David Tweedie

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets
    David Tweedie
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, NIA, NIH, Baltimore, MD 21224, USA
    Curr Alzheimer Res 4:378-85. 2007
  2. pmc Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease
    David Tweedie
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Neuroinflammation 9:106. 2012
  3. pmc Thalidomide Analogues Suppress Lipopolysaccharide-Induced Synthesis of TNF-α and Nitrite, an Intermediate of Nitric Oxide, in a Cellular Model of Inflammation
    David Tweedie
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Open Biochem J 5:37-44. 2011
  4. pmc Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease
    S Prasad Gabbita
    P2D Bioscience, Cincinnati, OH 45242, USA
    J Neuroinflammation 9:99. 2012
  5. pmc Changes in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury
    David Tweedie
    Drug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Dis 54:1-11. 2013
  6. pmc Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice
    David Tweedie
    Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Exp Neurol 239:170-82. 2013
  7. pmc TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
    Karim Belarbi
    Brain and Spinal Injury Center, University of California, San Francisco, California, USA
    J Neuroinflammation 9:23. 2012
  8. pmc A cellular model of inflammation for identifying TNF-alpha synthesis inhibitors
    David Tweedie
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    J Neurosci Methods 183:182-7. 2009
  9. pmc Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells
    Yazhou Li
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurochem 113:1621-31. 2010
  10. pmc Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis
    Yazhou Li
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e32008. 2012

