Research Topics
Genomes and GenesSpecies | James F TroendleSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Methods of adjusted comparison of mediansJames F Troendle
Office of Biostatistics Research, Division of Cardiovascular Sciences of the National Heart, Lung, and Blood Institute, NIH DHHS, Bld RLK2 Room 9195, Bethesda, MD 20892, USA
Biom J 54:481-93. 2012..We recommend the method based on comparison of the predicted values of the transformed outcomes, with careful attention to how close the resulting residual distribution is to normal...
Unbiased confidence intervals for the odds ratio of two independent binomial samples with application to case-control dataJ F Troendle
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Biometrics 57:484-9. 2001..A Bayesian confidence interval method and a large-sample chi2 procedure are included in the comparisons...- Multiple comparisons between two groups on multiple Bernoulli outcomes while accounting for covariatesJames F Troendle
Biometry and Mathematical Statistics Branch, Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
Stat Med 24:3581-91. 2005..The method is illustrated on a data set of 55 minor malformations of babies of diabetic and non-diabetic mothers... - Likelihood approaches to the non-parametric two-sample problem for right-censored dataJames F Troendle
Biometry and Mathematical Statistics Branch, Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
Stat Med 25:2284-98. 2006..Further, for Lehmann-type alternatives the likelihood-based methods have similar power to the logrank test, while for the non-Lehmann-type alternatives tried here the likelihood-based methods have superior power... 
Testing for group effect in a 2 x k heteroscedastic ANOVA modelJames F Troendle
Biometry and Mathematical Statistics Branch, National Institute of Child Health and Human Development, Bld 6100, Bethesda, MD 20892, USA
Biom J 50:571-83. 2008..The methodology is motivated and illustrated by an analysis of folate levels in the blood among two alcohol intake groups while accounting for gender...- Testing for genetic association with constrained models using triadsJ F Troendle
Division of Epidemiology, Statistics, and Prevention Research, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
Ann Hum Genet 73:225-30. 2009..The methods are applied to two SNPs on the methylenetetrahydrofolate reductase (MTHFR) gene with neural tube defect (NTD) triads... - Correction for multiplicity in genetic association studies of triads: the permutational TDTJames F Troendle
Biostatistics and Bioinformatics Branch of the Division of Epidemiology, Statistics, and Prevention Research of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
Ann Hum Genet 75:284-91. 2011..We conclude that permutation tests are more powerful for identifying disease-associated SNPs in candidate gene studies and are useful for analysis of triad studies... - Sequential testing for efficacy in clinical trials with non-transient effectsJames F Troendle
Biometry and Mathematical Statistics Branch, Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Stat Med 24:3239-50. 2005..The Bonferroni procedure is illustrated on the results of a real clinical trial of Pirfenidone on pulmonary fibrosis in Hermansky-Pudlak Syndrome... - Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study populationTonia C Carter
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7510, USA
Am J Med Genet A 155:14-21. 2011..The association between a variant in COMT and spina bifida implicates methylation and epigenetics in NTDs... - Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defectsFaith Pangilinan
Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
BMC Med Genet 13:62. 2012..g., MTHFR rs1801133 (677 C > T) and MTHFD1 rs2236225 (R653Q)) have been found to increase NTD risk. We hypothesized that variants in additional folate/B12 pathway genes contribute to NTD risk... - Testing reported associations of genetic risk factors for oral clefts in a large Irish study populationTonia C Carter
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Birth Defects Res A Clin Mol Teratol 88:84-93. 2010.... - Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status?James L Mills
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Am J Clin Nutr 94:495-500. 2011..This suggests that folate exacerbates vitamin B-12-related metabolic abnormalities... - A prospective evaluation of antral follicle function in women with 46,XX spontaneous primary ovarian insufficiencyZiad R Hubayter
Integrative Reproductive Medicine Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Fertil Steril 94:1769-74. 2010..To assess ovarian follicle function in women with 46,XX spontaneous primary ovarian insufficiency... - Folate-related gene polymorphisms as risk factors for cleft lip and cleft palateJames L Mills
Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Birth Defects Res A Clin Mol Teratol 82:636-43. 2008..This study examined four SNPs related to folate metabolism (MTHFR 677 C-->T, MTHFR 1298 A-->C, MTHFD1 1958 G-->A, and TC II 776 C-->G) in a large Irish population to clarify their relationship with clefts... - Sexual function in young women with spontaneous 46,XX primary ovarian insufficiencySophia N Kalantaridou
Integrative Reproductive Medicine Unit, Reproductive Biology and Medicine Branch, Intramural Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Fertil Steril 90:1805-11. 2008..To assess sexual function in women with spontaneous 46,XX primary ovarian insufficiency after at least 3 months of a standardized hormone replacement regimen... - Growth plate senescence is associated with loss of DNA methylationOla Nilsson
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Endocrinol 186:241-9. 2005.... - Reassessing the labor curve in nulliparous womenJun Zhang
