P A Tataranni

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Treatment of obesity: should we target the individual or society?
    P Antonio Tataranni
    Obesity, Diabetes and Energy Metabolism Unit, Clinical Diabetes and Nutrition Section, NIDDK NIH DHHS, 4212 N 16th Street, Room 541 A, Phoenix, AZ, USA
    Curr Pharm Des 9:1151-63. 2003
  2. ncbi request reprint Functional neuroimaging: a new generation of human brain studies in obesity research
    P A Tataranni
    CDNS, NIDDK NIH DHHS, Phoenix, AZ 85016, USA
    Obes Rev 4:229-38. 2003
  3. ncbi request reprint Metabolic syndrome: is there a pathophysiological common denominator?
    P A Tataranni
    Clinical Diabetes and Nutrition Section, NIDDK, NIH DHHS, Phoenix, Ariz, USA
    World Rev Nutr Diet 94:75-83. 2005
  4. pmc Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography
    P A Tataranni
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Phoenix, AZ 85016, USA
    Proc Natl Acad Sci U S A 96:4569-74. 1999
  5. ncbi request reprint Body weight gain in free-living Pima Indians: effect of energy intake vs expenditure
    P A Tataranni
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ 85016, USA
    Int J Obes Relat Metab Disord 27:1578-83. 2003
  6. ncbi request reprint Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
    B Vozarova
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 9:414-7. 2001
  7. ncbi request reprint Effect of satiation on brain activity in obese and lean women
    J F Gautier
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 9:676-84. 2001
  8. ncbi request reprint Ethnic differences in insulinemia and sympathetic tone as links between obesity and blood pressure
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Hypertension 36:531-7. 2000
  9. pmc Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes
    Y H Lee
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabetologia 48:1776-83. 2005
  10. ncbi request reprint Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 47:1555-61. 1998

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Treatment of obesity: should we target the individual or society?
    P Antonio Tataranni
    Obesity, Diabetes and Energy Metabolism Unit, Clinical Diabetes and Nutrition Section, NIDDK NIH DHHS, 4212 N 16th Street, Room 541 A, Phoenix, AZ, USA
    Curr Pharm Des 9:1151-63. 2003
    ..However, reversing the current pandemic will require a greater understanding not only of the molecular and physiological underpinnings, but also social and political causes of this disease...
  2. ncbi request reprint Functional neuroimaging: a new generation of human brain studies in obesity research
    P A Tataranni
    CDNS, NIDDK NIH DHHS, Phoenix, AZ 85016, USA
    Obes Rev 4:229-38. 2003
    ....
  3. ncbi request reprint Metabolic syndrome: is there a pathophysiological common denominator?
    P A Tataranni
    Clinical Diabetes and Nutrition Section, NIDDK, NIH DHHS, Phoenix, Ariz, USA
    World Rev Nutr Diet 94:75-83. 2005
  4. pmc Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography
    P A Tataranni
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Phoenix, AZ 85016, USA
    Proc Natl Acad Sci U S A 96:4569-74. 1999
    ..Although exploratory, the present study provides a foundation for investigating the human brain regions and cognitive operations that respond to nutritional stimuli...
  5. ncbi request reprint Body weight gain in free-living Pima Indians: effect of energy intake vs expenditure
    P A Tataranni
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ 85016, USA
    Int J Obes Relat Metab Disord 27:1578-83. 2003
    ..However, experimental evidence of the relative contribution of interindividual differences in energy intake and expenditure (resting or due to physical activity) to weight gain is limited...
  6. ncbi request reprint Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
    B Vozarova
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 9:414-7. 2001
    ....
  7. ncbi request reprint Effect of satiation on brain activity in obese and lean women
    J F Gautier
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 9:676-84. 2001
    ..It also lends additional support to the hypothesis that the paralimbic areas participate in a central orexigenic network modulated by the prefrontal cortex through feedback loops...
