R Troisi

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A linked-registry study of gestational factors and subsequent breast cancer risk in the mother
    Rebecca Troisi
    NIH, 6120 Executive Blvd, EPS 8096, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:835-47. 2013
  2. doi request reprint Medical conditions among adult offspring prenatally exposed to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Epidemiology 24:430-8. 2013
  3. pmc Breast cancer incidence in Mongolia
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Cancer Causes Control 23:1047-53. 2012
  4. pmc Urogenital abnormalities in men exposed to diethylstilbestrol in utero: a cohort study
    Julie R Palmer
    Slone Epidemiology Center of Boston University, Boston, MA, USA
    Environ Health 8:37. 2009
  5. doi request reprint Cord serum estrogens, androgens, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 in Chinese and U.S. Caucasian neonates
    Rebecca Troisi
    Dartmouth Hitchcock Medical Center, Room 854, 7297 Rubin Building, One Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Epidemiol Biomarkers Prev 17:224-31. 2008
  6. pmc Birth weight and breast cancer risk
    R Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Br J Cancer 94:1734-7. 2006
  7. ncbi request reprint Exploring the underlying hormonal mechanisms of prenatal risk factors for breast cancer: a review and commentary
    Rebecca Troisi
    Room 854, Dartmouth Hitchcock Medical Center, 7297 Rubin Building, One Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Epidemiol Biomarkers Prev 16:1700-12. 2007
  8. pmc Preeclampsia and maternal breast cancer risk by offspring gender: do elevated androgen concentrations play a role?
    R Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7246, USA
    Br J Cancer 97:688-90. 2007
  9. ncbi request reprint Preeclampsia risk in women exposed in utero to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Obstet Gynecol 110:113-20. 2007
  10. ncbi request reprint Cancer risk in women prenatally exposed to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Int J Cancer 121:356-60. 2007

Detail Information

Publications43

  1. pmc A linked-registry study of gestational factors and subsequent breast cancer risk in the mother
    Rebecca Troisi
    NIH, 6120 Executive Blvd, EPS 8096, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:835-47. 2013
    ..Women who were younger at their first live birth have a reduced breast cancer risk. Other pregnancy characteristics, including complications, also may affect risk but because they are rare, require large datasets to study...
  2. doi request reprint Medical conditions among adult offspring prenatally exposed to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Epidemiology 24:430-8. 2013
    ..Although prenatal exposure to DES is known to increase risks of vaginal/cervical adenocarcinoma and adverse reproductive outcomes in women, and urogenital anomalies in men, data on nonreproductive medical conditions are lacking...
  3. pmc Breast cancer incidence in Mongolia
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Cancer Causes Control 23:1047-53. 2012
    ..Mongolia's breast cancer experience is of interest because of its shared genetics but vastly different diet compared with other parts of Asia...
  4. pmc Urogenital abnormalities in men exposed to diethylstilbestrol in utero: a cohort study
    Julie R Palmer
    Slone Epidemiology Center of Boston University, Boston, MA, USA
    Environ Health 8:37. 2009
    ..Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women during the 1940s70s, has been shown to cause reproductive problems in the daughters. Studies of prenatally-exposed males have yielded conflicting results...
  5. doi request reprint Cord serum estrogens, androgens, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 in Chinese and U.S. Caucasian neonates
    Rebecca Troisi
    Dartmouth Hitchcock Medical Center, Room 854, 7297 Rubin Building, One Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Epidemiol Biomarkers Prev 17:224-31. 2008
    ..The meaning of the change in findings for estrogens after controlling for factors related to the pregnancy is unclear with regard to explaining international breast cancer differences...
  6. pmc Birth weight and breast cancer risk
    R Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Br J Cancer 94:1734-7. 2006
    ..In these data, high birth weight was associated with breast cancer risk in younger and in more educated women, but was not associated overall...
  7. ncbi request reprint Exploring the underlying hormonal mechanisms of prenatal risk factors for breast cancer: a review and commentary
    Rebecca Troisi
    Room 854, Dartmouth Hitchcock Medical Center, 7297 Rubin Building, One Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Epidemiol Biomarkers Prev 16:1700-12. 2007
    ..In addition, investigations should explore the possibility that in utero exposures may not act directly on the breast, but may alter other physiologic pathways such as hormone metabolism that have their effect on risk later in life...
  8. pmc Preeclampsia and maternal breast cancer risk by offspring gender: do elevated androgen concentrations play a role?
    R Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7246, USA
    Br J Cancer 97:688-90. 2007
    ..Androgen concentrations in male, preeclamptic pregnancies were consistent with the hypothesis that elevated pregnancy androgens might mediate this apparent modifying effect of fetal gender...
  9. ncbi request reprint Preeclampsia risk in women exposed in utero to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Obstet Gynecol 110:113-20. 2007
    ..To assess whether preeclampsia risk is elevated in pregnancies of diethylstilbestrol (DES)-exposed daughters...
  10. ncbi request reprint Cancer risk in women prenatally exposed to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Int J Cancer 121:356-60. 2007
    ..Given that the population is still young, continued follow-up is necessary to assess the overall carcinogenic impact of prenatal DES exposure...
  11. pmc Perinatal factors, growth and development, and osteosarcoma risk
    R Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7246, USA
    Br J Cancer 95:1603-7. 2006
    ..These data provide some evidence that osteosarcoma is related to size at birth and in early adolescence, while earlier puberty in male subjects may be protective...
  12. pmc Maternal, prenatal and perinatal characteristics and first trimester maternal serum hormone concentrations
    R Troisi
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, 6120 Executive Boulevard, Rockville, MD 20892 7246, USA
    Br J Cancer 99:1161-4. 2008
    ..Androgens and estrogens were higher in younger than older mothers. These data are consistent with elevated hormone concentrations mediating the breast cancer protection from a first pregnancy and pregnancies occurring at younger ages...
  13. ncbi request reprint Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies
    Rebecca Troisi
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7246, USA
    Int J Epidemiol 32:455-60. 2003
    ..Alterations in pregnancy hormone concentrations, particularly lower in utero exposure to oestrogen, are hypothesized to mediate this association...
  14. ncbi request reprint Maternal androgen and estrogen concentrations are not associated with blood pressure changes in uncomplicated pregnancies
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892 7246, USA
    Cancer Epidemiol Biomarkers Prev 15:2013-5. 2006
    ..These data are not consistent with the hypothesis that elevated androgen concentrations mediate the observed reduction in maternal breast cancer risk associated with increases in blood pressure over the pregnancy...
  15. ncbi request reprint Estrogen and androgen concentrations are not lower in the umbilical cord serum of pre-eclamptic pregnancies
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 12:1268-70. 2003
    ..06 and P = 0.12, respectively). These data do not support the hypothesis that the lower breast cancer risk in daughters of pre-eclamptic pregnancies is explained by lower in utero estrogen exposure...
  16. ncbi request reprint Correlation of serum hormone concentrations in maternal and umbilical cord samples
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:452-6. 2003
    ..Studies using maternal hormone concentrations as a proxy for the fetal environment should consider the misclassification resulting with the use of this marker...
  17. ncbi request reprint Associations of maternal and umbilical cord hormone concentrations with maternal, gestational and neonatal factors (United States)
    Rebecca Troisi
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892 7246, USA
    Cancer Causes Control 14:347-55. 2003
    ..However, data on hormonal levels related to these characteristics of pregnancy are sparse, particularly those from studies of the fetal circulation...
  18. pmc Mortality in women given diethylstilbestrol during pregnancy
    L Titus-Ernstoff
    Department of Community and Family Medicine, Dartmouth Medical School, and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Br J Cancer 95:107-11. 2006
    ..The association with breast cancer mortality was more evident in trial participants, who received high DES doses...
  19. ncbi request reprint In-utero and early life exposures in relation to risk of breast cancer
    N Potischman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7366, USA
    Cancer Causes Control 10:561-73. 1999
    ..The epidemiologic studies addressing these early factors will be reviewed, consistency with proposed biologic mechanisms will be addressed and recommendations for future research will be presented...
