D M Umbach

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc GLI1 genotypes do not predict basal cell carcinoma risk: a case control study
    Andrea Watson
    1Department of Pediatrics, University of Minnesota Duluth, Minnesota, USA
    Mol Cancer 8:113. 2009
  2. pmc Optimized mixed Markov models for motif identification
    Weichun Huang
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27606, USA
    BMC Bioinformatics 7:279. 2006
  3. pmc A response to information criterion-based clustering with order-restricted candidate profiles in short time-course microarray experiments
    Shyamal D Peddada
    Biostatistics Branch, National Institute of Environmental Health Sciences Research Triangle Park, NC 27709, USA
    BMC Bioinformatics 10:438. 2009
  4. pmc Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases
    Terrance P O'Hanlon
    Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Res Ther 13:R69. 2011
  5. ncbi request reprint On the determination of sample size
    David M Umbach
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Epidemiology 14:137-8. 2003
  6. pmc The use of case-parent triads to study joint effects of genotype and exposure
    D M Umbach
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 2233, USA
    Am J Hum Genet 66:251-61. 2000
  7. pmc Unit conversion as a source of misclassification in US birthweight data
    D M Umbach
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Public Health 90:127-9. 2000
  8. ncbi request reprint The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction
    J A Taylor
    Epidemiology Branch, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 58:3603-10. 1998
  9. pmc Making the most of case-mother/control-mother studies
    M Shi
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 168:541-7. 2008
  10. ncbi request reprint Association of cigarette smoking with amyotrophic lateral sclerosis
    F Kamel
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Neuroepidemiology 18:194-202. 1999

Collaborators

Detail Information

Publications57

  1. pmc GLI1 genotypes do not predict basal cell carcinoma risk: a case control study
    Andrea Watson
    1Department of Pediatrics, University of Minnesota Duluth, Minnesota, USA
    Mol Cancer 8:113. 2009
    ....
  2. pmc Optimized mixed Markov models for motif identification
    Weichun Huang
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27606, USA
    BMC Bioinformatics 7:279. 2006
    ..Identifying functional elements, such as transcriptional factor binding sites, is a fundamental step in reconstructing gene regulatory networks and remains a challenging issue, largely due to limited availability of training samples...
  3. pmc A response to information criterion-based clustering with order-restricted candidate profiles in short time-course microarray experiments
    Shyamal D Peddada
    Biostatistics Branch, National Institute of Environmental Health Sciences Research Triangle Park, NC 27709, USA
    BMC Bioinformatics 10:438. 2009
    ..1 is inefficient compared to the publicly available JAVA implementation. Our results on the false positive rate of ORIOGEN suggest some error in Figure three of Liu et al. 1, perhaps due to a programming error...
  4. pmc Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases
    Terrance P O'Hanlon
    Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Res Ther 13:R69. 2011
    ..The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders...
  5. ncbi request reprint On the determination of sample size
    David M Umbach
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Epidemiology 14:137-8. 2003
  6. pmc The use of case-parent triads to study joint effects of genotype and exposure
    D M Umbach
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 2233, USA
    Am J Hum Genet 66:251-61. 2000
    ..Because the needed assumptions likely hold in many situations, the likelihood-based approach should be broadly applicable for diseases in which probands commonly have living parents...
  7. pmc Unit conversion as a source of misclassification in US birthweight data
    D M Umbach
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Public Health 90:127-9. 2000
    ..This study explains why frequency polygons for US birthweights in 100-g weight classes appear spiky compared with their European counterparts...
  8. ncbi request reprint The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction
    J A Taylor
    Epidemiology Branch, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 58:3603-10. 1998
    ..Bladder cancer risk from smoking exposure is particularly high in those who inherit NAT2 slow alleles in combination with one or two copies of the NAT1*10 allele. A biological mechanism for this finding is suggested...
