have been reported to affect the outcome of natural and pegylated interferon and ribavirin-treated HCV infection...
  6. ncbi request reprint Serum fragmented cytokeratin 18 levels reflect the histologic activity score of nonalcoholic fatty liver disease more accurately than serum alanine aminotransferase levels
    Masaru Tsutsui
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Asahi, Matsumoto, Japan
    J Clin Gastroenterol 44:440-7. 2010
    ....
  7. doi request reprint Association of autoimmune pancreatitis with cytotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Gastroenterol 103:588-94. 2008
    ..As cytotoxic T-lymphocyte antigen 4 (CTLA4) polymorphisms have recently been linked with several autoimmune diseases, we sought to determine if CTLA4 polymorphisms and serum sCTLA4 levels were associated with AIP as well...
  8. doi request reprint Clinical significance of immunoglobulin G4-associated autoimmune hepatitis
    Takeji Umemura
    Division of Hepatology and Gastroenterology, Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    J Gastroenterol 46:48-55. 2011
    ..However, the epidemiology and clinical features of IgG4-associated AIH remain uncertain. The aim of this study was to determine the prevalence and the clinical, serological, and histological characteristics of IgG4-associated AIH...
  9. doi request reprint Association of serum cytokine levels with treatment response to pegylated interferon and ribavirin therapy in genotype 1 chronic hepatitis C patients
    Suguru Yoneda
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    J Infect Dis 203:1087-95. 2011
    ....
  10. ncbi request reprint A genomewide DNA microsatellite association study of Japanese patients with autoimmune hepatitis type 1
    Shuichi Yokosawa
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 45:384-90. 2007
    ..These results also suggested that the products of several genes interact to determine heritable susceptibility to AIH...
  11. doi request reprint Pretreatment prediction of virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients using viral and host factors
    Haruaki Shirakawa
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 48:1753-60. 2008
    ..In conclusion, a logistic regression model that includes the sequence of ISDR of the HCV, Th1/Th2 ratio, body weight, and neutrophil count can be useful for accurately predicting actual SVR rate before combination therapy...
  12. doi request reprint Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis
    Susumu Morita
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Hum Immunol 74:219-22. 2013
    ..No significant positive associations with either PBC susceptibility or progression were uncovered. These results indicate that TLR4 polymorphisms do not play a prominent role in the development of PBC in Japanese patients...
  13. doi request reprint Changes in the serum level of hepatitis B virus (HBV) surface antigen over the natural course of HBV infection
    Akihiro Matsumoto
    Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    J Gastroenterol 47:1006-13. 2012
    ..Despite its status as a potential biomarker of hepatitis B virus (HBV) response to interferon treatment, the changes in hepatitis B surface antigen (HBsAg) levels over the natural course of HBV carriers have not been analyzed sufficiently...
  14. doi request reprint Long-term outcome of Japanese patients with type 1 autoimmune hepatitis
    Kaname Yoshizawa
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 56:668-76. 2012
    ..020) analyses. The development of liver malignancy was also a possibility among AIH patients with multiple relapses. Severe adverse effects of corticosteroids were rare, even in patients who underwent long-term treatment...
  15. doi request reprint Clinical characteristics of young-onset ischemic colitis
    Takefumi Kimura
    Department of Internal Medicine, Division of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Dig Dis Sci 57:1652-9. 2012
    ..Although there have been reports of younger patients with IC, its clinical features remain unclear...
  16. pmc Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients
    Kei Kitahara
    Department of Internal Medicine, Shinshu University School of Medicine, Asahi Matsumoto, Japan
    Dis Markers 25:175-80. 2008
    ....
  17. doi request reprint Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection
    Satoru Joshita
    Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Hum Immunol 73:298-300. 2012
    ..2 mg/dl were associated with HCC onset. It appears that the IL28B SNP does not directly influence hepatocarcinogenesis in chronic HCV infection...
  18. doi request reprint Epidemiology of hepatocellular carcinoma in Japan
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    J Gastroenterol 44:102-7. 2009
    ..Better understanding of HCC unrelated to HCV and HBV, possibly caused by steatohepatitis and diabetes, should also be a major concern in future studies...
  19. ncbi request reprint Hepatitis B virus RNA is measurable in serum and can be a new marker for monitoring lamivudine therapy
    Akinori Rokuhara
    Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Gastroenterol 41:785-90. 2006
    ..Changes in the serum hepatitis B virus (HBV) RNA level during lamivudine therapy were compared to those in the serum HBV DNA and HBV core-related antigen (HBVcrAg) levels in 24 patients with chronic hepatitis B...
