B J Traynor

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
    Elisa Majounie
    Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Lancet Neurol 11:323-30. 2012
  2. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
  3. pmc Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis
    Qiuying Sha
    Department of Mathematical Sciences, Michigan Technological University, Houghton, MI, USA
    BMC Med Genet 10:86. 2009
  4. pmc The era of genomic epidemiology
    Bryan J Traynor
    Neuromuscular Diseases Research Group, Laboratory of Neurogenetics, NIA, and Neurogenetics Branch, NINDS, Bethesda, MD 20892 3720, USA
    Neuroepidemiology 33:276-9. 2009
  5. pmc Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients
    Bryan J Traynor
    Molecular Genetics Section, and Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:12335-8. 2010
  6. ncbi request reprint Neuroprotective agents for clinical trials in ALS: a systematic assessment
    B J Traynor
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, USA
    Neurology 67:20-7. 2006
  7. pmc Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease
    M A Nalls
    Molecular Genetics Section and Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A1014, 35 Convent Drive, Bethesda, MD 20892, USA
    Neurogenetics 10:183-90. 2009
  8. ncbi request reprint Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues
    G Logroscino
    Department of Epidemiology HSPH 3 819 Harvard University, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    J Neurol Neurosurg Psychiatry 79:6-11. 2008
  9. ncbi request reprint Functional outcome measures as clinical trial endpoints in ALS
    B J Traynor
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurology 63:1933-5. 2004
  10. pmc Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes
    J C Schymick
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, Maryland, USA
    J Neurol Neurosurg Psychiatry 78:754-6. 2007

Collaborators

Detail Information

Publications15

  1. pmc Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
    Elisa Majounie
    Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Lancet Neurol 11:323-30. 2012
    ..We aimed to accurately estimate the frequency of a hexanucleotide repeat expansion in C9orf72 that has been associated with a large proportion of cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)...
  2. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
    ..A new locus for amyotrophic lateral sclerosis--frontotemporal dementia (ALS-FTD) has recently been ascribed to chromosome 9p...
  3. pmc Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis
    Qiuying Sha
    Department of Mathematical Sciences, Michigan Technological University, Houghton, MI, USA
    BMC Med Genet 10:86. 2009
    ..About 95% of ALS patients are in "sporadic form"-meaning their disease is not associated with a family history of the disease. To date, the genetic factors of the sporadic form of ALS are poorly understood...
  4. pmc The era of genomic epidemiology
    Bryan J Traynor
    Neuromuscular Diseases Research Group, Laboratory of Neurogenetics, NIA, and Neurogenetics Branch, NINDS, Bethesda, MD 20892 3720, USA
    Neuroepidemiology 33:276-9. 2009
    ....
  5. pmc Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients
    Bryan J Traynor
    Molecular Genetics Section, and Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:12335-8. 2010
    ..47) or on gene expression in that region. These data illustrate the complexities associated with analyzing ALS phenotypes for association...
  6. ncbi request reprint Neuroprotective agents for clinical trials in ALS: a systematic assessment
    B J Traynor
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, USA
    Neurology 67:20-7. 2006
    ..Riluzole is currently the only Food and Drug Administration-approved treatment for ALS, but its effect on survival is modest...
  7. pmc Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease
    M A Nalls
    Molecular Genetics Section and Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A1014, 35 Convent Drive, Bethesda, MD 20892, USA
    Neurogenetics 10:183-90. 2009
    ..052-0.062). This research suggests a recessive component to the etiology of LOAD...
  8. ncbi request reprint Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues
    G Logroscino
    Department of Epidemiology HSPH 3 819 Harvard University, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    J Neurol Neurosurg Psychiatry 79:6-11. 2008
    ....
  9. ncbi request reprint Functional outcome measures as clinical trial endpoints in ALS
    B J Traynor
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurology 63:1933-5. 2004
    ..Rates of FVC% and ALFRS decline, but not of MVIC-arm or MVIC-grip, were independent predictors of survival...
  10. pmc Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes
    J C Schymick
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, Maryland, USA
    J Neurol Neurosurg Psychiatry 78:754-6. 2007
    ..Clinical and pathological overlap between amyotrophic lateral sclerosis (ALS) and FTD prompted us to screen PGRN in patients with ALS and ALS-FTD...
  11. doi request reprint Prevalence of SOD1 mutations in the Italian ALS population
    A Chio
    ALS Center, Department of Neuroscience, University of Torino, Via Cherasco 15, Torino 10126, Italy
    Neurology 70:533-7. 2008
    ..However, estimates of SOD1 mutation prevalence have been exclusively based on case series and clinic referral cohorts...
  12. ncbi request reprint Genetics of sporadic amyotrophic lateral sclerosis
    J C Schymick
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
    Hum Mol Genet 16:R233-42. 2007
    ..We also review whole genome association studies of ALS and discuss the potential of this methodology for identifying genes relevant to motor neuron degeneration...
  13. ncbi request reprint Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004
    O O'Toole
    Department of Neurology, Beaumont Hospital, and and RCSI, Dublin 9, Ireland
    J Neurol Neurosurg Psychiatry 79:30-2. 2008
    ..We conducted a prospective, population based study to examine trends in incidence and prevalence of amyotrophic lateral sclerosis (ALS) in Ireland from 1995 to 2004...
  14. ncbi request reprint A novel candidate region for ALS on chromosome 14q11.2
    M J Greenway
    Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland
    Neurology 63:1936-8. 2004
    ..These observations propose a candidate region for ALS on chromosome 14q11.2 and suggest that other genes with similar function to VEGF may be important in the pathogenesis of ALS...
  15. pmc Effect of a multidisciplinary amyotrophic lateral sclerosis (ALS) clinic on ALS survival: a population based study, 1996-2000
    B J Traynor
    Department of Neurology, Beaumont Hospital, Dublin, Ireland
    J Neurol Neurosurg Psychiatry 74:1258-61. 2003
    ..The impact of multidisciplinary management has not been previously evaluated...