Stanley J Szefler

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi Current concepts in asthma treatment in children
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Pediatr 16:299-304. 2004
  2. ncbi Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing
    Leonard B Bacharier
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1127-1135.e8. 2008
  3. ncbi Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children
    Ronina A Covar
    Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 122:741-747.e4. 2008
  4. ncbi Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma
    Robert S Zeiger
    Department of Pediatrics, University of California San Diego, San Diego, CA 92111, USA
    J Allergy Clin Immunol 117:45-52. 2006
  5. ncbi Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study
    Robert C Strunk
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1138-1144.e4. 2008
  6. ncbi Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezing
    Katherine Rivera-Spoljaric
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1077, USA
    J Pediatr 154:877-81.e4. 2009
  7. ncbi Characterization of within-subject responses to fluticasone and montelukast in childhood asthma
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:233-42. 2005
  8. ncbi Safety and application of induced sputum analysis in childhood asthma
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 114:575-82. 2004
  9. ncbi Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 126:545-51.e1-4. 2010
  10. ncbi Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma
    Gary L Larsen
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:861-7.e1. 2009

Detail Information

Publications90

  1. ncbi Current concepts in asthma treatment in children
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Pediatr 16:299-304. 2004
    ..The purpose of this review is to present current literature related to the management of childhood asthma...
  2. ncbi Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing
    Leonard B Bacharier
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1127-1135.e8. 2008
    ..Acute wheezing illnesses in preschoolers require better management strategies to reduce morbidity...
  3. ncbi Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children
    Ronina A Covar
    Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 122:741-747.e4. 2008
    ..Asthma exacerbations are a common cause of critical illness in children...
  4. ncbi Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma
    Robert S Zeiger
    Department of Pediatrics, University of California San Diego, San Diego, CA 92111, USA
    J Allergy Clin Immunol 117:45-52. 2006
    ..Outcome data are needed to base recommendations for controller asthma medication use in school-aged children...
  5. ncbi Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study
    Robert C Strunk
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1138-1144.e4. 2008
    ..Clinical trials in children with moderate-to-severe persistent asthma are limited...
  6. ncbi Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezing
    Katherine Rivera-Spoljaric
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1077, USA
    J Pediatr 154:877-81.e4. 2009
    ..To examine parent-reported signs and symptoms as antecedents of wheezing in preschool children with previous moderate to severe wheezing episodes, and to determine the predictive capacity of these symptom patterns for wheezing events...
  7. ncbi Characterization of within-subject responses to fluticasone and montelukast in childhood asthma
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:233-42. 2005
    ..Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients...
  8. ncbi Safety and application of induced sputum analysis in childhood asthma
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 114:575-82. 2004
    ..The Childhood Asthma Management Program (CAMP) study was designed to evaluate the long-term effects of budesonide and nedocromil compared with placebo in children with mild to moderate asthma across 8 centers...
  9. ncbi Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 126:545-51.e1-4. 2010
    ..A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses...
  10. ncbi Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma
    Gary L Larsen
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:861-7.e1. 2009
    ..Determination of the benefits and limitations of specific physiologic tests has not been well studied in long-term clinical pediatric trials...
  11. ncbi Asthma outcomes: biomarkers
    Stanley J Szefler
    National Jewish Health, Denver, Colorado, USA
    J Allergy Clin Immunol 129:S9-23. 2012
    ..Measurement of biomarkers has been incorporated within clinical research studies of asthma to characterize the population and associate the disease with environmental and therapeutic effects...
  12. ncbi Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone
    Theresa W Guilbert
    Department of Pediatrics, University of Wisconsin Madison, Wis 53716, USA
    J Allergy Clin Immunol 128:956-63.e1-7. 2011
    ..The effect on linear growth of daily long-term inhaled corticosteroid therapy in preschool-aged children with recurrent wheezing is controversial...
  13. ncbi Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids
    Monica Kraft
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 124:42-50. 2003
    ..To determine if persistent airway tissue mast cells are associated with treatment failure when patients discontinue inhaled corticosteroids (ICS)...
  14. ncbi Most nocturnal asthma symptoms occur outside of exacerbations and associate with morbidity
    Caroline C Horner
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 128:977-82.e1-2. 2011
    ..Although nocturnal awakenings help categorize asthma severity and control, their clinical significance has not been thoroughly studied...
