M C Udey

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Langerhans cells on guard in the epidermis: poised to dSEARCH and ...?
    Mark C Udey
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1908, USA
    J Invest Dermatol 126:705-7. 2006
  2. doi request reprint Langerhans cell dogma: another round of rejections
    Mark C Udey
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Invest Dermatol 128:1881-3. 2008
  3. pmc Wnt signaling influences the development of murine epidermal Langerhans cells
    Maria R Becker
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1902, USA
    J Invest Dermatol 131:1861-8. 2011
  4. pmc Epidermal Langerhans cells tune skin reactivity to contact allergens
    Mark C Udey
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1908, USA
    J Clin Invest 122:1602-5. 2012
  5. ncbi request reprint Characteristics and functions of murine cutaneous dendritic cells: a synopsis of recent developments
    M C Udey
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Mucosal Immunol 1:470-4. 2008
  6. ncbi request reprint Skin dendritic cells in immunity and autoimmunity
    Mark C Udey
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Investig Dermatol Symp Proc 9:15-7. 2004
  7. ncbi request reprint Characterization of Wnt gene expression in murine skin: possible involvement of epidermis-derived Wnt-4 in cutaneous epithelial-mesenchymal interactions
    A Saitoh
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Exp Cell Res 243:150-60. 1998
  8. pmc A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice
    T A Borkowski
    Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Invest 100:575-81. 1997
  9. ncbi request reprint Skin dendritic cells in murine cutaneous leishmaniasis
    M C Udey
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1908, USA
    Immunobiology 204:590-4. 2001
  10. pmc A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells
    T A Borkowski
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1908, USA
    J Exp Med 184:2417-22. 1996

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Langerhans cells on guard in the epidermis: poised to dSEARCH and ...?
    Mark C Udey
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1908, USA
    J Invest Dermatol 126:705-7. 2006
    ..Nishibu and colleagues illustrate how these approaches can be used to visualize Langerhans cells in vivo in real time, and to assess aspects of their behavior in unperturbed skin and after activation...
  2. doi request reprint Langerhans cell dogma: another round of rejections
    Mark C Udey
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Invest Dermatol 128:1881-3. 2008
    ..In this issue, Obhrai and coworkers explore the involvement of Langerhans cells in skin graft rejection and describe fascinating results...
  3. pmc Wnt signaling influences the development of murine epidermal Langerhans cells
    Maria R Becker
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1902, USA
    J Invest Dermatol 131:1861-8. 2011
    ..01) on P7, decreased LC densities (26%; P<0.05) on P14, and decreased EpCAM expression intensities on LCs as well (33%). In aggregate, these data suggest that Wnt signaling in skin influences LC development...
  4. pmc Epidermal Langerhans cells tune skin reactivity to contact allergens
    Mark C Udey
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1908, USA
    J Clin Invest 122:1602-5. 2012
    ..In this issue of the JCI, Gomez de Agüero et al. describe an elegant series of experiments that implicate LCs in tolerance induction, positioning these cells as key regulators of immunologic barrier function...
  5. ncbi request reprint Characteristics and functions of murine cutaneous dendritic cells: a synopsis of recent developments
    M C Udey
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Mucosal Immunol 1:470-4. 2008
    ..We can anticipate that detailed understanding of the biology of individual cutaneous accessory cells and their relationships with each other will continue to accumulate as these types of studies are actively pursued...
  6. ncbi request reprint Skin dendritic cells in immunity and autoimmunity
    Mark C Udey
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Investig Dermatol Symp Proc 9:15-7. 2004
  7. ncbi request reprint Characterization of Wnt gene expression in murine skin: possible involvement of epidermis-derived Wnt-4 in cutaneous epithelial-mesenchymal interactions
    A Saitoh
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Exp Cell Res 243:150-60. 1998
    ..These results indicate that several Wnt genes are expressed in adult murine epidermis and suggest that Wnt-4 proteins may be involved in epidermal-dermal interactions in mammalian skin...