  9. pmc Making the most of case-mother/control-mother studies
    M Shi
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 168:541-7. 2008
    ..Benefits are even more marked if, as is typical, information on genotype is missing for some individuals...
  10. ncbi request reprint Association of cigarette smoking with amyotrophic lateral sclerosis
    F Kamel
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Neuroepidemiology 18:194-202. 1999
    ..The association of cigarette smoking with ALS was not affected by adjusting for alcohol use. In contrast, the weak relationship of ALS with alcohol use was apparently due to confounding by smoking...
  11. ncbi request reprint DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk
    M C Stern
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, 27709, USA
    Cancer Epidemiol Biomarkers Prev 10:125-31. 2001
    ..70; 95% CI, 0.4-1.3), and provided limited evidence, albeit not statistically significant, for a gene-smoking interaction...
  12. ncbi request reprint Dietary intake of calcium, magnesium and antioxidants in relation to risk of amyotrophic lateral sclerosis
    M P Longnecker
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle, NC 27709, USA
    Neuroepidemiology 19:210-6. 2000
    ..Overall, these dietary factors were not related to risk of ALS, though modestly protective associations were suggested for magnesium and lycopene...
  13. ncbi request reprint Using pooled exposure assessment to improve efficiency in case-control studies
    C R Weinberg
    Biostatistics Branch, MD A3 03, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biometrics 55:718-26. 1999
    ..In settings where high assay costs constrain the number of people an investigator can afford to study, specimen pooling can make it possible to study more people and hence improve the study's statistical power with no increase in cost...
  14. pmc Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study
    J A Hoppin
    Epidemiology Branch, National Institute of Environmental Health Sciences, Epidemiology Branch, MD A3 05, PO Box 12233, Research Triangle Park, NC 27709 2233, USA
    Eur Respir J 34:1296-303. 2009
    ..There was little evidence that allergy alone was driving these associations. In conclusion, pesticides may be an overlooked contributor to asthma risk among farmers...
  15. ncbi request reprint Choosing a retrospective design to assess joint genetic and environmental contributions to risk
    C R Weinberg
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 152:197-203. 2000
    ..The investigator must also consider certain practical issues, such as the availability of parents or sibling controls...
  16. pmc Animal production and wheeze in the Agricultural Health Study: interactions with atopy, asthma, and smoking
    J A Hoppin
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709 2233, USA
    Occup Environ Med 60:e3. 2003
    ..Exposure to animals, their feeds, and by-products contribute to respiratory symptoms among farmers...
  17. pmc Smoking duration, intensity, and risk of Parkinson disease
    H Chen
    Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T W Alexander Dr, PO Box 12233, Mail Drop A3 05, Research Triangle Park, NC 27709, USA
    Neurology 74:878-84. 2010
    ..To evaluate the relative importance of smoking duration vs intensity in reducing the risk of Parkinson disease (PD)...
  18. ncbi request reprint Studying the epidemiology of attention-deficit hyperactivity disorder: screening method and pilot results
    A S Rowland
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Can J Psychiatry 46:931-40. 2001
    ..The methods developed for this study and the pitfalls we encountered illustrate the challenges involved in conducting population-based studies of ADHD...
  19. ncbi request reprint Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer
    D A Bell
    Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 55:3537-42. 1995
    ..12). This is the first study to test for cancer risk associated with the NAT1 gene, and these positive findings suggest that NAT1 alleles may be important genetic determinents of colorectal cancer risk...
  20. ncbi request reprint Lead exposure as a risk factor for amyotrophic lateral sclerosis
    F Kamel
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Neurodegener Dis 2:195-201. 2005
    ..Most previous case-control studies found an association of ALS with self-reported occupational exposure to lead, with increased risks of 2- to >4-fold. However, these results may have been affected by recall bias...
  21. ncbi request reprint Hepatitis B, aflatoxin B(1), and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China, and a meta-analysis of existing studies
    M C Stern
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 10:617-25. 2001
    ..0001). We found little evidence for an HBV-aflatoxin interaction modulating the presence of the p53 249(ser) mutation or any type of p53 mutation...
