Annika Thorsell

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Central neuropeptide Y in anxiety- and stress-related behavior and in ethanol intake
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 1108, USA
    Ann N Y Acad Sci 1148:136-40. 2008
  2. ncbi request reprint Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar Rats
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bethesda, Maryland 20892 1108, USA
    Alcohol Clin Exp Res 31:1302-7. 2007
  3. ncbi request reprint Neuropeptide Y (NPY) in alcohol intake and dependence
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, NIH NIAAA, Building 10 CRC Room 1 5330, 10 Center Drive, Bethesda, MD 20892 1108, USA
    Peptides 28:480-3. 2007
  4. doi request reprint Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: reduced appetite for calories and suppression of addictive-like behaviors
    Camilla Karlsson
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD, USA
    Pharmacol Biochem Behav 102:400-6. 2012
  5. pmc The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety
    Jesse R Schank
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Addict Biol 17:634-47. 2012
  6. pmc A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892, USA
    J Neurosci 33:10132-42. 2013
  7. pmc Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD 20892 1108, USA
    Pharmacol Biochem Behav 100:522-9. 2012
  8. pmc Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD, USA Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bethesda, MD, USA
    Addict Biol 19:27-36. 2014
  9. ncbi request reprint Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr, 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 211:367-75. 2010
  10. ncbi request reprint Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 1108, USA
    Biol Psychiatry 67:823-30. 2010

