Jeffery K Taubenberger

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Insights on influenza pathogenesis from the grave
    Jeffery K Taubenberger
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Room 3E19A 2, MSC 3203, Bethesda, MD 20892 3203, USA
    Virus Res 162:2-7. 2011
  2. pmc Influenza: the once and future pandemic
    Jeffery K Taubenberger
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Dr, Rm 3E19A 2, MSC 3203, Bethesda, MD 20892 3203, USA
    Public Health Rep 125:16-26. 2010
  3. pmc Pandemic influenza--including a risk assessment of H5N1
    J K Taubenberger
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Bethesda, MD 20892 3203, USA
    Rev Sci Tech 28:187-202. 2009
  4. pmc The pathology of influenza virus infections
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Annu Rev Pathol 3:499-522. 2008
  5. pmc Discovery and characterization of the 1918 pandemic influenza virus in historical context
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 12:581-91. 2007
  6. pmc An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice
    Matthew J Memoli
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Virology 393:338-45. 2009
  7. pmc Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus
    John C Kash
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Bethesda, MD 20892 3203, USA
    Influenza Other Respir Viruses 4:121-7. 2010
  8. pmc Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice
    Li Qi
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:9211-20. 2012
  9. pmc Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice
    Judith D Easterbrook
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Virology 432:39-44. 2012
  10. ncbi request reprint Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice
    John C Kash
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Free Radic Biol Med 67:235-247. 2013

Collaborators

Detail Information

Publications83

  1. pmc Insights on influenza pathogenesis from the grave
    Jeffery K Taubenberger
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Room 3E19A 2, MSC 3203, Bethesda, MD 20892 3203, USA
    Virus Res 162:2-7. 2011
    ..These studies have yielded much information about the origin and pathogenicity of the 1918 virus, but many questions still remain...
  2. pmc Influenza: the once and future pandemic
    Jeffery K Taubenberger
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Dr, Rm 3E19A 2, MSC 3203, Bethesda, MD 20892 3203, USA
    Public Health Rep 125:16-26. 2010
    ..Influenza pandemics have been reported for at least 500 years, with inter-pandemic intervals averaging approximately 40 years...
  3. pmc Pandemic influenza--including a risk assessment of H5N1
    J K Taubenberger
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Bethesda, MD 20892 3203, USA
    Rev Sci Tech 28:187-202. 2009
    ....
  4. pmc The pathology of influenza virus infections
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Annu Rev Pathol 3:499-522. 2008
    ....
  5. pmc Discovery and characterization of the 1918 pandemic influenza virus in historical context
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 12:581-91. 2007
    ....
  6. pmc An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice
    Matthew J Memoli
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Virology 393:338-45. 2009
    ....
  7. pmc Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus
    John C Kash
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Bethesda, MD 20892 3203, USA
    Influenza Other Respir Viruses 4:121-7. 2010
    ..Epidemiological evidence suggested that the current seasonal vaccine did not offer significant protection from the novel pandemic, and that people over the age of 50 were less susceptible to infection...
  8. pmc Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice
    Li Qi
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:9211-20. 2012
    ..While the mechanisms of influenza virus host switch, and particularly mammalian host adaptation are still only partly understood, these data suggest that the 1918 virus, whatever its origin, is very similar to avian influenza virus...
  9. pmc Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice
    Judith D Easterbrook
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Virology 432:39-44. 2012
    ..Human influenza vaccines that elicit not only HA, but also NA immunity may provide enhanced protection against the emergence of seasonal and pandemic viruses...
  10. ncbi request reprint Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice
    John C Kash
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Free Radic Biol Med 67:235-247. 2013
    ....
  11. pmc Examining the hemagglutinin subtype diversity among wild duck-origin influenza A viruses using ethanol-fixed cloacal swabs and a novel RT-PCR method
    Ruixue Wang
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virology 375:182-9. 2008
    ..This study further demonstrates the complex ecobiology of avian influenza A viruses in wild birds...
  12. pmc Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts
    Matthew J Memoli
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3203, USA
    Clin Infect Dis 50:1252-5. 2010
    ..We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of clinically significant resistance to peramivir...
  13. pmc Phylogenetic analysis of low pathogenicity H5N1 and H7N3 influenza A virus isolates recovered from sentinel, free flying, wild mallards at one study site during 2006
    Vivien G Dugan
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Virology 417:98-105. 2011
    ..Both findings provide further insight into the natural history of AIVs in natural reservoirs...
