Research Topics
Species | W H TheodoreSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
The postictal state: effects of age and underlying brain dysfunctionWilliam H Theodore
Clinical Epilepsy Section, National Institutes of Health, Bethesda, MD 20892, USA
Epilepsy Behav 19:118-20. 2010..Much additional information could be derived from the vast amount of video/EEG monitoring data available...
Reduced hippocampal 5HT1A PET receptor binding and depression in temporal lobe epilepsyWilliam H Theodore
Clinical Epilepsy Section, National Institute of Neurological Diseases and Stroke NIH, Bethesda, MD 20892, USA
Epilepsia 48:1526-30. 2007..Depression is common in people with epilepsy, and reduced 5HT1A binding has been reported in patients with primary depressive disorders...- Prognosis of children with partial epilepsy: MRI and serial 18FDG-PETW D Gaillard
Clinical Epilepsy Section, NINDS, Division of Intramural Research, Washington, DC, USA
Neurology 68:655-9. 2007..To study the evolution of cerebral glucose metabolism after partial seizure onset in children, and its relation to clinical variables... - Brain stimulation for epilepsyWilliam H Theodore
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA
Nat Clin Pract Neurol 1:64-5. 2005 - If not pharmacology, maybe physicsRonald P Lesser
Neurology 66:1468-9. 2006 
PET of serotonin 1A receptors and cerebral glucose metabolism for temporal lobectomyWilliam H Theodore
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Nucl Med 53:1375-82. 2012..The objective of this study was to compare 5-hydroxytryptamine receptor 1A (5-HT(1A)) PET with cerebral metabolic rate of glucose (CMRglc) PET for temporal lobectomy planning...- Serotonin 1A receptors, depression, and memory in temporal lobe epilepsyWilliam H Theodore
Clinical Epilepsy Section, NINDS NIH, Bethesda, Maryland 20892, USA
Epilepsia 53:129-33. 2012.... - Total cerebral volume is reduced in patients with localization-related epilepsy and a history of complex febrile seizuresWilliam H Theodore
Clinical Epilepsy Section, National Institutes of Health, Bldg 10, Room 5N 250, Bethesda, MD 20892, USA
Arch Neurol 60:250-2. 2003..Febrile seizures may lead to later epilepsy. They have been associated with hippocampal atrophy but their effect on total cerebral volume is unknown... - Brain stimulation for epilepsyW H Theodore
Clinical Epilepsy Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Acta Neurochir Suppl 97:261-72. 2007..Furthermore, other important issues are reviewed such as the selection criteria of patients for brain stimulation and the potential role of brain stimulation in the treatment of depression in epileptic patients... - Brain stimulation for epilepsyWilliam H Theodore
Clinical Epilepsy Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Lancet Neurol 3:111-8. 2004..Future investigations are likely to study extrathalamic sites of stimulation, and effects of stimulation contingent upon detection of or prediction of EEG patterns of epileptiform activity... - Epilepsy duration, febrile seizures, and cerebral glucose metabolismWilliam H Theodore
NIH, Clinical Epilepsy Section, Bethesda, Maryland 20892, USA
Epilepsia 45:276-9. 2004..It is uncertain whether these factors have the same influence on functional as on structural measures of the integrity of the epileptogenic zone... - Epilepsy and depression: imaging potential common factorsWilliam H Theodore
Clinical Epilepsy Section, NINDS NIH, Building 10 Room 5N 250, Bethesda, MD 20892, USA
Clin EEG Neurosci 35:38-45. 2004.... - Human herpes virus 6B: a possible role in epilepsy?William H Theodore
Clinical Epilepsy Section, NINDS, NIH, Bethesda, MD, USA
Epilepsia 49:1828-37. 2008.... - The effect of antiepileptic drugs on 5-HT-receptor binding measured by positron emission tomographyWilliam H Theodore
Clinical Epilepsy Section, National Institute of Neurological Diseases and Strokes, Bethesda, Maryland, USA
Epilepsia 47:499-503. 2006..Antiepileptic drugs may act on the serotonergic system, as shown in animal models, and thus affect receptor-binding measurements... - Epilepsy in North America: a report prepared under the auspices of the global campaign against epilepsy, the International Bureau for Epilepsy, the International League Against Epilepsy, and the World Health OrganizationWilliam H Theodore
