Research Topics
Species | D M UmbachSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
GLI1 genotypes do not predict basal cell carcinoma risk: a case control studyAndrea Watson
1Department of Pediatrics, University of Minnesota Duluth, Minnesota, USA
Mol Cancer 8:113. 2009....- Optimized mixed Markov models for motif identificationWeichun Huang
Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27606, USA
BMC Bioinformatics 7:279. 2006..Identifying functional elements, such as transcriptional factor binding sites, is a fundamental step in reconstructing gene regulatory networks and remains a challenging issue, largely due to limited availability of training samples... - A response to information criterion-based clustering with order-restricted candidate profiles in short time-course microarray experimentsShyamal D Peddada
Biostatistics Branch, National Institute of Environmental Health Sciences Research Triangle Park, NC 27709, USA
BMC Bioinformatics 10:438. 2009..1 is inefficient compared to the publicly available JAVA implementation. Our results on the false positive rate of ORIOGEN suggest some error in Figure three of Liu et al. 1, perhaps due to a programming error... - Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseasesTerrance P O'Hanlon
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Arthritis Res Ther 13:R69. 2011..The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders... 
On the determination of sample sizeDavid M Umbach
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709-2233, USA
Epidemiology 14:137-8. 2003- The use of case-parent triads to study joint effects of genotype and exposureD M Umbach
Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 2233, USA
Am J Hum Genet 66:251-61. 2000..Because the needed assumptions likely hold in many situations, the likelihood-based approach should be broadly applicable for diseases in which probands commonly have living parents... - Unit conversion as a source of misclassification in US birthweight dataD M Umbach
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Am J Public Health 90:127-9. 2000..This study explains why frequency polygons for US birthweights in 100-g weight classes appear spiky compared with their European counterparts... - The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interactionJ A Taylor
Epidemiology Branch, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Cancer Res 58:3603-10. 1998..Bladder cancer risk from smoking exposure is particularly high in those who inherit NAT2 slow alleles in combination with one or two copies of the NAT1*10 allele. A biological mechanism for this finding is suggested... - Making the most of case-mother/control-mother studiesM Shi
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Am J Epidemiol 168:541-7. 2008..Benefits are even more marked if, as is typical, information on genotype is missing for some individuals... - Association of cigarette smoking with amyotrophic lateral sclerosisF Kamel
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Neuroepidemiology 18:194-202. 1999..The association of cigarette smoking with ALS was not affected by adjusting for alcohol use. In contrast, the weak relationship of ALS with alcohol use was apparently due to confounding by smoking... - DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer riskM C Stern
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, 27709, USA
Cancer Epidemiol Biomarkers Prev 10:125-31. 2001..70; 95% CI, 0.4-1.3), and provided limited evidence, albeit not statistically significant, for a gene-smoking interaction... - Dietary intake of calcium, magnesium and antioxidants in relation to risk of amyotrophic lateral sclerosisM P Longnecker
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle, NC 27709, USA
Neuroepidemiology 19:210-6. 2000..Overall, these dietary factors were not related to risk of ALS, though modestly protective associations were suggested for magnesium and lycopene... - Using pooled exposure assessment to improve efficiency in case-control studiesC R Weinberg
Biostatistics Branch, MD A3 03, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Biometrics 55:718-26. 1999..In settings where high assay costs constrain the number of people an investigator can afford to study, specimen pooling can make it possible to study more people and hence improve the study's statistical power with no increase in cost... - Pesticide use and adult-onset asthma among male farmers in the Agricultural Health StudyJ A Hoppin
Epidemiology Branch, National Institute of Environmental Health Sciences, Epidemiology Branch, MD A3 05, PO Box 12233, Research Triangle Park, NC 27709 2233, USA
Eur Respir J 34:1296-303. 2009..There was little evidence that allergy alone was driving these associations. In conclusion, pesticides may be an overlooked contributor to asthma risk among farmers... - Choosing a retrospective design to assess joint genetic and environmental contributions to riskC R Weinberg
