EVERETT RAND SUTHERLAND

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi Asthma and atypical bacterial infection
    E Rand Sutherland
    National Jewish Medical and Research Center, Department of Medicine, 1400 Jackson St, J220, Denver, CO 80206, USA
    Chest 132:1962-6. 2007
  2. ncbi Outpatient treatment of chronic obstructive pulmonary disease: comparisons with asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 114:715-24; quiz 725. 2004
  3. ncbi Nocturnal asthma: underlying mechanisms and treatment
    E Rand Sutherland
    National Jewish Medical and Research Center and University of Colorado Health Sciences Center, 1400 Jackson Street, Room J 217, Denver, CO 80206, USA
    Curr Allergy Asthma Rep 5:161-7. 2005
  4. ncbi Body mass and glucocorticoid response in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 220 Denver, CO 80206, USA
    Am J Respir Crit Care Med 178:682-7. 2008
  5. ncbi Nocturnal asthma
    E Rand Sutherland
    National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 116:1179-86; quiz 1187. 2005
  6. ncbi Maximum exercise as an outcome in COPD: minimal clinically important difference
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado School of Medicine, 1400 Jackson St, J217, Denver, Colorado 80206, USA
    COPD 2:137-41. 2005
  7. ncbi N-acetylcysteine and exacerbations of chronic obstructive pulmonary disease
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    COPD 3:195-202. 2006
  8. ncbi Sham procedure versus usual care as the control in clinical trials of devices: which is better?
    E Rand Sutherland
    National Jewish Medical and Research Center and University of Colorado at Denver and Health Sciences Center, 1400 Jackson Street, J220 Denver, CO 80206, USA
    Proc Am Thorac Soc 4:574-6. 2007
  9. ncbi Obesity and asthma
    E Rand Sutherland
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 28:589-602, ix. 2008
  10. ncbi Physiologic correlates of distal lung inflammation in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 217, Denver, CO 80206, USA
    J Allergy Clin Immunol 113:1046-50. 2004

Research Grants

  1. Atypical Bacterial Infection as an Asthma Risk Factor
    EVERETT SUTHERLAND; Fiscal Year: 2005
  2. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT SUTHERLAND; Fiscal Year: 2007

Detail Information

Publications32

  1. ncbi Asthma and atypical bacterial infection
    E Rand Sutherland
    National Jewish Medical and Research Center, Department of Medicine, 1400 Jackson St, J220, Denver, CO 80206, USA
    Chest 132:1962-6. 2007
    ..Current studies will further define the role of macrolide antibiotics in the treatment of stable patients with asthma, ultimately determining whether these therapeutic agents have a place in asthma management...
  2. ncbi Outpatient treatment of chronic obstructive pulmonary disease: comparisons with asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 114:715-24; quiz 725. 2004
    ..Drug therapy consists of optimal bronchodilator therapy supplemented, when necessary, with either inhaled corticosteroids or theophylline. Nondrug therapies include pulmonary rehabilitation, supplemental oxygen, and surgery...
  3. ncbi Nocturnal asthma: underlying mechanisms and treatment
    E Rand Sutherland
    National Jewish Medical and Research Center and University of Colorado Health Sciences Center, 1400 Jackson Street, Room J 217, Denver, CO 80206, USA
    Curr Allergy Asthma Rep 5:161-7. 2005
    ..Treatment strategies in nocturnal asthma are similar to those used in persistent asthma, although dosing of medications to target optimum delivery during periods of nocturnal worsening is beneficial...
  4. ncbi Body mass and glucocorticoid response in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 220 Denver, CO 80206, USA
    Am J Respir Crit Care Med 178:682-7. 2008
    ..Obesity may alter glucocorticoid response in asthma...
  5. ncbi Nocturnal asthma
    E Rand Sutherland
    National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 116:1179-86; quiz 1187. 2005
    ..Treatment strategies in nocturnal asthma are similar to those used in persistent asthma, although dosing of medications to target optimum effect during periods of nocturnal worsening is beneficial...
  6. ncbi Maximum exercise as an outcome in COPD: minimal clinically important difference
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado School of Medicine, 1400 Jackson St, J217, Denver, Colorado 80206, USA
    COPD 2:137-41. 2005
    ..Further investigation is needed to develop and validate estimates of MCID for maximum exercise capacity and other key clinical outcomes in COPD...
  7. ncbi N-acetylcysteine and exacerbations of chronic obstructive pulmonary disease
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    COPD 3:195-202. 2006
    ..This analysis suggests treatment with N-acetylcysteine may be beneficial in a subset of patients with COPD...
  8. ncbi Sham procedure versus usual care as the control in clinical trials of devices: which is better?
    E Rand Sutherland
    National Jewish Medical and Research Center and University of Colorado at Denver and Health Sciences Center, 1400 Jackson Street, J220 Denver, CO 80206, USA
    Proc Am Thorac Soc 4:574-6. 2007
    ..This review addresses issues pertaining to the use of sham controls in clinical trials of devices and procedures and provides examples from the literature which demonstrate the importance of and controversy surrounding sham controls...
  9. ncbi Obesity and asthma
    E Rand Sutherland
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 28:589-602, ix. 2008
    ..We evaluate animal studies that provide biological underpinnings to an association between the two disorders and clinical and epidemiologic studies that suggest that the relationship between these two disorders is clinically important...
  10. ncbi Physiologic correlates of distal lung inflammation in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 217, Denver, CO 80206, USA
    J Allergy Clin Immunol 113:1046-50. 2004
    ..The distal lung is an important site of inflammation in asthma. Maximal midexpiratory flows and the ratio of maximal:partial flows are purported to reflect distal lung function...
  11. ncbi Immunomodulatory effects of melatonin in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Am J Respir Crit Care Med 166:1055-61. 2002
    ..M., suggesting chronic overstimulation in vivo. These results suggest differential immunomodulatory effects of melatonin based on asthma clinical phenotype and may indicate an adverse effect of exogenous melatonin in asthma...
  12. ncbi Inhaled corticosteroids reduce the progression of airflow limitation in chronic obstructive pulmonary disease: a meta-analysis
    E R Sutherland
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    Thorax 58:937-41. 2003
    ..However, the role of inhaled corticosteroids in the treatment of COPD is controversial. We hypothesised that inhaled corticosteroids reduce the progression of airflow limitation in COPD...
  13. ncbi Vitamin D levels, lung function, and steroid response in adult asthma
    E Rand Sutherland
    Department of Medicine, University of Colorado, Denver, Colorado, USA
    Am J Respir Crit Care Med 181:699-704. 2010
    ..Patients with asthma exhibit variable response to inhaled corticosteroids (ICS). Vitamin D is hypothesized to exert effects on phenotype and glucocorticoid (GC) response in asthma...
  14. ncbi Elevated serum melatonin is associated with the nocturnal worsening of asthma
    E Rand Sutherland
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:513-7. 2003
    ..CONCLUSIONS: Nocturnal asthma is associated with elevation and phase delay of peak serum melatonin levels. Elevated melatonin levels might contribute to the pathogenesis of nocturnal asthma...
  15. ncbi Obesity and asthma
    David A Beuther
