Yien Che Tsai

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A ubiquitin-binding rhomboid protease aimed at ERADication
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, 1050 Boyles Street, Frederick, MD 21701, USA
    Dev Cell 23:454-6. 2012
  2. pmc Ubiquitylation in ERAD: reversing to go forward?
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS Biol 9:e1001038. 2011
  3. pmc Dissecting the diverse functions of the metastasis suppressor CD82/KAI1
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States
    FEBS Lett 585:3166-73. 2011
  4. ncbi request reprint The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
    Nat Med 13:1504-9. 2007
  5. pmc Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78
    Ranabir Das
    Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
    Mol Cell 34:674-85. 2009
  6. pmc Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum
    Ayelet Shmueli
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, NCI, Frederick 21702, USA
    Biochem Biophys Res Commun 390:758-62. 2009
  7. pmc Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis
    Guillaume P Leboucher
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Mol Cell 47:547-57. 2012
  8. pmc Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, MD 20712, USA
    Mol Biol Cell 23:4484-94. 2012
  9. pmc Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation
    Zlatka Kostova
    Laboratory of Protein Dynamics and Signaling, Building 560 Room 22 103, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, United States
    Semin Cell Dev Biol 18:770-9. 2007
  10. pmc Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 107:16554-9. 2010

Collaborators

Detail Information

Publications12

  1. pmc A ubiquitin-binding rhomboid protease aimed at ERADication
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, 1050 Boyles Street, Frederick, MD 21701, USA
    Dev Cell 23:454-6. 2012
    ..2012) describe a role for a ubiquitin-binding rhomboid protease, RHBDL4, in degradation of select ERAD substrates. These findings and the significance of rhomboids and other intramembrane proteases are discussed...
  2. pmc Ubiquitylation in ERAD: reversing to go forward?
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS Biol 9:e1001038. 2011
    ..The implications of this work for understanding ERAD and the potential of expressing deubiquitylating enzyme domains for studying ubiquitin-mediated processes are discussed...
  3. pmc Dissecting the diverse functions of the metastasis suppressor CD82/KAI1
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States
    FEBS Lett 585:3166-73. 2011
    ..A common feature of these diverse effects is CD82 regulation of membrane organization as well as protein trafficking and interactions, which affects cellular signaling and intercellular communication...
  4. ncbi request reprint The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
    Nat Med 13:1504-9. 2007
    ....
  5. pmc Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78
    Ranabir Das
    Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
    Mol Cell 34:674-85. 2009
    ..These findings uncover a mechanism whereby allosteric effects on an E2 enhance E2-RING finger interactions and, consequently, ubiquitylation...
  6. pmc Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum
    Ayelet Shmueli
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, NCI, Frederick 21702, USA
    Biochem Biophys Res Commun 390:758-62. 2009
    ....
  7. pmc Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis
    Guillaume P Leboucher
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Mol Cell 47:547-57. 2012
    ..These findings demonstrate how proximal signaling events can influence both mitochondrial dynamics and apoptosis through phosphorylation-stimulated degradation of the mitochondrial fusion machinery...
  8. pmc Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, MD 20712, USA
    Mol Biol Cell 23:4484-94. 2012
    ..Our results suggest a need for additional studies before definitive mechanistic conclusions are drawn that might set the stage for development of drugs to manipulate gp78 function in metabolic disorders...
  9. pmc Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation
    Zlatka Kostova
    Laboratory of Protein Dynamics and Signaling, Building 560 Room 22 103, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, United States
    Semin Cell Dev Biol 18:770-9. 2007
    ..In this chapter we review our knowledge of both Saccharomyces cerevisiae and mammalian ERAD ubiquitin ligases. We focus on recent insights into these E3s, their associated proteins and potential mechanisms of action...
  10. pmc Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 107:16554-9. 2010
    ..We describe chimeric SNAP25-based ubiquitin ligases that target BoNT/A LC for degradation, reducing its duration in a cellular model for toxin persistence...
  11. ncbi request reprint Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
    Yili Yang
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, Maryland 21702, USA
    Cancer Res 67:9472-81. 2007
    ..These inhibitors can also be valuable tools for studying ubiquitylation...
  12. pmc The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site
    Bo Chen
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, Building 560, Room 22 103, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 103:341-6. 2006
    ..These results also provide proof of principle that interrupting a specific E2-E3 interaction can selectively inhibit ERAD...