M A Tucker

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
    L Zuo
    Sequana Therapeutics Inc, La Jolla, California 92037, USA
    Nat Genet 12:97-9. 1996
  2. ncbi request reprint Second primary cancers related to smoking and treatment of small-cell lung cancer. Lung Cancer Working Cadre
    M A Tucker
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 89:1782-8. 1997
  3. ncbi request reprint Clinically recognized dysplastic nevi. A central risk factor for cutaneous melanoma
    M A Tucker
    Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892 7372, USA
    JAMA 277:1439-44. 1997
  4. pmc The prevalence of common BRCA1 and BRCA2 mutations among Ashkenazi Jews
    P Hartge
    Division of Cancer Epidemiology and Statistics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7374, USA
    Am J Hum Genet 64:963-70. 1999
  5. ncbi request reprint Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations
    A M Goldstein
    Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7236, USA
    J Natl Cancer Inst 92:1006-10. 2000
  6. ncbi request reprint Rarity of CDK4 germline mutations in familial melanoma
    A M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Melanoma Res 12:51-5. 2002
  7. ncbi request reprint Gene-covariate interaction between dysplastic nevi and the CDKN2A gene in American melanoma-prone families
    A M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7236, USA
    Cancer Epidemiol Biomarkers Prev 9:889-94. 2000
  8. pmc A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families
    A M Goldstein
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Br J Cancer 85:527-30. 2001
  9. pmc CDKN2A mutations and melanoma risk in the Icelandic population
    A M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiologyand Genetics NCI NIH DHHS, Executive Plaza South, Room 7004, 6120 Executive Blvd MSC 7236, Bethesda, MD 20892 7236, USA
    J Med Genet 45:284-9. 2008
  10. pmc Two-locus linkage analysis of cutaneous malignant melanoma/dysplastic nevi
    A M Goldstein
    Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892 7372, USA
    Am J Hum Genet 58:1050-6. 1996

