C S Trempus

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi A farnesyl transferase inhibitor suppresses TPA-mediated skin tumor development without altering hyperplasia in the ras transgenic Tg.AC mouse
    C S Trempus
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Carcinog 27:24-33. 2000
  2. ncbi CD34 expression by hair follicle stem cells is required for skin tumor development in mice
    Carol S Trempus
    Cancer Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Res 67:4173-81. 2007
  3. ncbi Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34
    Carol S Trempus
    Cancer Biology Group, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Invest Dermatol 120:501-11. 2003
  4. ncbi Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mouse
    M S Battalora
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Carcinogenesis 22:651-9. 2001
  5. ncbi Photocarcinogenesis in the Tg.AC mouse: lomefloxacin and 8-methoxypsoralen
    C F Chignell
    Laboratory of Pharmacology and Chemistry, ETP, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 77:77-80. 2003
  6. ncbi Morphological characterization of spindle cell tumors induced in transgenic Tg.AC mouse skin
    S Asano
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:512-9. 1998
  7. ncbi A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer
    Thaned Kangsamaksin
    Department of Dermatology, Columbia University, New York, New York 10032, USA
    Mol Carcinog 46:579-84. 2007
  8. ncbi Comprehensive microarray transcriptome profiling of CD34-enriched mouse keratinocyte stem cells
    Carol S Trempus
    J Invest Dermatol 127:2904-7. 2007
  9. ncbi Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation
    Sung Jen Wei
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Mol Biol 383:693-712. 2008
  10. ncbi Activation of Akt and mTOR in CD34+/K15+ keratinocyte stem cells and skin tumors during multi-stage mouse skin carcinogenesis
    Nesrine I Affara
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:2805-20. 2006

Collaborators

Detail Information

Publications16

  1. ncbi A farnesyl transferase inhibitor suppresses TPA-mediated skin tumor development without altering hyperplasia in the ras transgenic Tg.AC mouse
    C S Trempus
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Carcinog 27:24-33. 2000
    ..AC mice. These studies demonstrate that TPA-induced epidermal hyperplasia is a ras-independent process, while papilloma development in response to TPA treatment requires the function of activated ras...
  2. ncbi CD34 expression by hair follicle stem cells is required for skin tumor development in mice
    Carol S Trempus
    Cancer Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Res 67:4173-81. 2007
    ..These data show that CD34 is required for TPA-induced hair follicle stem cell activation and tumor formation in mice...
  3. ncbi Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34
    Carol S Trempus
    Cancer Biology Group, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Invest Dermatol 120:501-11. 2003
    ....
  4. ncbi Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mouse
    M S Battalora
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Carcinogenesis 22:651-9. 2001
    ..This result suggests that, in the Tg.AC mouse, an age-dependent sensitivity to tumor promotion and the correlated induction of transgene expression are related to changes in cellular development in the follicular compartment of the skin...
  5. ncbi Photocarcinogenesis in the Tg.AC mouse: lomefloxacin and 8-methoxypsoralen
    C F Chignell
    Laboratory of Pharmacology and Chemistry, ETP, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 77:77-80. 2003
    ..01) than that in the other two groups. Our findings suggest that more studies need to be done before the Tg.AC mouse can be used with confidence to identify parenterally administered photocarcinogens...
  6. ncbi Morphological characterization of spindle cell tumors induced in transgenic Tg.AC mouse skin
    S Asano
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:512-9. 1998
    ..Attenuated desmosomes were also observed in these lesions by electron microscopy. These results indicate an epithelial origin for these malignancies; therefore, they should be classified as spindle cell carcinomas...
  7. ncbi A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer
    Thaned Kangsamaksin
    Department of Dermatology, Columbia University, New York, New York 10032, USA
    Mol Carcinog 46:579-84. 2007
    ..We note that, while strong evidence does support this hypothesis, experiments in progress may provide direct visualization of tumors derived from hair follicle stem cells...
  8. ncbi Comprehensive microarray transcriptome profiling of CD34-enriched mouse keratinocyte stem cells
    Carol S Trempus
    J Invest Dermatol 127:2904-7. 2007
  9. ncbi Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation
    Sung Jen Wei
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Mol Biol 383:693-712. 2008
    ....
  10. ncbi Activation of Akt and mTOR in CD34+/K15+ keratinocyte stem cells and skin tumors during multi-stage mouse skin carcinogenesis
    Nesrine I Affara
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:2805-20. 2006
    ..Strategies that target pAkt and pmTOR may deplete both cells within the CD34+/K]5+ KSCs compartment, as well as impacting the survival of nonproliferating suprabasal cells within pre-malignant papillomas...
  11. ncbi Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review
    Michael C Humble
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    Oncogene 24:8217-28. 2005
    ..The further exploration and elucidation of the molecular controls of transgene expression will enhance the usefulness of this mouse and enable a better understanding of the Tg.AC's discriminate response to chemical carcinogens...
  12. ncbi Activated Akt-1 in specific cell populations during multi-stage skin carcinogenesis
    Nesrine I Affara
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, College of Medicine, Columbus, Ohio 43210, USA
    Anticancer Res 24:2773-81. 2004
    ....
  13. ncbi Exposure of Tg.AC transgenic mice to benzene suppresses hematopoietic progenitor cells and alters gene expression in critical signaling pathways
    Veronica C Nwosu
    Department of Biology, North Carolina Central University, Durham, NC 27707, USA
    Toxicol Appl Pharmacol 196:37-46. 2004
    ..05) overexpressed in BZ-exposed mice. Two genes (c-myc and IL-2) approached significance (at P = 0.053). The pattern of gene expression was consistent with BZ toxicity and the suppression of HPCs...
  14. ncbi 12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells
    Sung Jen Wei
    National Center for Toxicogenomics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 279:5993-6004. 2004
    ....
  15. ncbi Identification of Dss1 as a 12-O-tetradecanoylphorbol-13-acetate-responsive gene expressed in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesis
    Sung Jen Wei
    National Center for Toxicogenomics and the Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:1758-68. 2003
    ..These results strongly suggest that Dss1 is a TPA-inducible gene that may play an important role in the early stages of skin carcinogenesis...
  16. ncbi Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, North Carolina27709, USA
    Cancer Res 68:8278-85. 2008
    ....