Affiliation: National Institutes of Health
- Naltrexone shortened opioid detoxification with buprenorphineA Umbricht
NIDA Intramural Research Program, Addiction Research Center, Baltimore, MD, USA
Drug Alcohol Depend 56:181-90. 1999..Peak withdrawal symptoms after naltrexone were of moderate intensity, suggesting that naltrexone combined with buprenorphine is an acceptable and safe treatment for shortened opioid detoxification and induction of naltrexone maintenance...
- Monitoring opiate use in substance abuse treatment patients with sweat and urine drug testingM A Huestis
Chemistry and Drug Metabolism Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
J Anal Toxicol 24:509-21. 2000..However, the percentage of false-negative results, at least in this treatment population, indicates that weekly sweat testing may be less sensitive than thrice weekly urine testing in detecting opiate use...
- Family history influence on drug abuse severity and treatment outcomeR W Pickens
Clinical Neurogenetics Section and Treatment Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Drug Alcohol Depend 61:261-70. 2001..Both effects remained significant after adjusting for gender and race. These results suggest that common genetic factors may underlie both susceptibility to heroin dependence and response to therapeutic methadone treatment...
- Intravenous buprenorphine and norbuprenorphine pharmacokinetics in humansM A Huestis
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
Drug Alcohol Depend 131:258-62. 2013..Prescribed sublingual (SL) buprenorphine is sometimes diverted for intravenous (IV) abuse, but no human pharmacokinetic data are available following high-dose IV buprenorphine...
- Therapeutic drug monitoring in methadone maintenance: choosing a matrixE T Moolchan
Department of Health and Human Services, National Institute of Health, National Institute of Drug Abuse, Baltimore, MD 21224, USA
J Addict Dis 20:55-73. 2001..However, saliva methadone concentrations are influenced by salivary pH, and future studies are needed to determine how to control for that. Administrative, medical, and social implications of methadone TDM are briefly discussed...
- Shaping cocaine abstinence by successive approximationK L Preston
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Consult Clin Psychol 69:643-54. 2001..A 2nd phase of the study showed that abstinence induced by escalating-value vouchers can be maintained by a nonescalating schedule, suggesting that contingency management can be practical as a maintenance treatment...
- Cyclazocine: comparison to hydromorphone and interaction with cocaineK L Preston
National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
Behav Pharmacol 15:91-102. 2004..This study is suggestive but not strongly supportive for the use of kappa-opiate drugs to diminish acute effects of cocaine administration or for the use of these kappa agonists in drug abuse treatment applications...