W H Theodore

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Brain stimulation for epilepsy
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA
    Nat Clin Pract Neurol 1:64-5. 2005
  2. pmc The postictal state: effects of age and underlying brain dysfunction
    William H Theodore
    Clinical Epilepsy Section, National Institutes of Health, Bethesda, MD 20892, USA
    Epilepsy Behav 19:118-20. 2010
  3. ncbi request reprint Reduced hippocampal 5HT1A PET receptor binding and depression in temporal lobe epilepsy
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Diseases and Stroke NIH, Bethesda, MD 20892, USA
    Epilepsia 48:1526-30. 2007
  4. ncbi request reprint Prognosis of children with partial epilepsy: MRI and serial 18FDG-PET
    W D Gaillard
    Clinical Epilepsy Section, NINDS, Division of Intramural Research, Washington, DC, USA
    Neurology 68:655-9. 2007
  5. ncbi request reprint If not pharmacology, maybe physics
    Ronald P Lesser
    Neurology 66:1468-9. 2006
  6. doi request reprint PET of serotonin 1A receptors and cerebral glucose metabolism for temporal lobectomy
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 53:1375-82. 2012
  7. pmc Serotonin 1A receptors, depression, and memory in temporal lobe epilepsy
    William H Theodore
    Clinical Epilepsy Section, NINDS NIH, Bethesda, Maryland 20892, USA
    Epilepsia 53:129-33. 2012
  8. ncbi request reprint Total cerebral volume is reduced in patients with localization-related epilepsy and a history of complex febrile seizures
    William H Theodore
    Clinical Epilepsy Section, National Institutes of Health, Bldg 10, Room 5N 250, Bethesda, MD 20892, USA
    Arch Neurol 60:250-2. 2003
  9. ncbi request reprint Brain stimulation for epilepsy
    W H Theodore
    Clinical Epilepsy Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Acta Neurochir Suppl 97:261-72. 2007
  10. ncbi request reprint Brain stimulation for epilepsy
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 3:111-8. 2004

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Brain stimulation for epilepsy
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA
    Nat Clin Pract Neurol 1:64-5. 2005
  2. pmc The postictal state: effects of age and underlying brain dysfunction
    William H Theodore
    Clinical Epilepsy Section, National Institutes of Health, Bethesda, MD 20892, USA
    Epilepsy Behav 19:118-20. 2010
    ..Much additional information could be derived from the vast amount of video/EEG monitoring data available...
  3. ncbi request reprint Reduced hippocampal 5HT1A PET receptor binding and depression in temporal lobe epilepsy
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Diseases and Stroke NIH, Bethesda, MD 20892, USA
    Epilepsia 48:1526-30. 2007
    ..Depression is common in people with epilepsy, and reduced 5HT1A binding has been reported in patients with primary depressive disorders...
  4. ncbi request reprint Prognosis of children with partial epilepsy: MRI and serial 18FDG-PET
    W D Gaillard
    Clinical Epilepsy Section, NINDS, Division of Intramural Research, Washington, DC, USA
    Neurology 68:655-9. 2007
    ..To study the evolution of cerebral glucose metabolism after partial seizure onset in children, and its relation to clinical variables...
  5. ncbi request reprint If not pharmacology, maybe physics
    Ronald P Lesser
    Neurology 66:1468-9. 2006
  6. doi request reprint PET of serotonin 1A receptors and cerebral glucose metabolism for temporal lobectomy
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 53:1375-82. 2012
    ..The objective of this study was to compare 5-hydroxytryptamine receptor 1A (5-HT(1A)) PET with cerebral metabolic rate of glucose (CMRglc) PET for temporal lobectomy planning...
  7. pmc Serotonin 1A receptors, depression, and memory in temporal lobe epilepsy
    William H Theodore
    Clinical Epilepsy Section, NINDS NIH, Bethesda, Maryland 20892, USA
    Epilepsia 53:129-33. 2012
    ....
