N Tjandra

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Residual dipolar couplings in protein structure determination
    Eva de Alba
    Laboratory of Biophysical Chemistry, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 278:89-106. 2004
  2. ncbi request reprint Structural basis for redox regulation of Yap1 transcription factor localization
    Matthew J Wood
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 5430, USA
    Nature 430:917-21. 2004
  3. ncbi request reprint Refinement of protein structure against non-redundant carbonyl 13C NMR relaxation
    Nico Tjandra
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 3503, Bethesda, MD 20892, USA
    J Biomol NMR 38:243-53. 2007
  4. ncbi request reprint Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission
    Motoshi Suzuki
    Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:21444-52. 2005
  5. ncbi request reprint 15N chemical shift anisotropy in protein structure refinement and comparison with NH residual dipolar couplings
    Rebecca S Lipsitz
    Laboratory of Biophysical Chemistry, Building 50, Room 3503, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8013, USA
    J Magn Reson 164:171-6. 2003
  6. ncbi request reprint Top-down approach in protein RDC data analysis: de novo estimation of the alignment tensor
    Kang Chen
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 3503, Bethesda, MD 20892, USA
    J Biomol NMR 38:303-13. 2007
  7. ncbi request reprint Residue-specific 13C' CSA tensor principal components for ubiquitin: correlation between tensor components and hydrogen bonding
    Robert A Burton
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Bethesda, Maryland 20892, USA
    J Am Chem Soc 129:1321-6. 2007
  8. ncbi request reprint Structural studies on the Ca2+-binding domain of human nucleobindin (calnuc)
    Eva de Alba
    Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 Center Drive, Bethesda, Maryland 20892, USA
    Biochemistry 43:10039-49. 2004
  9. ncbi request reprint Solution structure of human saposin C in a detergent environment
    Cheryl A Hawkins
    Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 Center Drive, Bethesda, MD 20892, USA
    J Mol Biol 346:1381-92. 2005
  10. ncbi request reprint Residual dipolar couplings in NMR structure analysis
    Rebecca S Lipsitz
    Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Biophys Biomol Struct 33:387-413. 2004

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Residual dipolar couplings in protein structure determination
    Eva de Alba
    Laboratory of Biophysical Chemistry, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 278:89-106. 2004
    ..Methods to measure RDCs and their application to protein structure determination are illustrated...
  2. ncbi request reprint Structural basis for redox regulation of Yap1 transcription factor localization
    Matthew J Wood
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 5430, USA
    Nature 430:917-21. 2004
    ..These results reveal the structural basis of redox-dependent Yap1 localization and provide a previously unknown mechanism of transcription factor regulation by reversible intramolecular disulphide bond formation...
  3. ncbi request reprint Refinement of protein structure against non-redundant carbonyl 13C NMR relaxation
    Nico Tjandra
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 3503, Bethesda, MD 20892, USA
    J Biomol NMR 38:243-53. 2007
    ..In addition, possible variations of the CSA tensor were addressed...
  4. ncbi request reprint Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission
    Motoshi Suzuki
    Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:21444-52. 2005
    ..Although the TPR-like helix bundle of Fis1 mediates the interaction with Dnm1 and Mdv1, the N terminus of Fis1 is a prerequisite to recruit Mdv1 to facilitate mitochondrial fission...
  5. ncbi request reprint 15N chemical shift anisotropy in protein structure refinement and comparison with NH residual dipolar couplings
    Rebecca S Lipsitz
    Laboratory of Biophysical Chemistry, Building 50, Room 3503, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8013, USA
    J Magn Reson 164:171-6. 2003
    ..This method should be amenable to any protein which can be studied by NMR. An analysis comparing the structural information provided by NH RDCs and the 15N Deltadelta is included...
  6. ncbi request reprint Top-down approach in protein RDC data analysis: de novo estimation of the alignment tensor
    Kang Chen
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 3503, Bethesda, MD 20892, USA
    J Biomol NMR 38:303-13. 2007
    ..This top-down approach is a robust method for alignment tensor estimation and also holds a promise for providing a protein topological fold using limited sets of RDCs...
  7. ncbi request reprint Residue-specific 13C' CSA tensor principal components for ubiquitin: correlation between tensor components and hydrogen bonding
    Robert A Burton
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Bethesda, Maryland 20892, USA
    J Am Chem Soc 129:1321-6. 2007
    ..These analyses hold future potential for exploration provided that more accurate data from a larger number of proteins and alignments become available...
  8. ncbi request reprint Structural studies on the Ca2+-binding domain of human nucleobindin (calnuc)
    Eva de Alba
    Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 Center Drive, Bethesda, Maryland 20892, USA
    Biochemistry 43:10039-49. 2004
    ..NMR relaxation data and structural studies of the folded domain indicate that it undergoes slow dynamics, suggesting that it is floppier and less compact than a globular domain...