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development NIH, Building 6100, Room 7B03, Bethesda, MD 20892, USA
Am J Obstet Gynecol 187:824-8. 2002..Our purpose was to examine the pattern of labor progression in nulliparous parturients in contemporary obstetric practice... - Sample size determination for phase II studies of new vaccinesMalla R Rao
National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Vaccine 20:3364-9. 2002..We also consider a setting in which the desire is to show that the difference between immune response rates for vaccine and control is greater than a specified value... - Hypothesis: Neonatal respiratory distress may be related to asymptomatic colonization with group B streptococciFeng Ying C Lin
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Pediatr Infect Dis J 25:884-8. 2006..We examined clinical and epidemiologic data on these relations... - Birthweight and gestational age effects on motor and social developmentMary L Hediger
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
Paediatr Perinat Epidemiol 16:33-46. 2002.... - The impact of parity on course of labor in a contemporary populationAnjel Vahratian
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Birth 33:12-7. 2006..The difference in duration of the active phase between nulliparas and multiparas is substantially smaller in a contemporary population... - Eye malformations in children with heavy alcohol exposure in uteroElizabeth Y Flanigan
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
J Pediatr 153:391-5. 2008..To determine whether children who do not develop fetal alcohol syndrome (FAS) despite heavy alcohol exposure are at risk for eye abnormalities... - Bone mineral density in estrogen-deficient young womenVaishali B Popat
Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
J Clin Endocrinol Metab 94:2277-83. 2009..Osteoporosis primarily affects postmenopausal women. However, young women with estrogen deficiency also are at increased risk for low bone density... - Methodological challenges in studying labour progression in contemporary practiceAnjel Vahratian
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Paediatr Perinat Epidemiol 20:72-8. 2006..Moreover, such detailed information could have important clinical implications towards reducing the rate of primary caesarean delivery in the United States... - Women with spontaneous 46,XX primary ovarian insufficiency (hypergonadotropic hypogonadism) have lower perceived social support than control womenSusan A Orshan
Integrated Reproductive Medicine Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
Fertil Steril 92:688-93. 2009..To test the hypothesis that women with spontaneous primary ovarian insufficiency differ from control women with regard to perceived social support and to investigate the relationship between perceived social support and self-esteem... - The effect of early epidural versus early intravenous analgesia use on labor progression: a natural experimentAnjel Vahratian
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Obstet Gynecol 191:259-65. 2004..CONCLUSION: Our data support recent American College of Obstetricians and Gynecologists guidelines that the restraining use of epidural analgesia at <4 cm of cervical dilation is unnecessary... - Testosterone deficiency in young women with 46,XX spontaneous premature ovarian failureSophia N Kalantaridou
Section on Women's Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Fertil Steril 86:1475-82. 2006..1 pg/mL). CONCLUSION(S): As a group, young women with 46,XX spontaneous premature ovarian failure have reduced circulating free-T levels, both during an interval off of estrogen therapy and while on physiologic transdermal E(2) therapy... - Normalization of serum luteinizing hormone levels in women with 46,XX spontaneous primary ovarian insufficiencyVaishali B Popat
Integrative Reproductive Medicine Unit, Reproductive Biology and Medicine Branch, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
Fertil Steril 89:429-33. 2008..To determine the proportion of women with primary ovarian insufficiency who achieve normal serum LH levels on transdermal E(2) therapy... - Labor progression and risk of cesarean delivery in electively induced nulliparasAnjel Vahratian
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Obstet Gynecol 105:698-704. 2005..Furthermore, elective induction in nulliparous women with an unfavorable cervix has a high rate of labor arrest and a substantially increased risk of cesarean delivery. LEVEL OF EVIDENCE: II-2... - Controlled trial of pamidronate in children with types III and IV osteogenesis imperfecta confirms vertebral gains but not short-term functional improvementAnne D Letocha
Section on Connective Tissue Disorders, BEMB, NICHD, NIH, Bethesda, Maryland 20892, USA
J Bone Miner Res 20:977-86. 2005..The treatment group did not experience decreased lower extremity long bone fractures, significant improvement in growth, ambulation, muscle strength, or pain. There was substantial variability in individual response to treatment... - Comparison of labor progression between induced and noninduced multiparous womenMatthew K Hoffman
Department of Obstetrics and Gynecology, Christiana Care Health Services, Newark, Delaware 19718, USA
Obstet Gynecol 107:1029-34. 2006..We sought to determine how labor progression of multiparous women who presented in spontaneous labor differed from those who were electively induced with and from those induced without preinduction cervical ripening... - Maternal prepregnancy overweight and obesity and the pattern of labor progression in term nulliparous womenAnjel Vahratian
Department of Maternal and Child Health, School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Obstet Gynecol 104:943-51. 2004..To examine the effect of maternal overweight and obesity on labor progression...