M Tachibana

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Evidence to suggest that expression of MITF induces melanocyte differentiation and haploinsufficiency of MITF causes Waardenburg syndrome type 2A
    M Tachibana
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
    Pigment Cell Res 10:25-33. 1997
  2. ncbi request reprint Assignment of the gene for a ubiquitin-conjugating enzyme (UBE2I) to human chromosome band 16p13.3 by in situ hybridization
    M Tachibana
    Laboratory of Molecular Genetics, National Institute of Deafness and Other Communications Disorders, NIH, Rockville, MD 20850, USA
    Cytogenet Cell Genet 75:222-3. 1996
  3. ncbi request reprint Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics
    M Tachibana
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland 20850, USA
    Nat Genet 14:50-4. 1996
  4. ncbi request reprint Epistatic relationship between Waardenburg syndrome genes MITF and PAX3
    A Watanabe
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland 20850, USA
    Nat Genet 18:283-6. 1998
  5. ncbi request reprint Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters
    T Udono
    Department of Molecular Biology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    Biochim Biophys Acta 1491:205-19. 2000
  6. ncbi request reprint Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p12.3
    M Tachibana
    Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892
    Hum Mol Genet 3:553-7. 1994
  7. ncbi request reprint Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus
    N Fuse
    Department of Molecular Biology and Applied Physiology Saitama Cancer Center, Saitama 362 080, Japan
    J Biochem 126:1043-51. 1999
  8. ncbi request reprint Genomic organization and chromosomal mapping of the basic helix-loop-helix factor OUT (Tcf23/TCF23)
    M Tachibana
    Department of Cell Biology, Institute for Virus Research, Kyoto University, Kyoto, Japan
    Cytogenet Cell Genet 94:23-5. 2001
  9. ncbi request reprint A second p53-related protein, p73L, with high homology to p73
    M Senoo
    Department of Molecular Oncology, Nippon Roche Research Center, Kanagawa, Japan
    Biochem Biophys Res Commun 248:603-7. 1998
  10. ncbi request reprint Cochlear melanocytes and MITF signaling
    M Tachibana
    Saitama Cancer Center, Research Institute, Japan
    J Investig Dermatol Symp Proc 6:95-8. 2001

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Evidence to suggest that expression of MITF induces melanocyte differentiation and haploinsufficiency of MITF causes Waardenburg syndrome type 2A
    M Tachibana
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
    Pigment Cell Res 10:25-33. 1997
    ....
  2. ncbi request reprint Assignment of the gene for a ubiquitin-conjugating enzyme (UBE2I) to human chromosome band 16p13.3 by in situ hybridization
    M Tachibana
    Laboratory of Molecular Genetics, National Institute of Deafness and Other Communications Disorders, NIH, Rockville, MD 20850, USA
    Cytogenet Cell Genet 75:222-3. 1996
  3. ncbi request reprint Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics
    M Tachibana
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland 20850, USA
    Nat Genet 14:50-4. 1996
    ..Our findings indicate that MITF is critically involved in melanocyte differentiation...
  4. ncbi request reprint Epistatic relationship between Waardenburg syndrome genes MITF and PAX3
    A Watanabe
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland 20850, USA
    Nat Genet 18:283-6. 1998
    ..These results provide evidence that PAX3 directly regulates MITF and suggest that the failure of this regulation due to PAX3 mutations causes the auditory-pigmentary symptoms in at least some individuals with WS1...
  5. ncbi request reprint Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters
    T Udono
    Department of Molecular Biology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    Biochim Biophys Acta 1491:205-19. 2000
    ..Therefore, alternative promoters provide the MITF gene with the diversity in transcriptional regulation and the capability of generating structurally different protein isoforms...
  6. ncbi request reprint Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p12.3
    M Tachibana
    Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892
    Hum Mol Genet 3:553-7. 1994
    ..These studies will help to verify if any of the hereditary pigment disturbances in humans are due to mutations in this gene...
  7. ncbi request reprint Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus
    N Fuse
    Department of Molecular Biology and Applied Physiology Saitama Cancer Center, Saitama 362 080, Japan
    J Biochem 126:1043-51. 1999
    ..Therefore, isoform multiplicity provides MITF with differential expression patterns as well as functional diversity...
