Myong Hee Sung

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Nonlinear dependencies of biochemical reactions for context-specific signaling dynamics
    Myong Hee Sung
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Rep 2:616. 2012
  2. pmc Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles
    Myong Hee Sung
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e7163. 2009
  3. pmc Dynamic effect of bortezomib on nuclear factor-kappaB activity and gene expression in tumor cells
    Myong Hee Sung
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Room B602, Bldg 41, 41 Library Dr, Bethesda, MD 20892, USA
    Mol Pharmacol 74:1215-22. 2008
  4. pmc Live cell imaging and systems biology
    Myong Hee Sung
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Wiley Interdiscip Rev Syst Biol Med 3:167-82. 2011
  5. ncbi request reprint Candidate epitope identification using peptide property models: application to cancer immunotherapy
    Myong Hee Sung
    Molecular Statistics and Bioinformatics Section, Biometric Research Branch, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd EPN 8146, MSC 7434, Bethesda, MD 20892, USA
    Methods 34:460-7. 2004
  6. ncbi request reprint In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics
    Myong Hee Sung
    Biometric Research Branch, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd EPN 8146, MSC 7434, Bethesda, MD 20892, USA
    Mol Pharmacol 66:70-5. 2004
  7. ncbi request reprint Genomewide conserved epitope profiles of HIV-1 predicted by biophysical properties of MHC binding peptides
    Myong Hee Sung
    Biometric Research Branch, National Cancer Institute, National Institutes of Health, 6130 Executive Boulevard EPN 8146, MSC 7434, Bethesda, MD 20892, USA
    J Comput Biol 11:125-45. 2004
  8. pmc Reprogramming the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level
    Tina B Miranda
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cancer Res 73:5130-9. 2013
  9. doi request reprint Interaction of the glucocorticoid receptor with the chromatin landscape
    Sam John
    Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 5055, USA
    Mol Cell 29:611-24. 2008
  10. pmc Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements
    Ofir Hakim
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
    Genome Res 21:697-706. 2011