  15. ncbi Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents
    Robert C Strunk
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    J Pediatr 154:682-7. 2009
    ..To determine whether long-term, continuous use of inhaled anti-inflammatory medications affects asthma outcomes in children with mild to moderate asthma after use is discontinued...
  16. ncbi The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial
    Richard J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:73-80. 2007
    ..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids...
  17. ncbi Progression of asthma measured by lung function in the childhood asthma management program
    Ronina A Covar
    Ira J. and Jacqueline Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 170:234-41. 2004
    ..The course and mechanisms of lung function reduction or slow lung growth velocity in children with asthma must be defined...
  18. ncbi Systemic effect comparisons of six inhaled corticosteroid preparations
    Richard J Martin
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 165:1377-83. 2002
    ..This study represents the first step in evaluation of ICS efficacy based on equisystemic (cortisol suppression) effects of a given ICS, rather than doses judged arbitrarily to be comparable on a microgram basis...
  19. ncbi Patient characteristics associated with improved outcomes with use of an inhaled corticosteroid in preschool children at risk for asthma
    Leonard B Bacharier
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63017, USA
    J Allergy Clin Immunol 123:1077-82, 1082.e1-5. 2009
    ..However, determination of baseline features associated with ICS responsiveness may identify children most likely to benefit from ICS treatment...
  20. ncbi Effect of montelukast on peripheral airflow obstruction in children with asthma
    Joseph D Spahn
    Division of Clinical Pharmacology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver 80206, USA
    Ann Allergy Asthma Immunol 96:541-9. 2006
    ..Montelukast is a widely used controller agent in childhood asthma. It is modestly effective in reducing symptoms, decreasing the need for rescue albuterol, and improving forced expiratory volume in 1 second (FEV1)...
  21. ncbi Predictors of remitting, periodic, and persistent childhood asthma
    Ronina A Covar
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:359-366.e3. 2010
    ..The course of mild to moderate persistent asthma in children is not clearly established...
  22. ncbi Key observations from the NHLBI Asthma Clinical Research Network
    Stanley J Szefler
    Department of Pediatrics, National Jewish Health and University of Colorado Denver, School of Medicine, Denver, Colorado 80206, USA
    Thorax 67:450-5. 2012
    ..This review highlights the major research observations from the ACRN that have impacted the current management of asthma...
  23. ncbi Minimizing attrition in a long-term clinical trial of pediatric asthma
    Bruce G Bender
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Ann Allergy Asthma Immunol 91:168-76. 2003
    ..Despite increased attention focused on the need to prevent patient attrition in long-term clinical trials, high dropout rates have threatened the success of numerous studies...
  24. ncbi Mild to moderate asthma affects lung growth in children and adolescents
    Robert C Strunk
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Allergy Clin Immunol 118:1040-7. 2006
    ..The effect of childhood asthma on lung growth is unclear...
  25. ncbi Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial
    Stanley J Szefler
    National Jewish Health, Denver, CO, USA
    Lancet 372:1065-72. 2008
    ....
  26. ncbi Comparative study of budesonide inhalation suspension and montelukast in young children with mild persistent asthma
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology and Allergy Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 120:1043-50. 2007
    ..Budesonide inhalation suspension and the leukotriene receptor antagonist montelukast have demonstrated efficacy in children with mild persistent asthma, but comparative long-term studies in young children are needed...
  27. ncbi Progression of asthma in childhood
    Ronina A Covar
    Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:700-7. 2005
    ..Additional efforts are necessary to understand the mechanisms involved in this phenomenon and to discover specific modalities of treatment to target the structural changes of airway remodeling...
  28. ncbi A trial of clarithromycin for the treatment of suboptimally controlled asthma
    E Rand Sutherland
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 126:747-53. 2010
    ..PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma...
  29. ncbi Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology and the Division of Allergy Clinical Immunology, Department of Pediatrics, Denver, Colorado, USA
    J Pediatr 142:469-75. 2003
    ..Exhaled nitric oxide (FE(NO)) was evaluated in children with asthma after 4 to 6 years of treatment with budesonide, nedocromil, or albuterol as needed...
