Research Topics
| Annika ThorsellSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Central neuropeptide Y in anxiety- and stress-related behavior and in ethanol intakeAnnika Thorsell
Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 1108, USA
Ann N Y Acad Sci 1148:136-40. 2008..Here, a brief summary of some work performed in our laboratory is presented that supports a role for NPY in regulation of stress responses and behaviors...
Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar RatsAnnika Thorsell
Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bethesda, Maryland 20892 1108, USA
Alcohol Clin Exp Res 31:1302-7. 2007....- Neuropeptide Y (NPY) in alcohol intake and dependenceAnnika Thorsell
Laboratory of Clinical and Translational Studies, NIH NIAAA, Building 10 CRC Room 1 5330, 10 Center Drive, Bethesda, MD 20892 1108, USA
Peptides 28:480-3. 2007..We propose the NPY system to be one of the most interesting target systems for the development of treatments for alcohol abuse and dependence... - Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: reduced appetite for calories and suppression of addictive-like behaviorsCamilla Karlsson
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD, USA
Pharmacol Biochem Behav 102:400-6. 2012..Here, we examined whether the MCH system plays a role both in caloric and motivational aspects of sugar intake... 
The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxietyJesse R Schank
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
Addict Biol 17:634-47. 2012..Our results provide additional evidence for the involvement of KOR in regulation of alcohol-related behaviors and provide support for KOR antagonists, including JDTic, to be evaluated as medications for alcoholism...- Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar ratsAndrea Cippitelli
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD 20892 1108, USA
Pharmacol Biochem Behav 100:522-9. 2012..The aim of the present study was to evaluate whether the CRH system is also recruited when non-dependent Wistar rats escalate to high alcohol intake in the intermittent (alternate days) model of drinking... - Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seekingAndrea Cippitelli
Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr 1 5330, Bethesda, MD 20892 1108, USA
Psychopharmacology (Berl) 208:417-26. 2010..Here, we examined whether neuropeptide Y (NPY), an endogenous anti-stress mediator, blocks reinstatement of alcohol-seeking induced by the pharmacological stressor yohimbine... - The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxietyAndrea Cippitelli
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Alcohol 45:567-76. 2011.... - Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar ratsAndrea Cippitelli
Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr, 1 5330, Bethesda, MD 20892 1108, USA
Psychopharmacology (Berl) 211:367-75. 2010..Melanin-concentrating hormone (MCH) is involved in regulation of appetitive behaviors as well as emotional reactivity and reward, behavioral domains relevant to alcohol addiction... - Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activationAndrea Cippitelli
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 1108, USA
Biol Psychiatry 67:823-30. 2010..Here, we examined whether the group II metabotropic glutamate receptor agonist LY379268 prevents neuronal death and learning deficits in a rat model of binge-like exposure to alcohol... - Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429Jesse R Schank
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Building 10 CRC, Room 1 5330, Bethesda, MD 20892 1108, USA
Psychopharmacology (Berl) 218:111-9. 2011..The role of the NK1 system for relapse-like behavior has not previously been examined... - Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in miceAnnika Thorsell
The Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, 10 CRC 1 5330, Bethesda, MD 20892 1108, USA
Psychopharmacology (Berl) 209:103-11. 2010..It remains unknown whether this reflects developmental effects or direct regulation of alcohol consumption by NK1R:s, and whether the reduced consumption reflects motivational effects... - Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptorsKarl Björk
Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
Addict Biol 15:299-303. 2010..One of these is D2-dependent, while the other is not. These findings illustrate that pharmacology of ethanol reward is likely more complex than that for other addictive drugs... - Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the bluesMarkus Heilig
Laboratory of Clinical and Translational Studies, National Inst on Alcohol Abuse and Alcoholism, National Inst of Health, Bethesda, MD, United States
Neurosci Biobehav Rev 35:334-44. 2010.... - The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in miceRose Marie Karlsson
Laboratory of Clinical and Translational Studies, NIH, National Institute of Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 1 15330, Bethesda, MD 20892 1375, USA
Psychopharmacology (Berl) 195:547-57. 2008..Neuropeptide Y (NPY) is implicated in the pathophysiology of affective illness. Multiple receptor subtypes (Y1R, Y2R, and Y5R) have been suggested to contribute to NPY's effects on rodent anxiety and depression-related behaviors... - Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxietyAnnika Thorsell