  8. ncbi request reprint Total cerebral volume is reduced in patients with localization-related epilepsy and a history of complex febrile seizures
    William H Theodore
    Clinical Epilepsy Section, National Institutes of Health, Bldg 10, Room 5N 250, Bethesda, MD 20892, USA
    Arch Neurol 60:250-2. 2003
    ..Febrile seizures may lead to later epilepsy. They have been associated with hippocampal atrophy but their effect on total cerebral volume is unknown...
  9. ncbi request reprint Brain stimulation for epilepsy
    W H Theodore
    Clinical Epilepsy Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Acta Neurochir Suppl 97:261-72. 2007
    ..Furthermore, other important issues are reviewed such as the selection criteria of patients for brain stimulation and the potential role of brain stimulation in the treatment of depression in epileptic patients...
  10. ncbi request reprint Brain stimulation for epilepsy
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 3:111-8. 2004
    ..Future investigations are likely to study extrathalamic sites of stimulation, and effects of stimulation contingent upon detection of or prediction of EEG patterns of epileptiform activity...
  11. ncbi request reprint Epilepsy duration, febrile seizures, and cerebral glucose metabolism
    William H Theodore
    NIH, Clinical Epilepsy Section, Bethesda, Maryland 20892, USA
    Epilepsia 45:276-9. 2004
    ..It is uncertain whether these factors have the same influence on functional as on structural measures of the integrity of the epileptogenic zone...
  12. ncbi request reprint Epilepsy and depression: imaging potential common factors
    William H Theodore
    Clinical Epilepsy Section, NINDS NIH, Building 10 Room 5N 250, Bethesda, MD 20892, USA
    Clin EEG Neurosci 35:38-45. 2004
    ....
  13. pmc Human herpes virus 6B: a possible role in epilepsy?
    William H Theodore
    Clinical Epilepsy Section, NINDS, NIH, Bethesda, MD, USA
    Epilepsia 49:1828-37. 2008
    ....
  14. ncbi request reprint The effect of antiepileptic drugs on 5-HT-receptor binding measured by positron emission tomography
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Diseases and Strokes, Bethesda, Maryland, USA
    Epilepsia 47:499-503. 2006
    ..Antiepileptic drugs may act on the serotonergic system, as shown in animal models, and thus affect receptor-binding measurements...
  15. ncbi request reprint Epilepsy in North America: a report prepared under the auspices of the global campaign against epilepsy, the International Bureau for Epilepsy, the International League Against Epilepsy, and the World Health Organization
    William H Theodore
    National Institutes of Health, Bethesda, Maryland 20892, USA
    Epilepsia 47:1700-22. 2006
    ....
  16. ncbi request reprint Transcranial magnetic stimulation for the treatment of seizures: a controlled study
    W H Theodore
    Clinical Epilepsy, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neurology 59:560-2. 2002
    ..To perform a controlled trial of transcranial magnetic stimulation (TMS)...
  17. ncbi request reprint Neuroimaging and the progression of epilepsy
    William H Theodore
    Clinical Epilepsy Section, National Institutes of Health, Building 10, Room 5N 250, Bethesda, MD 20892, USA
    Prog Brain Res 135:305-13. 2002
    ....
  18. ncbi request reprint When is positron emission tomography really necessary in epilepsy diagnosis?
    William H Theodore
    Clinical Epilepsy Section, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Neurol 15:191-5. 2002
    ..Positron emission tomography will continue to be of value in investigations of the pathophysiology of seizure disorders...
  19. pmc 18F-FCWAY and 18F-FDG PET in MRI-negative temporal lobe epilepsy
    Clarissa J Liew
    Clinical Epilepsy Section, National Institutes of Health, Bethesda, Maryland 20892, USA
    Epilepsia 50:234-9. 2009
    ..18)FCWAY PET might be valuable for detecting epileptic foci, and distinguishing mesial from lateral temporal foci in MRI-negative patients with TLE...
