Affiliation: National Institutes of Health
Tilly K, Bestor A, Jewett M, Rosa P. Rapid clearance of Lyme disease spirochetes lacking OspC from skin. Infect Immun. 2007;75:1517-9 pubmed
..We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission. ..
Fazzino L, Tilly K, Dulebohn D, Rosa P. Long-term survival of Borrelia burgdorferi lacking the hibernation promotion factor homolog in the unfed tick vector. Infect Immun. 2015;83:4800-10 pubmed publisher
..burgdorferi. We suggest either that BB0449 is associated with ribosomes under specific conditions not yet identified or that BB0449 of B. burgdorferi has a function other than ribosome conformation modulation. ..
Tilly K, Bestor A, Rosa P. Functional Equivalence of OspA and OspB, but Not OspC, in Tick Colonization by Borrelia burgdorferi. Infect Immun. 2016;84:1565-1573 pubmed publisher
Tilly K, Checroun C, Rosa P. Requirements for Borrelia burgdorferi plasmid maintenance. Plasmid. 2012;68:1-12 pubmed publisher
..Conversely, we were unable to inactivate bbb10 on cp26 of B. burgdorferi. Our results suggest that bbb12 is dispensable for cp26 maintenance, whereas bbb10, bbb11, and bbb13 play crucial roles in that process. ..
Kasumba I, Bestor A, Tilly K, Rosa P. Virulence of the Lyme disease spirochete before and after the tick bloodmeal: a quantitative assessment. Parasit Vectors. 2016;9:129 pubmed publisher
..Conditional priming of B. burgdorferi during tick feeding induces changes in addition to OspC that are required for infection of the mammalian host. ..
Tilly K, Bestor A, Rosa P. Lipoprotein succession in Borrelia burgdorferi: similar but distinct roles for OspC and VlsE at different stages of mammalian infection. Mol Microbiol. 2013;89:216-27 pubmed publisher