  8. pmc A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice
    T A Borkowski
    Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Invest 100:575-81. 1997
    ....
  9. ncbi request reprint Skin dendritic cells in murine cutaneous leishmaniasis
    M C Udey
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1908, USA
    Immunobiology 204:590-4. 2001
    ....
  10. pmc A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells
    T A Borkowski
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1908, USA
    J Exp Med 184:2417-22. 1996
    ..We conclude that endogenous TGF-beta 1 is essential for normal murine LC development or epidermal localization...
  11. ncbi request reprint Expression of gp40, the murine homologue of human epithelial cell adhesion molecule (Ep-CAM), by murine dendritic cells
    T A Borkowski
    Dermatology Branch, National Cancer Institute, Bethesda, MD 20892 1908, USA
    Eur J Immunol 26:110-4. 1996
    ..These results demonstrate that the putative homophilic adhesion molecule gp40 is expressed by subpopulations of DC in selected tissues; we propose that gp40 expression may have functional consequences for DC...
  12. pmc T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma)
    E W Shores
    Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892
    J Exp Med 187:1093-101. 1998
    ..A possible function for the differential expression of zeta family proteins may be to impart distinctive signaling properties to TCR complexes expressed on specific T cell populations...
  13. ncbi request reprint Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells
    M G Lee
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    J Immunol 152:5653-9. 1994
    ..E-cadherin may play a role in developmentally regulated interactions between early thymocytes and thymic stromal cells...
  14. ncbi request reprint Bacterial DNA and CpG-containing oligodeoxynucleotides activate cutaneous dendritic cells and induce IL-12 production: implications for the augmentation of Th1 responses
    T Jakob
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int Arch Allergy Immunol 118:457-61. 1999
    ....
  15. pmc The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    Y Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
    J Exp Med 194:1497-506. 2001
    ....
  16. ncbi request reprint Viral interference during simultaneous transduction with two independent helper-free retroviral vectors
    P S Walker
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1908, USA
    Hum Gene Ther 7:1131-8. 1996
    ..Thus, such dual transductions will likely require in vitro selection or the use of a single retrovirus which contains both desired genes on the same genome...
  17. ncbi request reprint Expression of E-cadherin by murine dendritic cells: E-cadherin as a dendritic cell differentiation antigen characteristic of epidermal Langerhans cells and related cells
    T A Borkowski
    Dermatology Branch, National Cancer Institute, Bethesda, MD 20892
    Eur J Immunol 24:2767-74. 1994
    ....
  18. ncbi request reprint Identification and characterization of an alternatively spliced isoform of mouse Langerin/CD207
    Elisabeth Riedl
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Invest Dermatol 123:78-86. 2004
    ..Developmentally regulated expression of Langerin isoforms provides a mechanism by which Langerin involvement in antigen uptake and processing could be regulated...
  19. ncbi request reprint Identification and characterization of endogenous Langerin ligands in murine extracellular matrix
    Yayoi Tada
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Massachusetts, USA
    J Invest Dermatol 126:1549-58. 2006
    ..Langerin may have an unanticipated role in cell-matrix interactions that modulate LC development, localization, or function...
  20. pmc Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity
    Florian Woelbing
    Department of Dermatology and 2Section for Pathophysiology, First Department of Internal Medicine, Johannes Gutenberg University, Mainz 55131, Germany
    J Exp Med 203:177-88. 2006
    ..major with different outcomes, and indicate that B cell-derived, parasite-reactive IgG and DC FcgammaRI and FcgammaRIII are essential for optimal development of protective immunity...
  21. pmc Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice
    Esther von Stebut
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    J Exp Med 198:191-9. 2003
    ..Differential production of IL-1 by C57BL/6 and BALB/c mice may provide a partial explanation for the disparate outcomes of infection in these mouse strains...