  20. ncbi request reprint Hippocampal volume and glucose metabolism in temporal lobe epileptic foci
    W H Theodore
    Clinical Epilepsy Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bldg 10, Room 5N 250, Bethesda, MD 20892 1408, USA
    Epilepsia 42:130-2. 2001
    ..Reports conflict on the relation of glucose metabolism to hippocampal volume in temporal lobe foci. Previous studies usually have used side-side ratios rather than regional metabolic rates...
  21. pmc 5-HT 1A receptors are reduced in temporal lobe epilepsy after partial-volume correction
    Giampiero Giovacchini
    PET Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1408, USA
    J Nucl Med 46:1128-35. 2005
    ..Previous PET studies reported decreased 5-HT 1A binding ipsilateral to epileptic foci but did not correct for the partial-volume effect (PVE) due to structural atrophy...
  22. ncbi request reprint PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy
    M T Toczek
    Clinical Epilepsy Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD 20892 1408, USA
    Neurology 60:749-56. 2003
    ....
  23. ncbi request reprint The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome
    H Siegel
    Clinical Epilepsy Section, Epilepsy Research Branch, NINDS, NIH, Bethesda, MD 20892, USA
    Epilepsy Res 34:91-7. 1999
    ..FBM's therapeutic effect on drop attacks is due in part to increased VPA levels, although the combination may be synergistic for the effect on total seizure number...
  24. ncbi request reprint Cognitive deficits in children with gelastic seizures and hypothalamic hamartoma
    C M Frattali
    Speech Language Pathology Section, Rehabilitation Medicine Department, W G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1604, USA
    Neurology 57:43-6. 2001
    ..To characterize the cognitive deficits in children with gelastic seizures and hypothalamic hamartoma and investigate the relationship of seizure severity to cognitive abilities...
  25. pmc Arterial spin labeling demonstrates that focal amygdalar glutamatergic agonist infusion leads to rapid diffuse cerebral activation
    J P Munasinghe
    MRI Research Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Acta Neurol Scand 121:209-16. 2010
    ..To investigate acute effects of intra-amygdalar excitatory amino acid administration on blood flow, relaxation time and apparent diffusion coefficient in rat brain...
  26. doi request reprint Towards a non-invasive interictal application of hypothermia for treating seizures: a feasibility and pilot study
    A Bagic
    EEG Section, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, MD, USA
    Acta Neurol Scand 118:240-4. 2008
    ..To evaluate the feasibility and safety of head-neck cooling in conscious normal volunteers (10) and patients with medically refractory epilepsy (5) without causing shivering...
  27. ncbi request reprint fMRI language task panel improves determination of language dominance
    W D Gaillard
    Department of Neurology, Children s National Medical Center, George Washington University School of Medicine, 111 Michigan Ave NW, Washington, DC 20010, USA
    Neurology 63:1403-8. 2004
    ..fMRI language tasks reliably identify language areas in presurgical epilepsy patients, but activation using single paradigms may disagree with the intracarotid amobarbital test (IAT)...
  28. ncbi request reprint Language dominance in partial epilepsy patients identified with an fMRI reading task
    W D Gaillard
    Department of Neurosciences, Children s National Medical Center, George Washington University School of Medicine, Washington, DC, USA
    Neurology 59:256-65. 2002
    ..fMRI language tasks readily identify frontal language areas; temporal activation has been less consistent. No studies have compared clinical visual judgment to quantitative region of interest (ROI) analysis...
  29. ncbi request reprint Functional anatomy of cognitive development: fMRI of verbal fluency in children and adults
    W D Gaillard
    Department of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    Neurology 54:180-5. 2000
    ..To identify age-dependent activation patterns of verbal fluency with functional MRI (fMRI)...
