J T Thomas

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1
    J T Thomas
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 17:58-64. 1997
  2. ncbi A human chondrodysplasia due to a mutation in a TGF-beta superfamily member
    J T Thomas
    Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 12:315-7. 1996
  3. ncbi Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation
    N Tsumaki
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 144:161-73. 1999
  4. ncbi Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development
    S C Chang
    Bone Research Branch, NIDR, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:28227-34. 1994
  5. ncbi Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the alpha 1(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid
    G A Wallis
    School of Biological Sciences, University of Manchester, UK
    Am J Hum Genet 54:169-78. 1994
  6. ncbi Assignment of a new TGF-beta superfamily member, human cartilage-derived morphogenetic protein-1, to chromosome 20q11.2
    K Lin
    Bone Research Branch, National Institute of Dental Research
    Genomics 34:150-1. 1996
  7. ncbi Mutations in CDMP1 cause autosomal dominant brachydactyly type C
    A Polinkovsky
    Nat Genet 17:18-9. 1997

Collaborators

Detail Information

Publications7

  1. ncbi Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1
    J T Thomas
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 17:58-64. 1997
    ..The mutation and its proposed mechanism of action provide the first human genetic indication that composite expression patterns of different BMPs dictate limb and digit morphogenesis...
  2. ncbi A human chondrodysplasia due to a mutation in a TGF-beta superfamily member
    J T Thomas
    Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 12:315-7. 1996
    ..The resulting phenotype provides direct evidence for the involvement of CDMP-1 in human skeletal development and represents the first human disorder attributable to a mutation in a TGF-beta superfamily member...
  3. ncbi Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation
    N Tsumaki
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 144:161-73. 1999
    ..These results indicate that CDMP-1 antagonizes the ventralization signals from the notochord. Our study suggests a molecular mechanism by which CDMP-1 regulates the formation, growth, and differentiation of the skeletal elements...
  4. ncbi Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development
    S C Chang
    Bone Research Branch, NIDR, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:28227-34. 1994
    ....
  5. ncbi Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the alpha 1(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid
    G A Wallis
    School of Biological Sciences, University of Manchester, UK
    Am J Hum Genet 54:169-78. 1994
    ....
  6. ncbi Assignment of a new TGF-beta superfamily member, human cartilage-derived morphogenetic protein-1, to chromosome 20q11.2
    K Lin
    Bone Research Branch, National Institute of Dental Research
    Genomics 34:150-1. 1996
  7. ncbi Mutations in CDMP1 cause autosomal dominant brachydactyly type C
    A Polinkovsky
    Nat Genet 17:18-9. 1997