  9. ncbi request reprint Solution structure of human saposin C in a detergent environment
    Cheryl A Hawkins
    Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 Center Drive, Bethesda, MD 20892, USA
    J Mol Biol 346:1381-92. 2005
    ..Their comparison reveals possible similarity in the type of protein/lipid interaction as well as structural components differentiating their quaternary structures and functional specificity...
  10. ncbi request reprint Residual dipolar couplings in NMR structure analysis
    Rebecca S Lipsitz
    Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Biophys Biomol Struct 33:387-413. 2004
    ..This review briefly describes the theory and methods for obtaining RDCs and then describes the range of biological applications where RDCs have been used...
  11. ncbi request reprint Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles
    Eva de Alba
    Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 Center Drive, Bethesda, Maryland 20892, USA
    Biochemistry 42:14729-40. 2003
    ..Since saposin C is a lysosomal protein and pH gradients occur in lysosomes, we propose that lipid degradation in the lysosome could be switched on and off by saposin C's reversible binding to membranes...
  12. ncbi request reprint On the accurate measurement of amide one-bond 15N-1H couplings in proteins: effects of cross-correlated relaxation, selective pulses and dynamic frequency shifts
    Eva de Alba
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    J Magn Reson 183:160-5. 2006
    ..Furthermore, the average difference of 1J(15N-1H) values at two magnetic fields closely agrees with the theoretical expected difference in the dynamic frequency shift...
  13. ncbi request reprint Interference between cross-correlated relaxation and the measurement of scalar and dipolar couplings by Quantitative J
    Eva de Alba
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Bethesda, Maryland, 20892, USA
    J Biomol NMR 35:1-16. 2006
    ..Furthermore, this analysis indicates that cross-correlated relaxation effects under isotropic and anisotropic media differ, indicating that errors are not cancelled in residual dipolar coupling measurements...
  14. pmc Ligand-free open-closed transitions of periplasmic binding proteins: the case of glutamine-binding protein
    Guillermo A Bermejo
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 49:1893-902. 2010
    ....
  15. pmc Determination of the solution-bound conformation of an amino acid binding protein by NMR paramagnetic relaxation enhancement: use of a single flexible paramagnetic probe with improved estimation of its sampling space
    Guillermo A Bermejo
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Chem Soc 131:9532-7. 2009
    ..Thus, by partitioning the protocol into "probe sampling" and "backbone sampling" stages, structures significantly closer to the X-ray structure of ligand-bound GlnBP were obtained...
  16. pmc Direct measurements of protein backbone 15N spin relaxation rates from peak line-width using a fully-relaxed Accordion 3D HNCO experiment
    Kang Chen
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 Center Drive, Bld 50, Room 3513, Bethesda, MD 20892, USA
    J Magn Reson 197:71-6. 2009
    ..In addition to comparable accuracy, the fully-relaxed Accordion HNCO method presented here allowed measurements of relaxation rates for resonances unresolved in 2D spectra, thus providing a more complete dynamic picture of the protein...
  17. ncbi request reprint Anisotropic rotational diffusion of perdeuterated HIV protease from 15N NMR relaxation measurements at two magnetic fields
    N Tjandra
    Laboratory of Chemical Physics, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0250, USA
    J Biomol NMR 8:273-84. 1996
    ....
  18. ncbi request reprint Defining long range order in NMR structure determination from the dependence of heteronuclear relaxation times on rotational diffusion anisotropy
    N Tjandra
    Laboratory of Chemical Physics, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0520, USA
    Nat Struct Biol 4:443-9. 1997
    ..The method is demonstrated using the N-terminal domain of Enzyme I,a protein of 259 residues comprising two distinct domains with a diffusion anisotropy(Dparallel/Dperpendicular)of approximately 2...
  19. ncbi request reprint Temperature dependence of protein backbone motion from carbonyl 13C and amide 15N NMR relaxation
    Shou Lin Chang
    Laboratory of Biophysical Chemistry, Building 50, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Magn Reson 174:43-53. 2005
    ....
  20. pmc 15N-1H scalar coupling perturbation: an additional probe for measuring structural changes due to ligand binding
    Junhe Ma
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Bethesda, Maryland 20892, USA
    J Am Chem Soc 131:9884-5. 2009
    ..Thus, amide scalar coupling perturbation can serve as an adjunct to chemical shift perturbation, providing additional information on both short-range and longer-range, allosteric structural changes...
  21. pmc NMR solution structure, stability, and interaction of the recombinant bovine fibrinogen alphaC-domain fragment
    Robert A Burton
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 Center Drive, Bethesda, Maryland 20892, USA
    Biochemistry 46:8550-60. 2007
    ....