  8. ncbi request reprint Ethnic differences in insulinemia and sympathetic tone as links between obesity and blood pressure
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Hypertension 36:531-7. 2000
    ..The lack of an increase in SNS activity with increasing adiposity and insulinemia in Pima Indians may contribute to the low prevalence of hypertension in this population...
  9. pmc Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes
    Y H Lee
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabetologia 48:1776-83. 2005
    ..The aim of this study was to characterise, in adipocytes from obese people, the most differentially expressed genes that might be relevant to the development of obesity...
  10. ncbi request reprint Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 47:1555-61. 1998
    ..This is the first study to demonstrate unequivocal metabolic effects of a highly selective beta3-adrenoceptor agonist in humans...
  11. ncbi request reprint Successful dieters have increased neural activity in cortical areas involved in the control of behavior
    A DelParigi
    Obesity and Diabetes Clinical Research Section, National Institutes of Health, Phoenix, AZ, USA
    Int J Obes (Lond) 31:440-8. 2007
    ..To investigate whether dietary restraint, a landmark of successful dieting, is associated with specific patterns of brain responses to the sensory experience of food and meal consumption...
  12. ncbi request reprint Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85106, USA
    Am J Clin Nutr 72:946-53. 2000
    ..An adaptive decrease in energy expenditure (EE) in response to 6 mo of severely restricted energy intake was shown in a classic semistarvation study-the Minnesota experiment...
  13. ncbi request reprint Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes Care 24:89-94. 2001
    ..We therefore assessed the predictive effect of insulin resistance and insulin secretory dysfunction separately for the progression from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and from IGT to diabetes...
  14. ncbi request reprint Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation stimulating protein concentration
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes Care 23:779-85. 2000
    ..We hypothesized that an elevated C3 concentration might be linked to insulin resistance and/or hyperinsulinemia, abnormalities commonly observed in association with the above conditions...
  15. ncbi request reprint Relationship between birth weight and body composition, energy metabolism, and sympathetic nervous system activity later in life
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 8:559-65. 2000
    ..Programming of metabolic, endocrine, and/or autonomic pathways during intrauterine development has been proposed to explain this association...
  16. ncbi request reprint Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 85:1087-94. 2000
    ..The metabolic responses to weight changes are highly variable among individuals, however...
  17. ncbi request reprint Exaggerated pancreatic polypeptide secretion in Pima Indians: can an increased parasympathetic drive to the pancreas contribute to hyperinsulinemia, obesity, and diabetes in humans?
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Metabolism 50:223-30. 2001
    ....
  18. ncbi request reprint Persistence of abnormal neural responses to a meal in postobese individuals
    A DelParigi
    Clinical Diabetes and Nutrition Section, VIDDK, JIH DHHS, Phoenix, AZ 85016, USA
    Int J Obes Relat Metab Disord 28:370-7. 2004
    ..To determine whether abnormal obese-like neural responses to a meal persist in postobese individuals, who achieved and maintained a normal body weight despite a past history of severe obesity...
  19. ncbi request reprint Changes in energy metabolism in response to 48 h of overfeeding and fasting in Caucasians and Pima Indians
    C Weyer
    Clinical Diabetes and Nutrition Section, NIDDK, National Institutes of Health, Phoenix, Arizona 85016, USA
    Int J Obes Relat Metab Disord 25:593-600. 2001
    ..To further examine this hypothesis, we assessed the changes in 24 h energy metabolism in response to short-term overfeeding and fasting in Caucasians (C) and Pima Indians (I), a population with a very high propensity for obesity...
  20. ncbi request reprint A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 49:2094-101. 2000
    ..Whether amelioration of basal insulin hypersecretion will prevent diabetes remains to be elucidated...
  21. ncbi request reprint Ad libitum food intake in humans after manipulation of glycogen stores
    S Snitker
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Am J Clin Nutr 65:941-6. 1997
    ..001). The findings suggest that 1) body glycogen stores play at most a minor role in short-term food intake regulation, and 2) in the short term, imbalances in glycogen stores are corrected by adjustments of macronutrient oxidation rates...