  30. ncbi request reprint Low incidence of abnormal (18)FDG-PET in children with new-onset partial epilepsy: a prospective study
    W D Gaillard
    Department of Neurology, Children s National Medical Center, The George Washington University School of Medicine, Washington, DC 20010, USA
    Neurology 58:717-22. 2002
    ..Patients with refractory partial epilepsy often exhibit regional hypometabolism. It is unknown whether the metabolic abnormalities are present at seizure onset or develop over time...
  31. ncbi request reprint Gonadal mosaicism in severe Pallister-Hall syndrome
    David Ng
    Genetic Disease Research Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 4472, USA
    Am J Med Genet A 124:296-302. 2004
    ..Published 2003 Wiley-Liss, Inc...
  32. ncbi request reprint Cortical dysplasia and epilepsy: functional imaging using single photon emission computed tomography and positron emission tomography
    Maria T Toczek
    Clinical Epilepsy Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1408, USA
    Neurosurg Clin N Am 13:71-86, viii. 2002
    ..This article reviews the role of functional imaging in the presurgical evaluation of this patient population...
  33. pmc Usefulness of pulsed arterial spin labeling MR imaging in mesial temporal lobe epilepsy
    Young Min Lim
    Clinical Epilepsy Section, NINDS, NIH, Bethesda, MD 20892, USA
    Epilepsy Res 82:183-9. 2008
    ..ASL-derived CBF measurements were compared with those derived from H(2)(15)O positron emission tomography (PET)...
  34. ncbi request reprint Activation of language cortex with automatic speech tasks
    S Y Bookheimer
    Epilepsy Research Branch, NINDS, National Institutes of Health, Bethesda, MD, USA
    Neurology 55:1151-7. 2000
    ..To identify automatic speech tasks that reliably demonstrate increased regional cerebral blood flow (rCBF) in Broca's and Wernicke's areas of the cortex using PET...
  35. ncbi request reprint Prognosis 30 years after temporal lobectomy
    Kathy Kelley
    Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
    Neurology 64:1974-6. 2005
    ..After a mean 29.9-year follow-up, 24 were seizure free, and 10 had died. Early seizure recurrence and invasive EEG studies predicted worse long-term outcome...
  36. ncbi request reprint Recent advances and trends in epilepsy imaging: pathogenesis and pathophysiology
    William H Theodore
    Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Rev Neurol Dis 1:53-9. 2004
    ..These studies have limited clinical value but suggest potential epileptogenic mechanisms. Imaging evaluation in epilepsy should be performed in an orderly sequence, guided by clinical and electroencephalographic data...
  37. pmc Temporal lobe epilepsy, depression, and hippocampal volume
    Sadat Shamim
    EEG Section, NINDS, NIH, Bethesda, Maryland, USA
    Epilepsia 50:1067-71. 2009
    ..To evaluate the relationship between hippocampal volume loss, depression, and epilepsy...
  38. ncbi request reprint Hypothalamic hamartomas and seizures: distinct natural history of isolated and Pallister-Hall syndrome cases
    Eilis A Boudreau
    Clinical Epilepsy Section and EEG and Sleep Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 1408, USA
    Epilepsia 46:42-7. 2005
    ..However, some patients, particularly those with other findings associated with Pallister-Hall syndrome (PHS), have a more benign course...
  39. ncbi request reprint Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections
    D Donati
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
    Neurology 61:1405-11. 2003
    ..Although the role of HHV-6 in human CNS disease remains to be fully defined, a number of studies have suggested that the CNS can be a site for persistent HHV-6 infection...
  40. ncbi request reprint Benzodiazepine withdrawal delirium with catatonic features. Occurrence in patients with partial seizure disorders
    P Hauser
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892
    Arch Neurol 46:696-9. 1989
    ..High-dose benzodiazepine therapy and a history of viral encephalitis may be risk factors for withdrawal delirium...
