Research Topics
| Gergely SzakacsSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cellsGergely Szakacs
Laboratory of Cell Biology, Center for Cancer Research, NCI, NIH, Bethesda, MD, 20892, USA
Cancer Cell 6:129-37. 2004..Unexpectedly, we also found and validated compounds whose activity is potentiated, rather than antagonized, by the MDR1 multidrug transporter. Such compounds may serve as leads for development...- Comparing solid tumors with cell lines: implications for identifying drug resistance genes in cancerGergely Szakacs
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Mol Interv 4:323-5. 2004..Because anti-tumor compounds are largely evaluated in cell culture assays, these compounds' therapeutic utility must be judged in light of genes described by Stein et al. that better predict tractability... - Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytesKevin G Chen
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Pigment Cell Res 18:102-12. 2005..Our findings indicate that expression of ABCB 5alpha/beta might possibly provide two novel molecular markers for differential diagnosis of melanomas and constitute potential molecular targets for therapy of melanomas... - The molecular mysteries underlying P-glycoprotein-mediated multidrug resistanceGergely Szakacs
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4254, USA
Cancer Biol Ther 3:382-4. 2004 
Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transportersMitsunori Okabe
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Mol Cancer Ther 7:3081-91. 2008..Our results indicate that the gene expression database can be used to identify SLCO and SLC22 family members that confer sensitivity to cancer cells...- Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cellsJae K Lee
Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 8322, USA
Genome Biol 4:R82. 2003..Global concordance is parameterized by a 'correlation of correlations' coefficient... - Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cellsMatthew D Hall
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Med Chem 52:3191-204. 2009..Together, the models serve as effective approaches for predicting structures with MDR1-selective activity and aid in directing the search for the mechanism of action of 1... - A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)Suresh V Ambudkar
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4256, USA
Trends Pharmacol Sci 26:385-7. 2005..Non-genetic transfer of the multidrug resistance phenotype raises fascinating questions about the mechanism and regulation of cell-surface membrane-protein-mediated spread of traits... 
The controversial role of ABC transporters in clinical oncologyAkina Tamaki
Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, Room 13N240, Bethesda, MD 20892, U S A
Essays Biochem 50:209-32. 2011..We discuss the challenges that remain in our effort to exploit decades of work on ABC transporters in oncology. In learning from past mistakes, it is hoped that ABC transporters can be developed as targets for clinical intervention...- Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membraneJill K Paterson
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 4256, USA
Biochemistry 46:9443-52. 2007..These studies are the first to demonstrate that ABCB6 exists in two molecular weight forms, is localized to both the outer mitochondrial membrane and the plasma membrane, and plays a functional role in the plasma membrane... - Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic miceJustina E Wu
Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:22913-25. 2004..These findings demonstrate that overexpression of ABCG5/G8 in the liver profoundly alters hepatic but not intestinal sterol transport, identifying distinct roles for liver and intestinal ABCG5/G8 in modulating sterol metabolism... - Genetic and functional studies of phosphatidyl-inositol 4-kinase type IIIαZsofia Szentpetery
Program for Developmental Neuroscience, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
Biochim Biophys Acta 1811:476-83. 2011..These data draw attention to PI4KIIIα as one of the genes found in Chr22q11, a region affected by chromosomal instability, but do not substantiate the existence of a functionally relevant short form of PI4KIIIα...