  22. ncbi request reprint 11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle
    S Nair
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetologia 47:1088-95. 2004
    ..We have shown that adipose tissue 11beta-HSD1 mRNA levels were associated with adiposity and insulinaemia. Here we conducted further expression and genetic association studies in Pima Indians...
  23. ncbi request reprint Role of lipids in development of noninsulin-dependent diabetes mellitus: lessons learned from Pima Indians
    P A Tataranni
    National Institutes of Health, National Institute of Diabetes and Digestive Kidney Diseases, Clinical Diabetes and Nutrition Section, Phoenix, Arizona 85016, USA
    Lipids 31:S267-70. 1996
    ....
  24. ncbi request reprint Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 86:1930-5. 2001
    ....
  25. pmc Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians
    S Nair
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Diabetologia 48:1784-8. 2005
    ..The aim of this study was to elucidate the potential role of adipocyte precursor cells (preadipocytes/stromal vascular cells [SVC])...
  26. ncbi request reprint The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Int J Obes Relat Metab Disord 26:1629-32. 2002
    ..These findings are consistent with a role of the Gln223Arg polymorphism in reducing peripheral and central leptin binding to the LEPR in humans. However, these effects do not seem to have a major impact on adiposity in this population...
  27. ncbi request reprint Exaggerated insulin secretion in Pima Indians and African-Americans but higher insulin resistance in Pima Indians compared to African-Americans and Caucasians
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabet Med 21:1090-5. 2004
    ....
  28. ncbi request reprint Comparison of plasma insulin levels after a mixed-meal challenge in children with and without intrauterine exposure to diabetes
    A D Salbe
    NIH NIDDK Obesity and Diabetes Clinical Research Section, 4212 North 16th Street, Room 541, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 92:624-8. 2007
    ..The diabetic intrauterine environment is a known risk factor for the development of diabetes in the offspring...
  29. ncbi request reprint Respiratory quotient is inversely associated with muscle sympathetic nerve activity
    S Snitker
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 83:3977-9. 1998
    ....
  30. ncbi request reprint Body mass index as a measure of adiposity in children and adolescents: relationship to adiposity by dual energy x-ray absorptiometry and to cardiovascular risk factors
    R S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
    J Clin Endocrinol Metab 86:4061-7. 2001
    ..Body mass index is strongly associated with measures of adiposity derived from dual energy x-ray absorptiometry. Both measures show similar associations with cardiovascular risk factors in Pima Indian children...
  31. ncbi request reprint Differences in oral temperature and body shape in two populations with different propensities for obesity
    B Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Ann N Y Acad Sci 967:516-21. 2002
    ..We hypothesized that Pima Indians, a population with a high prevalence of abdominal obesity, may have a lower surface area relative to volume, that is, lower radiating area, and therefore a higher body temperature compared to Caucasians...
  32. ncbi request reprint A Ser311Cys mutation in the human dopamine receptor D2 gene is associated with reduced energy expenditure
    P A Tataranni
    Clinical Diabetes and Nutrition Section, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Diabetes 50:901-4. 2001
    ....
  33. ncbi request reprint Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima Indians
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Phoenix, Arizona 85016, USA
    Mol Genet Metab 72:231-8. 2001
    ..c. abd. AS can be attributed to familial factors and that genetic variation in LMNA might not only underlie rare cases of FPLD, but may also contribute to variation in adipocyte size in the general population...
  34. ncbi request reprint Comparison of two software versions for assessment of body-composition analysis by DXA
    B Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 9:229-32. 2001
    ..To compare two software versions provided by Lunar CO: for assessment of body composition analysis by DXA...
  35. ncbi request reprint Effect of fat intake on energy balance
    P A Tataranni
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Ann N Y Acad Sci 819:37-43. 1997
    ..Genetics may influence nutrient partitioning by influencing the activity of key enzymes of intermediate metabolism, such as lipoprotein lipase, beta-hydroxyl acyl CoA dehydrogenase, and acetyl CoA carboxylase...