  41. pmc Association of human herpesvirus-6B with mesial temporal lobe epilepsy
    Julie Fotheringham
    Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Med 4:e180. 2007
    ....
  42. pmc Temporal lobectomy: resection volume, neuropsychological effects, and seizure outcome
    Sadat Shamim
    Clinical Epilepsy Section, NINDS, NIH, Bethesda, MD, USA
    Epilepsy Behav 16:311-4. 2009
    ..The goal of the work described here was to evaluate relationships among resection volume, seizure outcome, and cognitive morbidity after temporal lobectomy for intractable epilepsy...
  43. ncbi request reprint Cortical excitability during prolonged antiepileptic drug treatment and drug withdrawal
    H W Lee
    Clinical Epilepsy Section, National Institutes of Neurological Disorders and Stroke, Bethesda, MD, USA
    Clin Neurophysiol 116:1105-12. 2005
    ..The objective of the study was to determine whether plasma blood levels during chronic administration at therapeutic doses would accurately predict changes in corticomotor excitability...
  44. pmc Isolated seizures in rats do not cause neuronal injury
    M T Acosta
    Department of Neurology, Children s National Medical Center, Washington, DC, USA
    Acta Neurol Scand 125:30-7. 2012
    ..Previous studies have shown that status epilepticus can lead to neuronal injury. However, the effect of a small number of isolated seizures is uncertain...
  45. doi request reprint Increase in tiagabine serum concentration with coadministration of gemfibrozil
    Aaron H Burstein
    Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Pharmacother 43:379-82. 2009
    ..To report a case of possible acute tiagabine toxicity secondary to administration of gemfibrozil...
  46. ncbi request reprint Future directions for epilepsy research
    M P Jacobs
    National Institute of Neurological Disorders and Stroke, NIH, Rockville, MD 20892, USA
    Neurology 57:1536-42. 2001
    ..Integrated approaches, such as coupling imaging with electrophysiology, are central to progress in localizing regions of epilepsy development in people at risk and better seizure prediction and treatment for people with epilepsy...
  47. ncbi request reprint Neuroimaging reveals automatic speech coding during perception of written word meaning
    Benjamin Xu
    Epilepsy Research Branch, Cognitive Neuroscience Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuroimage 17:859-70. 2002
    ..These results also raise questions about including multiple cognitive tasks in the same neuroimaging sessions...
  48. pmc 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, Zurich, Switzerland
    Biol Psychiatry 62:1258-64. 2007
    ..For the first time, 5-HT(1A) receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews...
  49. ncbi request reprint A Korean kindred with autosomal dominant nocturnal frontal lobe epilepsy and mental retardation
    Yong Won Cho
    Department of Neurology, Georgetown University Hospital, Washington, D C 20007, USA
    Arch Neurol 60:1625-32. 2003
    ..A Korean family had distinctive clinical and neuroimaging features and carried the same genetic mutation that was found in a previously described Japanese kindred with autosomal dominant nocturnal frontal lobe epilepsy...
  50. ncbi request reprint Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society
    Jacqueline A French
    Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:410-23. 2004
    ....
  51. ncbi request reprint Implications of neuroimaging for the treatment of epilepsy
    William H Theodore
    Ann Neurol 53:286-8. 2003
  52. ncbi request reprint Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society
    Jacqueline A French
    Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:401-9. 2004
    ..S. Food and Drug Administration] in the treatment of children and adults with newly diagnosed partial and generalized epilepsies...
  53. ncbi request reprint Cerebral blood flow in temporal lobe epilepsy: a partial volume correction study
    Giampiero Giovacchini
    University Milano Bicocca, Via Olgettina 60, Milan, Italy
    Eur J Nucl Med Mol Imaging 34:2066-72. 2007
    ..The magnitude of this effect on cerebral blood flow (CBF) is unexplored. The aim of this study was to assess CBF deficits in TLE before and after magnetic resonance imaging-based partial volume correction (PVC)...