Giorgio Trinchieri

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The choices of a natural killer
    Giorgio Trinchieri
    Nat Immunol 4:509-10. 2003
  2. doi request reprint Cancer and inflammation: an old intuition with rapidly evolving new concepts
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702 1201, USA
    Annu Rev Immunol 30:677-706. 2012
  3. pmc MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18
    Rosalba Salcedo
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA
    J Exp Med 207:1625-36. 2010
  4. pmc Innate inflammation and cancer: Is it time for cancer prevention?
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute NIH, Building 560, Room 31 93, Frederick, MD 21702 1201 USA
    F1000 Med Rep 3:11. 2011
  5. doi request reprint Lymphocyte choriomeningitis virus plays hide-and-seek with type 1 interferon
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Cell Host Microbe 11:553-5. 2012
  6. pmc A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"
    Lisa H Butterfield
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15213, USA
    J Transl Med 6:81. 2008
  7. pmc Type I interferon: friend or foe?
    Giorgio Trinchieri
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    J Exp Med 207:2053-63. 2010
  8. pmc Interleukin-10 production by effector T cells: Th1 cells show self control
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Exp Med 204:239-43. 2007
  9. ncbi request reprint Cooperation of Toll-like receptor signals in innate immune defence
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Building 560, Room 31 93, Frederick, Maryland 21702 1201, USA
    Nat Rev Immunol 7:179-90. 2007
  10. ncbi request reprint Pillars of immunology: The birth of a cell type
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 560 Room 31 93, Frederick, MD 21702, USA
    J Immunol 178:3-4. 2007

Detail Information

Publications74

  1. ncbi request reprint The choices of a natural killer
    Giorgio Trinchieri
    Nat Immunol 4:509-10. 2003
  2. doi request reprint Cancer and inflammation: an old intuition with rapidly evolving new concepts
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702 1201, USA
    Annu Rev Immunol 30:677-706. 2012
    ..Different aspects of inflammation appear to regulate all phases of malignant disease, including susceptibility, initiation, progression, dissemination, morbidity, and mortality...
  3. pmc MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18
    Rosalba Salcedo
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA
    J Exp Med 207:1625-36. 2010
    ..This study revealed a previously unknown level of complexity surrounding MyD88 activities downstream of different receptors that impact tissue homeostasis and carcinogenesis...
  4. pmc Innate inflammation and cancer: Is it time for cancer prevention?
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute NIH, Building 560, Room 31 93, Frederick, MD 21702 1201 USA
    F1000 Med Rep 3:11. 2011
    ....
  5. doi request reprint Lymphocyte choriomeningitis virus plays hide-and-seek with type 1 interferon
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Cell Host Microbe 11:553-5. 2012
    ....
  6. pmc A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"
    Lisa H Butterfield
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15213, USA
    J Transl Med 6:81. 2008
    ..This foreword provides an overview of the task force and invites feedback from readers that might be incorporated in the discussions and in the final document...
  7. pmc Type I interferon: friend or foe?
    Giorgio Trinchieri
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    J Exp Med 207:2053-63. 2010
    ....
  8. pmc Interleukin-10 production by effector T cells: Th1 cells show self control
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Exp Med 204:239-43. 2007
    ..But this control may also limit the effectiveness of the immune response, resulting in a failure to fully eliminate pathogens...
  9. ncbi request reprint Cooperation of Toll-like receptor signals in innate immune defence
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Building 560, Room 31 93, Frederick, Maryland 21702 1201, USA
    Nat Rev Immunol 7:179-90. 2007
    ..This Review highlights recent advances in the newly emerging field of TLR cooperation and discusses their implications for the development of adjuvants and immunotherapies...
  10. ncbi request reprint Pillars of immunology: The birth of a cell type
    Giorgio Trinchieri
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 560 Room 31 93, Frederick, MD 21702, USA
    J Immunol 178:3-4. 2007
  11. pmc IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors
    Sid P Kerkar
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1502, USA
    J Clin Invest 121:4746-57. 2011
    ....
  12. pmc NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection
    Romina S Goldszmid
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Immunity 36:1047-59. 2012
    ....
  13. ncbi request reprint Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
    Noriho Iida
    Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA
    Science 342:967-70. 2013
    ..These findings underscore the importance of the microbiota in the outcome of disease treatment. ..
  14. pmc Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1β production in human macrophages
    Aleksey Novikov
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:2540-7. 2011
    ..tuberculosis infection the induction of type I IFNs is a major mechanism used for this purpose...