  30. ncbi Fluticasone propionate plasma concentration and systemic effect: effect of delivery device and duration of administration
    Glenn J Whelan
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 116:525-30. 2005
    ..Dry powder inhalers (DPIs) generate a larger particle size compared with metered-dose inhalers (MDIs), which affects pulmonary deposition, bioavailability, and subsequent systemic effects of fluticasone propionate (fluticasone)...
  31. ncbi A comparison of the clinical characteristics of children and adults with severe asthma
    Henry A Jenkins
    Division of Clinical Pharmacology, The Ira J. and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, National Jewish Medical and Research Center and, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Chest 124:1318-24. 2003
    ..Finally, disease severity in children and adults whose onset of asthma occurred in childhood was related to disease duration, but not in patients with onset of asthma in adulthood...
  32. ncbi Switching from conventional to extrafine aerosol beclomethasone dipropionate therapy in children: a 6-month, open- label, randomized trial
    Stanley J Szefler
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 110:45-50. 2002
    ..CONCLUSIONS: This study confirms that asthma control can be well maintained in children when switching from CFC-BDP+S to an HFA-BDP Autohaler at doses as low as 100 to 200 microg/d...
  33. ncbi Correlates of household smoking bans in low-income families of children with and without asthma
    Frederick S Wamboldt
    Division of Psychosocial Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Fam Process 47:81-94. 2008
    ..Even in disadvantaged families, mutable factors were associated with strict smoking bans. Increased dissemination and use of established public health strategies are needed to reduce children's SHS exposures...
  34. ncbi Achieving asthma control in the inner city: do the National Institutes of Health Asthma Guidelines really work?
    Stanley J Szefler
    Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado Denver School of Medicine, Denver, Colo, USA
    J Allergy Clin Immunol 125:521-6; quiz 527-8. 2010
    ..Based on the observations from the Asthma Control Evaluation study, we were impressed that a systematic guidelines-based approach improved asthma control significantly over the course of the 1-year treatment period...
  35. ncbi Steroid therapy for asthma in children
    Joseph D Spahn
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Opin Pediatr 19:300-5. 2007
    ..To highlight studies that have contributed significantly to our current knowledge of inhaled glucocorticoids in childhood asthma...
  36. ncbi The Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by the US Food and Drug Administration for monitoring therapy in asthma
    Philip E Silkoff
    National Jewish Medical and Research Center, Denver, Colorado, USA
    J Allergy Clin Immunol 114:1241-56. 2004
    ....
  37. ncbi The need for pediatric studies of allergy and asthma medications
    Stanley J Szefler
    National Jewish Medical and Research Center, 1400 Jackson Street, Room J304, Denver, CO 80206, USA
    Curr Allergy Asthma Rep 3:478-83. 2003
    ..In this review, we discuss the background for this effort and the continuing impact it will have on the future management of allergy and asthma in children...
  38. ncbi Safety profile of budesonide inhalation suspension in the pediatric population: worldwide experience
    Stanley J Szefler
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Ann Allergy Asthma Immunol 93:83-90. 2004
    ..To review the worldwide safety data for budesonide inhalation suspension (Pulmicort Respules) to provide a budesonide inhalation suspension pediatric tolerability profile...
  39. ncbi Histopathology of severe childhood asthma: a case series
    Henry A Jenkins
    Ira J. and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, Division of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, CO, USA
    Chest 124:32-41. 2003
    ..These findings suggest the need to look beyond inflammation to fully treat severe asthma and ultimately alter its progression...
  40. ncbi Economic burden of impairment in children with severe or difficult-to-treat asthma
    Stanley J Szefler
    National Jewish Health, Denver, Colorado, USA
    Ann Allergy Asthma Immunol 107:110-119.e1. 2011
    ..The cost associated with asthma impairment in children with severe asthma has not been determined...
  41. ncbi Pediatric asthma: an approach to pharmacogenetics analysis
    Stanley J Szefler
    Divisions of Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:434S-8S. 2003
  42. ncbi Advances in pediatric asthma in 2008: where do we go now?
    Stanley J Szefler
    Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:28-34. 2009
    ..A major step forward will be finding ways to implement the asthma guidelines...
  43. ncbi Advances in pediatric asthma in 2011: moving forward
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 129:60-8. 2012
    ....
  44. ncbi Lessons learned from variation in response to therapy in clinical trials
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:285-92; quiz 293-4. 2010
    ..This information now assists the clinician in personalizing asthma treatment at the time of initiating long-term control therapy...
  45. ncbi Managing severe asthma
    Sally Wenzel
    Division of Pulmonary Medicine, National Jewish Medical and Research Center, and the Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:508-11. 2006
  46. ncbi Medications as asthma triggers
    Ronina A Covar
    Department of Pediatrics, Division of Allergy Clinical Immunology, National Jewish Medical and Research Center, 1400 Jackson Street A303, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 25:169-90. 2005
    ..Fortunately, controller therapy for asthma and alternative or more selective medications for the treatment of these conditions are now available...
  47. ncbi Advances in pediatric and adult asthma
    Stanley J Szefler
    Division of Clinical Pharmacology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colo 80206, USA
    J Allergy Clin Immunol 115:470-7. 2005
    ..Asthma management is likely to change in the coming years from a strategy directed to the best outcome in groups of patients to an individualized approach to assessment and management...
  48. ncbi Significant variability in response to inhaled corticosteroids for persistent asthma
    Stanley J Szefler
    National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
    J Allergy Clin Immunol 109:410-8. 2002
    ..It is possible that higher doses of ICSs are necessary to manage more severe patients or to achieve goals of therapy not evaluated in this study, such as prevention of asthma exacerbations...
  49. ncbi Nocturnal awakening caused by asthma in children with mild-to-moderate asthma in the childhood asthma management program
    Robert C Strunk
    Department of Pediatrics, Washington University School of Medicine, Division of Allergy and Pulmonary Medicine, St Louis Children's Hospital, MO 63110, USA
    J Allergy Clin Immunol 110:395-403. 2002
    ..01). CONCLUSIONS: Nocturnal awakening occurred in one third of the children with mild-to-moderate asthma during a month of relative stability and appears to be an indicator of asthma that is becoming increasingly severe...
  50. ncbi Advances in childhood asthma: hygiene hypothesis, natural history, and management
    Andrew H Liu
    National Jewish Medical and Research Center, and the University of Colorado Health Sciences Center, Denver, CO, USA
    J Allergy Clin Immunol 111:S785-92. 2003
    ....
  51. ncbi Advances in pediatric asthma in 2012: moving toward asthma prevention
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 131:36-46. 2013
    ....
  52. ncbi Prevalence and correlates of household exposures to tobacco smoke and pets in children with asthma
    Frederick S Wamboldt
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Pediatr 141:109-15. 2002
    ..CONCLUSIONS: Smoke exposure and pet ownership are not related to one another in children with asthma and will require independent counseling strategies because they relate in different and opposite ways to socioeconomic status...
  53. ncbi Advances in pediatric asthma in 2007
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:614-9. 2008
    ..This review highlights journal articles that relate to these guideline topics...
  54. ncbi Asthma progression: can we and should we measure it?
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:598-600. 2008
  55. ncbi Identifying the child in need of asthma therapy
    Stanley J Szefler
    Department of Pediatrics, Division of Pediatric Clinical Pharmacology, National Jewish Medical and Research Center 1400 Jackson St, Room B121, Denver, CO 80206, USA
    Pediatr Clin North Am 50:577-91. 2003
    ..Recommendations have been made to integrate available resources in the United States to improve overall asthma outcomes for children...
  56. ncbi Single-dose pharmacokinetics of roflumilast in children and adolescents
    Kathleen A Neville
    Department of Pediatrics, University of Missouri Kansas City and the Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64079, USA
    J Clin Pharmacol 48:978-85. 2008
    ..1 and 0.8 microg/L per 1 microg/kg dose for adolescents and children, respectively), pharmacokinetic parameters for roflumilast and roflumilast N-oxide were not different between age groups and were similar to adults...
  57. ncbi Advances in pediatric asthma in 2010: addressing the major issues
    Stanley J Szefler
    Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
    J Allergy Clin Immunol 127:102-15. 2011
    ..Perhaps new directions in personalized medicine and improved health care access and communication will help maintain steady progress in alleviating the burden of this disease in children, especially young children...
