J A Taylor

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Epigenome-wide association study of breast cancer using prospectively collected sister study samples
    Zongli Xu
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 105:694-700. 2013
  2. ncbi request reprint How well do HapMap haplotypes identify common haplotypes of genes? A comparison with haplotypes of 334 genes resequenced in the environmental genome project
    Jack A Taylor
    National Institute of Environmental Health Science, MD A3 05, 111 Alexander Drive, P O Box 12233, Research Triangle Park, NC 27709, USA
    Cancer Epidemiol Biomarkers Prev 15:133-7. 2006
  3. ncbi request reprint The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction
    J A Taylor
    Epidemiology Branch, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 58:3603-10. 1998
  4. ncbi request reprint XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk
    Mariana C Stern
    Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis and the National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, 27709, USA
    Cancer Epidemiol Biomarkers Prev 11:1004-11. 2002
  5. ncbi request reprint CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1
    T R Devereux
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 31:68-73. 2001
  6. ncbi request reprint p53 mutations in bladder cancer: evidence for exogenous versus endogenous risk factors
    Jane C Schroeder
    Epidemiology Branch, National Institute of Environmental Health Sciences NIH, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 63:7530-8. 2003
  7. ncbi request reprint Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans
    D A Bell
    Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Carcinogenesis 14:1689-92. 1993
  8. ncbi request reprint Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement
    R J Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 58:5333-6. 1998
  9. ncbi request reprint Lead exposure as a risk factor for amyotrophic lateral sclerosis
    F Kamel
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Neurodegener Dis 2:195-201. 2005
  10. ncbi request reprint DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk
    M C Stern
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, 27709, USA
    Cancer Epidemiol Biomarkers Prev 10:125-31. 2001

Detail Information

Publications46

  1. pmc Epigenome-wide association study of breast cancer using prospectively collected sister study samples
    Zongli Xu
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 105:694-700. 2013
    ..Previous studies have suggested DNA methylation in blood is a potential epigenetic marker of cancer risk, but this has not been evaluated on a genome-wide scale in prospective studies for breast cancer...
  2. ncbi request reprint How well do HapMap haplotypes identify common haplotypes of genes? A comparison with haplotypes of 334 genes resequenced in the environmental genome project
    Jack A Taylor
    National Institute of Environmental Health Science, MD A3 05, 111 Alexander Drive, P O Box 12233, Research Triangle Park, NC 27709, USA
    Cancer Epidemiol Biomarkers Prev 15:133-7. 2006
    ..This inability to distinguish common haplotypes of genes may result in loss of power when examining haplotype-disease association...
  3. ncbi request reprint The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction
    J A Taylor
    Epidemiology Branch, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 58:3603-10. 1998
    ..Bladder cancer risk from smoking exposure is particularly high in those who inherit NAT2 slow alleles in combination with one or two copies of the NAT1*10 allele. A biological mechanism for this finding is suggested...
  4. ncbi request reprint XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk
    Mariana C Stern
    Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis and the National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, 27709, USA
    Cancer Epidemiol Biomarkers Prev 11:1004-11. 2002
    ..52). We found little evidence for a gene-gene-exposure, three-way interaction among the XPD codon 751 genotype, smoking, and the NAT1/NAT2 genotype...
  5. ncbi request reprint CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1
    T R Devereux
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 31:68-73. 2001
    ..Published 2001 Wiley-Liss, Inc...
  6. ncbi request reprint p53 mutations in bladder cancer: evidence for exogenous versus endogenous risk factors
    Jane C Schroeder
    Epidemiology Branch, National Institute of Environmental Health Sciences NIH, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 63:7530-8. 2003
    ..Estimates for p53 subtypes were imprecise but support in vitro evidence that some CpG G:C-A:T transitions may be caused by smoking and other environmental mutagens...
  7. ncbi request reprint Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans
    D A Bell
    Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Carcinogenesis 14:1689-92. 1993
    ..00) and in 128 African-Americans (WT = 0.36, M1 = 0.30, M2 = 0.22, M3 = 0.02 and M4 = 0.09) are significantly different (P < 0.0001). The M4 allele was not found in 372 unrelated Caucasians and appears to be of African origin...
  8. ncbi request reprint Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement
    R J Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 58:5333-6. 1998
    ..This is the first report of p53 inactivation due to a rearrangement involving Alu elements. This type of inactivation may go unnoticed when only traditional methods to detect p53 alterations are used...
  9. ncbi request reprint Lead exposure as a risk factor for amyotrophic lateral sclerosis
    F Kamel
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Neurodegener Dis 2:195-201. 2005
    ..Most previous case-control studies found an association of ALS with self-reported occupational exposure to lead, with increased risks of 2- to >4-fold. However, these results may have been affected by recall bias...
  10. ncbi request reprint DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk
    M C Stern
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, 27709, USA
    Cancer Epidemiol Biomarkers Prev 10:125-31. 2001
    ..70; 95% CI, 0.4-1.3), and provided limited evidence, albeit not statistically significant, for a gene-smoking interaction...
  11. ncbi request reprint Application of the GA/KNN method to SELDI proteomics data
    Leping Li
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
    Bioinformatics 20:1638-40. 2004
    ....
  12. ncbi request reprint Detection of pre-invasive lung cancer: technical aspects of the LIFE project
    Gordon P Flake
    Laboratory of Experimental Pathology, National Institute of Environmental Sciences, NIH, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 35:65-74. 2007
    ....
  13. ncbi request reprint Bayesian latent variable models for median regression on multiple outcomes
    David B Dunson
    Biostatistics Branch, MD A3 03, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Biometrics 59:296-304. 2003
    ..A Markov chain Monte Carlo algorithm is proposed for posterior computation, and the methods are applied to single-cell electrophoresis (comet assay) data from a genetic toxicology study...
  14. ncbi request reprint VEGF promoter haplotype and amyotrophic lateral sclerosis (ALS)
    Paul D Terry
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, Research Triangle Park, NC 27709, USA
    J Neurogenet 18:429-34. 2004
    ..7 - 13.4), consistent with the findings of the previous study. Given the wide confidence interval, our findings should be interpreted cautiously...
  15. pmc Amyotrophic lateral sclerosis, lead, and genetic susceptibility: polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genes
    Freya Kamel
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 111:1335-9. 2003
    ..These findings suggest that genetic susceptibility conferred by polymorphisms in ALAD may affect ALS risk, possibly through a mechanism related to internal lead exposure...
  16. ncbi request reprint N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus
    Glinda S Cooper
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
    J Rheumatol 31:76-80. 2004
    ..To examine the association between N-acetyl transferase (NAT) genotype (NAT1 and NAT2) and risk of developing systemic lupus erythematosus (SLE)...
  17. ncbi request reprint APE1 genotype and risk of bladder cancer: evidence for effect modification by smoking
    Paul D Terry
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Int J Cancer 118:3170-3. 2006
    ..Given the lack of established biological mechanisms, and suboptimal numbers of subjects in some exposure categories, our findings should be interpreted cautiously...
  18. pmc Maternal alcohol consumption, alcohol metabolism genes, and the risk of oral clefts: a population-based case-control study in Norway, 1996-2001
    Abee L Boyles
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
    Am J Epidemiol 172:924-31. 2010
    ..9, 95% CI: 0.2, 4.1). The teratogenic effect of alcohol may depend on the genetic capacity of the mother and fetus to metabolize alcohol...
  19. pmc SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies
    Zongli Xu
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 37:W600-5. 2009
    ..Finally, we provide an example using prostate cancer and demonstrate that this algorithm can select a small panel of SNPs that include many of the recently validated prostate cancer SNPs...
  20. pmc Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study
    Abee L Boyles
    Epidemiology Branch, NIEHS NIH, Durham, North Carolina 27709, USA
    Genet Epidemiol 33:247-55. 2009
    ..Despite strong evidence for genetic causes of oral facial clefts and the protective effects of maternal vitamins, we found no convincing indication that polymorphisms in these vitamin metabolism genes play an etiologic role...
  21. ncbi request reprint Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review
    Lawrence S Engel
    Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Am J Epidemiol 156:95-109. 2002
    ..45, 95% CI: -0.03, 0.93). These results indicate that, among populations studied to date, GSTM1 null status is associated with a modest increase in the risk of bladder cancer...
  22. pmc Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts
    Abee L Boyles
    Epidemiology Branch, National Institute of Environmental Health Sciences NIH, Durham, North Carolina 27709, USA
    Am J Med Genet A 146:440-9. 2008
    ..No associations were found between any of the polymorphisms and CPO. Genetic variations in the nine metabolic genes examined here do not confer a substantial degree of risk for clefts...