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Am J Epidemiol 152:197-203. 2000..The investigator must also consider certain practical issues, such as the availability of parents or sibling controls... - Animal production and wheeze in the Agricultural Health Study: interactions with atopy, asthma, and smokingJ A Hoppin
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709 2233, USA
Occup Environ Med 60:e3. 2003..Exposure to animals, their feeds, and by-products contribute to respiratory symptoms among farmers... - Smoking duration, intensity, and risk of Parkinson diseaseH Chen
Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T W Alexander Dr, PO Box 12233, Mail Drop A3 05, Research Triangle Park, NC 27709, USA
Neurology 74:878-84. 2010..To evaluate the relative importance of smoking duration vs intensity in reducing the risk of Parkinson disease (PD)... - Studying the epidemiology of attention-deficit hyperactivity disorder: screening method and pilot resultsA S Rowland
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
Can J Psychiatry 46:931-40. 2001..The methods developed for this study and the pitfalls we encountered illustrate the challenges involved in conducting population-based studies of ADHD... - Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancerD A Bell
Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Cancer Res 55:3537-42. 1995..12). This is the first study to test for cancer risk associated with the NAT1 gene, and these positive findings suggest that NAT1 alleles may be important genetic determinents of colorectal cancer risk... - Lead exposure as a risk factor for amyotrophic lateral sclerosisF Kamel
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Neurodegener Dis 2:195-201. 2005..Most previous case-control studies found an association of ALS with self-reported occupational exposure to lead, with increased risks of 2- to >4-fold. However, these results may have been affected by recall bias... - Hepatitis B, aflatoxin B(1), and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China, and a meta-analysis of existing studiesM C Stern
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
Cancer Epidemiol Biomarkers Prev 10:617-25. 2001..0001). We found little evidence for an HBV-aflatoxin interaction modulating the presence of the p53 249(ser) mutation or any type of p53 mutation... - A hybrid design for studying genetic influences on risk of diseases with onset early in lifeC R Weinberg
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Am J Hum Genet 77:627-36. 2005.... - Unexplained increases in cancer incidence in the United States from 1975 to 1994: possible sentinel health indicators?G E Dinse
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Annu Rev Public Health 20:173-209. 1999..Unexplained patterns of cancer incidence may signal changes in underlying risk factors and highlight the continuing need for research on cancer etiology and prevention... - Pesticides and adult respiratory outcomes in the agricultural health studyJane A Hoppin
Epidemiology Branch, National Institute of Environmental Healh Science, NIH, DHHS, Research Triangle Park, NC 27709 2233, USA
Ann N Y Acad Sci 1076:343-54. 2006..00-2.19) for farmers and 1.96 (95% CI = 1.05-3.66) for commercial applicators. Our wheeze results are consistent with recent animal models that support a role for organophosphates and respiratory outcomes... - Optimal sampling of rat liver tissue for toxicogenomic studiesJulie F Foley
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 34:795-801. 2006..Additionally, a powdered sample provided the advantages of a homogenous sample pool and the ability to use sample aliquots for other analyses to include proteomics, metabonomics, and other molecular techniques... - Antimutagenicity of cinnamaldehyde and vanillin in human cells: Global gene expression and possible role of DNA damage and repairAudrey A King
The Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
Mutat Res 616:60-9. 2007..These and other data lead us to propose that VAN and CIN may induce DNA damage that elicits recombinational DNA repair, which reduces spontaneous mutations... - Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health StudyJane A Hoppin
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 2233, USA
Occup Environ Med 64:334-41. 2007..Farmer's lung, or hypersensitivity pneumonitis, is an important contributor to respiratory morbidity among farmers... - Chronic bronchitis among nonsmoking farm women in the agricultural health studyMartin Valcin
Epidemiology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709 2233, USA
J Occup Environ Med 49:574-83. 2007..The purpose of this study was to examine agricultural risk factors for chronic bronchitis among nonsmoking farm women... - Identification of risk-related haplotypes with the use of multiple SNPs from nuclear familiesMin Shi
Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Am J Hum Genet 81:53-66. 2007..As an illustration, we reanalyze data from a previously reported orofacial cleft study, to now investigate both fetal and maternal effects of the IRF6 gene... - Head injury and amyotrophic lateral sclerosisHonglei Chen
