Toshiko Tanaka

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A genome-wide association analysis of serum iron concentrations
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    Blood 115:94-6. 2010
  2. pmc Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function
    Lisette Arnaud-Lopez
    Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
    Am J Hum Genet 82:1270-80. 2008
  3. pmc Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
    Toshiko Tanaka
    Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21225, USA
    Am J Clin Nutr 97:1395-402. 2013
  4. pmc Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data
    Li Ma
    Department of Animal Science, University of Minnesota, USA
    BMC Med Genet 11:55. 2010
  5. pmc Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    PLoS Genet 5:e1000338. 2009
  6. pmc Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD 21250, USA
    Am J Hum Genet 84:477-82. 2009
  7. pmc Caffeine and alcohol intakes and overall nutrient adequacy are associated with longitudinal cognitive performance among U.S. adults
    May A Beydoun
    Intramural Research Program NIA NIH IRP, National Institute on Aging, Baltimore, MD
    J Nutr 144:890-901. 2014
  8. pmc Genome-wide association scan of trait depression
    Antonio Terracciano
    National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Biol Psychiatry 68:811-7. 2010
  9. pmc Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples
    Antonio Terracciano
    National Institute on Aging, NIH, DHHS, Baltimore, Maryland 21224, USA
    Am J Med Genet B Neuropsychiatr Genet 150:1070-7. 2009
  10. pmc A higher adherence to a Mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women
    Sameera A Talegawkar
    Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Nutr 142:2161-6. 2012

