Kenneth K W To

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Aberrant promoter methylation of the ABCG2 gene in renal carcinoma
    Kenneth K W To
    Experimental Therapeutics Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Mol Cell Biol 26:8572-85. 2006
  2. pmc Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line
    Kenneth K W To
    Molecular Therapeutics Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 10, Room 13N220, 10 Center Drive, Bethesda, MD 20892 4255, USA
    Mol Cell Biol 28:5147-61. 2008
  3. pmc Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells
    Kenneth K W To
    Molecular Therapeutics Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Mol Cancer Res 6:151-64. 2008
  4. ncbi request reprint HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression
    Minori Koshiji
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell 17:793-803. 2005
  5. pmc The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
    Kenneth K W To
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 25:4784-94. 2006
  6. ncbi request reprint Hypoxic suppression of the cell cycle gene CDC25A in tumor cells
    Stefanie Hammer
    Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cell Cycle 6:1919-26. 2007
  7. pmc Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1
    Kenneth K W To
    Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 280:38102-7. 2005
  8. pmc Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan
    ZhiYong Liao
    Laboratory of Molecular Pharmacology, Bldg, 37, Rm 5068, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Mol Pharmacol 73:490-7. 2008
  9. pmc Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration
    Caterina Ierano
    Medical Oncology Branch, National Cancer Institute Bethesda, MD, USA
    Cancer Biol Ther 14:175-83. 2013
  10. ncbi request reprint Genetic instability: the dark side of the hypoxic response
    Kenneth K W To
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Cell Cycle 4:881-2. 2005

Collaborators

Detail Information

Publications13

  1. pmc Aberrant promoter methylation of the ABCG2 gene in renal carcinoma
    Kenneth K W To
    Experimental Therapeutics Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Mol Cell Biol 26:8572-85. 2006
    ..These data suggest that DNA methylation-dependent formation of a repressor complex in the CpG island contributes to inactivation of ABCG2...
  2. pmc Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line
    Kenneth K W To
    Molecular Therapeutics Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 10, Room 13N220, 10 Center Drive, Bethesda, MD 20892 4255, USA
    Mol Cell Biol 28:5147-61. 2008
    ..The removal of this epigenetic regulation by miRNA could be involved in the overexpression of ABCG2 in drug-resistant cancer cells...
  3. pmc Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells
    Kenneth K W To
    Molecular Therapeutics Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Mol Cancer Res 6:151-64. 2008
    ..These studies begin to address the differential effect of HDAC inhibitors widely observed in gene expression studies...
  4. ncbi request reprint HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression
    Minori Koshiji
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell 17:793-803. 2005
    ..These findings indicate that the regulation of DNA repair is an integral part of the hypoxic response, providing molecular insights into the mechanisms underlying hypoxia-induced genetic instability...
  5. pmc The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
    Kenneth K W To
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 25:4784-94. 2006
    ..Hence, our findings delineate a molecular pathway that functionally distinguishes HIF-1alpha from HIF-2alpha, and arguing a unique role for HIF-1alpha in tumor progression by promoting genomic instability...
  6. ncbi request reprint Hypoxic suppression of the cell cycle gene CDC25A in tumor cells
    Stefanie Hammer
    Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cell Cycle 6:1919-26. 2007
    ..Taken together, our studies indicate that hypoxia inhibits cell cycle progression by controlling the expression of various cell cycle genes...
  7. pmc Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1
    Kenneth K W To
    Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 280:38102-7. 2005
    ..Our finding also provided new insight into the pharmacological manipulation of the HIF prolyl hydroxylase for ischemic diseases...
  8. pmc Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan
    ZhiYong Liao
    Laboratory of Molecular Pharmacology, Bldg, 37, Rm 5068, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Mol Pharmacol 73:490-7. 2008
    ..Our studies suggest that selection for resistance to hCPT or BN80915 is primarily related to reduced Top1 expression at the transcriptional level, resulting in reduced enzyme levels...
  9. pmc Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration
    Caterina Ierano
    Medical Oncology Branch, National Cancer Institute Bethesda, MD, USA
    Cancer Biol Ther 14:175-83. 2013
    ..In conclusion, HDIs upregulated CXCR4 mRNA expression but impaired CXCL12-dependent signaling cascades through STAT3 and c-SRC, suggesting a potential role for HDIs in delaying or preventing metastatic processes in solid tumors...
  10. ncbi request reprint Genetic instability: the dark side of the hypoxic response
    Kenneth K W To
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Cell Cycle 4:881-2. 2005
    ..Therefore, our findings shed light on the mechanisms underlying hypoxia-induced genetic instability, an "adverse"effect of the hypoxic response, and yet a germane process to tumor survival and progression...
  11. ncbi request reprint Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation
    Yukio Kageyama
    Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 18:1028-30. 2004
    ..Hence, our findings indicate that Leu-574 is essential for recruiting PHD2/HPH2, thereby providing a molecular basis for modulating HIF-1alpha activity...
  12. ncbi request reprint In vitro and in vivo suppression of growth of hepatocellular carcinoma cells by novel traditional Chinese medicine-platinum anti-cancer agents
    Kenneth K W To
    School of Pharmacy, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    Anticancer Drugs 16:825-35. 2005
    ..The high potency of the novel TCM-Pt compounds against liver cancer and the minimal toxicity suggest that they have significant potential to be developed into useful Pt-based anti-tumor drugs...
  13. ncbi request reprint Protein phosphatase 2A inhibition and circumvention of cisplatin cross-resistance by novel TCM-platinum anticancer agents containing demethylcantharidin
    Kenneth K W To
    School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, Hong Kong
    Bioorg Med Chem 12:4565-73. 2004
    ..The results advocate a well-defined structure-activity requirement associating the PP2A-inhibiting demethylcantharidin with the circumvention of cisplatin cross-resistance demonstrated by TCM-Pt compounds 1-5...