  58. ncbi Advances in pediatric asthma 2006
    Stanley J Szefler
    Divisions of Pediatric Clinical Pharmacology, Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:558-62. 2007
    ..Application of biomarkers and genetics could be useful tools in individualizing our approach to the management of childhood asthma...
  59. ncbi Advancing asthma care: the glass is only half full!
    Stanley J Szefler
    Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, CO 80206, USA
    J Allergy Clin Immunol 128:485-94. 2011
    ..These advances should prompt the evolution of new strategies and new treatments to further reduce disease burden. It now becomes imperative to continue a focus on ways to further reduce the burden of asthma and prevent its onset...
  60. ncbi Corticosteroid therapy in asthma: predictors of responsiveness
    Christopher M Mjaanes
    National Jewish Medical and Research Center, 1400 Jackson Street, Office J304, Denver, CO 80209, USA
    Clin Chest Med 27:119-32, vii. 2006
    ..Clinical factors associated with steroid insensitivity, strategies for managing patients with steroid insensitivity, and underlying molecular mechanisms responsible for variable responses to corticosteroids are described...
  61. ncbi Budesonide inhalation suspension: a nebulized corticosteroid for persistent asthma
    Stanley J Szefler
    National Jewish Medical and Research Center, Denver, USA
    J Allergy Clin Immunol 109:730-42. 2002
    ..This article reviews the results of these studies, as well as the pharmacokinetics, pharmacodynamics, and clinical use of budesonide inhalation suspension...
  62. ncbi Advances in pediatric asthma in 2009: gaining control of childhood asthma
    Stanley J Szefler
    Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, 1400 Jackson St, Rm J304, Molly Blank Building, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:69-78. 2010
    ....
  63. ncbi New insights into asthma pathogenesis and treatment
    Stanley J Szefler
    Helen Wohlberg and Herman Lambert Chair in Pharmacokinetics, Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, CO 80206, USA
    Curr Opin Immunol 23:801-7. 2011
    ....
  64. ncbi The natural history of asthma and early intervention
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 109:S549-53. 2002
    ..The progress in defining asthma and targeting treatment toward specific pathophysiologic mechanisms should lead to better-defined optimal strategies for treating asthma in children...
  65. ncbi Altering the course of asthma: Introduction
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 109:S519-20. 2002
  66. ncbi Childhood asthma: new insights into management
    Joseph D Spahn
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver 80206, USA
    J Allergy Clin Immunol 109:3-13. 2002
    ....
  67. ncbi Montelukast for respiratory syncytial virus bronchiolitis: significant effect or provocative findings?
    Stanley J Szefler
    Am J Respir Crit Care Med 167:290-1. 2003
  68. ncbi Growth, systemic safety, and efficacy during 1 year of asthma treatment with different beclomethasone dipropionate formulations: an open-label, randomized comparison of extrafine and conventional aerosols in children
    Søren Pedersen
    paediatrisk afdeling, Kolding Sygehus, Kolding, Denmark
    Pediatrics 109:e92. 2002
    ....
  69. ncbi Bronchodilation and bronchoconstriction: predictors of future lung function in childhood asthma
    Kelan G Tantisira
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:1264-71. 2006
    ..Persistently low levels of lung function are associated with subsequent symptoms in patients with asthma as children...
  70. ncbi Nebulized budesonide inhalation suspension compared with cromolyn sodium nebulizer solution for asthma in young children: results of a randomized outcomes trial
    Jeffrey G Leflein
    Allergy and Immunology Associates of Ann Arbor, Ann Arbor, Michigan 48106, USA
    Pediatrics 109:866-72. 2002
    ..The objective of this study was to compare effects of nebulized budesonide inhalation suspension and cromolyn sodium nebulizer solution on asthma-related health outcomes in young children with asthma...
  71. ncbi Inhaled corticosteroids: past lessons and future issues
    David B Allen
    Division of Endocrinology, University of Wisconsin Children's Hospital, Madison 53792-4108, USA
    J Allergy Clin Immunol 112:S1-40. 2003
    ....
  72. ncbi Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children
    Robert C Strunk
    Washington University School of Medicine, St Louis, MO, USA
    J Allergy Clin Immunol 112:883-92. 2003
    ..It is a noninvasive technique that could be used in decisional management of children with asthma...
