Toshiko Tanaka

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function
    Lisette Arnaud-Lopez
    Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
    Am J Hum Genet 82:1270-80. 2008
  2. ncbi A genome-wide association analysis of serum iron concentrations
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    Blood 115:94-6. 2010
  3. ncbi Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data
    Li Ma
    Department of Animal Science, University of Minnesota, USA
    BMC Med Genet 11:55. 2010
  4. ncbi Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    PLoS Genet 5:e1000338. 2009
  5. ncbi Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD 21250, USA
    Am J Hum Genet 84:477-82. 2009
  6. ncbi Genome-wide association scan of trait depression
    Antonio Terracciano
    National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Biol Psychiatry 68:811-7. 2010
  7. ncbi Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples
    Antonio Terracciano
    National Institute on Aging, NIH, DHHS, Baltimore, Maryland 21224, USA
    Am J Med Genet B Neuropsychiatr Genet 150:1070-7. 2009
  8. ncbi Mediterranean diet and mobility decline in older persons
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
    Exp Gerontol 46:303-8. 2011
  9. ncbi Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging
    Francesco Giallauria
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, 3001 South Hanover Street, Baltimore, Maryland 21225, USA
    J Clin Endocrinol Metab 97:3717-23. 2012
  10. ncbi COL4A1 is associated with arterial stiffness by genome-wide association scan
    Kirill V Tarasov
    Laboratory of Cardiovascular Science, Laboratory of Genetics, Clinical Research Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Circ Cardiovasc Genet 2:151-8. 2009

Detail Information

Publications19

  1. ncbi Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function
    Lisette Arnaud-Lopez
    Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
    Am J Hum Genet 82:1270-80. 2008
    ..This would affect production of T4 and T3 and feedback to alter TSH release by the pituitary. PDE8B may thus provide a candidate target for the treatment of thyroid dysfunction...
  2. ncbi A genome-wide association analysis of serum iron concentrations
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    Blood 115:94-6. 2010
    ..Our results confirm the association of TMPRSS6 variants with iron level and provide further evidence of association with other anemia-related phenotypes...
  3. ncbi Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data
    Li Ma
    Department of Animal Science, University of Minnesota, USA
    BMC Med Genet 11:55. 2010
    ..Here, we report single-locus and epistasis SNP effects on TC and HDL-C using the Framingham Heart Study (FHS) data...
  4. ncbi Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    PLoS Genet 5:e1000338. 2009
    ..The ELOVL2 SNP was associated with docosapentanoic and DHA but not with EPA in GOLDN. These findings show that polymorphisms of genes encoding enzymes in the metabolism of PUFA contribute to plasma concentrations of fatty acids...
  5. ncbi Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD 21250, USA
    Am J Hum Genet 84:477-82. 2009
    ..The ALPL gene likely influences the catabolism of vitamin B6 while FUT2 interferes with absorption of vitamin B12. These findings highlight mechanisms that affect vitamin B6, vitamin B12 and homocysteine serum levels...
  6. ncbi Genome-wide association scan of trait depression
    Antonio Terracciano
    National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Biol Psychiatry 68:811-7. 2010
    ..Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders...
  7. ncbi Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples
    Antonio Terracciano
    National Institute on Aging, NIH, DHHS, Baltimore, Maryland 21224, USA
    Am J Med Genet B Neuropsychiatr Genet 150:1070-7. 2009
    ..Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5-HTT variants and Neuroticism-related traits...
  8. ncbi Mediterranean diet and mobility decline in older persons
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
    Exp Gerontol 46:303-8. 2011
    ..High adherence to a Mediterranean-style diet is associated with a slower decline of mobility over time in community-dwelling older persons. If replicated, this observation is highly relevant in terms of public health...
  9. ncbi Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging
    Francesco Giallauria
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, 3001 South Hanover Street, Baltimore, Maryland 21225, USA
    J Clin Endocrinol Metab 97:3717-23. 2012
    ..The importance of vitamin D for bone health has long been acknowledged. Recent evidence suggests that vitamin D can also play a role in reducing the risk of several other diseases, including cardiovascular disease...
  10. ncbi COL4A1 is associated with arterial stiffness by genome-wide association scan
    Kirill V Tarasov
    Laboratory of Cardiovascular Science, Laboratory of Genetics, Clinical Research Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Circ Cardiovasc Genet 2:151-8. 2009
    ..Heritability and linkage studies have pointed toward a genetic component affecting PWV. We conducted a genome-wide association study to identify single-nucleotide polymorphisms (SNPs) associated with PWV...
  11. ncbi New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    ..These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney...
  12. ncbi A network-based approach to prioritize results from genome-wide association studies
    Nirmala Akula
    Mood and Anxiety Section, Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 6:e24220. 2011
    ..NIMMI is a simple, user-friendly, open-source software tool that efficiently combines genetic association data with biological networks, translating GWAS findings into biological hypotheses...
  13. ncbi Multiple loci are associated with white blood cell phenotypes
    Michael A Nalls
    Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 7:e1002113. 2011
    ....
  14. ncbi Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, United States of America
    Am J Hum Genet 84:123-33. 2009
    ..002). Our findings might shed light on the controversial relationship between lipid-soluble anti-oxidant nutrients and human health...
  15. ncbi Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults
    May A Beydoun
    National Institute on Aging, Intramural Research Program, NIH, Baltimore, MD, USA
    Am J Clin Nutr 95:163-78. 2012
    ..Vitamin D receptor (VDR) and the megalin gene polymorphism's link with longitudinal cognitive change remains unclear...
  16. ncbi Nutritional determinants of mobility
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
    Curr Opin Clin Nutr Metab Care 13:625-9. 2010
    ..This review summarizes the recent literature showing the associations between different nutrients and mobility-related outcomes in older adults...
  17. ncbi BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism
    Antonio Terracciano
    National Institute on Aging, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 35:1083-9. 2010
    ..Our findings support the association between the BDNF Met variant and introversion and suggest that BDNF interacts with the serotonin transporter gene to influence neuroticism...
  18. ncbi Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
    Santhi K Ganesh
    National Human Genome Research Institute, Division of Intramural Research, Bethesda, MD, USA
    Nat Genet 41:1191-8. 2009
    ..This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures...
  19. ncbi Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:101-4; discussion 105. 2009
    ..Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels...