Gergely Szakacs

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells
    Gergely Szakacs
    Laboratory of Cell Biology, Center for Cancer Research, NCI, NIH, Bethesda, MD, 20892, USA
    Cancer Cell 6:129-37. 2004
  2. ncbi request reprint Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistance
    Xing Jie Liang
    Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda 20892 4256, Maryland, USA
    Anticancer Res 25:4113-22. 2005
  3. ncbi request reprint Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance
    Jean Philippe Annereau
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4256, USA
    Mol Pharmacol 66:1397-405. 2004
  4. pmc Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells
    Matthew D Hall
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 52:3191-204. 2009
  5. pmc Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
    Mitsunori Okabe
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Mol Cancer Ther 7:3081-91. 2008
  6. pmc Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer
    Joseph A Ludwig
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:4808-15. 2006
  7. ncbi request reprint Comparing solid tumors with cell lines: implications for identifying drug resistance genes in cancer
    Gergely Szakacs
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Mol Interv 4:323-5. 2004
  8. pmc Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells
    Jae K Lee
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 8322, USA
    Genome Biol 4:R82. 2003
  9. pmc A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)
    Suresh V Ambudkar
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4256, USA
    Trends Pharmacol Sci 26:385-7. 2005
  10. pmc Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes
    Kevin G Chen
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Pigment Cell Res 18:102-12. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells
    Gergely Szakacs
    Laboratory of Cell Biology, Center for Cancer Research, NCI, NIH, Bethesda, MD, 20892, USA
    Cancer Cell 6:129-37. 2004
    ..Unexpectedly, we also found and validated compounds whose activity is potentiated, rather than antagonized, by the MDR1 multidrug transporter. Such compounds may serve as leads for development...
  2. ncbi request reprint Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistance
    Xing Jie Liang
    Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda 20892 4256, Maryland, USA
    Anticancer Res 25:4113-22. 2005
    ..We conclude that K+ and H+ homeostasis are not critical factors in cisplatin resistance since they affect cisplatin resistance differently in KB and BEL-7404 cells...
  3. ncbi request reprint Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance
    Jean Philippe Annereau
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4256, USA
    Mol Pharmacol 66:1397-405. 2004
    ..The custom-designed ABC-Tox microarray presented here will be helpful to elucidate mechanisms leading to anticancer drug resistance...
  4. pmc Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells
    Matthew D Hall
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 52:3191-204. 2009
    ..Together, the models serve as effective approaches for predicting structures with MDR1-selective activity and aid in directing the search for the mechanism of action of 1...
  5. pmc Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
    Mitsunori Okabe
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Mol Cancer Ther 7:3081-91. 2008
    ..Our results indicate that the gene expression database can be used to identify SLCO and SLC22 family members that confer sensitivity to cancer cells...
  6. pmc Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer
    Joseph A Ludwig
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:4808-15. 2006
    ..This article shows that NSC73306 kills cells with intrinsic or acquired P-gp-induced MDR and indirectly acts to eliminate resistance to MDR1 substrates...
  7. ncbi request reprint Comparing solid tumors with cell lines: implications for identifying drug resistance genes in cancer
    Gergely Szakacs
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Mol Interv 4:323-5. 2004
    ..Because anti-tumor compounds are largely evaluated in cell culture assays, these compounds' therapeutic utility must be judged in light of genes described by Stein et al. that better predict tractability...
  8. pmc Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells
    Jae K Lee
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 8322, USA
    Genome Biol 4:R82. 2003
    ..Global concordance is parameterized by a 'correlation of correlations' coefficient...
  9. pmc A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)
    Suresh V Ambudkar
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4256, USA
    Trends Pharmacol Sci 26:385-7. 2005
    ..Non-genetic transfer of the multidrug resistance phenotype raises fascinating questions about the mechanism and regulation of cell-surface membrane-protein-mediated spread of traits...
  10. pmc Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes
    Kevin G Chen
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Pigment Cell Res 18:102-12. 2005
    ..Our findings indicate that expression of ABCB 5alpha/beta might possibly provide two novel molecular markers for differential diagnosis of melanomas and constitute potential molecular targets for therapy of melanomas...
  11. ncbi request reprint The molecular mysteries underlying P-glycoprotein-mediated multidrug resistance
    Gergely Szakacs
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4254, USA
    Cancer Biol Ther 3:382-4. 2004
  12. ncbi request reprint Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane
    Jill K Paterson
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 4256, USA
    Biochemistry 46:9443-52. 2007
    ..These studies are the first to demonstrate that ABCB6 exists in two molecular weight forms, is localized to both the outer mitochondrial membrane and the plasma membrane, and plays a functional role in the plasma membrane...
  13. doi request reprint The controversial role of ABC transporters in clinical oncology
    Akina Tamaki
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, Room 13N240, Bethesda, MD 20892, U S A
    Essays Biochem 50:209-32. 2011
    ..We discuss the challenges that remain in our effort to exploit decades of work on ABC transporters in oncology. In learning from past mistakes, it is hoped that ABC transporters can be developed as targets for clinical intervention...
  14. ncbi request reprint Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice
    Justina E Wu
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:22913-25. 2004
    ..These findings demonstrate that overexpression of ABCG5/G8 in the liver profoundly alters hepatic but not intestinal sterol transport, identifying distinct roles for liver and intestinal ABCG5/G8 in modulating sterol metabolism...
  15. pmc Genetic and functional studies of phosphatidyl-inositol 4-kinase type IIIα
    Zsofia Szentpetery
    Program for Developmental Neuroscience, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1811:476-83. 2011
    ..These data draw attention to PI4KIIIα as one of the genes found in Chr22q11, a region affected by chromosomal instability, but do not substantiate the existence of a functionally relevant short form of PI4KIIIα...