  73. ncbi Systematic review of the evidence regarding potential complications of inhaled corticosteroid use in asthma: collaboration of American College of Chest Physicians, American Academy of Allergy, Asthma, and Immunology, and American College of Allergy, Asthm
    Frank T Leone
    Jefferson Medical College, Thomas Jefferson University, 1015 Chestnut Street, Suite M100, Philadelphia, PA 19107, USA
    Chest 124:2329-40. 2003
    ....
  74. ncbi Advances in adult and pediatric asthma
    Andrea J Apter
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Allergy Clin Immunol 117:512-8. 2006
    ..Meanwhile, more effective health care strategies must be developed to reduce the reported disparities in asthma care noted in our patient populations...
  75. ncbi beta-Adrenergic receptor polymorphisms and response to salmeterol
    Michael E Wechsler
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Am J Respir Crit Care Med 173:519-26. 2006
    ..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists...
  76. ncbi Long-term inhaled corticosteroids in preschool children at high risk for asthma
    Theresa W Guilbert
    Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    N Engl J Med 354:1985-97. 2006
    ..It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma...
  77. ncbi Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 175:228-34. 2007
    ..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well...
  78. ncbi Daily versus as-needed corticosteroids for mild persistent asthma
    Homer A Boushey
    University of California at San Francisco, San Francisco, USA
    N Engl J Med 352:1519-28. 2005
    ..Further studies are required to determine whether this novel approach to treatment should be recommended...
  79. ncbi Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial
    Christine A Sorkness
    Clinical Science Center, University of Wisconsin, Madison, WI 53792, USA
    J Allergy Clin Immunol 119:64-72. 2007
    ..More evidence is needed on which to base recommendations for treatment of mild-moderate persistent asthma in school-aged children...
  80. ncbi Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma
    Stephen C Lazarus
    University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 175:783-90. 2007
    ..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control...
  81. ncbi Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:720-7. 2005
    ..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued...
  82. ncbi Demographic and clinical characteristics of children and adolescents with severe or difficult-to-treat asthma
    Bradley E Chipps
    Capital Allergy and Respiratory Disease Center, Sacramento, CA 95819, USA
    J Allergy Clin Immunol 119:1156-63. 2007
    ..Young patients with severe or difficult-to-treat asthma are an understudied population...
  83. ncbi Understanding mild persistent asthma in children: the next frontier
    Hans Bisgaard
    Danish Paediatric Asthma Center, Department of Paediatrics, University Hospital of Copenhagen, DK 2900 Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 115:708-13. 2005
    ..There is a need for further investigation into the true prevalence of mild persistent asthma in children and adolescents, and optimal treatment...
  84. ncbi Airway remodeling: therapeutic target or not?
    Stanley J Szefler
    Am J Respir Crit Care Med 171:672-3. 2005
  85. ncbi The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
    J Allergy Clin Immunol 121:1167-74. 2008
    ....
  86. ncbi Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma
    Theresa W Guilbert
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    J Allergy Clin Immunol 114:1282-7. 2004
    ....
  87. ncbi Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial
    Elliot Israel
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 364:1505-12. 2004
    ..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial...
  88. ncbi The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network
    Theresa W Guilbert
    Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, PO Box 245073, Tucson, AZ 85724, USA
    Control Clin Trials 25:286-310. 2004
    ..These measures were chosen to reflect the progression of the disease from intermittent wheezing to persistent asthma and measurement of the extent of airflow limitation and airway reactivity...
  89. ncbi Advances in adult and pediatric asthma
    Andrea J Apter
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, USA
    J Allergy Clin Immunol 113:407-14. 2004
    ..Our community has a strong commitment to health care quality, education, and delivery. The Journal will reflect this commitment with a new section devoted to these issues...
  90. ncbi A general class of correlation coefficients for the 2 x 2 crossover design
    Vernon M Chinchilli
    Department of Health Evaluation Sciences, Penn State College of Medicine, Hershey, PA, USA
    Biom J 47:644-53. 2005
    ..We illustrate the methodology using data from the CLIC trial of the Childhood Asthma Research and Education (CARE) Network...