  22. ncbi request reprint Requirements for Th1-dependent immunity against infection with Leishmania major
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Microbes Infect 6:1102-9. 2004
    ..Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted...
  23. ncbi request reprint Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice
    Axel P Nigg
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Immunol 178:7251-8. 2007
    ..Thus, in addition to IL-1alphabeta, strain-dependent differences in the release of other DC-derived factors such as IL-12p80 may influence genetically determined disease outcome...
  24. ncbi request reprint Dendritic cells transduced with protein antigens induce cytotoxic lymphocytes and elicit antitumor immunity
    Naotaka Shibagaki
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Building 10 Room 12N238, Bethesda, MD 20892, USA
    J Immunol 168:2393-401. 2002
    ..This straightforward vaccination strategy may translate into DC-based treatments for patients with cancer and other serious diseases...
  25. ncbi request reprint CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:3992-4000. 2002
    ..The low dose, intradermal challenge model reveals that CD8(+) T cells play an essential role in both pathogenesis of and immunity to primary infection with L. major in the skin...
  26. ncbi request reprint Skin-derived macrophages from Leishmania major-susceptible mice exhibit interleukin-12- and interferon-gamma-independent nitric oxide production and parasite killing after treatment with immunostimulatory DNA
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Invest Dermatol 119:621-8. 2002
    ..In addition, CpG-containing immunostimulatory oligodeoxynucleotides may also act locally on skin macrophages to facilitate Leishmania clearance by inducing nitric oxide production...
  27. ncbi request reprint MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis
    Melanie Neutzner
    Dermatology Branch and Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Res 67:6777-85. 2007
    ..MFG-E8 and its homologue Del1 may represent relevant targets in cancer and other diseases in which angiogenesis is prominent...
  28. ncbi request reprint Stem cell activity of human side population and alpha6 integrin-bright keratinocytes defined by a quantitative in vivo assay
    Atsushi Terunuma
    Dermatology Branch, National Cancer Institute NIH, Bldg 10 Room 12N260, 10 Center Drive MSC 1908, Bethesda, MD 20892 1908, USA
    Stem Cells 25:664-9. 2007
    ..These results definitively demonstrate that human alpha6-bright/CD71-dim keratinocytes are enriched with KSCs, whereas SP-KCs are not...
  29. ncbi request reprint Distinct roles for IL-1 receptor type I signaling in early versus established Leishmania major infections
    Susanna Lopez Kostka
    Department of Dermatology, Johannes Gutenberg University Mainz, Mainz, Germany
    J Invest Dermatol 126:1582-9. 2006
    ..Effects of IL-1 on disease outcome may be related to levels of IL-1RI on Th subpopulations...
  30. ncbi request reprint Dendritic cells transduced with TAT protein transduction domain-containing tyrosinase-related protein 2 vaccinate against murine melanoma
    Naotaka Shibagaki
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1908, USA
    Eur J Immunol 33:850-60. 2003
    ..This approach should be clinically applicable, and offers theoretical and practical advantages to those that are in current use...
  31. ncbi request reprint Genetic immunization with LYVE-1 cDNA yields function-blocking antibodies against native protein
    Adela R Cardones
    Dermatology, National Cancer Institute, National Institutes of Health, 10 Center Drive, Room 12N258, Bethesda, MD 20892, USA
    Microvasc Res 71:32-9. 2006
    ..In summary, gene gun-assisted delivery of cDNA encoding LYVE-1 into skin resulted in reliable production of antisera that specifically and functionally recognized native LYVE-1 protein...
  32. ncbi request reprint Gone fishin' in 2005-insights into the inner workings of dendritic cells
    Mark C Udey
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Invest Dermatol 124:vi-vii. 2005
  33. ncbi request reprint An in vivo competitive repopulation assay system to evaluate human keratinocyte stem cells
    Atsushi Terunuma
    J Invest Dermatol 123:993-5. 2004