Collaborators

Detail Information

Publications28

  1. ncbi request reprint TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets
    David Tweedie
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, NIA, NIH, Baltimore, MD 21224, USA
    Curr Alzheimer Res 4:378-85. 2007
    ..Additionally, we consider the utilization of thalidomide-derived agents as anti-TNF-alpha therapeutics in the setting of neuroinflammation...
  2. pmc Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease
    David Tweedie
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Neuroinflammation 9:106. 2012
    ..Elevated TNF-α levels are commonly detected in the clinic and animal models of AD...
  3. pmc Thalidomide Analogues Suppress Lipopolysaccharide-Induced Synthesis of TNF-α and Nitrite, an Intermediate of Nitric Oxide, in a Cellular Model of Inflammation
    David Tweedie
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Open Biochem J 5:37-44. 2011
    ..Specific analogues of thalidomide effectively suppressed the generation of both TNF-α and nitrite at well-tolerated doses...
  4. pmc Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease
    S Prasad Gabbita
    P2D Bioscience, Cincinnati, OH 45242, USA
    J Neuroinflammation 9:99. 2012
    ..Current Alzheimer's disease interventions are symptomatic treatments with limited efficacy that do not address etiology. Thus, a critical need exists for novel treatments directed towards modifying the pathophysiology and progression...
  5. pmc Changes in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury
    David Tweedie
    Drug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Dis 54:1-11. 2013
    ..Based upon observations of increasing numbers of personnel displaying TBI related emotional and behavioral changes in militarized zones, the development of efficacious therapies will become a national if not a global priority...
  6. pmc Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice
    David Tweedie
    Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Exp Neurol 239:170-82. 2013
    ..These data suggest a strong beneficial action of Ex-4 in managing secondary events induced by a traumatic brain injury...
  7. pmc TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
    Karim Belarbi
    Brain and Spinal Injury Center, University of California, San Francisco, California, USA
    J Neuroinflammation 9:23. 2012
    ..Our study was aimed to evaluate the therapeutic potential of a novel analog of thalidomide, 3,6'-dithiothalidomide (DT), an agent with anti-TNF-α activity, in a model of chronic neuroinflammation...
  8. pmc A cellular model of inflammation for identifying TNF-alpha synthesis inhibitors
    David Tweedie
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    J Neurosci Methods 183:182-7. 2009
    ..The utility of the TNF-alpha cellular assay lies in its simplicity and robust nature, providing a tool for initial pharmacological screening to allow for the rapid identification novel TNF-alpha lowering agents...
  9. pmc Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells
    Yazhou Li
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurochem 113:1621-31. 2010
    ....
  10. pmc Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis
    Yazhou Li
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e32008. 2012
    ..Together, our results suggest that GLP-1 receptor agonists warrant further evaluation to assess whether their neuroprotective potential is of therapeutic relevance in ALS...
  11. pmc GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
    Yazhou Li
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 106:1285-90. 2009
    ..Our findings demonstrate that Ex-4 can protect neurons against metabolic and oxidative insults, and they provide preclinical support for the therapeutic potential for Ex-4 in the treatment of stroke and PD...
  12. ncbi request reprint Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease?
    David Tweedie
    Section on Drug Design and Delivery, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    J Alzheimers Dis 10:9-16. 2006
    ..Using subtoxic concentrations of neurine, elevations in AbetaPP and Abeta1-40 peptide levels were detected in conditioned media samples...
  13. ncbi request reprint Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases
    Kathryn A Frankola
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    CNS Neurol Disord Drug Targets 10:391-403. 2011
    ....
  14. doi request reprint Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury
    Nigel H Greig
    Drug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA Electronic address
    Alzheimers Dement 10:S62-75. 2014
    ..In view of the mechanisms underpinning these disorders as well as TBI, we review the literature and recent studies assessing GLP-1 receptor agonists as a potential treatment strategy for mild to moderate TBI. ..
  15. ncbi request reprint Differentiation of pluripotent embryonic stem cells into cardiomyocytes
    Kenneth R Boheler
    National Institutes of Health, National Institute on Aging, Baltimore, MD 21224, USA
    Circ Res 91:189-201. 2002
    ..This review summarizes the current state of ES cell-derived cardiogenesis and provides an overview of how genomic strategies coupled with this in vitro differentiation system can be applied to cardiac research...
  16. doi request reprint 3,6'-dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation
    Jeong Seon Yoon
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci Res 91:671-80. 2013
    ..These findings suggest that anti-inflammatory mechanisms underlie the therapeutic actions of 3,6-DT in an animal model of stroke...
  17. ncbi request reprint Apoptotic and behavioral sequelae of mild brain trauma in mice
    David Tweedie
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Neurosci Res 85:805-15. 2007
    ....
  18. doi request reprint Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity
    Weiming Luo
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Bioorg Med Chem 19:3965-72. 2011
    ....
  19. doi request reprint 3,6'-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit
    Isabella Russo
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, NIH, Bethesda, MD, USA
    J Neurochem 122:1181-92. 2012
    ..Understanding the modulation of neurogenesis, and its relationship with memory function could open new therapeutic interventions for AD and other neurodegenerative disorders with an inflammatory component...
  20. pmc GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease
    Yazhou Li
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA
    J Alzheimers Dis 19:1205-19. 2010
    ..Together, these results suggest a potential value of Ex-4 in AD, particularly when associated with T2DM or glucose intolerance...
  21. pmc Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine
    Weiming Luo
    Drug Design and Development Section, Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 49:2174-85. 2006
    ....
  22. pmc Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders
    Isidro Salcedo
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Br J Pharmacol 166:1586-99. 2012
    ..Herein, we review the physiological role of GLP-1 in the nervous system, focused towards the potential benefit of GLP-1R stimulation as an immediately translatable treatment strategy for acute and chronic neurological disorders...
  23. pmc The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development
    Huang Tian Yang
    National Institute on Aging, Laboratory of Cardiovascular Science, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 99:9225-30. 2002
    ....
  24. ncbi request reprint SAGE identification of gene transcripts with profiles unique to pluripotent mouse R1 embryonic stem cells
    Sergey V Anisimov
    NIH, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Genomics 79:169-76. 2002
    ..The data from this study provide a starting point for detailed transcriptome analyses of stem cells...
  25. ncbi request reprint Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells
    Ji Dong Fu
    Laboratory of Molecular Cardiology of Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    FASEB J 20:181-3. 2006
    ..We conclude that functional SR and control of RyR2-mediated SR Ca2+ release directly contribute to the spontaneous and beta-adrenergic receptor-stimulated contraction of ESCMs, even at very immature stages of development...
  26. ncbi request reprint Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine
    Mohammad A Kamal
    Enzymoics, 7 Peterlee Pl, Hebersham, NSW 2770, Australia
    J Alzheimers Dis 10:43-51. 2006
    ..In synopsis, the characterization of the kinetic parameters of BuChE and BNC, described herein, is both aiding in the design of novel agents and optimizing their translation toward clinical use...
  27. ncbi request reprint Differential effects of two hexahydropyrroloindole carbamate-based anticholinesterase drugs on the amyloid beta protein pathway involved in Alzheimer's disease
    Debomoy K Lahiri
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuromolecular Med 9:157-68. 2007
    ..The divergent actions of these two structurally related drugs on the amyloid pathway indicate that the mechanisms underpinning the cholinergic and the amyloid-lowering properties for this class of drugs are independent of each other...
  28. doi request reprint Tetrahydrofurobenzofuran cymserine, a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate, enzyme kinetic analysis
    Mohammad A Kamal
    Department of Medical and Molecular Biosciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia
    J Neural Transm 115:889-98. 2008
    ..THFBFC proved to be a potent competitive inhibitor of human BuChE and, like its isomer dihydrobenzodioxepine cymserine, is a potentially interesting AD drug candidate...