  14. pmc Rapid selection of a transmissible multidrug-resistant influenza A/H3N2 virus in an immunocompromised host
    Matthew J Memoli
    Respiratory Virus Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MSC 3203 33 North Dr, Bethesda, MD 20892 3203, USA
    J Infect Dis 201:1397-403. 2010
    ..Antigenic drift and genetic variations during prolonged influenza infection have been demonstrated. In this report we describe a multidrug-resistant H3N2 influenza virus isolated from an immunocompromised patient after 5 days of therapy...
  15. pmc The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase
    Brett W Jagger
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    MBio 1:. 2010
    ....
  16. pmc In vivo evaluation of pathogenicity and transmissibility of influenza A(H1N1)pdm09 hemagglutinin receptor binding domain 222 intrahost variants isolated from a single immunocompromised patient
    Matthew J Memoli
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virology 428:21-9. 2012
    ....
  17. pmc Role of sialic acid binding specificity of the 1918 influenza virus hemagglutinin protein in virulence and pathogenesis for mice
    Li Qi
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208921, USA
    J Virol 83:3754-61. 2009
    ..Changing alpha2-3 to alpha2-6 binding specificity did not increase the lethality of an avian-adapted hemagglutinin. Thus, the 1918 hemagglutinin contains murine virulence determinants independent of receptor binding specificity...
  18. pmc Different evolutionary trajectories of European avian-like and classical swine H1N1 influenza A viruses
    Eleca J Dunham
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3203, USA
    J Virol 83:5485-94. 2009
    ..Thus, in the context of emergence of an influenza A virus strain via a host switch event, it is difficult to predict what specific polygenic changes are needed for mammalian adaptation...
  19. pmc Historical thoughts on influenza viral ecosystems, or behold a pale horse, dead dogs, failing fowl, and sick swine
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Influenza Other Respir Viruses 4:327-37. 2010
    ..To understand human influenza in a historical context of viral circulation in avian species, mammals, and in the environment...
  20. pmc Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferrets
    Matthew J Memoli
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 203:348-57. 2011
    ....
  21. pmc The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding
    Li Qi
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virology 412:426-34. 2011
    ..In contrast, the virus expressing the HA of a seasonal influenza strain induced only mild disease with little lung pathology in infected mice and exhibited strong in vitro binding to SP-D...
  22. pmc Immunization with 1976 swine H1N1- or 2009 pandemic H1N1-inactivated vaccines protects mice from a lethal 1918 influenza infection
    Judith D Easterbrook
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Influenza Other Respir Viruses 5:198-205. 2011
    ..Epidemiological and laboratory animal studies show that protection from severe 2009 pH1N1 infection is conferred by vaccination or prior infection with 1976 swH1N1 or 1918...
  23. pmc Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak
    Zong Mei Sheng
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:16416-21. 2011
    ..These findings have important implications for understanding the origins and evolution of pandemic influenza viruses...
  24. pmc The evolutionary genetics and emergence of avian influenza viruses in wild birds
    Vivien G Dugan
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 4:e1000076. 2008
    ....
  25. pmc An avian outbreak associated with panzootic equine influenza in 1872: an early example of highly pathogenic avian influenza?
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Influenza Other Respir Viruses 4:373-7. 2010
    ..To our knowledge the scientific literature contains no mention of the nationwide 1872 poultry outbreak...
  26. pmc Recent human influenza A/H3N2 virus evolution driven by novel selection factors in addition to antigenic drift
    Matthew J Memoli
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 200:1232-41. 2009
    ....
  27. pmc High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded autopsy lung tissue sample from the 1918 influenza pandemic
    Yong Li Xiao
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Pathol 229:535-45. 2013
    ..This methodological approach should assist in the analysis of FFPE tissue samples isolated over the past century from a variety of diseases...
  28. pmc Lethal synergism of 2009 pandemic H1N1 influenza virus and Streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses
    John C Kash
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    MBio 2:. 2011
    ..This study reveals that the extent of lung damage during viral infection influences the severity of secondary bacterial infections and may help explain some differences in mortality during influenza pandemics...
  29. pmc The 1918 influenza pandemic: lessons for 2009 and the future
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Crit Care Med 38:e10-20. 2010
    ..Thus, we must remain vigilant and use the knowledge we have gained from 1918 and other influenza pandemics to direct targeted research and pandemic influenza preparedness planning, emphasizing prevention, containment, and treatment...
