Christopher D Toscano

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Experience-dependent regulation of zif268 gene expression and spatial learning
    Christopher D Toscano
    Molecular Neurotoxicology Laboratory, Division of Toxicological Sciences, Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Exp Neurol 200:209-15. 2006
  2. pmc Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Biol 8:R14. 2007
  3. ncbi request reprint Lead exposure alters cyclic-AMP response element binding protein phosphorylation and binding activity in the developing rat brain
    Christopher D Toscano
    Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Room W2001, Baltimore, MD 21205, USA
    Brain Res Dev Brain Res 145:219-28. 2003
  4. pmc Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892, USA
    Brain Res Bull 75:598-609. 2008
  5. ncbi request reprint Calcium/calmodulin-dependent protein kinase II activity and expression are altered in the hippocampus of Pb2+-exposed rats
    Christopher D Toscano
    Division of Toxicological Sciences, Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Brain Res 1044:51-8. 2005
  6. ncbi request reprint Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure
    Tomas R Guilarte
    Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Ann Neurol 53:50-6. 2003
  7. pmc The cyclooxygenase-2 pathway via the PGE₂ EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination
    Sara Palumbo
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, Maryland, USA
    J Neurochem 121:418-27. 2012
  8. ncbi request reprint Lead neurotoxicity: from exposure to molecular effects
    Christopher D Toscano
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Brain Res Brain Res Rev 49:529-54. 2005
  9. pmc NMDA-induced seizure intensity is enhanced in COX-2 deficient mice
    Christopher D Toscano
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurotoxicology 29:1114-20. 2008
  10. pmc Altered mRNA editing and expression of ionotropic glutamate receptors after kainic acid exposure in cyclooxygenase-2 deficient mice
    Luca Caracciolo
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e19398. 2011

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Experience-dependent regulation of zif268 gene expression and spatial learning
    Christopher D Toscano
    Molecular Neurotoxicology Laboratory, Division of Toxicological Sciences, Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Exp Neurol 200:209-15. 2006
    ..Our study further defines parameters that make environmental enrichment effective in enhancing learning performance and the findings may be helpful in the translation of this intervention to the human condition...
  2. pmc Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Biol 8:R14. 2007
    ....
  3. ncbi request reprint Lead exposure alters cyclic-AMP response element binding protein phosphorylation and binding activity in the developing rat brain
    Christopher D Toscano
    Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Room W2001, Baltimore, MD 21205, USA
    Brain Res Dev Brain Res 145:219-28. 2003
    ..These disruptions in pCREB expression and binding activity of CREB family members during the ontogeny of the rat brain begin to decipher intracellular mechanisms of Pb(2+) neurotoxicity...
  4. pmc Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892, USA
    Brain Res Bull 75:598-609. 2008
    ..Our results suggest that PTGS-2 activity and its specific products may modulate neuronal excitability by affecting GABAergic neurotransmission. Further, inhibition of PTGS-2, but not PTGS-1, may increase the susceptibility to seizures...
  5. ncbi request reprint Calcium/calmodulin-dependent protein kinase II activity and expression are altered in the hippocampus of Pb2+-exposed rats
    Christopher D Toscano
    Division of Toxicological Sciences, Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Brain Res 1044:51-8. 2005
    ..These findings indicate effects of developmental Pb2+ exposure on CaMKII, a component of calcium signaling associated with synaptic plasticity, learning, and memory...
  6. ncbi request reprint Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure
    Tomas R Guilarte
    Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Ann Neurol 53:50-6. 2003
    ..We propose environmental enrichment as a basis for the treatment of childhood Pb2+ intoxication...
  7. pmc The cyclooxygenase-2 pathway via the PGE₂ EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination
    Sara Palumbo
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, Maryland, USA
    J Neurochem 121:418-27. 2012
    ..These data indicate that the PGE₂ EP2 receptor contributes to oligodendrocyte apoptosis and open possible new therapeutic approaches for multiple sclerosis...
  8. ncbi request reprint Lead neurotoxicity: from exposure to molecular effects
    Christopher D Toscano
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Brain Res Brain Res Rev 49:529-54. 2005
    ..Finally, the latest research offers some hope that the devastating effects of childhood Pb(2+) intoxication in a child's ability to learn may be reversible if the appropriate stimulatory environment is provided...
  9. pmc NMDA-induced seizure intensity is enhanced in COX-2 deficient mice
    Christopher D Toscano
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurotoxicology 29:1114-20. 2008
    ..Furthermore, increased levels of prostaglandins after seizures are associated with consistent manifestation of neuronal damage...
  10. pmc Altered mRNA editing and expression of ionotropic glutamate receptors after kainic acid exposure in cyclooxygenase-2 deficient mice
    Luca Caracciolo
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e19398. 2011
    ..The overstimulation of glutamate receptors as a consequence of COX-2 gene deletion suggests a functional coupling between COX-2 and the glutamatergic system...
  11. ncbi request reprint Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain
    Christopher D Toscano
    Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Room W2001, Baltimore, MD 21205, USA
    Brain Res Dev Brain Res 139:217-26. 2002
    ....