  22. pmc Structural basis for capping protein sequestration by myotrophin (V-1)
    Adam Zwolak
    Laboratory of Molecular Biophysics, HLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:25767-81. 2010
    ..These results can explain how V-1 inactivates barbed end capping by CP and why V-1 is incapable of uncapping CP-capped actin filaments, the two signature biochemical activities of V-1...
  23. ncbi request reprint Hydrogen bonding in high-resolution protein structures: a new method to assess NMR protein geometry
    Rebecca S Lipsitz
    Laboratory of Biophysical Chemistry, Building 50, Room 3503, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8013, USA
    J Am Chem Soc 124:10621-6. 2002
    ..The angle and distance limits found in our correlation for the backbone hydrogen-bond geometry can be used to evaluate the quality of protein structures and for further NMR structure refinement...
  24. pmc Backbone (15)N relaxation analysis of the N-terminal domain of the HTLV-I capsid protein and comparison with the capsid protein of HIV-1
    Claudia C Cornilescu
    Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Protein Sci 12:973-81. 2003
    ..The beta-hairpin and CyP-A loop exhibit different mobility in HTLV-I and HIV-1. The overall hydrodynamic property of the HTLV-I capsid NTD is quite distinct from the HIV-1...
  25. ncbi request reprint Overall structure and sugar dynamics of a DNA dodecamer from homo- and heteronuclear dipolar couplings and 31P chemical shift anisotropy
    Zhengrong Wu
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Biomol NMR 26:297-315. 2003
    ....
  26. ncbi request reprint The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle
    Motoshi Suzuki
    Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Biol 334:445-58. 2003
    ....
  27. ncbi request reprint Use of dipolar 1H-15N and 1H-13C couplings in the structure determination of magnetically oriented macromolecules in solution
    N Tjandra
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0520, USA
    Nat Struct Biol 4:732-8. 1997
    ..The method is demonstrated on a complex of the DNA-binding domain of the transcription factor GATA-1 with a 16 base pair oligodeoxyribonucleotide...
  28. ncbi request reprint Determination of the residue-specific 15N CSA tensor principal components using multiple alignment media
    Robert A Burton
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Bethesda, Maryland, 20892, USA
    J Biomol NMR 35:249-59. 2006
    ..Am. Chem. Soc. 122, 10143-10154]. Significant deviations from the averages coincide with residues in beta-strand or extended regions, while alpha-helical residue tensor components cluster close to the average values...
  29. ncbi request reprint Completely automated, highly error-tolerant macromolecular structure determination from multidimensional nuclear overhauser enhancement spectra and chemical shift assignments
    John Kuszewski
    Contribution from the Division of Computational Bioscience, Building 12A, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892 5624, USA
    J Am Chem Soc 126:6258-73. 2004
    ..The limits of the method are explored using simulated data on the 56-residue B1 domain of Streptococcal protein G...
  30. pmc A practical implementation of cross-spectrum in protein backbone resonance assignment
    Kang Chen
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Magn Reson 203:208-12. 2010
    ..The cross-spectrum principle is expected to offer an easy, practical, and more quantitative approach for heteronuclear backbone resonance assignment...
  31. pmc Extended model free approach to analyze correlation functions of multidomain proteins in the presence of motional coupling
    Kang Chen
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Chem Soc 130:12745-51. 2008
    ....
  32. pmc Solution NMR structure of selenium-binding protein from Methanococcus vannielii
    Motoshi Suzuki
    Laboratory of Molecular Biophysics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:25936-43. 2008
    ..Therefore, a different selenium precursor or other factors might be needed to facilitate opening of this loop to expose Cys(59) for selenium binding...
  33. pmc Refined solution structure and backbone dynamics of HIV-1 Nef
    S Grzesiek
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0520, USA
    Protein Sci 6:1248-63. 1997
    ..A refined structure has been determined based on additional constraints for side-chain and backbone dihedral angles derived from a large number of three-bond J-coupling and ROE data...
  34. ncbi request reprint Structural analysis of the N-terminal domain of the human T-cell leukemia virus capsid protein
    C C Cornilescu
    Laboratory of Biophysical Chemistry, Bldg 3, NHLBI, NIH, Bethesda, MD, 20892 0380, USA
    J Mol Biol 306:783-97. 2001
    ..Comparison of three-dimensional structures is expected to elucidate the relationships between the retroviral capsid protein structure and its function...
  35. ncbi request reprint Solution structure of calcium-free calmodulin
    H Kuboniwa
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0520, USA
    Nat Struct Biol 2:768-76. 1995
    ..This arrangement is qualitatively similar to that observed in the crystal structure of the Ca(2+)-free N-terminal domain of troponin C...
  36. ncbi request reprint Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling
    E de Alba
    Laboratory of Biophysical Chemistry, Building 3 National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892 0380, USA
    J Mol Biol 291:927-39. 1999
    ..We suggest that other structural differences between the two proteins may be related to the process of binding as well as to a distinct efficiency in their respective GTPase activating function...