  30. pmc Obese mice have increased morbidity and mortality compared to non-obese mice during infection with the 2009 pandemic H1N1 influenza virus
    Judith D Easterbrook
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Influenza Other Respir Viruses 5:418-25. 2011
    ..Obesity has been identified as an independent risk factor for severe or fatal infection with 2009 pandemic H1N1 influenza (2009 pH1N1), but was not previously recognized for previous pandemic or seasonal influenza infections...
  31. pmc Influenza virus evolution, host adaptation, and pandemic formation
    Jeffery K Taubenberger
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Host Microbe 7:440-51. 2010
    ..Here, we review the evolution of influenza A viruses in their reservoir hosts and discuss genetic changes associated with introduction of novel viruses into humans, leading to pandemics and the establishment of seasonal viruses...
  32. pmc Molecular basis for broad neuraminidase immunity: conserved epitopes in seasonal and pandemic H1N1 as well as H5N1 influenza viruses
    Hongquan Wan
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 87:9290-300. 2013
    ....
  33. pmc Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 198:962-70. 2008
    ..Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics...
  34. pmc The role of radiology in influenza: novel H1N1 and lessons learned from the 1918 pandemic
    Daniel J Mollura
    Radiology and Imaging Sciences, National Institutes of Health, Clinical Center, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Am Coll Radiol 7:690-7. 2010
    ..The broad range of current imaging capabilities will make it possible to study influenza at the cellular level, in animal models, and in human clinical trials to elucidate the pathogenesis of severe illness and improve clinical outcomes...
  35. pmc Methods for molecular surveillance of influenza
    Ruixue Wang
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Expert Rev Anti Infect Ther 8:517-27. 2010
    ....
  36. ncbi request reprint Capturing a killer flu virus
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, MD, USA
    Sci Am 292:48-57. 2005
  37. pmc Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques
    David Safronetz
    Laboratory of Virology, Hamilton, Montana, USA
    J Virol 85:1214-23. 2011
    ..Differences in virulence may explain more severe disease, as was seen with certain individuals infected with the emerged pandemic influenza virus. Thus, the nonhuman primate model closely mimics influenza in humans...
  38. pmc Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells
    Asunción Martínez-Antón
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Am J Respir Cell Mol Biol 49:384-95. 2013
    ..Therefore, changes in specific miRNAs during human airway epithelial cell differentiation control gene and protein expression important for differentiation. ..
  39. pmc Age- and sex-specific mortality associated with the 1918-1919 influenza pandemic in Kentucky
    Cecile Viboud
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 207:721-9. 2013
    ..Here we characterize pandemic-related mortality by single year of age in a unique statewide Kentucky data set and explore breakpoints in the age curves...
  40. pmc Detection of seasonal H3N2 influenza A virus by type-specific TaqMan minor groove binder probe assay
    Ruixue Wang
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Diagn Microbiol Infect Dis 70:281-4. 2011
    ..We describe a specific minor groove binder TaqMan assay for H3N2 viruses with a detection limit of 16.5 standard DNA copies...
  41. pmc Effect of preservative on recoverable RT-PCR amplicon length from influenza A virus in bird feces
    David L Evers
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Avian Dis 51:965-8. 2007
    ..These results suggest that this approach is feasible in the field and that preserved specimens might be better assayed molecularly when preserved in guanidine or commercial buffers...
  42. pmc The next influenza pandemic: can it be predicted?
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 2520, USA
    JAMA 297:2025-7. 2007
  43. pmc The Natural History of Influenza Infection in the Severely Immunocompromised vs Nonimmunocompromised Hosts
    Matthew J Memoli
    Laboratory of Infectious Diseases, Viral Pathogenesis and Evolution Section
    Clin Infect Dis 58:214-24. 2014
    ..Clinical trials registration, ClinicalTrials.gov identifier NCT00533182. ..
  44. pmc Influenza in pregnancy
    Matthew J Memoli
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of HealthOffice of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Influenza Other Respir Viruses 7:1033-9. 2013
    ....
  45. pmc Engineering H5N1 avian influenza viruses to study human adaptation
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 486:335-40. 2012
    ....
  46. pmc Influenza and the origins of The Philips Collection, Washington, DC
    David M Morens
    National Institutes of Health, Bethesda, MD, USA
    Emerg Infect Dis 12:78-80. 2006
  47. pmc Pandemic influenza's 500th anniversary
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Infect Dis 51:1442-4. 2010
    ..It seems likely that, in the foreseeable future, we may be able to greatly reduce the burden of influenza pandemics with improved vaccines and other scientific and public health approaches...