  15. pmc Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome
    Kevin Shenderov
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:5722-30. 2013
    ..Taken together, these findings suggest a general strategy for the rational design of Th17-skewing adjuvants by combining agonists of the CARD9 pathway with inflammasome activators...
  16. pmc IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis
    Christophe Cataisson
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    J Exp Med 209:1689-702. 2012
    ..Collectively, these results demonstrate that MyD88 exerts a cell-intrinsic function in RAS-mediated transformation of keratinocytes...
  17. doi request reprint National Institutes of Health Center for Human Immunology Conference, September 2009
    Robert B Nussenblatt
    Laboratory of Immunology, National Eye Institute, Maryland 20892, USA
    Ann N Y Acad Sci 1200:E1-23. 2010
    ..The human immunology meeting was held in the Clinical Center of the National Institutes of Health, Bethesda, Maryland, on September 3 and 4, 2009...
  18. pmc TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production
    Romina S Goldszmid
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 204:2591-602. 2007
    ....
  19. pmc Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts
    Sid P Kerkar
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Res 70:6725-34. 2010
    ..Our findings reveal an approach to genetically modify T cells to reduce the cell number needed, eliminate the need for vaccines or systemic IL-2, and improve immunotherapy efficacy based on adoptive transfer of gene-engineered T cells...
  20. doi request reprint TGF-β signaling in myeloid cells is required for tumor metastasis
    Yanli Pang
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Discov 3:936-51. 2013
    ..This is in contrast to the previously reported tumor-suppressing phenotypes in fibroblasts, epithelial cells, and T cells. ..
  21. pmc Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells
    Annie W Lau-Kilby
    Immune Tolerance Section, Diabetes Branch, National Institute of Diabetes, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:2408-13. 2011
    ..This pathway may have implications for the loss of immune tolerance: Reduced IL-2 signaling may lead to increased DC number and T-cell stimulatory capacity...
  22. pmc Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans
    Lyudmila Lyakh
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
    Immunol Rev 226:112-31. 2008
    ..The ability of various stimuli to induce Th17 cells depends not only on their induction of IL-23, IL-6, and TGF-beta production in DCs but also on their ability to activate directly or indirectly the inflammasome and to induce IL-1beta...
  23. doi request reprint Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity
    Lisa A Ridnour
    Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Cancer Res 19:1340-6. 2013
    ....
  24. pmc Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow
    Rosalba Salcedo
    Science Applications International Corporation, National Cancer Institute Frederick, MD 21702, USA
    J Immunol 182:4328-38. 2009
    ..These studies demonstrate that IL-27 and IL-2 synergistically induce complete tumor regression and long-term survival in mice bearing widely metastatic neuroblastoma tumors...
  25. pmc Host immune response to infection and cancer: unexpected commonalities
    Romina S Goldszmid
    Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA
    Cell Host Microbe 15:295-305. 2014
    ....
  26. pmc MyD88 and its divergent toll in carcinogenesis
    Rosalba Salcedo
    Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 217023, USA
    Trends Immunol 34:379-89. 2013
    ....
  27. pmc Production of type I interferons: plasmacytoid dendritic cells and beyond
    Carine Asselin-Paturel
    Laboratory for Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:461-5. 2005
    ..Here we discuss recent data that begin to reveal the unique molecular mechanisms underlying the remarkably rapid and efficient type I IFN production by pDCs...
  28. doi request reprint Reinforcing suppression using regulators: a new link between STAT3, IL-23, and Tregs in tumor immunosuppression
    C Andrew Stewart
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
    Cancer Cell 15:81-3. 2009
    ..STAT3 also mediates IL-23's effect of activating tumor-infiltrating regulatory T cells...
  29. pmc Interferon-γ links ultraviolet radiation to melanomagenesis in mice
    M Raza Zaidi
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Nature 469:548-53. 2011
    ..Our data reveal an unanticipated role for IFN-γ in promoting melanocytic cell survival/immunoevasion, identifying a novel candidate therapeutic target for a subset of melanoma patients...
  30. doi request reprint Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis
    Michael J Molloy
    Program in Barrier Immunity and Repair, Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Host Microbe 14:318-28. 2013
    ..Altogether, our study describes a mechanism by which the host rapidly contains commensal pathobiont outgrowth during infection. Further, these results reveal Fpr1 as a major mediator of host commensal interaction during dysbiosis...
