Research Topics
Species | Trey SunderlandSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Geriatric psychiatry: coming of age in AmericaTrey Sunderland
National Institute of Mental Health 9000 Rockville Pike Building 10, