Christina T Teng

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals
    Christina T Teng
    DNTP, Biomolecular Screening Branch, Division, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States Electronic address
    Biochem Biophys Res Commun 444:177-81. 2014
  2. pmc Bisphenol A affects androgen receptor function via multiple mechanisms
    Christina Teng
    DNTP Biomolecular Screening Branch, National Institute of Environmental Health Sciences, National Institutes of Health NIH, Research Triangle Park, NC, USA
    Chem Biol Interact 203:556-64. 2013
  3. pmc Fasting induces the expression of PGC-1α and ERR isoforms in the outer stripe of the outer medulla (OSOM) of the mouse kidney
    Christina T Teng
    Biomolecular Screening Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e26961. 2011
  4. doi request reprint Lactoferrin: the path from protein to gene
    Christina T Teng
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD K202, PO Box 12233, Research Triangle Park, NC 27709, USA
    Biometals 23:359-64. 2010
  5. ncbi request reprint Single nucleotide polymorphisms (SNPs) in human lactoferrin gene
    Christina T Teng
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander, PO Box 12233, NC 27709, USA
    Biochem Cell Biol 84:381-4. 2006
  6. ncbi request reprint Factors regulating lactoferrin gene expression
    Christina T Teng
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
    Biochem Cell Biol 84:263-7. 2006
  7. pmc Interplay between estrogen-related receptor alpha (ERRalpha) and gamma (ERRgamma) on the regulation of ERRalpha gene expression
    Zhiping Zhang
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD E2 01, Research Triangle Park, NC 27709, USA
    Mol Cell Endocrinol 264:128-41. 2007
  8. ncbi request reprint Estrogen stimulates estrogen-related receptor alpha gene expression through conserved hormone response elements
    Dianxin Liu
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 144:4894-904. 2003
  9. pmc Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1
    Yin Li
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 24:969-80. 2010
  10. doi request reprint PGC-1alpha induces dynamic protein interactions on the ERRalpha gene multi-hormone response element nucleosome in kidney cells
    Liangli Wang
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem J 416:407-19. 2008