  31. pmc LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells
    Selinda J Orr
    Cancer and Inflammation Program, National Cancer Institute Frederick, Frederick, Maryland, United States of America
    PLoS Pathog 9:e1003357. 2013
    ..In addition, these findings are likely to be relevant to other infectious diseases that require IL-12 family cytokines and an IFN-γ response for pathogen clearance...
  32. doi request reprint The price of immunity
    Romina S Goldszmid
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, Frederick, Maryland, USA
    Nat Immunol 13:932-8. 2012
    ..In this Review we will discuss the protective and pathogenic effects of host-commensal microbiota mutualism on the immune response and illustrate some examples of collateral tissue and systemic damage caused by immunity to pathogens...
  33. ncbi request reprint At 17, in-10's passion need not inflame
    C Andrew Stewart
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NCI Frederick, Frederick, MD 21702, USA
    Immunity 34:460-2. 2011
    ..In this issue of Immunity, Chaudhry et al. (2011) and Huber et al. (2011) report that control of Th17 cell responses during colonic inflammation requires direct signaling by IL-10 in regulatory T cells and Th17 cells...
  34. pmc Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation
    Andre Boonstra
    Division of Immunoregulation, The National Institute for Medical Research NIMR, NW7 1AA London, United Kingdom
    J Exp Med 197:101-9. 2003
    ..Thus, the net effect of antigen dose, the state of maturation of the DCs together with the stimulation of DCs by pathogen-derived products, will determine whether a Th1 or Th2 response develops...
  35. pmc Ikaros is required for plasmacytoid dendritic cell differentiation
    David Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
    Blood 108:4025-34. 2006
    ..These studies suggest that Ikaros controls pDC differentiation by silencing a large array of genes...
  36. ncbi request reprint MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo
    Thomas Delale
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Immunol 175:6723-32. 2005
    ....
  37. pmc Reciprocal activating interaction between natural killer cells and dendritic cells
    Franca Gerosa
    Department of Pathology, Section of Immunology, University of Verona, 37100 Verona, Italy
    J Exp Med 195:327-33. 2002
    ..These data demonstrated for the first time a bidirectional cross talk between NK cells and DC, in which NK cells activated by IL-2 or by mature DC induce DC maturation...
  38. ncbi request reprint Interleukin-12 and the regulation of innate resistance and adaptive immunity
    Giorgio Trinchieri
    Laboratory for Immunological Research, Schering Plough Research Institute, 27 chemin des Peupliers, B P 11, 69571 Dardilly, France
    Nat Rev Immunol 3:133-46. 2003
    ....
  39. pmc Type I interferon dependence of plasmacytoid dendritic cell activation and migration
    Carine Asselin-Paturel
    Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly 69571, France
    J Exp Med 201:1157-67. 2005
    ..These data demonstrate that mouse pDCs differ from cDCs in the in vivo response to TLR ligands, in terms of pattern and type I IFN requirement for activation and migration...
  40. pmc Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody
    Alain P Vicari
    Schering Plough Laboratory for Immunological Research, BP11, 27 chemin des Peupliers, 69571 Dardilly, France
    J Exp Med 196:541-9. 2002
    ..Subsequently, CpG plus anti-IL-10R treatment showed robust antitumor therapeutic activity exceeding by far that of CpG alone, and elicited antitumor immune memory...
  41. ncbi request reprint Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production
    Nathalie Bendriss-Vermare
    Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
    J Leukoc Biol 78:954-66. 2005
    ....
  42. ncbi request reprint Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity
    Christopher E Andoniou
    Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crowley 6009, Western Australia, Australia
    Nat Immunol 6:1011-9. 2005
    ..Notably, adoptive transfer of MCMV-activated CD11b(+) DCs resulted in improved control of MCMV infection, indicating that these cells participate in controlling viral replication in vivo...
  43. ncbi request reprint The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions
    Franca Gerosa
    Department of Pathology, Section of Immunology, University of Verona, Verona, Italy
    J Immunol 174:727-34. 2005
    ..These data suggest that the reciprocal functional interaction between NK cells and either pDC or myeloid DC may play an important physiological role in the regulation of both innate resistance and adaptive immunity to infections...
  44. ncbi request reprint Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, Section of Pharmacology, University of Perugia, 06126 Perugia, Italy
    Int Immunol 17:1429-38. 2005
    ..Therefore, although pDCs do not mediate IDO-dependent tolerance constitutively, multiple ligands and cytokines will contribute to the expression of a tolerogenic phenotype by pDCs in the mouse...