Detail Information

Publications26

  1. pmc A genome-wide association analysis of serum iron concentrations
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    Blood 115:94-6. 2010
    ..Our results confirm the association of TMPRSS6 variants with iron level and provide further evidence of association with other anemia-related phenotypes...
  2. pmc Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function
    Lisette Arnaud-Lopez
    Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
    Am J Hum Genet 82:1270-80. 2008
    ..This would affect production of T4 and T3 and feedback to alter TSH release by the pituitary. PDE8B may thus provide a candidate target for the treatment of thyroid dysfunction...
  3. pmc Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
    Toshiko Tanaka
    Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21225, USA
    Am J Clin Nutr 97:1395-402. 2013
    ..Macronutrient intake varies substantially between individuals, and there is evidence that this variation is partly accounted for by genetic variants...
  4. pmc Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data
    Li Ma
    Department of Animal Science, University of Minnesota, USA
    BMC Med Genet 11:55. 2010
    ..Here, we report single-locus and epistasis SNP effects on TC and HDL-C using the Framingham Heart Study (FHS) data...
  5. pmc Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    PLoS Genet 5:e1000338. 2009
    ..The ELOVL2 SNP was associated with docosapentanoic and DHA but not with EPA in GOLDN. These findings show that polymorphisms of genes encoding enzymes in the metabolism of PUFA contribute to plasma concentrations of fatty acids...
  6. pmc Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD 21250, USA
    Am J Hum Genet 84:477-82. 2009
    ..The ALPL gene likely influences the catabolism of vitamin B6 while FUT2 interferes with absorption of vitamin B12. These findings highlight mechanisms that affect vitamin B6, vitamin B12 and homocysteine serum levels...
  7. pmc Caffeine and alcohol intakes and overall nutrient adequacy are associated with longitudinal cognitive performance among U.S. adults
    May A Beydoun
    Intramural Research Program NIA NIH IRP, National Institute on Aging, Baltimore, MD
    J Nutr 144:890-901. 2014
    ..Further longitudinal studies conducted on larger samples of adults are needed to determine whether dietary factors individually or in combination are modifiers of cognitive trajectories among adults. ..
  8. pmc Genome-wide association scan of trait depression
    Antonio Terracciano
    National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Biol Psychiatry 68:811-7. 2010
    ..Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders...
  9. pmc Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples
    Antonio Terracciano
    National Institute on Aging, NIH, DHHS, Baltimore, Maryland 21224, USA
    Am J Med Genet B Neuropsychiatr Genet 150:1070-7. 2009
    ..Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5-HTT variants and Neuroticism-related traits...
  10. pmc A higher adherence to a Mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women
    Sameera A Talegawkar
    Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Nutr 142:2161-6. 2012
    ..48 (95% CI: 0.27, 0.86)] but not with feelings of exhaustion and poor muscle strength. In community-dwelling older adults, higher adherence to a Mediterranean-style diet was inversely associated with the development of frailty...
  11. pmc Mediterranean diet and mobility decline in older persons
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
    Exp Gerontol 46:303-8. 2011
    ..High adherence to a Mediterranean-style diet is associated with a slower decline of mobility over time in community-dwelling older persons. If replicated, this observation is highly relevant in terms of public health...
  12. pmc Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging
    Francesco Giallauria
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, 3001 South Hanover Street, Baltimore, Maryland 21225, USA
    J Clin Endocrinol Metab 97:3717-23. 2012
    ..The importance of vitamin D for bone health has long been acknowledged. Recent evidence suggests that vitamin D can also play a role in reducing the risk of several other diseases, including cardiovascular disease...
  13. pmc COL4A1 is associated with arterial stiffness by genome-wide association scan
    Kirill V Tarasov
    Laboratory of Cardiovascular Science, Laboratory of Genetics, Clinical Research Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Circ Cardiovasc Genet 2:151-8. 2009
    ..Heritability and linkage studies have pointed toward a genetic component affecting PWV. We conducted a genome-wide association study to identify single-nucleotide polymorphisms (SNPs) associated with PWV...
  14. pmc Alzheimer's disease risk genes and the age-at-onset phenotype
    Madhav Thambisetty
    Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 34:2696.e1-5. 2013
    ..None of the other AD risk genes influenced AAO of AD. Our results suggest that besides APOE, other genes associated with AD risk do not exert large effects on the AAO phenotype of AD...
  15. pmc Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
    Santhi K Ganesh
    National Human Genome Research Institute, Division of Intramural Research, Bethesda, MD, USA
    Nat Genet 41:1191-8. 2009
    ..This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures...
  16. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    ..These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney...
  17. pmc Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, United States of America
    Am J Hum Genet 84:123-33. 2009
    ..002). Our findings might shed light on the controversial relationship between lipid-soluble anti-oxidant nutrients and human health...
  18. pmc A network-based approach to prioritize results from genome-wide association studies
    Nirmala Akula
    Mood and Anxiety Section, Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 6:e24220. 2011
    ..NIMMI is a simple, user-friendly, open-source software tool that efficiently combines genetic association data with biological networks, translating GWAS findings into biological hypotheses...
  19. pmc Multiple loci are associated with white blood cell phenotypes
    Michael A Nalls
    Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 7:e1002113. 2011
    ....
  20. pmc GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease
    Yun Liu
    Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 94:485-95. 2014
    ..This type of correlated methylation structure has implications for both biological functions of DNA methylation and for the design, analysis, and interpretation of epigenome-wide association studies. ..
  21. pmc SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits
    Osorio D Meirelles
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Eur J Hum Genet 21:673-9. 2013
    ..It can also be applied in the optimization of experimental designs or usage of measuring devices. SHAVE is fast and easy to run, written in R and freely available online...
  22. pmc Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults
    May A Beydoun
    National Institute on Aging, Intramural Research Program, NIH, Baltimore, MD, USA
    Am J Clin Nutr 95:163-78. 2012
    ..Vitamin D receptor (VDR) and the megalin gene polymorphism's link with longitudinal cognitive change remains unclear...
  23. pmc Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD
    Nadia N Hansel
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hum Genet 132:79-90. 2013
    ..Genes within these regions were expressed in relevant lung cells and their expression related to airflow limitation suggesting they may represent novel candidate genes for COPD susceptibility...
  24. pmc Nutritional determinants of mobility
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
    Curr Opin Clin Nutr Metab Care 13:625-9. 2010
    ..This review summarizes the recent literature showing the associations between different nutrients and mobility-related outcomes in older adults...
  25. pmc BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism
    Antonio Terracciano
    National Institute on Aging, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 35:1083-9. 2010
    ..Our findings support the association between the BDNF Met variant and introversion and suggest that BDNF interacts with the serotonin transporter gene to influence neuroticism...
  26. doi request reprint Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:101-4; discussion 105. 2009
    ..Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels...