J T Thomas

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1
    J T Thomas
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 17:58-64. 1997
  2. ncbi request reprint A human chondrodysplasia due to a mutation in a TGF-beta superfamily member
    J T Thomas
    Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 12:315-7. 1996
  3. pmc Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation
    N Tsumaki
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 144:161-73. 1999
  4. ncbi request reprint Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development
    S C Chang
    Bone Research Branch, NIDR, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:28227-34. 1994
  5. pmc Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the alpha 1(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid
    G A Wallis
    School of Biological Sciences, University of Manchester, UK
    Am J Hum Genet 54:169-78. 1994
  6. ncbi request reprint Assignment of a new TGF-beta superfamily member, human cartilage-derived morphogenetic protein-1, to chromosome 20q11.2
    K Lin
    Bone Research Branch, National Institute of Dental Research
    Genomics 34:150-1. 1996
  7. ncbi request reprint Mutations in CDMP1 cause autosomal dominant brachydactyly type C
    A Polinkovsky
    Nat Genet 17:18-9. 1997

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1
    J T Thomas
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 17:58-64. 1997
    ..The mutation and its proposed mechanism of action provide the first human genetic indication that composite expression patterns of different BMPs dictate limb and digit morphogenesis...
  2. ncbi request reprint A human chondrodysplasia due to a mutation in a TGF-beta superfamily member
    J T Thomas
    Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 12:315-7. 1996
    ..The resulting phenotype provides direct evidence for the involvement of CDMP-1 in human skeletal development and represents the first human disorder attributable to a mutation in a TGF-beta superfamily member...
  3. pmc Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation
    N Tsumaki
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 144:161-73. 1999
    ..These results indicate that CDMP-1 antagonizes the ventralization signals from the notochord. Our study suggests a molecular mechanism by which CDMP-1 regulates the formation, growth, and differentiation of the skeletal elements...
  4. ncbi request reprint Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development
    S C Chang
    Bone Research Branch, NIDR, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:28227-34. 1994
    ....
  5. pmc Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the alpha 1(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid
    G A Wallis
    School of Biological Sciences, University of Manchester, UK
    Am J Hum Genet 54:169-78. 1994
    ....
  6. ncbi request reprint Assignment of a new TGF-beta superfamily member, human cartilage-derived morphogenetic protein-1, to chromosome 20q11.2
    K Lin
    Bone Research Branch, National Institute of Dental Research
    Genomics 34:150-1. 1996
  7. ncbi request reprint Mutations in CDMP1 cause autosomal dominant brachydactyly type C
    A Polinkovsky
    Nat Genet 17:18-9. 1997