Research Topics
Genomes and Genes | Yien Che TsaiSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
A ubiquitin-binding rhomboid protease aimed at ERADicationYien Che Tsai
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, 1050 Boyles Street, Frederick, MD 21701, USA
Dev Cell 23:454-6. 2012..2012) describe a role for a ubiquitin-binding rhomboid protease, RHBDL4, in degradation of select ERAD substrates. These findings and the significance of rhomboids and other intramembrane proteases are discussed...- Dissecting the diverse functions of the metastasis suppressor CD82/KAI1Yien Che Tsai
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States
FEBS Lett 585:3166-73. 2011..A common feature of these diverse effects is CD82 regulation of membrane organization as well as protein trafficking and interactions, which affects cellular signaling and intercellular communication... - Ubiquitylation in ERAD: reversing to go forward?Yien Che Tsai
Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, Maryland, United States of America
PLoS Biol 9:e1001038. 2011..The implications of this work for understanding ERAD and the potential of expressing deubiquitylating enzyme domains for studying ubiquitin-mediated processes are discussed... 
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradationYien Che Tsai
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
Nat Med 13:1504-9. 2007....- Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78Ranabir Das
Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
Mol Cell 34:674-85. 2009..These findings uncover a mechanism whereby allosteric effects on an E2 enhance E2-RING finger interactions and, consequently, ubiquitylation... - Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulumAyelet Shmueli
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, NCI, Frederick 21702, USA
Biochem Biophys Res Commun 390:758-62. 2009.... - Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosisGuillaume P Leboucher
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
Mol Cell 47:547-57. 2012..These findings demonstrate how proximal signaling events can influence both mitochondrial dynamics and apoptosis through phosphorylation-stimulated degradation of the mitochondrial fusion machinery... - Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradationZlatka Kostova
Laboratory of Protein Dynamics and Signaling, Building 560 Room 22 103, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, United States
Semin Cell Dev Biol 18:770-9. 2007..In this chapter we review our knowledge of both Saccharomyces cerevisiae and mammalian ERAD ubiquitin ligases. We focus on recent insights into these E3s, their associated proteins and potential mechanisms of action... - Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome systemYien Che Tsai
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 107:16554-9. 2010..We describe chimeric SNAP25-based ubiquitin ligases that target BoNT/A LC for degradation, reducing its duration in a cellular model for toxin persistence... - Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeuticsYili Yang
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, Maryland 21702, USA
Cancer Res 67:9472-81. 2007..These inhibitors can also be valuable tools for studying ubiquitylation... - Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome systemYien Che Tsai
Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, MD 20712, USA
Mol Biol Cell 23:4484-94. 2012..Our results suggest a need for additional studies before definitive mechanistic conclusions are drawn that might set the stage for development of drugs to manipulate gp78 function in metabolic disorders... - The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding siteBo Chen
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, Building 560, Room 22 103, National Cancer Institute, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 103:341-6. 2006..These results also provide proof of principle that interrupting a specific E2-E3 interaction can selectively inhibit ERAD...