Tobias S Ulmer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Amide proton relaxation measurements employing a highly deuterated protein
    Tobias S Ulmer
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    J Magn Reson 166:190-201. 2004
  2. ncbi Structure and dynamics of micelle-bound human alpha-synuclein
    Tobias S Ulmer
    Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:9595-603. 2005
  3. ncbi Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants
    Tobias S Ulmer
    Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:43179-87. 2005
  4. ncbi Quantitative J correlation methods for the accurate measurement of 13C'-13Calpha dipolar couplings in proteins
    Christopher P Jaroniec
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0520, USA
    J Biomol NMR 30:181-94. 2004
  5. ncbi Evaluation of backbone proton positions and dynamics in a small protein by liquid crystal NMR spectroscopy
    Tobias S Ulmer
    Contribution from the Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Am Chem Soc 125:9179-91. 2003
  6. ncbi The effects of dissolved oxygen upon amide proton relaxation and chemical shift in a perdeuterated protein
    Tobias S Ulmer
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Magn Reson 157:181-9. 2002
  7. ncbi Calcium dependence of the interaction between calmodulin and anthrax edema factor
    Tobias S Ulmer
    Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:29261-6. 2003
  8. ncbi Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit
    Tobias S Ulmer
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Biochemistry 42:8307-12. 2003
  9. ncbi SH3-SH2 domain orientation in Src kinases: NMR studies of Fyn
    Tobias S Ulmer
    Department of Biochemistry, University of Oxford, South Parks Road, United Kingdom
    Structure 10:901-11. 2002
  10. ncbi Structural determinants of integrin recognition by talin
    Begoña García-Alvarez
    Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 11:49-58. 2003

Collaborators

Detail Information

Publications13

  1. ncbi Amide proton relaxation measurements employing a highly deuterated protein
    Tobias S Ulmer
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    J Magn Reson 166:190-201. 2004
    ..In addition to a high sensitivity to structural parameters, model calculations predict 1H(N) relaxation rates to exhibit pronounced sensitivity to internal dynamics...
  2. ncbi Structure and dynamics of micelle-bound human alpha-synuclein
    Tobias S Ulmer
    Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:9595-603. 2005
    ....
  3. ncbi Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants
    Tobias S Ulmer
    Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:43179-87. 2005
    ..Moreover, aS-micelle immersion correlates well with fast and slow aS backbone dynamics, allowing a rare insight into protein-micelle interplay...
  4. ncbi Quantitative J correlation methods for the accurate measurement of 13C'-13Calpha dipolar couplings in proteins
    Christopher P Jaroniec
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0520, USA
    J Biomol NMR 30:181-94. 2004
    ..Remarkably, the dipolar couplings determined for GB3 are in even better agreement with the recently refined 1.1-angstroms X-ray structure than the input (13)C'-(13)C(alpha) couplings used for the refinement...
  5. ncbi Evaluation of backbone proton positions and dynamics in a small protein by liquid crystal NMR spectroscopy
    Tobias S Ulmer
    Contribution from the Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Am Chem Soc 125:9179-91. 2003
    ....
  6. ncbi The effects of dissolved oxygen upon amide proton relaxation and chemical shift in a perdeuterated protein
    Tobias S Ulmer
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Magn Reson 157:181-9. 2002
    ..5 bar (the maximum pressure used in this study). For most (1)H(N) resonances, small deltadelta(O(2))((1)H(N)) hyperfine chemical shifts could be detected between oxygen pressures of 1 bar and 9.5 bar...
  7. ncbi Calcium dependence of the interaction between calmodulin and anthrax edema factor
    Tobias S Ulmer
    Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:29261-6. 2003
    ..This Ca2+ dependence of the EF-CaM interaction differs from that observed for most other CaM targets, which normally interact only with the Ca2+-bound CaM domains and become active following the transition to the four Ca2+ state...
  8. ncbi Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit
    Tobias S Ulmer
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Biochemistry 42:8307-12. 2003
    ..These results suggest that perturbation of the beta3 tail membrane-proximal region is associated with talin-mediated integrin activation...
  9. ncbi SH3-SH2 domain orientation in Src kinases: NMR studies of Fyn
    Tobias S Ulmer
    Department of Biochemistry, University of Oxford, South Parks Road, United Kingdom
    Structure 10:901-11. 2002
    ..The observed average domain orientation indicates that a large SH3-SH2 domain closure is required to reach the inactive state. The implications of these results for Src regulation are discussed...
  10. ncbi Structural determinants of integrin recognition by talin
    Begoña García-Alvarez
    Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 11:49-58. 2003
    ..In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the integrin beta 3 tail, providing structural paradigms for integrin linkage to the cell interior...
  11. ncbi Insight into disulfide bond catalysis in Chlamydia from the structure and function of DsbH, a novel oxidoreductase
    Thien Thi Mac
    Department of Biochemistry and Molecular Biology and Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 283:824-32. 2008
    ....
  12. doi Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles
    Tong Lay Lau
    Department of Biochemistry and Molecular Biology and Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, California 90033, USA
    Biochemistry 47:4008-16. 2008
    ..In the micelle, residues L717-I721 are also embedded but deviate from linear alpha-helical conformation in contrast to I693-K716, which closely resemble the bicelle structure...
  13. doi Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules
    Jampani Nageswara Rao
    Department of Biochemistry and Molecular Biology and Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90033, USA
    Biochemistry 47:4651-6. 2008
    ....