National Institutes of Health, Bethesda, Maryland 20892, USA
Epilepsia 47:1700-22. 2006.... - Transcranial magnetic stimulation for the treatment of seizures: a controlled studyW H Theodore
Clinical Epilepsy, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Neurology 59:560-2. 2002..To perform a controlled trial of transcranial magnetic stimulation (TMS)... - Neuroimaging and the progression of epilepsyWilliam H Theodore
Clinical Epilepsy Section, National Institutes of Health, Building 10, Room 5N 250, Bethesda, MD 20892, USA
Prog Brain Res 135:305-13. 2002.... - When is positron emission tomography really necessary in epilepsy diagnosis?William H Theodore
Clinical Epilepsy Section, National Institutes of Health, Bethesda, Maryland 20892, USA
Curr Opin Neurol 15:191-5. 2002..Positron emission tomography will continue to be of value in investigations of the pathophysiology of seizure disorders... - 18F-FCWAY and 18F-FDG PET in MRI-negative temporal lobe epilepsyClarissa J Liew
Clinical Epilepsy Section, National Institutes of Health, Bethesda, Maryland 20892, USA
Epilepsia 50:234-9. 2009..18)FCWAY PET might be valuable for detecting epileptic foci, and distinguishing mesial from lateral temporal foci in MRI-negative patients with TLE... - Hippocampal volume and glucose metabolism in temporal lobe epileptic fociW H Theodore
Clinical Epilepsy Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bldg 10, Room 5N 250, Bethesda, MD 20892 1408, USA
Epilepsia 42:130-2. 2001..Reports conflict on the relation of glucose metabolism to hippocampal volume in temporal lobe foci. Previous studies usually have used side-side ratios rather than regional metabolic rates... - 5-HT 1A receptors are reduced in temporal lobe epilepsy after partial-volume correctionGiampiero Giovacchini
PET Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1408, USA
J Nucl Med 46:1128-35. 2005..Reduction of 5-HT 1A receptors in the ipsilateral hippocampus may contribute to depressive symptoms in TLE patients... - PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsyM T Toczek
Clinical Epilepsy Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD 20892-1408, USA
Neurology 60:749-56. 2003..Mean [18F]FCWAY V AI in IMT was greater than mean HV AI, but the difference was not significant. CONCLUSION: These findings support the hypothesis of reduced serotonin receptor binding in temporal lobe epileptic foci... - The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndromeH Siegel
Clinical Epilepsy Section, Epilepsy Research Branch, NINDS, NIH, Bethesda, MD 20892, USA
Epilepsy Res 34:91-7. 1999..FBM's therapeutic effect on drop attacks is due in part to increased VPA levels, although the combination may be synergistic for the effect on total seizure number... - Cognitive deficits in children with gelastic seizures and hypothalamic hamartomaC M Frattali
Speech Language Pathology Section, Rehabilitation Medicine Department, W G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1604, USA
Neurology 57:43-6. 2001..To characterize the cognitive deficits in children with gelastic seizures and hypothalamic hamartoma and investigate the relationship of seizure severity to cognitive abilities... - Arterial spin labeling demonstrates that focal amygdalar glutamatergic agonist infusion leads to rapid diffuse cerebral activationJ P Munasinghe
MRI Research Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Acta Neurol Scand 121:209-16. 2010..To investigate acute effects of intra-amygdalar excitatory amino acid administration on blood flow, relaxation time and apparent diffusion coefficient in rat brain... - Towards a non-invasive interictal application of hypothermia for treating seizures: a feasibility and pilot studyA Bagic
EEG Section, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, MD, USA
Acta Neurol Scand 118:240-4. 2008..To evaluate the feasibility and safety of head-neck cooling in conscious normal volunteers (10) and patients with medically refractory epilepsy (5) without causing shivering... - fMRI language task panel improves determination of language dominanceW D Gaillard
Department of Neurology, Children s National Medical Center, George Washington University School of Medicine, 111 Michigan Ave NW, Washington, DC 20010, USA