Collaborators

Detail Information

Publications30

  1. pmc Nonlinear dependencies of biochemical reactions for context-specific signaling dynamics
    Myong Hee Sung
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Rep 2:616. 2012
    ....
  2. pmc Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles
    Myong Hee Sung
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e7163. 2009
    ..We propose that negative feedback loops do not simply terminate signaling, but rather promote oscillations of NF-kappaB in the nucleus, and these oscillations are functionally advantageous...
  3. pmc Dynamic effect of bortezomib on nuclear factor-kappaB activity and gene expression in tumor cells
    Myong Hee Sung
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Room B602, Bldg 41, 41 Library Dr, Bethesda, MD 20892, USA
    Mol Pharmacol 74:1215-22. 2008
    ....
  4. pmc Live cell imaging and systems biology
    Myong Hee Sung
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Wiley Interdiscip Rev Syst Biol Med 3:167-82. 2011
    ..We argue that incorporation of such quantitative live-cell imaging methods is critical for the progress of systems biology...
  5. ncbi request reprint Candidate epitope identification using peptide property models: application to cancer immunotherapy
    Myong Hee Sung
    Molecular Statistics and Bioinformatics Section, Biometric Research Branch, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd EPN 8146, MSC 7434, Bethesda, MD 20892, USA
    Methods 34:460-7. 2004
    ..The candidate epitopes identified by such a computational approach must be evaluated experimentally but the approach can provide an efficient and focused strategy for anti-cancer immunotherapy development...
  6. ncbi request reprint In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics
    Myong Hee Sung
    Biometric Research Branch, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd EPN 8146, MSC 7434, Bethesda, MD 20892, USA
    Mol Pharmacol 66:70-5. 2004
    ..Such kinetic analyses of the "drugged" molecular system will facilitate optimal drug target selection and the development of treatment protocols for a molecularly targeted therapy...
  7. ncbi request reprint Genomewide conserved epitope profiles of HIV-1 predicted by biophysical properties of MHC binding peptides
    Myong Hee Sung
    Biometric Research Branch, National Cancer Institute, National Institutes of Health, 6130 Executive Boulevard EPN 8146, MSC 7434, Bethesda, MD 20892, USA
    J Comput Biol 11:125-45. 2004
    ..As an essential step in designing vaccines, the revealed patterns may provide valuable information in identifying the immunologically important regions...
  8. pmc Reprogramming the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level
    Tina B Miranda
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cancer Res 73:5130-9. 2013
    ..The unveiling of this mechanism is important for understanding cellular interactions between ER and GR and may represent a general mechanism for cross-talk between nuclear receptors in human disease...
  9. doi request reprint Interaction of the glucocorticoid receptor with the chromatin landscape
    Sam John
    Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 5055, USA
    Mol Cell 29:611-24. 2008
    ..Furthermore, the widespread requirement for chromatin remodeling supports the recent hypothesis that the rapid exchange of receptor proteins occurs during nucleosome reorganization...
  10. pmc Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements
    Ofir Hakim
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
    Genome Res 21:697-706. 2011
    ..Numerous open chromatin loci may be arranged in nuclear domains that are poised to respond to diverse signals in general and to permit efficient gene regulation...
  11. pmc Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism
    Ty C Voss
    Laboratory of Receptor Biology and Gene Expression, Building 41, B602, 41 Library Drive, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 146:544-54. 2011
    ..Temporally sparse transcription factor-DNA interactions induce local chromatin reorganization, resulting in transient access for binding of secondary regulatory factors...
  12. pmc Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding
    Simon C Biddie
    Laboratory of Receptor Biology and Gene Expression, B602, Building 41, 41 Library Drive, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 43:145-55. 2011
    ..We propose a model in which the basal occupancy of transcription factors acts to prime chromatin and direct inducible transcription factors to select regions in the genome...
  13. pmc Overlapping chromatin-remodeling systems collaborate genome wide at dynamic chromatin transitions
    Stephanie A Morris
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Struct Mol Biol 21:73-81. 2014
    ..These findings provide a dynamic view of chromatin organization and highlight the differential contributions of remodelers to chromatin maintenance in higher eukaryotes. ..
  14. doi request reprint Chromatin accessibility pre-determines glucocorticoid receptor binding patterns
    Sam John
    Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 43:264-8. 2011
    ..The results define a framework for understanding regulatory factor-genome interactions and provide a molecular basis for the tissue selectivity of steroid pharmaceuticals and other agents that intersect the living genome...
  15. pmc ELL facilitates RNA polymerase II pause site entry and release
    Jung S Byun
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, Maryland 20892, USA
    Nat Commun 3:633. 2012
    ..Thus, ELL has an early and essential role during rapid high-amplitude gene expression that is required for both Pol II pause site entry and release...
  16. pmc Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation
    Ofir Hakim
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genome Res 23:462-72. 2013
    ..Such subnuclear environments have significant implications for efficient functioning of the mature effector lymphocytes...
  17. ncbi request reprint T-cell epitope prediction with combinatorial peptide libraries
    Myong Hee Sung
    Molecular Statistics and Bioinformatics Section, Biometric Research Branch, National Cancer Institute, National Institutes of Health, 6130 Executive Boulevard, EPN 8146, MSC 7434, Bethesda, MD 20892 7434, USA
    J Comput Biol 9:527-39. 2002
    ..Here, we present statistical models for elucidating the recognition profile of a TCR using combinatorial library proliferation assay data and known MHC binding data...
  18. pmc Kinetic complexity of the global response to glucocorticoid receptor action
    Sam John
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
    Endocrinology 150:1766-74. 2009
    ..Thus, the cellular response to GR stimulation involves a highly orchestrated series of regulatory actions and not simply a binary response to hormone...
  19. pmc Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation
    Kyong Rim Kieffer-Kwon
    Genomics and Immunity, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 155:1507-20. 2013
    ..We propose that organisms rely on a dynamic enhancer landscape to control basic cellular functions in a tissue-specific manner. ..
  20. doi request reprint Quantitative analysis of genome-wide chromatin remodeling
    Songjoon Baek
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 833:433-41. 2012
    ..These approaches enabled by DNaseI-seq represent a powerful new methodology that reveals mechanisms of transcriptional regulation...
  21. pmc DNA methylation status predicts cell type-specific enhancer activity
    Malgorzata Wiench
    Center for Cancer Research, Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD, USA
    EMBO J 30:3028-39. 2011
    ..The findings present a unique link between tissue-specific chromatin accessibility, DNA methylation and transcription factor binding and show that DNA methylation can be an integral component of gene regulation by nuclear receptors...
  22. pmc 3D shortcuts to gene regulation
    Ofir Hakim
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Cell Biol 22:305-13. 2010
    ..Thus the spatial architecture of the genome has attracted a lot of interest and has intensified its significance in modern cell biology. Here we discuss current methods, concepts, and controversies in this rapidly evolving field...
  23. ncbi request reprint Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis
    Bibiana Bielekova
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:3893-904. 2004
    ..These data have important implications for autoimmunity research and should be considered in the development of Ag-specific therapies in MS...
  24. doi request reprint Artificial intelligence methods for predicting T-cell epitopes
    Yingdong Zhao
    National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Methods Mol Biol 409:217-25. 2007
    ..For predicting T-cell epitopes for an MHC class II-restricted TCC, we built a shift model that integrated MHC-binding data and data from T-cell proliferation assay against a combinatorial library of peptide mixtures...
  25. pmc Combinatorial probabilistic chromatin interactions produce transcriptional heterogeneity
    Ty C Voss
    Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    J Cell Sci 122:345-56. 2009
    ....
  26. doi request reprint Switching of the relative dominance between feedback mechanisms in lipopolysaccharide-induced NF-κB signaling
    Myong Hee Sung
    1Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 7:ra6. 2014
    ....
  27. doi request reprint More to Hi-C than meets the eye
    Myong Hee Sung
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 43:1047-8. 2011
    ....
  28. ncbi request reprint Wnt pathway mutations selected by optimal beta-catenin signaling for tumorigenesis
    Kwang Hyun Cho
    College of Medicine, Seoul National University, Jongno gu, Seoul 110 799, South Korea
    FEBS Lett 580:3665-70. 2006
    ....
  29. ncbi request reprint In silico identification of the key components and steps in IFN-gamma induced JAK-STAT signaling pathway
    Zhike Zi
    Institute of Bioinformatics, MOE Key Laboratory of Bioinformatics, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    FEBS Lett 579:1101-8. 2005
    ..We find that suppressor of cytokine signaling-1, nuclear phosphatases, cytoplasmic STAT1, and the corresponding reaction steps are sensitive perturbation points of this pathway...