  45. pmc Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo
    Marc Dalod
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Exp Med 195:517-28. 2002
    ..They also illustrate the plasticity of cellular sources for innate cytokines in vivo and provide new insights into the roles of IFNs in shaping immune responses to viruses...
  46. ncbi request reprint In vivo manipulation of dendritic cell migration and activation to elicit antitumour immunity
    Alain P Vicari
    Schering Plough Laboratory for Immunological Research, 69571 Dardilly, France
    Novartis Found Symp 256:241-54; discussion 254-69. 2004
    ..Subsequently, CpG plus anti-IL10R treatment showed robust antitumour therapeutic activity exceeding by far that of CpG alone, and elicited antitumour immune memory...
  47. ncbi request reprint OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells
    Estelle Merck
    Laboratory for Immunological Research, Schering Plough, 27 chemin des Peupliers, BP11, 69571 Dardilly Cedex, France
    Blood 104:1386-95. 2004
    ..hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response...
  48. ncbi request reprint The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses
    Giorgio Trinchieri
    Schering Plough Research Institute, Laboratory for Immunological Research, 69571 Dardilly, France
    Immunity 19:641-4. 2003
    ..2003; Villarino et al., 2003), indicate that they mediate complex and well-differentiated functions...
  49. ncbi request reprint Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody
    Carine Asselin-Paturel
    Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
    J Immunol 171:6466-77. 2003
    ..The higher ability of 129Sv mice to produce IFN-alpha in vivo is related to a higher number of pDC, but also to a higher ability of pDC from 129Sv mice to produce IFN-alpha in vitro in response to viral stimulation...
  50. pmc The inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12
    Béatrice Vanbervliet
    Laboratory for Immunological Research, Schering Plough, 27 chemin des Peupliers, BP 11, 69571 Dardilly, France
    J Exp Med 198:823-30. 2003
    ....
  51. ncbi request reprint Origin and filiation of human plasmacytoid dendritic cells
    Francine Briere
    Laboratory for Immunological Research, Schering Plough, Dardilly, France
    Hum Immunol 63:1081-93. 2002
    ..Hopefully, novel markers will allow delineation of the relationships between dendritic cells at different stages of differentiation/maturation along the myeloid and lymphoid lineages...
  52. ncbi request reprint IFN-gamma and IL-12 differentially regulate CC-chemokine secretion and CCR5 expression in human T lymphocytes
    Giuliana Losana
    Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
    J Leukoc Biol 72:735-42. 2002
    ....
  53. ncbi request reprint Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals
    Jihed Chehimi
    HIV Immunopathogenesis Laboratory, Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 168:4796-801. 2002
    ..The persistent impairment of certain DC subsets may result in a sustained defect in DC-mediated innate immune functions despite an effective treatment regimen...
  54. pmc The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor
    Michel Gilliet
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Exp Med 195:953-8. 2002
    ..Human IPCs and mouse IPCs display different ability to produce IL-12p70. Large numbers of mouse IPCs can now be obtained from total bone marrow culture...
  55. ncbi request reprint Tumour escape from immune surveillance through dendritic cell inactivation
    Alain P Vicari
    Schering Plough Research Institute, Laboratory for Immunological Research, Dardilly, France
    Semin Cancer Biol 12:33-42. 2002
    ..We will review the current knowledge of the physiopathology of DC in cancer, which paves the way for novel strategies of therapeutic intervention...
  56. ncbi request reprint Interleukin-12 in anti-tumor immunity and immunotherapy
    Mario P Colombo
    Department of Experimental Oncology, Immunotherapy and Gene Therapy Unit, Istituto Nazionale Tumori, Via G Venezian 1, Milan 20133, Italy
    Cytokine Growth Factor Rev 13:155-68. 2002
    ..However, excessive clinical toxicity and modest clinical response observed in the clinical trials point to the necessity to plan protocols that minimize toxicity without affecting the anti-tumor effect of IL-12...
  57. ncbi request reprint Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 173:3748-54. 2004
    ..These data prospect novel functions for both pDCs and the CD200-CD200R pair in the mouse. At the same time, these data underscore the possible unifying role of the IDO mechanism in immune tolerance...
  58. ncbi request reprint Interleukin-10 in viral diseases and cancer: exiting the labyrinth?
    Alain P Vicari
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Immunol Rev 202:223-36. 2004
    ..In the present review, we emphasize how these multiple roles define IL-10 as an adaptive molecule, constantly tuning the host response against dangerous and resourceful pathogens...