  48. pmc Pandemic and seasonal influenza: therapeutic challenges
    Matthew J Memoli
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Drug Discov Today 13:590-5. 2008
    ....
  49. pmc Fatal 1918 pneumonia case complicated by erythrocyte sickling
    Zong Mei Sheng
    National Institutes of Health, Bethesda, Maryland, USA
    Emerg Infect Dis 16:2000-1. 2010
    ..The inheritance pattern of sickle cell anemia was determined in 1949; in 1957, Ingram identified the single amino acid change in hemoglobin S (4)...
  50. doi request reprint Characterization of the Noncoding Regions of the 1918 Influenza A H1N1 Virus
    Ruixue Wang
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 88:1815-8. 2014
    ..No growth differences between the NCR variant 1918 influenza viruses were noted. ..
  51. doi request reprint Rapid sequencing of influenza A virus vRNA, cRNA and mRNA non-coding regions
    Ruixue Wang
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol Methods 195:26-33. 2014
    ..This modified method may also be used to characterize the NCRs of influenza A virus samples in which the RNA has been degraded. ..
  52. pmc HASP server: a database and structural visualization platform for comparative models of influenza A hemagglutinin proteins
    Xavier I Ambroggio
    Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    BMC Bioinformatics 14:197. 2013
    ..Sequencing efforts thus far have generated nearly 9,000 distinct hemagglutinin amino acid sequences...
  53. ncbi request reprint Ewing sarcoma family of tumors in unusual sites: confirmation by rt-PCR
    Atif A Ahmed
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Pediatr Dev Pathol 9:488-95. 2006
    ..Accurate diagnosis of Ewing sarcoma family of tumors is crucial for the management of patients, and when found in such rare locations, diagnosis should be supported by immunohistochemical and/or molecular genetic studies...
  54. ncbi request reprint Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus
    Ann H Reid
    Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Boulevard, Building 101, Rockville, Maryland 20850, USA
    Nat Rev Microbiol 2:909-14. 2004
    ..Determining whether a pandemic influenza virus can emerge by different mechanisms will affect the scope and focus of surveillance and prevention efforts...
  55. pmc 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants
    Ann H Reid
    Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Rockville, MD 20850 3125, USA
    Emerg Infect Dis 9:1249-53. 2003
  56. ncbi request reprint The origin of the 1918 pandemic influenza virus: a continuing enigma
    Ann H Reid
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Blvd, Building 101, Room 1057, Rockville, MD 20850 3125, USA
    J Gen Virol 84:2285-92. 2003
    ..Determining whether pandemic influenza virus strains can emerge via different pathways will affect the scope and focus of surveillance and prevention efforts...
  57. pmc Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus
    Terrence M Tumpey
    Southeast Poultry Research Laboratory, United States Department of Agriculture, Athens, GA 30605, USA
    Proc Natl Acad Sci U S A 99:13849-54. 2002
    ..These data suggest that current antiviral strategies would be effective in curbing the dangers of a re-emergent 1918 or 1918-like virus...
  58. pmc Characterization of the 1918 "Spanish" influenza virus matrix gene segment
    Ann H Reid
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
    J Virol 76:10717-23. 2002
    ....
  59. pmc 1917 avian influenza virus sequences suggest that the 1918 pandemic virus did not acquire its hemagglutinin directly from birds
    Thomas G Fanning
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
    J Virol 76:7860-2. 2002
    ....
  60. pmc Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice
    Terrence M Tumpey
    Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    J Virol 79:14933-44. 2005
    ....
  61. ncbi request reprint Heading off an influenza pandemic
    Edward C Holmes
    Science 309:989. 2005
  62. pmc The origin and virulence of the 1918 "Spanish" influenza virus
    Jeffery K Taubenberger
    Department of Molecular Pathology Armed Forces Institute of Pathology Rockville, Maryland, USA
    Proc Am Philos Soc 150:86-112. 2006
    ..This information should help elucidate how pandemic influenza virus strains emerge and what genetic features contribute to virulence in humans...
  63. ncbi request reprint Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution
    Elodie Ghedin
    The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland 20850, USA
    Nature 437:1162-6. 2005
    ..All data from this project are being deposited, without delay, in public archives...
  64. ncbi request reprint Characterization of the reconstructed 1918 Spanish influenza pandemic virus
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases DVRD, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    Science 310:77-80. 2005
    ..Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus...