Neurology 63:1403-8. 2004..fMRI language tasks reliably identify language areas in presurgical epilepsy patients, but activation using single paradigms may disagree with the intracarotid amobarbital test (IAT)... - Language dominance in partial epilepsy patients identified with an fMRI reading taskW D Gaillard
Department of Neurosciences, Children s National Medical Center, George Washington University School of Medicine, Washington, DC, USA
Neurology 59:256-65. 2002..fMRI language tasks readily identify frontal language areas; temporal activation has been less consistent. No studies have compared clinical visual judgment to quantitative region of interest (ROI) analysis... - Functional anatomy of cognitive development: fMRI of verbal fluency in children and adultsW D Gaillard
Department of Neurology, Children s National Medical Center, Washington, DC 20010, USA
Neurology 54:180-5. 2000..To identify age-dependent activation patterns of verbal fluency with functional MRI (fMRI)... - Low incidence of abnormal (18)FDG-PET in children with new-onset partial epilepsy: a prospective studyW D Gaillard
Department of Neurology, Children s National Medical Center, The George Washington University School of Medicine, Washington, DC 20010, USA
Neurology 58:717-22. 2002..Patients with refractory partial epilepsy often exhibit regional hypometabolism. It is unknown whether the metabolic abnormalities are present at seizure onset or develop over time... - Gonadal mosaicism in severe Pallister-Hall syndromeDavid Ng
Genetic Disease Research Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 4472, USA
Am J Med Genet A 124:296-302. 2004..Published 2003 Wiley-Liss, Inc... - Cortical dysplasia and epilepsy: functional imaging using single photon emission computed tomography and positron emission tomographyMaria T Toczek
Clinical Epilepsy Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1408, USA
Neurosurg Clin N Am 13:71-86, viii. 2002..This article reviews the role of functional imaging in the presurgical evaluation of this patient population... - Usefulness of pulsed arterial spin labeling MR imaging in mesial temporal lobe epilepsyYoung Min Lim
Clinical Epilepsy Section, NINDS, NIH, Bethesda, MD 20892, USA
Epilepsy Res 82:183-9. 2008..ASL-derived CBF measurements were compared with those derived from H(2)(15)O positron emission tomography (PET)... - Activation of language cortex with automatic speech tasksS Y Bookheimer
Epilepsy Research Branch, NINDS, National Institutes of Health, Bethesda, MD, USA
Neurology 55:1151-7. 2000..To identify automatic speech tasks that reliably demonstrate increased regional cerebral blood flow (rCBF) in Broca's and Wernicke's areas of the cortex using PET... - Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resectionsD Donati
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
Neurology 61:1405-11. 2003..The amplification of HHV-6 from hippocampal and temporal lobe astrocytes of MTLE warrants further investigation into the possible role of HHV-6 in the development of MTLE... - Prognosis 30 years after temporal lobectomyKathy Kelley
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
Neurology 64:1974-6. 2005..After a mean 29.9-year follow-up, 24 were seizure free, and 10 had died. Early seizure recurrence and invasive EEG studies predicted worse long-term outcome... - Recent advances and trends in epilepsy imaging: pathogenesis and pathophysiologyWilliam H Theodore
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Rev Neurol Dis 1:53-9. 2004..These studies have limited clinical value but suggest potential epileptogenic mechanisms. Imaging evaluation in epilepsy should be performed in an orderly sequence, guided by clinical and electroencephalographic data... - Temporal lobe epilepsy, depression, and hippocampal volumeSadat Shamim
EEG Section, NINDS, NIH, Bethesda, Maryland, USA
Epilepsia 50:1067-71. 2009..To evaluate the relationship between hippocampal volume loss, depression, and epilepsy... - Hypothalamic hamartomas and seizures: distinct natural history of isolated and Pallister-Hall syndrome casesEilis A Boudreau
Clinical Epilepsy Section and EEG and Sleep Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892-1408, USA