  36. ncbi request reprint The role of glucose allostasis in type 2 diabetes
    Michael Stumvoll
    Medizinische Klinik der Universität, Otfried Muller Str 10, 72076 Tuebingen, Germany
    Rev Endocr Metab Disord 5:99-103. 2004
  37. ncbi request reprint Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians
    Lijun Ma
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, 4212 N 16th St, Phoenix, AZ 85016, USA
    Diabetes 53:2696-9. 2004
    ..We conclude that variations in MC4R may account for a small portion of obesity in Pima Indians, but they do not explain the overall high prevalence of obesity in this Native American population...
  38. ncbi request reprint Taste preferences and body weight changes in an obesity-prone population
    Arline D Salbe
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Am J Clin Nutr 79:372-8. 2004
    ..Taste preferences for highly palatable foods rich in sugar and fat may underlie the current epidemic of obesity...
  39. ncbi request reprint Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight
    Norbert Stefan
    The Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Metabolism 53:904-11. 2004
    ..We conclude that interaction of multiple defects may contribute to increased susceptibility to type 2 diabetes among individuals with LBW...
  40. ncbi request reprint A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians
    Peter Kovacs
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 53:1915-9. 2004
    ..Our findings indicate that the Val1483Ile substitution in FAS is protective against obesity in Pima Indians, an effect possibly explained by the role of this gene in the regulation of substrate oxidation...
  41. ncbi request reprint Parasympathetic blockade attenuates augmented pancreatic polypeptide but not insulin secretion in Pima Indians
    Barbora Vozarova de Courten
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 53:663-71. 2004
    ..However, the hyperinsulinemia of this population does not appear to be due to increased vagal input to pancreatic beta-cells...
  42. ncbi request reprint Subcutaneous abdominal preadipocyte differentiation in vitro inversely correlates with central obesity
    Paska A Permana
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Am J Physiol Endocrinol Metab 286:E958-62. 2004
    ..The lower differentiation potential of preadipocytes in the obese subjects might be due, at least partly, to decreased glucocorticoid receptor expression...
  43. ncbi request reprint High serum resistin is associated with an increase in adiposity but not a worsening of insulin resistance in Pima Indians
    Barbora Vozarova de Courten
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, NIH DHHS, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Diabetes 53:1279-84. 2004
    ..We unexpectedly found that high serum resistin levels do predict future increases in percent body fat. Our data suggest that resistin promotes obesity but not obesity-associated insulin resistance in humans...
  44. ncbi request reprint Negative relationship between fasting plasma ghrelin concentrations and ad libitum food intake
    Arline D Salbe
    National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Clinical Diabetes and Nutrition Section, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 89:2951-6. 2004
    ..This unexpected finding that low FxGhr predict ad libitum food intake suggests that the role of endogenous ghrelin in the regulation of energy homeostasis remains uncertain...
  45. ncbi request reprint Interaction between an 11betaHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians
    Paul W Franks
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 E Indian School Rd, Phoenix, AZ 85014, USA
    Hypertension 44:681-8. 2004
    ..These data demonstrate association between genetic variability at 11betaHSD1 with hypertension, but these effects are modified by environmental factors...
  46. ncbi request reprint Sensory experience of food and obesity: a positron emission tomography study of the brain regions affected by tasting a liquid meal after a prolonged fast
    Angelo DelParigi
    Clinical Diabetes and Nutrition Section, NIDDK NIH, DHHS, Phoenix, AZ 85016, USA
    Neuroimage 24:436-43. 2005
    ..These results provide a new perspective on the understanding of the neuroanatomical correlates of abnormal eating behavior and their relationship with obesity in humans...