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, 10 CRC 1E 5330, Bethesda, MD 20892 1108, USA
Exp Biol Med (Maywood) 235:1163-7. 2010..e. stressors, and their differential adaptations during transition from an acute to a chronic stress exposure state... - Neurokinin 1 receptor antagonism as a possible therapy for alcoholismDavid T George
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Science 319:1536-9. 2008..Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism... - D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse modelMette Skinbjerg
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
Neuroimage 50:1402-7. 2010..In addition, this study demonstrates the utility of small animal PET to study receptor trafficking in vivo in genetically modified mice... - Brain neuropeptide Y (NPY) in stress and alcohol dependenceMarkus Heilig
Neurotec, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
Rev Neurosci 13:85-94. 2002..Recent data additionally point to a role of NPY in the regulation of alcohol intake, and alcohol dependence emerges as a novel potential indication for compounds targeting the NPY system... - Long-term neurobehavioral effects of alcohol or nicotine exposure in adolescent animal modelsCraig J Slawecki
The Scripps Research Institute, Department of Neuropharmacology, CVN14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Ann N Y Acad Sci 1021:448-52. 2004..These findings support the hypothesis that adolescents are uniquely susceptible to the effects of chronic alcohol and nicotine exposure... - Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependenceRoberto Rimondini
Neurotec, Karolinska Institutet, M57, Huddinge University Hospital, SE 14186 Huddinge, Sweden
Neurosci Lett 375:129-33. 2005..This may render the NPY system, and Y2 receptors in particular, an attractive target for treatment of alcohol dependence... - Effects of neuropeptide Y on appetitive and consummatory behaviors associated with alcohol drinking in wistar rats with a history of ethanol exposureAnnika Thorsell
The Scripps Research Institute, Department of Neuropharmacology, La Jolla, California 92037, USA
Alcohol Clin Exp Res 29:584-90. 2005..Furthermore, NPY has a greater impact on the consummatory factors mediating ethanol intake than appetitive factors mediating ethanol seeking... - Effects of neuropeptide Y and corticotropin-releasing factor on ethanol intake in Wistar rats: interaction with chronic ethanol exposureAnnika Thorsell
The Scripps Research Institute, Department of Neuropharmacology, Mail Drop CVN-14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Behav Brain Res 161:133-40. 2005..Furthermore, the results presented here suggest that a balance between the stress-related peptides NPY and CRF may be involved in the regulation of ethanol intake... - Antagonism of neuropeptide YY1 receptors does not inhibit ethanol's effects on cortical EEG and ERPs in Wistar ratsCraig J Slawecki
The Scripps Research Institute, Department of Neuropharmacology, CFN 14, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Stud Alcohol 66:559-66. 2005..In the present study, the NPY Y1 receptor antagonist BIBP3226 was administered alone or in combination with a moderate dose of ethanol to determine whether it interacted with the neurobehavioral effects of ethanol... - The effects of social isolation on neuropeptide Y levels, exploratory and anxiety-related behaviors in ratsAnnika Thorsell
The Scripps Research Institute, Department of Neuropharmacology (CVN-14, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA
Pharmacol Biochem Behav 83:28-34. 2006.... - 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholismDonald R Gehlert
Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Neurosci 27:2718-26. 2007..Based on these findings, MTIP is a promising candidate for treatment of alcohol dependence... - Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar ratsAnnika Thorsell
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road SP30 2400, La Jolla, CA 92037, USA
Brain 130:1330-7. 2007..Repeated withdrawal in combination with a history of alcohol consumption significantly elevated alcohol intake, and the amygdala may mediate the transition to high-drinking states in this model... - Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking testChristian Möller
Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
Prog Neuropsychopharmacol Biol Psychiatry 26:119-22. 2002..GLP-1 may participate in the control of fear-induced suppression of behavior, probably via action in the amygdala... - Effect of social isolation on ethanol consumption and substance P/neurokinin expression in Wistar ratsAnnika Thorsell
The Scripps Research Institute, Department of Neuropharmacology (CVN-14, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
Alcohol 36:91-7. 2005..These data indicate that endogenous SP and neurokinin levels are reduced by isolation housing, but this was not associated with alterations in drinking levels using a two-bottle choice procedure... - Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphismMarkus Heilig
Karolinska Institutet, Neurotec Department, Division of Psychiatry, Huddinge University Hospital, M57, SE 141 86, Stockholm, Sweden
J Psychiatr Res 38:113-21. 2004..Our present findings are in line with an extensive animal literature, and further support the notion that impaired NPY function could contribute to depressive illness...