D B Thompson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Human primary myoblast cell cultures from non-diabetic insulin resistant subjects retain defects in insulin action
    D B Thompson
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Invest 98:2346-50. 1996
  2. ncbi request reprint A physical map at 1p31 encompassing the acute insulin response locus and the leptin receptor
    D B Thompson
    Clinical Diabetes and Nutrition Section, National Institute Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Genomics 39:227-30. 1997
  3. ncbi request reprint Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians
    D B Thompson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, AZ 85016, USA
    Hum Mol Genet 6:675-9. 1997
  4. pmc An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians
    R E Pratley
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Invest 101:1757-64. 1998
  5. ncbi request reprint Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians
    R A Norman
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016 5319, USA
    Diabetes 45:1229-32. 1996
  6. pmc Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11q21-q22. Pima Diabetes Gene Group
    R A Norman
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016 5319, USA
    Am J Hum Genet 60:166-73. 1997
  7. pmc An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
    R L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Am J Hum Genet 63:1130-8. 1998
  8. ncbi request reprint The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Int J Obes Relat Metab Disord 26:1629-32. 2002
  9. pmc Identification of Mutator insertional mutants of starch-branching enzyme 2a in corn
    S L Blauth
    The Biotechnology Institute, Pennsylvania State University, University Park, Pennsylvania 16802
    Plant Physiol 125:1396-405. 2001

Detail Information

Publications9

  1. pmc Human primary myoblast cell cultures from non-diabetic insulin resistant subjects retain defects in insulin action
    D B Thompson
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Invest 98:2346-50. 1996
    ..The retention of insulin resistance in myoblast derived cell cultures is consistent with the expression of an underlying biochemical defect in insulin resistant skeletal muscle...
  2. ncbi request reprint A physical map at 1p31 encompassing the acute insulin response locus and the leptin receptor
    D B Thompson
    Clinical Diabetes and Nutrition Section, National Institute Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Genomics 39:227-30. 1997
    ..In addition, we have used this contig to construct a physical map encompassing approximately 9 Mb of DNA in this region...
  3. ncbi request reprint Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians
    D B Thompson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, AZ 85016, USA
    Hum Mol Genet 6:675-9. 1997
    ..Nucleotides at three noncoding polymorphic sites were found exclusively in obese Pima Indians. This demonstrates an association between variation at the leptin receptor gene and obesity in humans...
  4. pmc An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians
    R E Pratley
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Invest 101:1757-64. 1998
    ..None of the linkages exceeded a LOD score of 3.6 (a 5% probability of occurring in a genome-wide scan). These findings must, therefore, be considered tentative until extended in this population or replicated in others...
  5. ncbi request reprint Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians
    R A Norman
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016 5319, USA
    Diabetes 45:1229-32. 1996
    ..No significant linkages were found in an analysis of all sibships or in an analysis restricted to discordant sib pairs...
  6. pmc Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11q21-q22. Pima Diabetes Gene Group
    R A Norman
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016 5319, USA
    Am J Hum Genet 60:166-73. 1997
    ..Evidence for linkage at 3p24.2-p22 did not change. No association was detected for any marker in the region. Although several genes are known in the 11q21-q22 region, none have been implicated as candidate genes for obesity...
  7. pmc An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
    R L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Am J Hum Genet 63:1130-8. 1998
    ..Sib-pair analyses suggest additional potential diabetes-susceptibility loci on chromosomes 1q and 7q...
  8. ncbi request reprint The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Int J Obes Relat Metab Disord 26:1629-32. 2002
    ..These findings are consistent with a role of the Gln223Arg polymorphism in reducing peripheral and central leptin binding to the LEPR in humans. However, these effects do not seem to have a major impact on adiposity in this population...
  9. pmc Identification of Mutator insertional mutants of starch-branching enzyme 2a in corn
    S L Blauth
    The Biotechnology Institute, Pennsylvania State University, University Park, Pennsylvania 16802
    Plant Physiol 125:1396-405. 2001
    ..This correlation suggests a specific role for SBEIIa in leaves, which may be necessary for normal plant development...