  22. pmc A hybrid design for studying genetic influences on risk of diseases with onset early in life
    C R Weinberg
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 77:627-36. 2005
    ....
  23. ncbi request reprint Unexplained increases in cancer incidence in the United States from 1975 to 1994: possible sentinel health indicators?
    G E Dinse
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Annu Rev Public Health 20:173-209. 1999
    ..Unexplained patterns of cancer incidence may signal changes in underlying risk factors and highlight the continuing need for research on cancer etiology and prevention...
  24. ncbi request reprint Pesticides and adult respiratory outcomes in the agricultural health study
    Jane A Hoppin
    Epidemiology Branch, National Institute of Environmental Healh Science, NIH, DHHS, Research Triangle Park, NC 27709 2233, USA
    Ann N Y Acad Sci 1076:343-54. 2006
    ..00-2.19) for farmers and 1.96 (95% CI = 1.05-3.66) for commercial applicators. Our wheeze results are consistent with recent animal models that support a role for organophosphates and respiratory outcomes...
  25. pmc Optimal sampling of rat liver tissue for toxicogenomic studies
    Julie F Foley
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 34:795-801. 2006
    ..Additionally, a powdered sample provided the advantages of a homogenous sample pool and the ability to use sample aliquots for other analyses to include proteomics, metabonomics, and other molecular techniques...
  26. pmc Antimutagenicity of cinnamaldehyde and vanillin in human cells: Global gene expression and possible role of DNA damage and repair
    Audrey A King
    The Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mutat Res 616:60-9. 2007
    ..These and other data lead us to propose that VAN and CIN may induce DNA damage that elicits recombinational DNA repair, which reduces spontaneous mutations...
  27. pmc Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study
    Jane A Hoppin
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 2233, USA
    Occup Environ Med 64:334-41. 2007
    ..Farmer's lung, or hypersensitivity pneumonitis, is an important contributor to respiratory morbidity among farmers...
  28. pmc Chronic bronchitis among nonsmoking farm women in the agricultural health study
    Martin Valcin
    Epidemiology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709 2233, USA
    J Occup Environ Med 49:574-83. 2007
    ..The purpose of this study was to examine agricultural risk factors for chronic bronchitis among nonsmoking farm women...
  29. pmc Identification of risk-related haplotypes with the use of multiple SNPs from nuclear families
    Min Shi
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 81:53-66. 2007
    ..As an illustration, we reanalyze data from a previously reported orofacial cleft study, to now investigate both fetal and maternal effects of the IRF6 gene...
  30. pmc Head injury and amyotrophic lateral sclerosis
    Honglei Chen
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 166:810-6. 2007
    ..7, 95 percent CI: 1.3, 2.2). In this study population, physical injuries to other body parts, including the trunk, arms, or legs, were not related to ALS risk. These data support the notion that head injury may increase the risk of ALS...
  31. pmc Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study
    Jane A Hoppin
    NIEHS Epidemiology Branch, MD A3 05, P O Box 12233, Research Triangle Park, NC 27709 2233, USA
    Am J Respir Crit Care Med 177:11-8. 2008
    ..Risk factors for asthma among farm women are understudied...
  32. pmc Pesticide use and chronic bronchitis among farmers in the Agricultural Health Study
    Jane A Hoppin
    Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709 2233, USA
    Am J Ind Med 50:969-79. 2007
    ..Farmers have increased risk for chronic bronchitis. Few investigators have considered pesticides...
  33. pmc Using risk-based sampling to enrich cohorts for endpoints, genes, and exposures
    Clarice R Weinberg
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 166:447-55. 2007
    ....
  34. pmc Association of lead exposure with survival in amyotrophic lateral sclerosis
    Freya Kamel
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:943-7. 2008
    ..Reasons for the variability in survival among ALS cases are unknown but may include exposure to environmental neurotoxicants...