  20. doi request reprint Offspring of women exposed in utero to diethylstilbestrol (DES): a preliminary report of benign and malignant pathology in the third generation
    Linda Titus-Ernstoff
    Department of Community and Family Medicine, Dartmouth Medical School, and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Epidemiology 19:251-7. 2008
    ..Specifically, these studies show an elevated incidence of reproductive tumors in the female offspring of prenatally-exposed mice...
  21. ncbi request reprint Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk
    C Schairer
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Rockville, MD 20852 7234, USA
    JAMA 283:485-91. 2000
    ..Whether menopausal hormone replacement therapy using a combined estrogen-progestin regimen increases risk of breast cancer beyond that associated with estrogen alone is unknown...
  22. ncbi request reprint Plasma volume expansion in pregnancy: implications for biomarkers in population studies
    Jessica M Faupel-Badger
    Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, MSC 4254, 37 Convent Drive, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:1720-3. 2007
    ..We present PVE as a topic for consideration in population-based studies, examples of the types of studies where PVE may be relevant, and our own analysis of one such study in the text below...
  23. pmc Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Am J Obstet Gynecol 199:653.e1-10. 2008
    ..The objective of the study was to determine whether blood pressure increases are associated with maternal angiogenic factors in uncomplicated and preeclamptic pregnancies...
  24. ncbi request reprint Germ-line genetic variation of TP53 in osteosarcoma
    Sharon A Savage
    Pediatric Oncology Branch, CCR, NCI, NIH, Bethesda, Maryland
    Pediatr Blood Cancer 49:28-33. 2007
    ..We hypothesized that genetic variation in TP53 could be associated with OS risk based on its critical role in cell growth and effect of somatic mutations in OS tumors...
  25. ncbi request reprint Fruit and vegetable intakes and the risk of colorectal cancer in the Breast Cancer Detection Demonstration Project follow-up cohort
    Andrew Flood
    Division of Cancer Epidemiology and Genetics, The National Cancer Institute, Bethesda, MD 20892, USA
    Am J Clin Nutr 75:936-43. 2002
    ..Recent findings have cast doubt on the hypothesis that high intakes of fruit and vegetables are associated with a reduced risk of colorectal cancer...
  26. ncbi request reprint Menopausal hormone replacement therapy and risk of ovarian cancer
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, MSC 7234, Rockville, MD 20852, USA
    JAMA 288:334-41. 2002
    ..The association between menopausal hormone replacement therapy and ovarian cancer is unclear...
  27. ncbi request reprint Pregnancy hormone concentrations across ethnic groups: implications for later cancer risk
    Nancy Potischman
    Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 4005 EPN, 6130 Executive Boulevard, Bethesda, Maryland 20892 7344, USA
    Cancer Epidemiol Biomarkers Prev 14:1514-20. 2005
    ..These data are consistent with hypotheses that in utero hormonal exposures may explain some of the ethnic group differences in cancer risk...
  28. ncbi request reprint Menstrual and reproductive characteristics of women whose mothers were exposed in utero to diethylstilbestrol (DES)
    Linda Titus-Ernstoff
    Department of Community and Family Medicine, Dartmouth Medical School, and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Int J Epidemiol 35:862-8. 2006
    ..We report menstrual and reproductive characteristics in a unique cohort comprising daughters of women exposed prenatally to DES...
  29. pmc Pregnancy weight gain is not associated with maternal or mixed umbilical cord estrogen and androgen concentrations
    Jessica M Faupel-Badger
    Division of Cancer Prevention and Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7105, USA
    Cancer Causes Control 20:263-7. 2009
    ..Our results are not consistent with an effect of pregnancy weight gain being mediated by this pathway as reflected by hormone concentrations at the end of pregnancy...
  30. ncbi request reprint Perinatal characteristics and breast cancer risk in daughters: a Scandinavian population-based study
    R Troisi
    1 Divisions of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    J Dev Orig Health Dis 4:35-41. 2013
    ..Other pregnancy characteristics, including complications such as preeclampsia, do not appear to be involved in later breast carcinogenesis in young women. ..
  31. ncbi request reprint Psychosexual characteristics of men and women exposed prenatally to diethylstilbestrol
    Linda Titus-Ernstoff
    Dartmouth Hitchcock Medical Center, Dartmouth Medical School, and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Epidemiology 14:155-60. 2003
    ..The adverse effects of prenatal exposure on the genitourinary tract in men and the reproductive tract in women are well established, but the possible effects on psychosexual characteristics remain largely unknown...