  23. ncbi request reprint Mutations in tetranucleotide repeats following DNA damage depend on repeat sequence and carcinogenic agent
    Robbert J C Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 62:6052-60. 2002
    ..Our results are compatible with the hypothesis that sporadic microsatellite mutations in human cancer may reflect DNA damage caused by carcinogen exposure...
  24. ncbi request reprint Differences in base excision repair capacity may modulate the effect of dietary antioxidant intake on prostate cancer risk: an example of polymorphisms in the XRCC1 gene
    Carla H van Gils
    Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 11:1279-84. 2002
    ..The data give some support for our hypothesis but should be regarded as preliminary, because it is limited by small sample size. We discuss what kind of data and what kind of studies are needed for future evaluation of this hypothesis...
  25. ncbi request reprint Hepatitis B, aflatoxin B(1), and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China, and a meta-analysis of existing studies
    M C Stern
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 10:617-25. 2001
    ..0001). We found little evidence for an HBV-aflatoxin interaction modulating the presence of the p53 249(ser) mutation or any type of p53 mutation...
  26. ncbi request reprint Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect
    H Chen
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Lancet 347:295-7. 1996
    ..Both GST M1 (GSTM1) and GST theta 1 (GSTT1) genes have a "null" variant allele, in which the entire gene is absent. We tested whether the homozygous null genotype of GSTM1 and GSTT1 altered the risk for MDS...
  27. ncbi request reprint Analytical and statistical methods to evaluate microsatellite allelic imbalance in small amounts of DNA
    Robbert J C Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Lab Invest 84:649-57. 2004
    ..Our method allows the reliable detection of AI with very small amounts of DNA, and is sufficiently quantitative to assess allelic ratios in nonclonal tissue specimens...
  28. ncbi request reprint No association between SOD2 or NQO1 genotypes and risk of bladder cancer
    Paul D Terry
    Epidemiology Branch, NIEHS, NIH, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Cancer Epidemiol Biomarkers Prev 14:753-4. 2005
  29. ncbi request reprint Tag SNP selection for candidate gene association studies using HapMap and gene resequencing data
    Zongli Xu
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Eur J Hum Genet 15:1063-70. 2007
    ..Finally, we generalized the greedy algorithm proposed by Carlson et al (2004) to select tag SNPs for multiple populations and implemented the algorithm into a freely available software package mPopTag...
  30. pmc TAGster: efficient selection of LD tag SNPs in single or multiple populations
    Zongli Xu
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Bioinformatics 23:3254-5. 2007
    ..AVAILABILITY: The software Package TAGster is freely available at http://www.niehs.nih.gov/research/resources/software/tagster/..
  31. ncbi request reprint A novel host cell reactivation assay to assess homologous recombination capacity in human cancer cell lines
    R J Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biochem Biophys Res Commun 281:212-9. 2001
    ..Future application in normal cells may be useful to identify genetic determinants controlling genomic integrity or to detect differences in DNA repair capacity in individuals...
  32. ncbi request reprint DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk
    Mariana C Stern
    Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 11:939-43. 2002
    ..In this study, we found some evidence for a gene-gene interaction between the XRCC1 codon 194 and XRCC3 codon 241 polymorphisms (P = 0.09) and some support for a possible gene-gene-smoking three-way interaction (P = 0.08)...
  33. ncbi request reprint Splice variants but not mutations of DNA polymerase beta are common in bladder cancer
    Tracy E Thompson
    Molecular and Genetic Epidemiology Group, The Laboratory of Molecular Carcinogenesis, The National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Res 62:3251-6. 2002
    ..We examine alternative splicing in terms of the information content of splice donor and acceptor site sequences, and discuss possible explanations for the predominant splicing event, the loss of exon 2...
  34. ncbi request reprint Chromosomal abnormalities in bronchial epithelium from smokers, nonsmokers, and lung cancer patients
    Robbert J C Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Cancer Genet Cytogenet 159:137-42. 2005
    ..These specific alterations were found almost exclusively in patients with a history of tobacco smoking. The results did not indicate that general chromosomal abnormalities are a useful marker for tobacco smoke exposure or cancer risk...