  47. ncbi request reprint Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans
    Yan Guo
    Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Obesity (Silver Spring) 14:1562-70. 2006
    ..To explore the potential role of the endogenous peptide YY (PYY) in the long-term regulation of body weight and energy homeostasis...
  48. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue and prospective changes in body weight and insulin resistance
    Juraj Koska
    Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ 85016, USA
    Obesity (Silver Spring) 14:1515-22. 2006
    ....
  49. ncbi request reprint Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring
    Paul W Franks
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona, USA
    Diabetes 55:460-5. 2006
    ..Thus, prevention of offspring type 2 diabetes may require strategies that focus on improving gestational glucose tolerance even within the normal range...
  50. ncbi request reprint In pursuit of neural risk factors for weight gain in humans
    Angelo DelParigi
    Obesity and Diabetes Clinical Research Section, PECRB, NIDDK, NIH, DHHS, Phoenix, AZ, USA
    Neurobiol Aging 26:50-5. 2005
    ....
  51. ncbi request reprint Habitual physical activity in children: the role of genes and the environment
    Paul W Franks
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014, USA
    Am J Clin Nutr 82:901-8. 2005
    ..Understanding the factors that contribute to physical inactivity in children is important because sedentary behavior strongly relates to metabolic disorders such as obesity and diabetes...
  52. ncbi request reprint Pancreatic polypeptide is involved in the regulation of body weight in pima Indian male subjects
    Juraj Koska
    Clinical Diabetes and Nutrition Section, National Institutes of Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th St, Rm 5 41, Phoenix, AZ 85016, USA
    Diabetes 53:3091-6. 2004
    ..However this contribution appears to be more complex than anticipated because of the opposite effect of fasting and postprandial PP on the risk of future weight gain...
  53. ncbi request reprint Lack of relationship between calcium intake and body size in an obesity-prone population
    Colleen A Venti
    Obesity and Diabetes Clinical Research Section, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ 85016, USA
    J Am Diet Assoc 105:1401-7. 2005
    ..Dietary calcium intake, especially from dairy products, may have a protective effect against obesity. This study aimed to determine if calcium intake is associated with body weight and adiposity in Pima Indians, an obesity-prone population...
  54. ncbi request reprint Are we addicted to food?
    Angelo Del Parigi
    Clinical Diabetes and Nutrition Section, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 11:493-5. 2003
  55. pmc Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men
    Lijun Ma
    Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th St, Phoenix, AZ 85016, USA
    Diabetes 54:1598-602. 2005
    ..001 and P = 0.002, respectively). Our data suggest that the PYY-Y2R pathway may influence body weight through a sex-specific mechanism, but this finding requires confirmation in other populations...
  56. pmc Intrauterine exposure to diabetes is a determinant of hemoglobin A(1)c and systolic blood pressure in pima Indian children
    Joy C Bunt
    Obesity and Clinical Diabetes Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Room 541 A, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 90:3225-9. 2005
    ....
  57. ncbi request reprint High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 51:455-61. 2002
    ..These findings are consistent with the hypothesis that a chronic activation of the immune system may play a role in the pathogenesis of type 2 diabetes...
  58. ncbi request reprint Reduced early insulin secretion in the etiology of type 2 diabetes mellitus in Pima Indians
    Clifton Bogardus
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Phoenix, Arizona, USA
    Diabetes 51:S262-4. 2002
    ..However, the genetic determinants require elucidation: correlation of the acute insulin response with the age of parental diabetes onset in fathers as well as mothers indicates a mechanism independent of the diabetic uterine environment...
  59. ncbi request reprint Plasma adiponectin and endogenous glucose production in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, Department of Health and Human Services, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes Care 26:3315-9. 2003
    ..Whereas associations of plasma adiponectin with muscle insulin sensitivity in humans have been examined, this has not been done for the liver...
  60. ncbi request reprint Glucose allostasis
    Michael Stumvoll
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 52:903-9. 2003
    ..With increasing severity and over time, the allostatic load (increase in glycemia) may have pathological consequences, such as the development of type 2 diabetes...