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Am J Epidemiol 166:810-6. 2007..7, 95 percent CI: 1.3, 2.2). In this study population, physical injuries to other body parts, including the trunk, arms, or legs, were not related to ALS risk. These data support the notion that head injury may increase the risk of ALS... - Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health StudyJane A Hoppin
NIEHS Epidemiology Branch, MD A3 05, P O Box 12233, Research Triangle Park, NC 27709 2233, USA
Am J Respir Crit Care Med 177:11-8. 2008..Risk factors for asthma among farm women are understudied... - Pesticide use and chronic bronchitis among farmers in the Agricultural Health StudyJane A Hoppin
Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709 2233, USA
Am J Ind Med 50:969-79. 2007..Farmers have increased risk for chronic bronchitis. Few investigators have considered pesticides... - Using risk-based sampling to enrich cohorts for endpoints, genes, and exposuresClarice R Weinberg
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Am J Epidemiol 166:447-55. 2007.... - Association of lead exposure with survival in amyotrophic lateral sclerosisFreya Kamel
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Environ Health Perspect 116:943-7. 2008..Reasons for the variability in survival among ALS cases are unknown but may include exposure to environmental neurotoxicants... - Application of the GA/KNN method to SELDI proteomics dataLeping Li
Biostatistics Branch, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
Bioinformatics 20:1638-40. 2004..AVAILABILITY: The source code of the program and documentation on how to use it are freely available to non-commercial users at http://dir.niehs.nih.gov/dirbb/lifiles/softlic.htm.. - Pesticides associated with wheeze among commercial pesticide applicators in the Agricultural Health StudyJane A Hoppin
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709 2233, USA
Am J Epidemiol 163:1129-37. 2006..40, 95% CI: 1.24, 4.65). These results add to the emerging literature linking organophosphate insecticides and respiratory health and suggest a role for chlorimuron-ethyl... - Gene selection and clustering for time-course and dose-response microarray experiments using order-restricted inferenceShyamal D Peddada
Biostatistics Branch, Laboratory of Molecular Carcinogenesis, Research Triangle Park, NC 27709, USA
Bioinformatics 19:834-41. 2003..In this example, our method was able to identify several biologically interesting genes that previous analyses failed to reveal... - Mutations in tetranucleotide repeats following DNA damage depend on repeat sequence and carcinogenic agentRobbert J C Slebos
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
Cancer Res 62:6052-60. 2002..Our results are compatible with the hypothesis that sporadic microsatellite mutations in human cancer may reflect DNA damage caused by carcinogen exposure... - DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer riskMariana C Stern
Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
Cancer Epidemiol Biomarkers Prev 11:939-43. 2002..In this study, we found some evidence for a gene-gene interaction between the XRCC1 codon 194 and XRCC3 codon 241 polymorphisms (P = 0.09) and some support for a possible gene-gene-smoking three-way interaction (P = 0.08)... - Diesel exhaust, solvents, and other occupational exposures as risk factors for wheeze among farmersJane A Hoppin
Epidemiology Branch and Biostatistics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709 2233, USA
Am J Respir Crit Care Med 169:1308-13. 2004..89, 3.73), an indication of daily solvent exposure. These results add to the growing body of evidence of adverse respiratory effects of diesel exposure on the lung and suggest exposure to solvents may contribute as well... - Lead exposure and amyotrophic lateral sclerosisFreya Kamel
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Epidemiology 13:311-9. 2002..Previous interview-based studies have suggested that exposure to neurotoxicants including metals might be related to ALS... - Chemical predictors of wheeze among farmer pesticide applicators in the Agricultural Health StudyJane A Hoppin
Epidemiology Branch and Biostatistics Branch, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709 2233, USA
Am J Respir Crit Care Med 165:683-9. 2002..5 (95% CI 1.2,1.9). Inclusion of crops and animals into these models did not significantly alter the observed OR. These associations, though small, suggest an independent role for specific pesticides in respiratory symptoms of farmers... - Patterns of pesticide use and their determinants among wives of farmer pesticide applicators in the Agricultural Health StudyEllen F Kirrane
Coda Inc, Durham, North Carolina, USA
J Occup Environ Med 46:856-65. 2004..Farm women reporting the heaviest pesticide use could exacerbate their exposure by engaging in practices that could increase pesticide contact... - VEGF promoter haplotype and amyotrophic lateral sclerosis (ALS)Paul D Terry