  35. ncbi request reprint Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells
    Hyeon Woo Yim
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Lett 246:24-33. 2007
    ..An increase in telomerase activity in normal bronchial epithelium might extend the lifespan of cells at risk for malignant transformation, and thus contribute to lung carcinogenesis...
  36. ncbi request reprint Expression of CYP1A1 and CYP1A2 genes in human liver
    H Schweikl
    Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Pharmacogenetics 3:239-49. 1993
    ..Therefore, sequence changes in the coding region of CYP1A2 did not account for the poor expression of CYP1A2 in this individual...
  37. ncbi request reprint HRAS1 variable number of tandem repeats polymorphism and risk of bladder cancer
    Carla H van Gils
    Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Int J Cancer 100:414-8. 2002
    ..4) and for those with 2 rare alleles 3.2 (95% CI = 0.8-13.7). The number of incident cases was too small to draw firm conclusions on a possible association with a subgroup of tumors with a poor prognosis. Published 2002 Wiley-Liss, Inc...
  38. pmc Cadmium is a mutagen that acts by inhibiting mismatch repair
    Yong Hwan Jin
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Nat Genet 34:326-9. 2003
    ..In extracts of human cells, cadmium inhibited at least one step leading to mismatch removal. Together, our data show that a high level of genetic instability can result from environmental impediment of a mutation-avoidance system...
  39. ncbi request reprint Mini-and microsatellite mutations in children from Chernobyl accident cleanup workers
    Robbert J C Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    Mutat Res 559:143-51. 2004
    ..In conclusion, our results do not support an increased level of germline minisatellite mutations but suggest a modest increase in germline mutations in tetranucleotide repeats. Small sample size, however, limited statistical power...
  40. pmc XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks
    Julie K Horton
    Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Res 18:48-63. 2008
    ..XRCC1(-/-) cells are also sensitized by PARP inhibition demonstrating that PARP-mediated poly(ADP-ribosyl)ation plays a role in modulation of cytotoxicity beyond recruitment of XRCC1 to sites of DNA damage...
  41. ncbi request reprint Variants of developmental genes (TGFA, TGFB3, and MSX1) and their associations with orofacial clefts: a case-parent triad analysis
    Astanand Jugessur
    Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
    Genet Epidemiol 24:230-9. 2003
    ..The effect of this TGFA genotype was even stronger among children homozygous for the MSX1-CA A4 allele, raising the possibility of interaction between these two genes...
  42. ncbi request reprint Exploring the effects of methylenetetrahydrofolate reductase gene variants C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads
    Astanand Jugessur
    Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
    Am J Epidemiol 157:1083-91. 2003
    ..These findings suggest a possible role of MTHFR and folic acid in the causation of orofacial clefts, but the strength and direction of these effects remain to be clarified...
  43. ncbi request reprint Cleft palate, transforming growth factor alpha gene variants, and maternal exposures: assessing gene-environment interactions in case-parent triads
    Astanand Jugessur
    Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
    Genet Epidemiol 25:367-74. 2003
    ..7, 95% CI=0.2-15.7). In conclusion, we find little evidence of interaction between the child's genotypes at TGFA TaqI and various exposures for cleft palate, with the possible exception of folic acid intake...
  44. ncbi request reprint Lycopene intake and prostate cancer risk: effect modification by plasma antioxidants and the XRCC1 genotype
    Michael Goodman
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Nutr Cancer 55:13-20. 2006
    ..01). Although limited by small sample size, these findings indicate that the association between lycopene and prostate cancer is complex and may be modified by other antioxidants and by XRCC1 genotype...
  45. pmc Antimutagenicity of cinnamaldehyde and vanillin in human cells: Global gene expression and possible role of DNA damage and repair
    Audrey A King
    The Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mutat Res 616:60-9. 2007
    ..These and other data lead us to propose that VAN and CIN may induce DNA damage that elicits recombinational DNA repair, which reduces spontaneous mutations...
  46. ncbi request reprint DNA repair gene polymorphisms and probability of p53 mutation in bladder cancer
    Mariana C Stern
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, USA
    Mol Carcinog 45:715-9. 2006
    ..7; 95% CI = 1.1-13). Our data provide some limited support for the hypothesis that mutations in the p53 gene in bladder cancer may differ according to the presence or absence of certain DNA repair gene variants...