  61. ncbi request reprint The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Hum Genet 112:409-13. 2003
    ..001). These findings are consistent with a role for genetic determinants of inflammation in the development of T2DM in both Native Americans and Caucasians...
  62. ncbi request reprint Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Am J Physiol Endocrinol Metab 284:E1156-61. 2003
    ..However, in subjects who have progressed to a state of IGT, chronically elevated NEFA seem to have a deleterious effect on insulin-secretory capacity...
  63. ncbi request reprint High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome
    Angelo DelParigi
    Clinical Diabetes and Nutrition Section, National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 87:5461-4. 2002
    ..56). This is the first evidence that ghrelin, a novel orexigenic hormone, is elevated in subjects with PWS. Our finding suggests that ghrelin may be responsible, at least in part, for the hyperphagia observed in PWS...
  64. ncbi request reprint Sex differences in the human brain's response to hunger and satiation
    Angelo Del Parigi
    Clinical Diabetes and Nutrition Section, NIDDK, NIH, Phoenix, AZ 85016, USA
    Am J Clin Nutr 75:1017-22. 2002
    ..Recent neuroimaging studies have provided functional maps of the human cerebral areas activated in response to hunger and satiation...
  65. ncbi request reprint Plasma adiponectin levels are not associated with fat oxidation in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 10:1016-20. 2002
    ..To test the hypothesis that low adiponectin is associated with low fat oxidation in humans...
  66. ncbi request reprint Plasma adiponectin concentrations in children: relationships with obesity and insulinemia
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 87:4652-6. 2002
    ....
  67. ncbi request reprint Low plasma adiponectin concentrations do not predict weight gain in humans
    Barbora Vozarova
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:2964-7. 2002
    ..Therefore, the predictive effect of low plasma adiponectin concentrations on the development of type 2 diabetes seems to be mediated by factors other than increased adiposity...
  68. ncbi request reprint Assessing risk factors for obesity between childhood and adolescence: II. Energy metabolism and physical activity
    Arline D Salbe
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Pediatrics 110:307-14. 2002
    ....
  69. ncbi request reprint Assessing risk factors for obesity between childhood and adolescence: I. Birth weight, childhood adiposity, parental obesity, insulin, and leptin
    Arline D Salbe
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Pediatrics 110:299-306. 2002
    ..To assess the effects of body weight, body composition, parental obesity, and metabolic variables on the development of obesity in a large cohort of 5-year-old Native American children with a high propensity for obesity...
  70. ncbi request reprint Tasting a liquid meal after a prolonged fast is associated with preferential activation of the left hemisphere
    Angelo Del Parigi
    Obesity, Diabetes and Energy Metabolism Unit, Clinical Diabetes and Nutrition Section, NIDDK NIH, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Neuroreport 13:1141-5. 2002
    ..This raises the possibility that the physiological context in which perception takes place (i.e. extreme vs moderate vs no hunger) may importantly affect the brain representation of chemosensory stimuli...
  71. ncbi request reprint Adiponectin and development of type 2 diabetes in the Pima Indian population
    Robert S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA
    Lancet 360:57-8. 2002
    ..01) and individuals with high concentrations of this protein were less likely to develop type 2 diabetes than those with low concentrations (incidence rate ratio 0.63 [95% CI 0.43-0.92]; p=0.02)...
  72. ncbi request reprint High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1889-95. 2002
    ..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes...
  73. ncbi request reprint Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Room 5 41, Phoenix, AZ 85016, USA
    Diabetes 52:1544-50. 2003
    ....
  74. ncbi request reprint Higher prevalence of type 2 diabetes, metabolic syndrome and cardiovascular diseases in gypsies than in non-gypsies in Slovakia
    Barbora Vozarova de Courten
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N, 16th Street, Rm 5 41, Phoenix, AZ 85016, USA
    Diabetes Res Clin Pract 62:95-103. 2003
    ..Our aim was to determine the prevalence of type 2 diabetes mellitus (T2DM), metabolic syndrome and cardiovascular diseases in Gypsies and non-Gypsies living in the same region of southern Slovakia...