Collaborators

Detail Information

Publications20

  1. doi request reprint Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals
    Christina T Teng
    DNTP, Biomolecular Screening Branch, Division, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States Electronic address
    Biochem Biophys Res Commun 444:177-81. 2014
    ..These cell lines will be useful for identifying environmental chemicals that modulate this important pathway. ..
  2. pmc Bisphenol A affects androgen receptor function via multiple mechanisms
    Christina Teng
    DNTP Biomolecular Screening Branch, National Institute of Environmental Health Sciences, National Institutes of Health NIH, Research Triangle Park, NC, USA
    Chem Biol Interact 203:556-64. 2013
    ..Although BPA was able to bind AR, the nuclear translocation was reduced. Furthermore, BPA was unable to induce functional foci in the nuclei and is consistent with the transient transfection study that BPA is unable to activate AR...
  3. pmc Fasting induces the expression of PGC-1α and ERR isoforms in the outer stripe of the outer medulla (OSOM) of the mouse kidney
    Christina T Teng
    Biomolecular Screening Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e26961. 2011
    ..However, the effect of fasting on the expression of endogenous PGC-1α, ERRα and ERRγ in the kidney is not known...
  4. doi request reprint Lactoferrin: the path from protein to gene
    Christina T Teng
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD K202, PO Box 12233, Research Triangle Park, NC 27709, USA
    Biometals 23:359-64. 2010
    ..Additionally, study was further extended to investigating the human lactoferrin protein and gene. Lastly the expression of lactoferrin in various tissues of both human and rodent under various physiological conditions were examined...
  5. ncbi request reprint Single nucleotide polymorphisms (SNPs) in human lactoferrin gene
    Christina T Teng
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander, PO Box 12233, NC 27709, USA
    Biochem Cell Biol 84:381-4. 2006
    ..The data will serve as a basis from which study the association of lactoferrin polymorphism and disease...
  6. ncbi request reprint Factors regulating lactoferrin gene expression
    Christina T Teng
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
    Biochem Cell Biol 84:263-7. 2006
    ..This review will outline novel information relating to general gene regulation and will discuss the current understanding of the regulation of lactoferrin gene expression by nuclear receptors and transcription factors...
  7. pmc Interplay between estrogen-related receptor alpha (ERRalpha) and gamma (ERRgamma) on the regulation of ERRalpha gene expression
    Zhiping Zhang
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD E2 01, Research Triangle Park, NC 27709, USA
    Mol Cell Endocrinol 264:128-41. 2007
    ..These data suggested that ERRalpha and ERRgamma regulate ERRalpha gene expression with different molecular mechanisms...
  8. ncbi request reprint Estrogen stimulates estrogen-related receptor alpha gene expression through conserved hormone response elements
    Dianxin Liu
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 144:4894-904. 2003
    ..Estrogen treatment further enhanced the association of ER alpha and MHREs in vivo. The present study demonstrated that the ERR alpha gene is a downstream target of ER alpha...
  9. pmc Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1
    Yin Li
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 24:969-80. 2010
    ..These findings provide insight into the molecular mechanisms of GPER-1/ERRalpha-mediated signaling and may be relevant to what happens in breast cancer cells escaping inhibitory control by TAM...
  10. doi request reprint PGC-1alpha induces dynamic protein interactions on the ERRalpha gene multi-hormone response element nucleosome in kidney cells
    Liangli Wang
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem J 416:407-19. 2008
    ..By using the siRNA (small interfering RNA) knockdown approach, we discovered that ERRgamma was involved in the initial phase, but not in the later phase, of PGC-1alpha-induced ERRalpha expression...
  11. ncbi request reprint Differential expression and estrogen response of lactoferrin gene in the female reproductive tract of mouse, rat, and hamster
    Christina T Teng
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 67:1439-49. 2002
    ..The present study demonstrates differential expression and estrogen responsiveness of the lactoferrin gene in different regions of the female rodent reproductive tract and variation among the rodent species studied...
  12. ncbi request reprint An intronic alternative promoter of the human lactoferrin gene is activated by Ets
    Dianxin Liu
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD E2 01, Research Triangle Park, NC 27709, USA
    Biochem Biophys Res Commun 301:472-9. 2003
    ..The GFP-tagged lactoferrin is present in the cytoplasm whereas GFP-tagged Delta LF is found in both nucleus and cytoplasm as examined by fluorescence and confocal microscopy...
  13. ncbi request reprint Estrogen-related receptors-stimulated monoamine oxidase B promoter activity is down-regulated by estrogen receptors
    Zhiping Zhang
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 20:1547-61. 2006
    ..These studies provide new insight into the relationship between ERalpha, ERbeta, ERRalpha, and ERRgamma in modulation of MAO-B gene activity...
  14. ncbi request reprint Lactoferrin gene expression and regulation: an overview
    Christina T Teng
    Laboratory of Reproductive and Developmental Toxicology, Gene Regulation Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem Cell Biol 80:7-16. 2002
    ..This article provides an overview on lactoferrin expression and regulation in different species...
  15. pmc Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes
    Yin Li
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, Division of Intramural Research, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 121:459-66, 466e1-6. 2013
    ..However, the diversity of EDC effects and mechanisms of action are poorly understood.Objectives: We examined the agonistic activity of EDCs through ERα and ERβ. We also investigated the effects of EDCs on ER-mediated target genes...
  16. ncbi request reprint Methoxychlor stimulates the mouse lactoferrin gene promoter through a GC-rich element
    Zhiping Zhang
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem Cell Biol 80:23-6. 2002
    ..Whether the effect of methoxychlor requires the AP1/CREB binding element has yet to be established; however, the present finding provides an alternative signaling pathway for the xenoestrogens...
  17. ncbi request reprint Lactoferrin gene expression is estrogen responsive in human and rhesus monkey endometrium
    Christina T Teng
    Gene Regulation Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Hum Reprod 8:58-67. 2002
    ..In conclusion, this study has shown that lactoferrin gene expression is responsive to estrogen in primate endometrium...
  18. pmc Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function
    Zhiping Zhang
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 31:2196-208. 2003
    ..Furthermore, using the GST pull-down approach, we showed that phosphorylation of KLF5 enhances its interaction with CBP. The results of the present study provide a mechanism for KLF5 transactivation function...
  19. ncbi request reprint Detection of exon polymorphisms in the human lactoferrin gene
    Li Herng Eric Liu
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park, NC 27709, USA
    Biochem Cell Biol 80:17-22. 2002
    ..Nonetheless, the present analysis suggests that genetic polymorphisms of the lactoferrin gene exist in selected exons and additional mutations of the lactoferrin gene do occur in the cancer cells...
  20. ncbi request reprint Full length and delta lactoferrin display differential cell localization dynamics, but do not act as tumor markers or significantly affect the expression of other genes
    Gary S Goldberg
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Med Chem 1:57-64. 2005
    ..Moreover, both forms of lactoferrin failed to substantially modulate the expression of other genes. Thus, lactoferrin does not seem to directly control gene expression or inhibit tumor cell growth...