Collaborators

Detail Information

Publications32

  1. doi request reprint Central neuropeptide Y in anxiety- and stress-related behavior and in ethanol intake
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 1108, USA
    Ann N Y Acad Sci 1148:136-40. 2008
    ..Here, a brief summary of some work performed in our laboratory is presented that supports a role for NPY in regulation of stress responses and behaviors...
  2. ncbi request reprint Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar Rats
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bethesda, Maryland 20892 1108, USA
    Alcohol Clin Exp Res 31:1302-7. 2007
    ....
  3. ncbi request reprint Neuropeptide Y (NPY) in alcohol intake and dependence
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, NIH NIAAA, Building 10 CRC Room 1 5330, 10 Center Drive, Bethesda, MD 20892 1108, USA
    Peptides 28:480-3. 2007
    ..We propose the NPY system to be one of the most interesting target systems for the development of treatments for alcohol abuse and dependence...
  4. doi request reprint Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: reduced appetite for calories and suppression of addictive-like behaviors
    Camilla Karlsson
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD, USA
    Pharmacol Biochem Behav 102:400-6. 2012
    ..Here, we examined whether the MCH system plays a role both in caloric and motivational aspects of sugar intake...
  5. pmc The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety
    Jesse R Schank
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Addict Biol 17:634-47. 2012
    ..Our results provide additional evidence for the involvement of KOR in regulation of alcohol-related behaviors and provide support for KOR antagonists, including JDTic, to be evaluated as medications for alcoholism...
  6. pmc A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892, USA
    J Neurosci 33:10132-42. 2013
    ..Together, these data provide an initial validation of the NPSR as a therapeutic target in alcoholism...
  7. pmc Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD 20892 1108, USA
    Pharmacol Biochem Behav 100:522-9. 2012
    ..The aim of the present study was to evaluate whether the CRH system is also recruited when non-dependent Wistar rats escalate to high alcohol intake in the intermittent (alternate days) model of drinking...
  8. pmc Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD, USA Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bethesda, MD, USA
    Addict Biol 19:27-36. 2014
    ..These results suggest that elevated circulating Cort in part mediates EtOH-induced neurotoxicity in the brain through activation of Type II GC receptors...
  9. ncbi request reprint Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr, 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 211:367-75. 2010
    ..Melanin-concentrating hormone (MCH) is involved in regulation of appetitive behaviors as well as emotional reactivity and reward, behavioral domains relevant to alcohol addiction...
  10. ncbi request reprint Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 1108, USA
    Biol Psychiatry 67:823-30. 2010
    ..Here, we examined whether the group II metabotropic glutamate receptor agonist LY379268 prevents neuronal death and learning deficits in a rat model of binge-like exposure to alcohol...
  11. ncbi request reprint The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Alcohol 45:567-76. 2011
    ....
  12. ncbi request reprint Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 208:417-26. 2010
    ..Here, we examined whether neuropeptide Y (NPY), an endogenous anti-stress mediator, blocks reinstatement of alcohol-seeking induced by the pharmacological stressor yohimbine...
  13. pmc Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429
    Jesse R Schank
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Building 10 CRC, Room 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 218:111-9. 2011
    ..The role of the NK1 system for relapse-like behavior has not previously been examined...
  14. doi request reprint Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice
    Annika Thorsell
    The Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, 10 CRC 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 209:103-11. 2010
    ..It remains unknown whether this reflects developmental effects or direct regulation of alcohol consumption by NK1R:s, and whether the reduced consumption reflects motivational effects...
  15. pmc Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors
    Karl Björk
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Addict Biol 15:299-303. 2010
    ..One of these is D2-dependent, while the other is not. These findings illustrate that pharmacology of ethanol reward is likely more complex than that for other addictive drugs...
  16. pmc Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Inst on Alcohol Abuse and Alcoholism, National Inst of Health, Bethesda, MD, United States
    Neurosci Biobehav Rev 35:334-44. 2010
    ....
  17. ncbi request reprint The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, NIH, National Institute of Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 1 15330, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 195:547-57. 2008
    ..Neuropeptide Y (NPY) is implicated in the pathophysiology of affective illness. Multiple receptor subtypes (Y1R, Y2R, and Y5R) have been suggested to contribute to NPY's effects on rodent anxiety and depression-related behaviors...
  18. doi request reprint Neurokinin 1 receptor antagonism as a possible therapy for alcoholism
    David T George
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Science 319:1536-9. 2008
    ..Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism...
  19. doi request reprint Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxiety
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, 10 CRC 1E 5330, Bethesda, MD 20892 1108, USA
    Exp Biol Med (Maywood) 235:1163-7. 2010
    ..e. stressors, and their differential adaptations during transition from an acute to a chronic stress exposure state...
  20. pmc D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model
    Mette Skinbjerg
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    Neuroimage 50:1402-7. 2010
    ..In addition, this study demonstrates the utility of small animal PET to study receptor trafficking in vivo in genetically modified mice...
  21. ncbi request reprint Brain neuropeptide Y (NPY) in stress and alcohol dependence
    Markus Heilig
    Neurotec, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Rev Neurosci 13:85-94. 2002
    ..Recent data additionally point to a role of NPY in the regulation of alcohol intake, and alcohol dependence emerges as a novel potential indication for compounds targeting the NPY system...
  22. ncbi request reprint Effects of neuropeptide Y and corticotropin-releasing factor on ethanol intake in Wistar rats: interaction with chronic ethanol exposure
    Annika Thorsell
    The Scripps Research Institute, Department of Neuropharmacology, Mail Drop CVN 14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Behav Brain Res 161:133-40. 2005
    ..Furthermore, the results presented here suggest that a balance between the stress-related peptides NPY and CRF may be involved in the regulation of ethanol intake...
  23. ncbi request reprint Antagonism of neuropeptide YY1 receptors does not inhibit ethanol's effects on cortical EEG and ERPs in Wistar rats
    Craig J Slawecki
    The Scripps Research Institute, Department of Neuropharmacology, CFN 14, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Stud Alcohol 66:559-66. 2005
    ..In the present study, the NPY Y1 receptor antagonist BIBP3226 was administered alone or in combination with a moderate dose of ethanol to determine whether it interacted with the neurobehavioral effects of ethanol...
  24. ncbi request reprint The effects of social isolation on neuropeptide Y levels, exploratory and anxiety-related behaviors in rats
    Annika Thorsell
    The Scripps Research Institute, Department of Neuropharmacology CVN 14, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 83:28-34. 2006
    ....
  25. ncbi request reprint Effects of neuropeptide Y on appetitive and consummatory behaviors associated with alcohol drinking in wistar rats with a history of ethanol exposure
    Annika Thorsell
    The Scripps Research Institute, Department of Neuropharmacology, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 29:584-90. 2005
    ..The current study was designed to determine whether NPY differentially alters ethanol-associated appetitive behavior (i.e., lever pressing) or ethanol consumption in Wistar rats with a history of ethanol vapor exposure...
  26. ncbi request reprint 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism
    Donald R Gehlert
    Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 27:2718-26. 2007
    ..Based on these findings, MTIP is a promising candidate for treatment of alcohol dependence...
  27. pmc Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats
    Annika Thorsell
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road SP30 2400, La Jolla, CA 92037, USA
    Brain 130:1330-7. 2007
    ..Repeated withdrawal in combination with a history of alcohol consumption significantly elevated alcohol intake, and the amygdala may mediate the transition to high-drinking states in this model...
  28. ncbi request reprint Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence
    Roberto Rimondini
    Neurotec, Karolinska Institutet, M57, Huddinge University Hospital, SE 14186 Huddinge, Sweden
    Neurosci Lett 375:129-33. 2005
    ..This may render the NPY system, and Y2 receptors in particular, an attractive target for treatment of alcohol dependence...
  29. ncbi request reprint Long-term neurobehavioral effects of alcohol or nicotine exposure in adolescent animal models
    Craig J Slawecki
    The Scripps Research Institute, Department of Neuropharmacology, CVN14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1021:448-52. 2004
    ..These findings support the hypothesis that adolescents are uniquely susceptible to the effects of chronic alcohol and nicotine exposure...
  30. ncbi request reprint Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test
    Christian Möller
    Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Prog Neuropsychopharmacol Biol Psychiatry 26:119-22. 2002
    ..GLP-1 may participate in the control of fear-induced suppression of behavior, probably via action in the amygdala...
  31. ncbi request reprint Effect of social isolation on ethanol consumption and substance P/neurokinin expression in Wistar rats
    Annika Thorsell
    The Scripps Research Institute, Department of Neuropharmacology CVN 14, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol 36:91-7. 2005
    ..These data indicate that endogenous SP and neurokinin levels are reduced by isolation housing, but this was not associated with alterations in drinking levels using a two-bottle choice procedure...
  32. ncbi request reprint Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism
    Markus Heilig
    Karolinska Institutet, Neurotec Department, Division of Psychiatry, Huddinge University Hospital, M57, SE 141 86, Stockholm, Sweden
    J Psychiatr Res 38:113-21. 2004
    ..Our present findings are in line with an extensive animal literature, and further support the notion that impaired NPY function could contribute to depressive illness...