C S Trempus
Affiliation: National Institutes of Health
- A farnesyl transferase inhibitor suppresses TPA-mediated skin tumor development without altering hyperplasia in the ras transgenic Tg.AC mouseC S Trempus
Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Mol Carcinog 27:24-33. 2000..AC mice. These studies demonstrate that TPA-induced epidermal hyperplasia is a ras-independent process, while papilloma development in response to TPA treatment requires the function of activated ras...
- CD34 expression by hair follicle stem cells is required for skin tumor development in miceCarol S Trempus
Cancer Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Cancer Res 67:4173-81. 2007..These data show that CD34 is required for TPA-induced hair follicle stem cell activation and tumor formation in mice...
- Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34Carol S Trempus
Cancer Biology Group, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Invest Dermatol 120:501-11. 2003....
- Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mouseM S Battalora
Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
Carcinogenesis 22:651-9. 2001..This result suggests that, in the Tg.AC mouse, an age-dependent sensitivity to tumor promotion and the correlated induction of transgene expression are related to changes in cellular development in the follicular compartment of the skin...
- Photocarcinogenesis in the Tg.AC mouse: lomefloxacin and 8-methoxypsoralenC F Chignell
Laboratory of Pharmacology and Chemistry, ETP, NIEHS, NIH, Research Triangle Park, NC 27709, USA
Photochem Photobiol 77:77-80. 2003..01) than that in the other two groups. Our findings suggest that more studies need to be done before the Tg.AC mouse can be used with confidence to identify parenterally administered photocarcinogens...
- Morphological characterization of spindle cell tumors induced in transgenic Tg.AC mouse skinS Asano
Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 26:512-9. 1998..Attenuated desmosomes were also observed in these lesions by electron microscopy. These results indicate an epithelial origin for these malignancies; therefore, they should be classified as spindle cell carcinomas...
- A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancerThaned Kangsamaksin
Department of Dermatology, Columbia University, New York, New York 10032, USA
Mol Carcinog 46:579-84. 2007..We note that, while strong evidence does support this hypothesis, experiments in progress may provide direct visualization of tumors derived from hair follicle stem cells...
- Comprehensive microarray transcriptome profiling of CD34-enriched mouse keratinocyte stem cellsCarol S Trempus
J Invest Dermatol 127:2904-7. 2007
- Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradationSung Jen Wei
Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Mol Biol 383:693-712. 2008....
- Activation of Akt and mTOR in CD34+/K15+ keratinocyte stem cells and skin tumors during multi-stage mouse skin carcinogenesisNesrine I Affara
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
Anticancer Res 26:2805-20. 2006..Strategies that target pAkt and pmTOR may deplete both cells within the CD34+/K]5+ KSCs compartment, as well as impacting the survival of nonproliferating suprabasal cells within pre-malignant papillomas...
- Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a reviewMichael C Humble
Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
Oncogene 24:8217-28. 2005..The further exploration and elucidation of the molecular controls of transgene expression will enhance the usefulness of this mouse and enable a better understanding of the Tg.AC's discriminate response to chemical carcinogens...
- Activated Akt-1 in specific cell populations during multi-stage skin carcinogenesisNesrine I Affara
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, College of Medicine, Columbus, Ohio 43210, USA
Anticancer Res 24:2773-81. 2004....
- Exposure of Tg.AC transgenic mice to benzene suppresses hematopoietic progenitor cells and alters gene expression in critical signaling pathwaysVeronica C Nwosu
Department of Biology, North Carolina Central University, Durham, NC 27707, USA
Toxicol Appl Pharmacol 196:37-46. 2004..05) overexpressed in BZ-exposed mice. Two genes (c-myc and IL-2) approached significance (at P = 0.053). The pattern of gene expression was consistent with BZ toxicity and the suppression of HPCs...
- 12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cellsSung Jen Wei
National Center for Toxicogenomics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 279:5993-6004. 2004....
- Identification of Dss1 as a 12-O-tetradecanoylphorbol-13-acetate-responsive gene expressed in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesisSung Jen Wei
National Center for Toxicogenomics and the Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 278:1758-68. 2003..These results strongly suggest that Dss1 is a TPA-inducible gene that may play an important role in the early stages of skin carcinogenesis...
- Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamicsMichael P Waalkes
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, North Carolina27709, USA
Cancer Res 68:8278-85. 2008....