Cristina M Tato

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Helper T cell differentiation enters a new era: le roi est mort; vive le roi!
    Cristina M Tato
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:809-12. 2006
  2. ncbi request reprint Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
    Nat Immunol 7:937-45. 2006
  3. pmc Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
  4. pmc Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    Hiroaki Takatori
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Exp Med 206:35-41. 2009
  5. pmc Distinct regulation of interleukin-17 in human T helper lymphocytes
    Zhi Chen
    National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 1820, USA
    Arthritis Rheum 56:2936-46. 2007
  6. pmc Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii
    Wendy T Watford
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:2803-12. 2008
  7. ncbi request reprint Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    Arian Laurence
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 26:371-81. 2007
  8. ncbi request reprint TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 8:1390-7. 2007
  9. pmc Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Exp Med 204:65-71. 2007
  10. ncbi request reprint Immunology: what does it mean to be just 17?
    Cristina M Tato
    Nature 441:166-8. 2006

Collaborators

Detail Information

Publications10

  1. pmc Helper T cell differentiation enters a new era: le roi est mort; vive le roi!
    Cristina M Tato
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:809-12. 2006
    ..The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17-related cytokine IL-25 is essential for Th2 responses in two infectious disease models...
  2. ncbi request reprint Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
    Nat Immunol 7:937-45. 2006
    ..Thus IL-27, a potent inhibitor of T(H)-17 cell development, may be a useful target for treating inflammatory diseases mediated by these cells...
  3. pmc Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
    ..These data indicate an alternative mode for T(H)17 differentiation. Consistent with genetic data linking IL23R with autoimmunity, our findings re-emphasize the importance of IL-23 and therefore may have therapeutic implications...
  4. pmc Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    Hiroaki Takatori
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Exp Med 206:35-41. 2009
    ..Thus, it appears that splenic LTi-like cells are a rapid source of IL-17 and IL-22, which might contribute to dynamic organization of secondary lymphoid organ structure or host defense...
  5. pmc Distinct regulation of interleukin-17 in human T helper lymphocytes
    Zhi Chen
    National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 1820, USA
    Arthritis Rheum 56:2936-46. 2007
    ..The present study was undertaken to assess the effects on naive human CD4+ T cells of cytokines known to promote murine Th17 cells...
  6. pmc Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii
    Wendy T Watford
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:2803-12. 2008
    ..These data underscore the role of Tpl2 as a regulator of T helper cell lineage decisions and demonstrate that Tpl2 has an important functional role in the regulation of Th1 responses...
  7. ncbi request reprint Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    Arian Laurence
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 26:371-81. 2007
    ..We conclude that in addition to the promotion of activation-induced cell death of lymphocytes and the generation of Treg cells, inhibition of Th17 polarization appears to be an important function of IL-2...
  8. ncbi request reprint TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 8:1390-7. 2007
    ..Our findings suggest that full acquisition of pathogenic function by effector T(H)-17 cells is mediated by IL-23 rather than by TGF-beta and IL-6...
  9. pmc Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Exp Med 204:65-71. 2007
    ....
  10. ncbi request reprint Immunology: what does it mean to be just 17?
    Cristina M Tato
    Nature 441:166-8. 2006