  8. ncbi request reprint Genomic organization and chromosomal mapping of the basic helix-loop-helix factor OUT (Tcf23/TCF23)
    M Tachibana
    Department of Cell Biology, Institute for Virus Research, Kyoto University, Kyoto, Japan
    Cytogenet Cell Genet 94:23-5. 2001
    ..By in silico searching, we further found the human counterpart of the mouse OUT gene (TCF23) in the draft human genome sequence and assigned it to 2p24-->p23...
  9. ncbi request reprint A second p53-related protein, p73L, with high homology to p73
    M Senoo
    Department of Molecular Oncology, Nippon Roche Research Center, Kanagawa, Japan
    Biochem Biophys Res Commun 248:603-7. 1998
    ..6%) and to p73 (87.8%). Northern blot analysis, which demonstrated that the expression profiles of p73L and p73 mRNAs are distinct in some tissues, implies that p73 and p73L may have separate, distinct roles in different tissues...
  10. ncbi request reprint Cochlear melanocytes and MITF signaling
    M Tachibana
    Saitama Cancer Center, Research Institute, Japan
    J Investig Dermatol Symp Proc 6:95-8. 2001
    ..If not all, certainly many roads lead to MITF in melanocytes...
  11. ncbi request reprint Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance
    K Takeda
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Hum Mol Genet 9:125-32. 2000
    ..These findings suggest that the Ser298 is important for MITF function and is phosphorylated probably by GSK3beta...
  12. ncbi request reprint Characterization of density-dependent regulation of the tyrosinase gene promoter: role of protein kinase C
    H Mahalingam
    Department of Biochemistry and Molecular Biology, Marshall University School of Medicine, Huntington, West Virginia 25755, USA
    Exp Cell Res 237:83-92. 1997
    ..These results suggest that chronic PDBu treatment might inhibit tyrosinase expression (and subsequent melanogenesis) by affecting the amount or function of MITF...
  13. ncbi request reprint Linkage among esterase-6 (Es-6), neural cell adhesion molecule (NCAM), and apolipoprotein C-III (apoc-3) genes on rat chromosome 8
    E Kobayashi
    Imamichi Institute for Animal Reproduction, Ibaraki, Japan
    Mamm Genome 3:656-8. 1992
  14. ncbi request reprint Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets
    D Chen
    Section on Human Biochemical Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochem Mol Med 60:27-37. 1997
    ....
  15. ncbi request reprint Localization of a Moloney murine leukemia virus integration site gene, Mlvi2, on rat chromosome 2
    T Kunieda
    Imamichi Institute for Animal Reproduction, Fukaya, Japan
    Mamm Genome 7:924-5. 1996
  16. ncbi request reprint Localization of a Na+,K(+)-ATPase alpha 2 subunit gene, Atp1a2, on rat chromosome 13
    E Kobayashi
    Imamichi Institute for Animal Reproduction, Fukaya, Japan
    Mamm Genome 6:889. 1995
  17. pmc Analyses of loss-of-function mutations of the MITF gene suggest that haploinsufficiency is a cause of Waardenburg syndrome type 2A
    Y Nobukuni
    Clinical Neurogenetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
    Am J Hum Genet 59:76-83. 1996
    ....
  18. ncbi request reprint A genetic linkage map of rat chromosome 5 reveals extensive linkage conservation with mouse chromosome 4
    E Kobayashi
    Imamichi Institute for Animal Reproduction, Fukaya, Japan
    Mamm Genome 5:222-4. 1994
    ..The linkage map indicates an extensive linkage conservation between the loci on rat Chr 5 and those on mouse Chr 4...
  19. ncbi request reprint Localization of the interleukin-3 gene to rat chromosome 10 by linkage analyses with a variable number of tandem repeats (VNTR)
    T Kunieda
    Imamichi Institute for Animal Reproduction, Ibaraki, Japan
    Mamm Genome 3:464-6. 1992
  20. ncbi request reprint Four strains of spontaneously hyperlipidemic (SHL) mice: phenotypic distinctions determined by genetic backgrounds
    Y Matsushima
    Research Institute, Saitama Cancer Center, Ina, Japan
    J Atheroscler Thromb 8:71-9. 2001
    ..This polymorphism may be related to the most severe atherosclerosis observed in B6.KOR-Apoe(shl). It is most likely that combination of such polymorphisms is due to the genetic background accountable for phenotype distinctions...