  20. doi request reprint Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase
    Naoki Tanaka
    Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Liver Int 28:1104-11. 2008
    ..Therefore, we aimed at exploring the singular effects of HCV on glucose metabolism through analysis of HCV carriers with persistently normal serum aminotransferase...
  21. ncbi request reprint Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits
    Goro Tsuruta
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    J Gastroenterol 45:666-72. 2010
    ..This prompted us to evaluate the incidence and clinical characteristics of NAFLD among junior high school students...
  22. pmc Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Dis Markers 31:223-9. 2011
    ..Our findings provide the first evidence that KCNA3 is associated with AIP and suggest that KCNA3 may influence the risk for AIP...
  23. pmc STAT4 gene polymorphisms are associated with susceptibility and ANA status in primary biliary cirrhosis
    Satoru Joshita
    Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Dis Markers 2014:727393. 2014
    ..032, and rs10181656; P = 0.031) were associated with ANA status, but not with AMA positivity. Our findings confirm that STAT4 is involved in PBC susceptibility and may play a role in ANA status in the Japanese population. ..
  24. doi request reprint Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis
    Takeji Umemura
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 55:506-11. 2012
    ..0012; OR = 3.96). Furthermore, the frequency of serine at position 57 (P = 0.0000015; OR = 1.83) of the DRβchain differed the most in patients with PBC, compared with healthy subjects...
  25. doi request reprint A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients
    Satoru Joshita
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hum Immunol 71:520-4. 2010
    ..This study showed a total of 11 candidate PBC susceptibility or resistance regions. In particular, the A2BP1 gene might play a pivotal role for susceptibility to PBC...
  26. pmc Human Leukocyte Antigen Class II Haplotypes Affect Clinical Characteristics and Progression of Type 1 Autoimmune Hepatitis in Japan
    Takeji Umemura
    Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    PLoS ONE 9:e100565. 2014
    ..Additional sequencing of the entire HLA region is required to more precisely identify the genetic components of AIH. ..
  27. pmc KIR, HLA, and IL28B variant predict response to antiviral therapy in genotype 1 chronic hepatitis C patients in Japan
    Yuichi Nozawa
    Division of Hepatology and Gastroenterology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    PLoS ONE 8:e83381. 2013
    ..0067). In conclusion, combinations of KIR3DL1/HLA-Bw4, KIR2DL2/HLA-C1, and a genetic variant of the IL28B gene are predictive of the response to PEG-IFN and ribavirin therapy in Japanese patients infected with genotype 1b HCV. ..
  28. doi request reprint Serum chemokine levels are associated with the outcome of pegylated interferon and ribavirin therapy in patients with chronic hepatitis C
    Suguru Yoneda
    Departments of Medicine, Division of Hepatology and Gastroenterology Department of Legal Medicine, Shinshu University School of Medicine Department of Pharmacy, Shinshu University Hospital, Matsumoto, Japan
    Hepatol Res 41:587-93. 2011
    ..Conclusion:  Serum MIP-1β levels may predict the response to HCV treatment with pegylated interferon and ribavirin and are associated with amino acid substitutions in the ISDR...
  29. ncbi request reprint Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population
    Naoki Tanaka
    Division of Gastroenterology, Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Liver Int 26:956-63. 2006
    ..We aimed to test this possibility and to isolate factors that may indicate NASH...
  30. ncbi request reprint Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese
    Takeji Umemura
    Department of Internal Medicine, Divisions of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatol Res 38:689-95. 2008
    ..Conclusion: These data suggest that the CTLA4 polymorphism is not associated with susceptibility to type 1 AIH in the Japanese population...
  31. ncbi request reprint Clinical significance of SEN virus infection in patients on maintenance haemodialysis
    Nobuhiko Kobayashi
    Second Department of Internal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Nephrol Dial Transplant 18:348-52. 2003
    ..The SEN virus (SENV) has been identified as a putative new hepatitis virus. This study was conducted to clarify the clinical significance of SENV infection in patients on haemodialysis...
  32. ncbi request reprint Hepatocellular carcinoma: recent trends in Japan
    Kendo Kiyosawa
    Department of Internal Medicine, Gastroenterology, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, Nagano Prefecture 390 8621, Japan
    Gastroenterology 127:S17-26. 2004
    ..Better understanding of HCC unrelated to HCV and HBV and possibly because of steatohepatitis and diabetes should also be a major concern in future studies...
  33. doi request reprint Mortality secondary to fulminant hepatic failure in patients with prior resolution of hepatitis B virus infection in Japan
    Takeji Umemura
    Department of Internal Medicine, Hepatology, and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Clin Infect Dis 47:e52-6. 2008
    ..Because one-fourth of cases develop into fulminant hepatic failure and mortality is 100%, management of HBV reactivation in patients with resolved HBV infection should be discussed...
  34. doi request reprint Down-regulation of SREBP-1c is associated with the development of burned-out NASH
    Tadanobu Nagaya
    Department of Gastroenterology, Shinshu University School of Medicine, Japan
    J Hepatol 53:724-31. 2010
    ..We aimed to explore the changes in hepatic fatty acid (FA) and TG metabolism with disease progression...
  35. doi request reprint Early detection of interstitial pneumonia by monitoring KL-6 in a chronic hepatitis C patient undergoing pegylated interferon and ribavirin therapy
    Yuki Ichikawa-Yamada
    Department of Medicine, Division of Gastroenterology and Hepatology Department of Radiology, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatol Res 41:904-9. 2011
    ....
  36. doi request reprint Cytokine profiles affecting the pathogenesis of autoimmune hepatitis in Japanese patients
    Atsushi Kamijo
    Departments of Medicine Legal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatol Res 41:350-7. 2011
    ..Conclusion:  Our results suggest that a complex interplay of several cytokines, especially pro-inflammatory and T-helper 17 cytokines and regulatory T-cell suppression by IL-12p40 may play a pivotal role in the pathogenesis of AIH...
  37. ncbi request reprint Liver dysfunction and thrombocytopenia diagnosed as intravascular large B-cell lymphoma using a timely and accurate transjugular liver biopsy
    Nodoka Sekiguchi
    Department of Medicine, Shinshu University School of Medicine, Japan
    Intern Med 52:1903-8. 2013
    ..TJLB is therefore a timely and accurate diagnostic approach for IVLBCL, especially when a bleeding tendency and ascites are noted. ..
  38. doi request reprint De novo autoimmune hepatitis following living-donor liver transplantation for primary biliary cirrhosis
    Kaname Yoshizawa
    Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Clin Transplant 22:385-90. 2008
    ..In conclusion, recipient immune cells attacked the allogeneic transplanted liver of the patient via de novo AIH, although the exact participation of autoimmune mechanisms is unclear...
  39. ncbi request reprint A case of pyogenic liver abscess infected with Fusobacterium necrophorum depicted by microscopy and confirmed by tissue culture
    Yuichi Nozawa
    Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Japan
    Intern Med 50:1815-9. 2011
    ..Fusobacterium necrophorum is a rare bacterium causing potentially fatal liver abscesses in humans. Clinicians should bear Fusobacterium necrophorum in mind when treating patients with an enlarged solitary liver abscess...
  40. ncbi request reprint Fulminant hepatitis after allogenic bone marrow transplantation caused by reactivation of hepatitis B virus with gene mutations in the core promotor region
    Kiyoshi Kitano
    Department of Internal Medicine, Matsumoto National Hospital, Matsumoto, Japan
    Eur J Haematol 77:255-8. 2006
    ..On analysis of the HBV-DNA, two adjacent gene mutations in the core promoter region (T1762/A1764) were detected. Increased replication of the mutated HBV might have caused HBV reactivation which progressed to fulminant hepatitis...
  41. ncbi request reprint Patients with and without loss of hepatitis B virus DNA after hepatitis B e antigen seroconversion have different virological characteristics
    Noriko Misawa
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    J Med Virol 78:68-73. 2006
    ..It was therefore considered that the seroconversion was caused mainly by a decrease in viral replication in the inactive replication group, and mainly by a decrease in HBe antigen production in the active replication group...
  42. pmc A novel immunoglobulin-immunoglobulin interaction in autoimmunity
    Shigeyuki Kawa
    Center for Health, Safety and Environmental Management, Shinshu University, Matsumoto, Japan
    PLoS ONE 3:e1637. 2008
    ..In the future, the relevance of NRF, beyond autoimmune pancreatitis, in both diagnosis/prognosis as well as pathophysiology of autoimmune and other systemic diseases where IgG4's role seems paramount, needs to be systematically assessed...
  43. ncbi request reprint Immunoglobin G4-hepatopathy: association of immunoglobin G4-bearing plasma cells in liver with autoimmune pancreatitis
    Takeji Umemura
    Department of Internal Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 46:463-71. 2007
    ..These features were ameliorated by steroid therapy, suggesting that the liver is concurrently affected in AIP, and that liver biopsies can provide significant information in the clinical evaluation and diagnosis of AIP...
  44. ncbi request reprint Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis
    Masao Ota
    Department of Legal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Immunogenetics 59:45-52. 2007
    ..The two critical HLA regions for susceptibility to AIP are limited to the HLA-DRB1*0405-DQB1*0401 in the class II and the ABCF1 proximal to C3-2-11, telomeric of HLA-E, in the class I regions...
  45. ncbi request reprint A patient with advanced hepatocellular carcinoma treated with sorafenib tosylate showed massive tumor lysis with avoidance of tumor lysis syndrome
    Satoru Joshita
    Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Intern Med 49:991-4. 2010
    ..In conclusion, clinicians should bear in mind not only the published adverse effects, but also massive tumor lysis, when treating patients with large tumor burden by sorafenib...
  46. ncbi request reprint Assessment of KL-6 as a tumor marker in patients with hepatocellular carcinoma
    Amal Gad
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    World J Gastroenterol 11:6607-12. 2005
    ..To investigate the clinical significance of KL-6 as a tumor marker of HCC in two different ethnic groups with chronic liver disease consecutively encountered at outpatient clinics...
  47. ncbi request reprint Severe alcoholic hepatitis with extremely high neutrophil count successfully treated by granulocytapheresis
    Kentaro Okubo
    Department of Medicine, Shinshu University School of Medicine, Matsumoto
    Intern Med 45:155-8. 2006
    ..We could conclude that granulocytapheresis and ulinastatin can be very effective in reducing cytokines and neutrophil-elastase, and in improving the general status of SAH patients...
  48. ncbi request reprint Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis
    Takeji Umemura
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Clin Immunol 122:338-42. 2007
    ....
  49. ncbi request reprint A case of well-differentiated cholangiolocellular carcinoma visualized with contrast-enhanced ultrasonography using Sonazoid
    Satoru Joshita
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinsu University School of Medicine, Matsumoto, Japan
    Hepatol Res 39:207-12. 2009
    ..In light of the above findings and the rarity of CoCC, it is helpful to incorporate the results of several imagings, such as CT, MRI, angiography and CEUS with a second-generation contrast agent when clinically diagnosing CoCC...
  50. doi request reprint Genetic background of autoimmune hepatitis in Japan
    Kaname Yoshizawa
    Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    J Gastroenterol 46:42-7. 2011
    ....
  51. ncbi request reprint Sclerosing cholangitis associated with autoimmune pancreatitis
    Shigeyuki Kawa
    Center for Health, Safety and Environmental Management, Shinshu University, Matsumoto, Japan
    Hepatol Res 37:S487-95. 2007
    ..The pathogenesis of AIP and SC-AIP remains unclear. The complement activation system of the classical pathway may be contributing in some cases...
  52. ncbi request reprint Epidemiology of hepatocellular carcinoma in Japan
    Takeji Umemura
    Department of Internal Medicine, Gastroenterology, and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatol Res 37:S95-S100. 2007
    ..Interferon therapy for chronic hepatitis C has reduced the risk factors for development of HCC, especially among patients with sustained response...
  53. ncbi request reprint Prevalence of SEN viruses among injection drug users in the San Francisco Bay area
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    J Infect Dis 188:13-8. 2003
    ..05; 95% CI, 2.62-18.95). SENV strains are common among San Francisco Bay area IDUs, and prevalence varies demographically within this group...
  54. ncbi request reprint [Epidemiology of SEN virus infection--prevalence of SEN virus infection and its background in Japan]
    Takeji Umemura
    Department of Medicine, Shinshu University School of Medicine
    Nihon Rinsho 62:602-5. 2004
  55. ncbi request reprint Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis
    Takeji Umemura
    Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1184, USA
    J Infect Dis 188:1545-52. 2003
    ..The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated...
  56. ncbi request reprint [Molecular biology of SEN virus]
    Takeji Umemura
    Department of Medicine, Shinshu University School of Medicine
    Nihon Rinsho 62:593-7. 2004
  57. ncbi request reprint SEN virus: epidemiology and characteristics of a transfusion-transmitted virus
    Jun Akiba
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    Transfusion 45:1084-8. 2005
    ..Nevertheless, SEN-V appears to be transmitted by transfusion, and further studies may reveal more about its role in the future...
  58. ncbi request reprint Observation of positive selection within hypervariable regions of a newly identified DNA virus (SEN virus)(1)
    Takeji Umemura
    Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    FEBS Lett 510:171-4. 2002
    ..32 x 10(-4) per site per year. Since this rate is close to RNA viruses and higher than other DNA viruses, the SEN-V might be replicated by machinery with poor or no proofreading function...