  59. ncbi request reprint Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts
    Jordi C Ochando
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Nat Immunol 7:652-62. 2006
    ..Thus, alloantigen-presenting pDCs home to the lymph nodes in tolerogenic conditions, where they mediate alloantigen-specific Treg cell development and allograft tolerance...
  60. ncbi request reprint Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals
    Andre Boonstra
    Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 177:7551-8. 2006
    ....
  61. ncbi request reprint Distinct and overlapping roles of interleukin-10 and CD25+ regulatory T cells in the inhibition of antitumor CD8 T-cell responses
    Christophe Dercamp
    Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
    Cancer Res 65:8479-86. 2005
    ..Our results point out major redundant and nonredundant roles for IL-10 and T(reg) in the inhibition of TIDC-mediated generation of antitumor CD8 T-cell response...
  62. ncbi request reprint Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH
    Odette de Bouteiller
    Laboratory for Immunological Research, Schering Plough Research Institute, 27 chemin des Peupliers, 69571 Dardilly Cedex, France
    J Biol Chem 280:38133-45. 2005
    ..These observations demonstrate that engagement of TLR3 by poly(I-C) at an acidic pH, probably in early phagolysosomes or endosomes, induces receptor aggregation leading to signaling...
  63. pmc Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs
    Uzma A Hasan
    Infections and Cancer Biology Group, International Agency for Research on Cancer IARC WHO, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Proc Natl Acad Sci U S A 104:8047-52. 2007
    ..These findings reveal a previously uncharacterized function of TLR signaling in cell proliferation and survival...
  64. ncbi request reprint IL-10 or not IL-10: that is the question
    Dragana Jankovic
    Nat Immunol 8:1281-3. 2007
  65. pmc Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells
    Franca Gerosa
    Department of Pathology, Section of Immunology, University of Verona, 37134 Verona, Italy
    J Exp Med 205:1447-61. 2008
    ..Thus, the differential ability of pathogens to induce antigen-presenting cells to produce cytokines regulates the immune response to infection...
  66. pmc Plasmacytoid dendritic cells mediate oral tolerance
    Anne Goubier
    INSERM, U851, 21 Avenue Tony Garnier, Lyon F 69007, France
    Immunity 29:464-75. 2008
    ..These data demonstrate that oral tolerance relies on Ag presentation by pDC to T cells and suggest that pDC could represent a key therapeutic target for intestinal and systemic inflammatory diseases...
  67. ncbi request reprint CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells
    Claudya Tenca
    Department of Experimental Medicine, Human Anatomy Section, University of Genoa, Italy
    J Immunol 174:6757-63. 2005
    ..Thus, CD85j is an inhibiting receptor that is functional in human DCs...
  68. pmc A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
    Gregory Gautier
    Laboratory for Immunological Research, Schering Plough, 69571 Dardilly, France
    J Exp Med 201:1435-46. 2005
    ..Moreover, analysis of interferon regulatory factors (IRF) regulation in moDC suggests a role for IRF7/8 in mediating IRF3-independent type I IFN and possibly IL-12p35 synthesis in response to TLR7/8...
  69. ncbi request reprint Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection
    Cristiana Guiducci
    Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
    Cancer Res 65:3437-46. 2005
    ....
  70. ncbi request reprint Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88
    Uzma Hasan
    Schering Plough Research Institute, Laboratory for Immunological Research, Dardilly, France
    J Immunol 174:2942-50. 2005
    ..However, a complete TLR10 sequence could be detected in the rat genome, indicating that a functional copy may be preserved in this species...
  71. ncbi request reprint Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses
    Estelle Merck
    Laboratory for Immunological Research, Schering Plough, 27 chemin des Peupliers, BP11, 69571 Dardilly Cedex, France
    Blood 105:3623-32. 2005
    ..Altogether, these data suggest that hOSCAR may modulate the responses of both innate resistance and adaptive immunity...
  72. ncbi request reprint Plasmacytoid dendritic cells in immunity
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 5:1219-26. 2004
    ..Here we review recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human diseases...
  73. ncbi request reprint Are dendritic cells afraid of commitment?
    Anne O'Garra
    Nat Immunol 5:1206-8. 2004
  74. ncbi request reprint Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils
    Estelle Merck
    Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
    J Immunol 176:3149-56. 2006
    ..Overall, our data demonstrate that hOSCAR is a functional receptor on monocytes and neutrophils, involved in the induction of the primary proinflammatory cascade and the initiation of downstream immune responses...