Detail Information

Publications28

  1. ncbi request reprint Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
    L Zuo
    Sequana Therapeutics Inc, La Jolla, California 92037, USA
    Nat Genet 12:97-9. 1996
  2. ncbi request reprint Second primary cancers related to smoking and treatment of small-cell lung cancer. Lung Cancer Working Cadre
    M A Tucker
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 89:1782-8. 1997
    ..We designed a multi-institution study to investigate the risk among survivors of developing second primary cancers other than small-cell lung carcinoma...
  3. ncbi request reprint Clinically recognized dysplastic nevi. A central risk factor for cutaneous melanoma
    M A Tucker
    Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892 7372, USA
    JAMA 277:1439-44. 1997
    ..To investigate the relationship of number and type of nevi to the development of melanoma...
  4. pmc The prevalence of common BRCA1 and BRCA2 mutations among Ashkenazi Jews
    P Hartge
    Division of Cancer Epidemiology and Statistics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7374, USA
    Am J Hum Genet 64:963-70. 1999
    ..Even with accurate estimates of the likelihood of carrying a mutation and the likelihood of developing cancer if a mutation is detected, the most vexing clinical problems remain...
  5. ncbi request reprint Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations
    A M Goldstein
    Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7236, USA
    J Natl Cancer Inst 92:1006-10. 2000
    ..CDKN2A is a tumor suppressor gene that encodes p16 (which inhibits activity of the cyclin D1-CDK4 complex) with germline mutations detected in 10%-25% of melanoma-prone families, some of whom are also prone to pancreatic cancer...
  6. ncbi request reprint Rarity of CDK4 germline mutations in familial melanoma
    A M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Melanoma Res 12:51-5. 2002
    ..In summary, although CDK4 is a melanoma susceptibility gene, it plays a minor role in hereditary melanoma...
  7. ncbi request reprint Gene-covariate interaction between dysplastic nevi and the CDKN2A gene in American melanoma-prone families
    A M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7236, USA
    Cancer Epidemiol Biomarkers Prev 9:889-94. 2000
    ..8) versus those with CDKN2A mutations (OR, 3.3; 95% confidence interval, 1.1-10.0; complete-cases method). The CDKN2A-DN interaction illustrates the complex etiology of melanoma and needs to be confirmed in a larger sample of families...
  8. pmc A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families
    A M Goldstein
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Br J Cancer 85:527-30. 2001
    ..All seven families had a haplotype consistent with a common ancestor/founder for this mutation. In addition, the mutation appears to have originated 34-52 generations ago (1-LOD-unit support interval 13-98 generations)...
  9. pmc CDKN2A mutations and melanoma risk in the Icelandic population
    A M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiologyand Genetics NCI NIH DHHS, Executive Plaza South, Room 7004, 6120 Executive Blvd MSC 7236, Bethesda, MD 20892 7236, USA
    J Med Genet 45:284-9. 2008
    ..Germline CDKN2A mutations have been observed in 20-40% of high risk, melanoma prone families; however, little is known about their prevalence in population based series of melanoma cases and controls...
  10. pmc Two-locus linkage analysis of cutaneous malignant melanoma/dysplastic nevi
    A M Goldstein
    Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892 7372, USA
    Am J Hum Genet 58:1050-6. 1996
    ..Thus, the application of 2L models may be useful to help unravel the complexities of familial melanoma...
  11. pmc Prospective risk of cancer in CDKN2A germline mutation carriers
    A M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
    J Med Genet 41:421-4. 2004
    ..For non-population-based studies, risks could also be biased because of cancer occurrence prior to family ascertainment...
  12. ncbi request reprint A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers
    W W Wang
    Laboratory of Population Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 10:955-60. 2001
    ..The biochemical basis of this risk modifier is currently unknown...
  13. pmc Combined risk factors for melanoma in a Mediterranean population
    M T Landi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892 7236, USA
    Br J Cancer 85:1304-10. 2001
    ....
  14. ncbi request reprint Apparent anticipation in familial melanoma
    A M Goldstein
    Harvard Medical School, Department of Pathology, Beth Israel Hospital, Boston, MA 02215, USA
    Melanoma Res 6:441-6. 1996
    ..Although increased surveillance may partly explain the results, additional studies should evaluate melanoma risk factors, genetic and/or environmental, across generations to examine the reasons for the apparent anticipation...
  15. ncbi request reprint Germline p16 mutations in familial melanoma
    C J Hussussian
    Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892
    Nat Genet 8:15-21. 1994
    ..Functional analyses of these mutations will confirm those causally related to the development of familial melanoma...
  16. ncbi request reprint Recent trends in cutaneous melanoma incidence among whites in the United States
    A Jemal
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 93:678-83. 2001
    ....
  17. pmc Common genetic variants in the 9p21 region and their associations with multiple tumours
    F Gu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Br J Cancer 108:1378-86. 2013
    ..The chromosome 9p21.3 region has been implicated in the pathogenesis of multiple cancers...
  18. ncbi request reprint Gene environment interactions in a cohort of irradiated retinoblastoma patients
    R A Kleinerman
    Division of Cancer, Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Radiat Res 163:701-2. 2005
  19. ncbi request reprint The APCI1307K allele and cancer risk in a community-based study of Ashkenazi Jews
    T Woodage
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 20:62-5. 1998
    ..Risk of developing colorectal, breast and other cancers were compared between genotyped I1307K carriers and non-carriers and their first-degree relatives...
  20. ncbi request reprint Familial eosinophilia: clinical and laboratory results on a U.S. kindred
    A Y Lin
    Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Am J Med Genet 76:229-37. 1998
    ..2q21.2). A gene mapping study is currently underway to study the underlying genetic mechanism(s) of this syndrome...
  21. ncbi request reprint Inguinal hernia in patients with Ewing sarcoma: a clue to etiology
    J U Cope
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7362, USA
    Med Pediatr Oncol 34:195-9. 2000
    ..Most of these hernias were inguinal. Because these anomalies were also reported previously in two case series, we looked for inguinal hernias in a different population of ES patients...
  22. pmc Mutation testing in melanoma families: INK4A, CDK4 and INK4D
    J A Newton Bishop
    ICRF Cancer Medicine Research Unit, St James s University Hospital, Leeds, UK
    Br J Cancer 80:295-300. 1999
    ..The p19 gene was sequenced in DNA from the 42 UK families and six additional US families. No mutations were identified...
  23. ncbi request reprint CDKN2A mutations in multiple primary melanomas
    J Monzon
    Institute of Medical Sciences, University of Toronto, ON, Canada
    N Engl J Med 338:879-87. 1998
    ..We hypothesized that this predisposition might be due to germ-line CDKN2A mutations...
  24. ncbi request reprint Parity, oral contraceptives, and the risk of ovarian cancer among carriers and noncarriers of a BRCA1 or BRCA2 mutation
    B Modan
    Department of Clinical Epidemiology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    N Engl J Med 345:235-40. 2001
    ..Multiparity and the use of oral contraceptives reduce the risk of ovarian cancer, but their effects on this risk in women with a BRCA1 or BRCA2 mutation are unclear...
  25. pmc Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma
    K Laud
    Service de Genetique, Institut Gustave Roussy, 94800 Villejuif, France
    J Med Genet 43:39-47. 2006
    ..Comprehensive analysis of the 9p21 locus including the CDKN2A, ARF, and CDKN2B genes in 53 individuals from melanoma index cases considered to be at heightened risk of melanoma...
  26. ncbi request reprint Mutations associated with familial melanoma impair p16INK4 function
    K Ranade
    Nat Genet 10:114-6. 1995
    ..Our data provide a biochemical rationale for the hypothesis that carriers of certain p16INK4 mutations are at increased risk of developing melanoma...
  27. pmc A genome screen of families at high risk for Hodgkin lymphoma: evidence for a susceptibility gene on chromosome 4
    L R Goldin
    J Med Genet 42:595-601. 2005
  28. ncbi request reprint Parenchymal-stromal interactions in neoplasia. Theoretical considerations and observations in melanocytic neoplasia
    W H Clark
    Department of Pathology, Harvard Medical School, The Beth Israel Hospital, Pathology Services, Inc, Cambridge, MA 02215, USA
    Acta Oncol 34:749-57. 1995
    ..The changes in neoplastic stroma proceed in concert with the changes in the parenchyma characteristic of melanocytic tumor progression...