  35. ncbi request reprint Application of the GA/KNN method to SELDI proteomics data
    Leping Li
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
    Bioinformatics 20:1638-40. 2004
    ....
  36. ncbi request reprint Pesticides associated with wheeze among commercial pesticide applicators in the Agricultural Health Study
    Jane A Hoppin
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709 2233, USA
    Am J Epidemiol 163:1129-37. 2006
    ..40, 95% CI: 1.24, 4.65). These results add to the emerging literature linking organophosphate insecticides and respiratory health and suggest a role for chlorimuron-ethyl...
  37. ncbi request reprint Gene selection and clustering for time-course and dose-response microarray experiments using order-restricted inference
    Shyamal D Peddada
    Biostatistics Branch, Laboratory of Molecular Carcinogenesis, Research Triangle Park, NC 27709, USA
    Bioinformatics 19:834-41. 2003
    ..In this example, our method was able to identify several biologically interesting genes that previous analyses failed to reveal...
  38. ncbi request reprint Mutations in tetranucleotide repeats following DNA damage depend on repeat sequence and carcinogenic agent
    Robbert J C Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 62:6052-60. 2002
    ..Our results are compatible with the hypothesis that sporadic microsatellite mutations in human cancer may reflect DNA damage caused by carcinogen exposure...
  39. ncbi request reprint DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk
    Mariana C Stern
    Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 11:939-43. 2002
    ..In this study, we found some evidence for a gene-gene interaction between the XRCC1 codon 194 and XRCC3 codon 241 polymorphisms (P = 0.09) and some support for a possible gene-gene-smoking three-way interaction (P = 0.08)...
  40. ncbi request reprint Diesel exhaust, solvents, and other occupational exposures as risk factors for wheeze among farmers
    Jane A Hoppin
    Epidemiology Branch and Biostatistics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709 2233, USA
    Am J Respir Crit Care Med 169:1308-13. 2004
    ..89, 3.73), an indication of daily solvent exposure. These results add to the growing body of evidence of adverse respiratory effects of diesel exposure on the lung and suggest exposure to solvents may contribute as well...
  41. ncbi request reprint Lead exposure and amyotrophic lateral sclerosis
    Freya Kamel
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Epidemiology 13:311-9. 2002
    ..Previous interview-based studies have suggested that exposure to neurotoxicants including metals might be related to ALS...
  42. ncbi request reprint Chemical predictors of wheeze among farmer pesticide applicators in the Agricultural Health Study
    Jane A Hoppin
    Epidemiology Branch and Biostatistics Branch, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709 2233, USA
    Am J Respir Crit Care Med 165:683-9. 2002
    ..5 (95% CI 1.2,1.9). Inclusion of crops and animals into these models did not significantly alter the observed OR. These associations, though small, suggest an independent role for specific pesticides in respiratory symptoms of farmers...
  43. ncbi request reprint Patterns of pesticide use and their determinants among wives of farmer pesticide applicators in the Agricultural Health Study
    Ellen F Kirrane
    Coda Inc, Durham, North Carolina, USA
    J Occup Environ Med 46:856-65. 2004
    ..Farm women reporting the heaviest pesticide use could exacerbate their exposure by engaging in practices that could increase pesticide contact...
  44. ncbi request reprint VEGF promoter haplotype and amyotrophic lateral sclerosis (ALS)
    Paul D Terry
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, Research Triangle Park, NC 27709, USA
    J Neurogenet 18:429-34. 2004
    ..7 - 13.4), consistent with the findings of the previous study. Given the wide confidence interval, our findings should be interpreted cautiously...
  45. ncbi request reprint No association between SOD2 or NQO1 genotypes and risk of bladder cancer
    Paul D Terry
    Epidemiology Branch, NIEHS, NIH, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Cancer Epidemiol Biomarkers Prev 14:753-4. 2005
  46. ncbi request reprint Retinal degeneration and other eye disorders in wives of farmer pesticide applicators enrolled in the agricultural health study
    Ellen F Kirrane
    CODA, Inc, Durham, NC 27709, USA
    Am J Epidemiol 161:1020-9. 2005
    ..These findings suggest that exposure to some fungicides and other pesticides may increase the risk of retinal degeneration and warrant further investigation...