  32. ncbi request reprint Time to pregnancy and secondary sex ratio in men exposed prenatally to diethylstilbestrol
    Lauren A Wise
    Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
    Am J Epidemiol 166:765-74. 2007
    ..92 (95% confidence interval: 0.80, 1.04) comparing the exposed with the unexposed. In conclusion, prenatal DES exposure was not associated with a significant decrease in either fecundability or secondary sex ratio...
  33. ncbi request reprint Risk of breast cancer in women exposed to diethylstilbestrol in utero: prelimiinary results (United States)
    Julie R Palmer
    Slone Epidemiology Unit, Boston University School of Medicine, MA 02215, USA
    Cancer Causes Control 13:753-8. 2002
    ..We evaluated the relation of in-utero DES exposure to the risk of adult breast cancer...
  34. ncbi request reprint Birth size and subsequent risk for prostate cancer: a prospective population-based study in Norway
    Tom I L Nilsen
    Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
    Int J Cancer 113:1002-4. 2005
    ..These results support the hypothesis that factors that determine intrauterine growth could be important for aggressive forms of prostate cancer in adulthood...
  35. ncbi request reprint Risk of benign gynecologic tumors in relation to prenatal diethylstilbestrol exposure
    Lauren A Wise
    Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
    Obstet Gynecol 105:167-73. 2005
    ..To investigate the association between prenatal diethylstilbestrol (DES) exposure and risk of benign gynecologic tumors...
  36. ncbi request reprint Breast cancer incidence in women prenatally exposed to maternal cigarette smoke
    William C Strohsnitter
    Department of Obstetrics and Gynecology, Tufts New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    Epidemiology 16:342-5. 2005
    ..At the start of this study, cigarette smoking history was obtained directly from the mother...
  37. ncbi request reprint Prenatal diethylstilbestrol exposure and risk of breast cancer
    Julie R Palmer
    Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 15:1509-14. 2006
    ..The findings support the hypothesis that prenatal hormone levels influence breast cancer risk...
  38. ncbi request reprint Hypospadias in sons of women exposed to diethylstilbestrol in utero
    Julie R Palmer
    Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
    Epidemiology 16:583-6. 2005
    ..Dutch investigators have reported a 20-fold increase in risk of hypospadias among sons of women who were exposed to DES in utero. We assessed this relation in data from an ongoing study of DES-exposed persons...
  39. doi request reprint The association between in utero cigarette smoke exposure and age at menopause
    William C Strohsnitter
    Department of Obstetrics and Gynecology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Epidemiol 167:727-33. 2008
    ..The possibility that active cigarette smoking modifies this effect is also suggested...
  40. ncbi request reprint Reproductive outcomes in men with prenatal exposure to diethylstilbestrol
    Kimberly M Perez
    Department of Social and Preventive Medicine, University of Buffalo, State of New York, Buffalo, New York, USA
    Fertil Steril 84:1649-56. 2005
    ..To examine prenatal diethylstilbestrol (DES) exposure in relation to male reproductive outcomes...
  41. ncbi request reprint Age at natural menopause in women exposed to diethylstilbestrol in utero
    Elizabeth E Hatch
    Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    Am J Epidemiol 164:682-8. 2006
    ..Age at menopause has been related, albeit inconsistently, to several exposures, but, to the authors' knowledge, this is the first study to suggest that a prenatal exposure may influence reproductive lifespan...
  42. pmc Secondary sex ratio among women exposed to diethylstilbestrol in utero
    Lauren A Wise
    Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:1314-9. 2007
    ..Previous studies have suggested an association between endocrine-disrupting compounds and secondary sex ratio...
  43. doi request reprint Cervical screening and general physical examination behaviors of women exposed in utero to diethylstilbestrol
    Elizabeth A Camp
    School of Public Health, University of Texas Health Science Center, Houston, TX, USA
    J Low Genit Tract Dis 12:111-7. 2008
    ..To estimate whether women exposed in utero to diethylstilbestrol (DES) report receiving more cervical and general physical examinations compared to unexposed women...