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, Research Triangle Park, NC 27709, USA
J Neurogenet 18:429-34. 2004..7 - 13.4), consistent with the findings of the previous study. Given the wide confidence interval, our findings should be interpreted cautiously... - No association between SOD2 or NQO1 genotypes and risk of bladder cancerPaul D Terry
Epidemiology Branch, NIEHS, NIH, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Cancer Epidemiol Biomarkers Prev 14:753-4. 2005 - Retinal degeneration and other eye disorders in wives of farmer pesticide applicators enrolled in the agricultural health studyEllen F Kirrane
CODA, Inc, Durham, NC 27709, USA
Am J Epidemiol 161:1020-9. 2005..These findings suggest that exposure to some fungicides and other pesticides may increase the risk of retinal degeneration and warrant further investigation... - Accurate anchoring alignment of divergent sequencesWeichun Huang
Biostatistics Branch, The National Institute of Environmental Health Sciences/NIH, Research Triangle Park, NC 27709, USA
Bioinformatics 22:29-34. 2006..AVAILABILITY: ACANA software and test sequence data are publicly available at http://BioMedEmpire.org/.. - APE1 genotype and risk of bladder cancer: evidence for effect modification by smokingPaul D Terry
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Int J Cancer 118:3170-3. 2006..Given the lack of established biological mechanisms, and suboptimal numbers of subjects in some exposure categories, our findings should be interpreted cautiously... - Amyotrophic lateral sclerosis, lead, and genetic susceptibility: polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genesFreya Kamel
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 111:1335-9. 2003..These findings suggest that genetic susceptibility conferred by polymorphisms in ALAD may affect ALS risk, possibly through a mechanism related to internal lead exposure... - Prevalence of medication treatment for attention deficit-hyperactivity disorder among elementary school children in Johnston County, North CarolinaAndrew S Rowland
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
Am J Public Health 92:231-4. 2002..This study estimated the prevalence of medication treatment for attention deficit-hyperactivity disorder (ADHD) among elementary school children in a North Carolina county... - Pilot studies of estrogen-related physical findings in infantsJudy C Bernbaum
Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Environ Health Perspect 116:416-20. 2008..We wanted to study whether soy formula prolonged the physiologic estrogenization of newborns, but available quantitative descriptions of the natural history of breast and genital development are inadequate for study design... - Analytical and statistical methods to evaluate microsatellite allelic imbalance in small amounts of DNARobbert J C Slebos
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Lab Invest 84:649-57. 2004..Our method allows the reliable detection of AI with very small amounts of DNA, and is sufficiently quantitative to assess allelic ratios in nonclonal tissue specimens... - Mini-and microsatellite mutations in children from Chernobyl accident cleanup workersRobbert J C Slebos
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
Mutat Res 559:143-51. 2004..In conclusion, our results do not support an increased level of germline minisatellite mutations but suggest a modest increase in germline mutations in tetranucleotide repeats. Small sample size, however, limited statistical power... - Transcriptional functionality of germ line p53 mutants influences cancer phenotypePaola Monti
Molecular Mutagenesis Unit, Department of Translational Oncology, National Cancer Research Institute, Genoa, Italy
Clin Cancer Res 13:3789-95. 2007..umd.be:2072/index.html). We have investigated the extent to which the functional features of p53 mutant alleles determine clinical features in patients who have inherited these alleles and have developed cancer... - A random-periods model for expression of cell-cycle genesDelong Liu
Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 101:7240-5. 2004..The model permits estimation of and hypothesis testing about biologically meaningful parameters that characterize cycling genes... - Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cellsHyeon Woo Yim
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Cancer Lett 246:24-33. 2007..An increase in telomerase activity in normal bronchial epithelium might extend the lifespan of cells at risk for malignant transformation, and thus contribute to lung carcinogenesis... 
The shifting subtypes of ADHD: classification depends on how symptom reports are combinedAndrew S Rowland
Department of Family and Community Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
J Abnorm Child Psychol 36:731-43. 2008..We conclude the ADHD subtype distribution is sensitive to how symptom information is combined and that standardization of the subtyping process is required to advance our understanding of the correlates of different ADHD subtypes...