  75. ncbi request reprint Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians
    Christian Weyer
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street Rm 5 41, Phoenix, AZ 85016, USA
    Atherosclerosis 161:233-42. 2002
    ..Thus, obesity and insulin resistance appear to be associated with low-grade inflammation and endothelial dysfunction, respectively, even in an obesity- and diabetes-prone population with relatively low propensity for atherosclerosis...
  76. ncbi request reprint Genome-wide linkage analysis of serum adiponectin in the Pima Indian population
    Robert S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
    Diabetes 52:2419-25. 2003
    ..Our data suggest that quantitative trait loci on chromosomes 2, 3, 9, and 10 may influence circulating adiponectin concentrations in the Pima population...
  77. ncbi request reprint Weight, adiposity, and physical activity as determinants of an insulin sensitivity index in pima Indian children
    Joy C Bunt
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona, USA
    Diabetes Care 26:2524-30. 2003
    ..To determine whether measures of physical activity are related to an insulin sensitivity index ([ISI] 10(4)/fasting insulin x glucose) independent of weight or adiposity in children...
  78. ncbi request reprint Cross-sectional and prospective relationships of fasting plasma ghrelin concentrations with anthropometric measures in pima Indian children
    Joy C Bunt
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 88:3756-61. 2003
    ..These data do not support a direct relationship between the fasting plasma ghrelin concentration and subsequent relative changes in height or weight in growing children...
  79. ncbi request reprint Effect of cortisol on muscle sympathetic nerve activity in Pima Indians and Caucasians
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Human Services, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 88:3218-26. 2003
    ..However, an acute release of cortisol is likely to more effectively contain sympathoexcitation during stress in Pima Indians than in Caucasians, which may be an important mechanism of cardioprotection in this Native American population...
  80. ncbi request reprint Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians
    Robert S Lindsay
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 88:2738-44. 2003
    ..Our data support the hypothesis that increased regeneration of cortisol in adipose tissue influences metabolic sequelae of human obesity...
  81. ncbi request reprint Effect of a diabetic environment in utero on predisposition to type 2 diabetes
    Eugene Sobngwi
    Department of Endocrinology and Diabetes, Saint Louis Hospital, Assistance Publique, Hopitaux de Paris, University of Paris VII Medical School, Paris, France
    Lancet 361:1861-5. 2003
    ..Type 2 diabetes is affected by genetics and environmental factors. We aimed to assess the effect of an in-utero diabetic environment independently of the genetic background for type 2 diabetes...
  82. ncbi request reprint Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1884-8. 2002
    ..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans...
  83. ncbi request reprint Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian
    Jonathan Krakoff
    Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
    Diabetes Care 26:1745-51. 2003
    ....
  84. ncbi request reprint UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates
    Xiaolin Yang
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Mol Genet Metab 75:369-73. 2002
    ..38, P=0.02, adjusted for age, sex, fat mass, and fat-free mass) and lipid oxidation rate (adjusted for age, sex, and percent body fat) during a euglycemic clamp with infusion of insulin at a physiologic concentration (r=0.42, P=0.01)...
  85. ncbi request reprint Relation between physical activity and obesity
    Arline D Salbe
    Am J Clin Nutr 78:193-4; author reply 194-5. 2003
  86. ncbi request reprint Microarray gene expression profiling in obesity and insulin resistance
    Paska A Permana
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Nutrition 20:134-8. 2004
  87. ncbi request reprint Neuroimaging and obesity: mapping the brain responses to hunger and satiation in humans using positron emission tomography
    Angelo Del Parigi
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Ann N Y Acad Sci 967:389-97. 2002
    ..PET studies might help to unravel the neuropathophysiology underlying human obesity...