    National Jewish Medical and Research Center, 1400 Jackson Street, J220, Denver, CO 80206, USA
    Am J Respir Crit Care Med 174:112-9. 2006
    ..Further research is warranted to synthesize these disparate observations into a cohesive understanding of the relationship between obesity and asthma...
  16. ncbi Hypothalamic-pituitary-adrenal axis dysfunction during sleep in nocturnal asthma
    E Rand Sutherland
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:405S. 2003
  17. ncbi Interleukin-4 and interleukin-13 augment the proliferative effect of dexamethasone on distal lung fibroblasts
    Christina C Lewis
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:356S. 2003
  18. ncbi Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies
    David A Beuther
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J220, Denver, CO 80206, USA
    Am J Respir Crit Care Med 175:661-6. 2007
    ..Although obesity has been implicated as an asthma risk factor, there is heterogeneity in the published literature regarding its role in asthma incidence, particularly in men...
  19. ncbi Distal lung inflammation in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, USA
    Ann Allergy Asthma Immunol 89:119-24; quiz 124-5, 211. 2002
    ....
  20. ncbi Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colo, USA
    J Allergy Clin Immunol 112:819-27; quiz 828. 2003
    ..The contrasting inflammatory phenotypes of asthma and COPD have important implications for clinical and physiologic manifestations of disease, as well as for therapy...
  21. ncbi Comparative effect of body mass index on response to asthma controller therapy
    E Rand Sutherland
    Department of Medicine, National Jewish Health, Denver, Colorado, USA
    Allergy Asthma Proc 31:20-5. 2010
    ..05). FP produced a significantly greater clinical response for normal, overweight, and obese subjects compared with montelukast. Irrespective of BMI, FP appears to be the more effective asthma controller therapy...
  22. ncbi Altered pituitary-adrenal interaction in nocturnal asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, USA
    J Allergy Clin Immunol 112:52-7. 2003
    ..Conversely, adrenal response to corticotropin might be enhanced in nonnocturnal asthma, attenuating nocturnal worsening of airway inflammation...
  23. ncbi Body mass index and phenotype in subjects with mild-to-moderate persistent asthma
    E Rand Sutherland
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:1328-34.e1. 2009
    ..Although obesity has been hypothesized to worsen asthma, data from studies of subjects with well-characterized asthma are lacking...
  24. ncbi Atypical bacterial pneumonia and asthma risk
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Asthma 41:863-8. 2004
    ..Prospective studies are warranted to more fully evaluate the importance of atypical bacterial pneumonia as an asthma risk factor...
  25. ncbi Obesity and pulmonary function testing
    David A Beuther
    National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:1100-1. 2005
  26. ncbi Safety of sputum induction in moderate-to-severe chronic obstructive pulmonary disease
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Respir Med 96:482-6. 2002
    ..A protocol for sputum induction which restricts the use of hypertonic saline based on lung function is both safe and effective in subjects with moderate to severe COPD...
  27. ncbi A trial of clarithromycin for the treatment of suboptimally controlled asthma
    E Rand Sutherland
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 126:747-53. 2010
    ..PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma...
  28. ncbi Predictors of rehospitalization and death after a severe exacerbation of COPD
    Ryan McGhan
    Denver Health and Hospital Authority, Denver, CO, USA
    Chest 132:1748-55. 2007
    ..Patients who survive a severe exacerbation of COPD are at high risk of rehospitalization for COPD and death. The objective of this study was to determine predictors of these events in a large cohort of Veterans Affairs (VA) patients...
  29. ncbi Airway fibroblasts exhibit a synthetic phenotype in severe asthma
    Christina C Lewis
    Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Medical and Research Center, Denver, Colo, USA
    J Allergy Clin Immunol 115:534-40. 2005
    ..Platelet-derived growth factor (PDGF) may have a significant role in airway remodeling in asthma, because it is a powerful inductor of many airway fibroblast activities such as collagen synthesis...
  30. ncbi Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Am J Respir Crit Care Med 181:438-45. 2010
    ..Epidermal growth factor receptor (EGFR) activation is implicated in mucin hypersecretion in chronic obstructive pulmonary disease (COPD)...
  31. ncbi Management of chronic obstructive pulmonary disease
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, USA
    N Engl J Med 350:2689-97. 2004
  32. ncbi Increased expression of platelet-derived growth factor receptor-beta in airway fibroblasts of severe asthmatics
    Christina C Lewis
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:428S-9S. 2003

Research Grants4

  1. Atypical Bacterial Infection as an Asthma Risk Factor
    EVERETT SUTHERLAND; Fiscal Year: 2005
    ..The candidate is intent upon using this award to support a career development program that will ensure his success as an academic physician-scientist with a focus on patient-oriented research in diseases of the lungs...
  2. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT SUTHERLAND; Fiscal Year: 2007
    ..End of Abstract) ..