  37. pmc Identification of an ordered compact structure within the recombinant bovine fibrinogen alphaC-domain fragment by NMR
    Robert A Burton
    Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 Center Drive, Bethesda, Maryland 20892, USA
    Biochemistry 45:2257-66. 2006
    ..The low stability of the alphaC-domain suggests a possible explanation for the previously observed intra- and intermolecular interactions of these domains in fibrinogen and fibrin...
  38. pmc Characterization of the N-terminal tail domain of histone H3 in condensed nucleosome arrays by hydrogen exchange and NMR
    Hidenori Kato
    Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Chem Soc 131:15104-5. 2009
    ....
  39. pmc Solution NMR characterizations of oligomerization and dynamics of equine infectious anemia virus matrix protein and its interaction with PIP2
    Kang Chen
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8013, USA
    Biochemistry 47:1928-37. 2008
    ....
  40. ncbi request reprint An ab initio study of amide proton shift tensor dependence on local protein structure
    Yugal Sharma
    Laboratory of Biophysical Chemistry, Building 50, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8013, USA
    J Am Chem Soc 124:327-35. 2002
    ..Antisymmetric tensor elements were found to be relatively small. This study permits separation of various local structure contributions to the amide proton shielding tensor that complements scarce experimental data...
  41. pmc Molecular basis for barbed end uncapping by CARMIL homology domain 3 of mouse CARMIL-1
    Adam Zwolak
    Laboratory of Molecular Biophysics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:29014-26. 2010
    ..Together, these results offer a mechanistic explanation for the barbed end uncapping activity of CARMIL, and they identify the basic patch on CP as a crucial regulatory site...
  42. ncbi request reprint Specific non-native hydrophobic interactions in a hidden folding intermediate: implications for protein folding
    Hanqiao Feng
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 42:12461-5. 2003
    ..More generally, these results illustrate an approach for determining the high-resolution structure of folding intermediates...
  43. ncbi request reprint Temperature dependence of domain motions of calmodulin probed by NMR relaxation at multiple fields
    Shou Lin Chang
    Laboratory of Biophysical Chemistry, Building 50, National Heart, Lung, and Blood Institute and Laboratory of Chemical Physics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Chem Soc 125:11379-84. 2003
    ..Our analysis of the NMR relaxation data quantifies subtle changes in the interdomain dynamics and provides an additional tool to monitor conformational changes in multidomain proteins...
  44. ncbi request reprint Analysis of slow interdomain motion of macromolecules using NMR relaxation data
    J L Baber
    Laboratory of Biophysical Chemistry, Building 3, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-0380, USA
    J Am Chem Soc 123:3953-9. 2001
    ....
  45. ncbi request reprint Measurement of 1H3'-31P dipolar couplings in a DNA oligonucleotide by constant-time NOESY difference spectroscopy
    Z Wu
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Biomol NMR 19:367-70. 2001
    ..Isotropic values are in good agreement with values reported previously. Dipolar couplings are in excellent agreement with the NMR structure for this dodecamer, and to a somewhat lesser extent with the X-ray structures...
  46. ncbi request reprint High precision solution structure of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K, a c-myc transcription factor
    J L Baber
    National Heart, Lung, and Blood Institute, National Institutes of Health, Building 3, Bethesda, MD, 20892 0380, USA
    J Mol Biol 289:949-62. 1999
    ....
  47. pmc Weak alignment of biomacromolecules in collagen gels: an alternative way to yield residual dipolar couplings for NMR measurements
    Junhe Ma
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Bethesda, Maryland 20892, USA
    J Am Chem Soc 130:16148-9. 2008
    ..The collagen gels showed good pH and detergent tolerance. These advantages of collagen gels make it a promising candidate for the alignment of large biomolecules or membrane protein-detergent complexes in the magnetic field...
  48. ncbi request reprint The Xplor-NIH NMR molecular structure determination package
    Charles D Schwieters
    Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Building 12A, 20892 5624, Bethesda, MD, USA
    J Magn Reson 160:65-73. 2003
    ..Support for these scripting languages also facilitates interaction with existing external programs for structure analysis, structure manipulation, visualization, and spectral analysis...
  49. ncbi request reprint Structural and dynamics studies of the D54A mutant of human T cell leukemia virus-1 capsid protein
    Fadila Bouamr
    Howard Hughes Medical Institute, New York, New York, USA
    J Biol Chem 280:6792-801. 2005
    ....
  50. pmc BAX activation is initiated at a novel interaction site
    Evripidis Gavathiotis
    Department of Pediatric Oncology and the Program in Cancer Chemical Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 455:1076-81. 2008
    ..Thus, we have now defined a BAX interaction site for direct activation, establishing a new target for therapeutic modulation of apoptosis...