  65. ncbi request reprint Characterization of the 1918 influenza virus polymerase genes
    Jeffery K Taubenberger
    Department of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, Maryland 20850, USA
    Nature 437:889-93. 2005
    ..The sequence changes identified here may be important in the adaptation of influenza viruses to humans...
  66. pmc Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918
    Martha I Nelson
    Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS Pathog 4:e1000012. 2008
    ..Intra-subtype reassortment therefore appears to be a more important process in the evolution and epidemiology of H1N1 influenza A virus than previously realized...
  67. pmc The genomic and epidemiological dynamics of human influenza A virus
    Andrew Rambaut
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, UK
    Nature 453:615-9. 2008
    ..These results suggest a sink-source model of viral ecology in which new lineages are seeded from a persistent influenza reservoir, which we hypothesize to be located in the tropics, to sink populations in temperate regions...
  68. pmc The relationship between encephalitis lethargica and influenza: a critical analysis
    Sherman McCall
    Department of Clinical Pathology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    J Neurovirol 14:177-85. 2008
    ..Almost 100 years after the EL epidemic, its etiology remains enigmatic, raising the possibility of a recurrence of EL in a future influenza pandemic...
  69. pmc Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
    John C Kash
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nature 443:578-81. 2006
    ..Moreover, understanding the contribution of host immune responses to virulent influenza virus infections is an important starting point for the identification of prognostic indicators and the development of novel antiviral therapies...
  70. pmc A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity
    Laurel Glaser
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 79:11533-6. 2005
    ..Mutation of this single amino acid back to the avian consensus resulted in a preference for the avian receptor...
  71. pmc Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza
    Gary K Geiss
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 99:10736-41. 2002
    ....
  72. ncbi request reprint SARS-CoV virus-host interactions and comparative etiologies of acute respiratory distress syndrome as determined by transcriptional and cytokine profiling of formalin-fixed paraffin-embedded tissues
    Tracey Baas
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    J Interferon Cytokine Res 26:309-17. 2006
    ....
  73. pmc Influenza revisited
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, Maryland, USA
    Emerg Infect Dis 12:1-2. 2006
  74. ncbi request reprint Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus
    James Stevens
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 312:404-10. 2006
    ....
  75. pmc 1918 Influenza: the mother of all pandemics
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
    Emerg Infect Dis 12:15-22. 2006
    ..But, the viral genome alone is unlikely to provide answers to some critical questions. Understanding the 1918 pandemic and its implications for future pandemics requires careful experimentation and in-depth historical analysis...
  76. ncbi request reprint Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities
    James Stevens
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 355:1143-55. 2006
    ..The glycan array thus provides highly detailed profiles of influenza receptor specificity that can be used to map the evolution of new human pathogenic strains, such as the H5N1 avian influenza...
  77. ncbi request reprint Successful explantation of a ventricular assist device following fulminant influenza type A-associated myocarditis
    Paul C McGovern
    Division of Infectious Diseases, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 21:290-3. 2002
    ..This case suggests those patients with fulminant viral myocarditis and refractory ventricular arrhythmias may be supported successfully with ventricular assist devices until myocardial recovery takes place...
  78. ncbi request reprint Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore
    Teri J Franks
    Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Wshington, DC 20306, USA
    Hum Pathol 34:743-8. 2003
    ..Understanding the pathology of DAD in SARS patients may provide the basis for therapeutic strategies. Further studies of the pathogenesis of SARS may reveal new insight into the mechanisms of DAD...
  79. ncbi request reprint Fixed and frozen flu: the 1918 influenza and lessons for the future
    Jeffery K Taubenberger
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Rockville, MD 20850 3125, USA
    Avian Dis 47:789-91. 2003
  80. ncbi request reprint Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus
    James Stevens
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 303:1866-70. 2004
    ....
  81. pmc Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus
    John C Kash
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195 8070, USA
    J Virol 78:9499-511. 2004
    ..These studies document clear differences in gene expression profiles that were correlated with pulmonary disease pathology induced by virulent and attenuated influenza virus infections...
  82. pmc Novel origin of the 1918 pandemic influenza virus nucleoprotein gene
    Ann H Reid
    Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Blvd, Building 101, Rockville, MD 20850 3125, USA
    J Virol 78:12462-70. 2004
    ....
  83. pmc Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus
    Terrence M Tumpey
    Southeast Poultry Research Laboratory, Agricultural Research Service, U S Department of Agriculture, Athens, GA 30605, USA
    Proc Natl Acad Sci U S A 101:3166-71. 2004
    ..These data suggest a strategy of vaccination that would be effective against a reemergent 1918 or 1918-like virus...