Epilepsia 46:42-7. 2005..Patients with HH with or without seizures should be evaluated carefully for other clinical manifestations of PHS, particularly before surgery is considered... - Cortical excitability during prolonged antiepileptic drug treatment and drug withdrawalH W Lee
Clinical Epilepsy Section, National Institutes of Neurological Disorders and Stroke, Bethesda, MD, USA
Clin Neurophysiol 116:1105-12. 2005..SIGNIFICANCE: The transient decrease in r-MT associated with acute AED withdrawal could represent a physiological substrate contributing to AED withdrawal seizures... - Benzodiazepine withdrawal delirium with catatonic features. Occurrence in patients with partial seizure disordersP Hauser
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892
Arch Neurol 46:696-9. 1989..High-dose benzodiazepine therapy and a history of viral encephalitis may be risk factors for withdrawal delirium... - Association of human herpesvirus-6B with mesial temporal lobe epilepsyJulie Fotheringham
Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Med 4:e180. 2007.... - Temporal lobectomy: resection volume, neuropsychological effects, and seizure outcomeSadat Shamim
Clinical Epilepsy Section, NINDS, NIH, Bethesda, MD, USA
Epilepsy Behav 16:311-4. 2009..The goal of the work described here was to evaluate relationships among resection volume, seizure outcome, and cognitive morbidity after temporal lobectomy for intractable epilepsy... - Isolated seizures in rats do not cause neuronal injuryM T Acosta
Department of Neurology, Children s National Medical Center, Washington, DC, USA
Acta Neurol Scand 125:30-7. 2012..Previous studies have shown that status epilepticus can lead to neuronal injury. However, the effect of a small number of isolated seizures is uncertain... - Increase in tiagabine serum concentration with coadministration of gemfibrozilAaron H Burstein
Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA
Ann Pharmacother 43:379-82. 2009..To report a case of possible acute tiagabine toxicity secondary to administration of gemfibrozil... - Future directions for epilepsy researchM P Jacobs
National Institute of Neurological Disorders and Stroke, NIH, Rockville, MD 20892, USA
Neurology 57:1536-42. 2001..Integrated approaches, such as coupling imaging with electrophysiology, are central to progress in localizing regions of epilepsy development in people at risk and better seizure prediction and treatment for people with epilepsy... - Neuroimaging reveals automatic speech coding during perception of written word meaningBenjamin Xu
Epilepsy Research Branch, Cognitive Neuroscience Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
Neuroimage 17:859-70. 2002..These results also raise questions about including multiple cognitive tasks in the same neuroimaging sessions... - 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depressionGregor Hasler
Department of Psychiatry, University Hospital, Culmannstrasse 8, Zurich, Switzerland
Biol Psychiatry 62:1258-64. 2007..For the first time, 5-HT(1A) receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews... - A Korean kindred with autosomal dominant nocturnal frontal lobe epilepsy and mental retardationYong Won Cho
Department of Neurology, Georgetown University Hospital, Washington, D C 20007, USA
Arch Neurol 60:1625-32. 2003..A Korean family had distinctive clinical and neuroimaging features and carried the same genetic mutation that was found in a previously described Japanese kindred with autosomal dominant nocturnal frontal lobe epilepsy... - Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:410-23. 2004.... - Implications of neuroimaging for the treatment of epilepsyWilliam H Theodore
Ann Neurol 53:286-8. 2003 - Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:401-9. 2004..S. Food and Drug Administration] in the treatment of children and adults with newly diagnosed partial and generalized epilepsies... - Cerebral blood flow in temporal lobe epilepsy: a partial volume correction studyGiampiero Giovacchini
University Milano Bicocca, Via Olgettina 60, Milan, Italy
Eur J Nucl Med Mol Imaging 34:2066-72. 2007..The magnitude of this effect on cerebral blood flow (CBF) is unexplored. The aim of this study was to assess CBF deficits in TLE before and after magnetic resonance imaging-based partial volume correction (PVC)...