  47. ncbi request reprint Accurate anchoring alignment of divergent sequences
    Weichun Huang
    Biostatistics Branch, The National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    Bioinformatics 22:29-34. 2006
    ..Obtaining high quality alignments of divergent homologous sequences for cross-species sequence comparison remains a challenge...
  48. ncbi request reprint APE1 genotype and risk of bladder cancer: evidence for effect modification by smoking
    Paul D Terry
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Int J Cancer 118:3170-3. 2006
    ..Given the lack of established biological mechanisms, and suboptimal numbers of subjects in some exposure categories, our findings should be interpreted cautiously...
  49. pmc Amyotrophic lateral sclerosis, lead, and genetic susceptibility: polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genes
    Freya Kamel
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 111:1335-9. 2003
    ..These findings suggest that genetic susceptibility conferred by polymorphisms in ALAD may affect ALS risk, possibly through a mechanism related to internal lead exposure...
  50. pmc Prevalence of medication treatment for attention deficit-hyperactivity disorder among elementary school children in Johnston County, North Carolina
    Andrew S Rowland
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Am J Public Health 92:231-4. 2002
    ..This study estimated the prevalence of medication treatment for attention deficit-hyperactivity disorder (ADHD) among elementary school children in a North Carolina county...
  51. pmc Pilot studies of estrogen-related physical findings in infants
    Judy C Bernbaum
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Environ Health Perspect 116:416-20. 2008
    ..We wanted to study whether soy formula prolonged the physiologic estrogenization of newborns, but available quantitative descriptions of the natural history of breast and genital development are inadequate for study design...
  52. ncbi request reprint Analytical and statistical methods to evaluate microsatellite allelic imbalance in small amounts of DNA
    Robbert J C Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Lab Invest 84:649-57. 2004
    ..Our method allows the reliable detection of AI with very small amounts of DNA, and is sufficiently quantitative to assess allelic ratios in nonclonal tissue specimens...
  53. ncbi request reprint Mini-and microsatellite mutations in children from Chernobyl accident cleanup workers
    Robbert J C Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    Mutat Res 559:143-51. 2004
    ..In conclusion, our results do not support an increased level of germline minisatellite mutations but suggest a modest increase in germline mutations in tetranucleotide repeats. Small sample size, however, limited statistical power...
  54. pmc Transcriptional functionality of germ line p53 mutants influences cancer phenotype
    Paola Monti
    Molecular Mutagenesis Unit, Department of Translational Oncology, National Cancer Research Institute, Genoa, Italy
    Clin Cancer Res 13:3789-95. 2007
    ..umd.be:2072/index.html). We have investigated the extent to which the functional features of p53 mutant alleles determine clinical features in patients who have inherited these alleles and have developed cancer...
  55. pmc A random-periods model for expression of cell-cycle genes
    Delong Liu
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 101:7240-5. 2004
    ..The model permits estimation of and hypothesis testing about biologically meaningful parameters that characterize cycling genes...
  56. ncbi request reprint Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells
    Hyeon Woo Yim
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Lett 246:24-33. 2007
    ..An increase in telomerase activity in normal bronchial epithelium might extend the lifespan of cells at risk for malignant transformation, and thus contribute to lung carcinogenesis...
  57. pmc The shifting subtypes of ADHD: classification depends on how symptom reports are combined
    Andrew S Rowland
    Department of Family and Community Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Abnorm Child Psychol 36:731-43. 2008
    ..We conclude the ADHD subtype distribution is sensitive to how symptom information is combined and that standardization of the subtyping process is required to advance our understanding of the correlates of different ADHD subtypes...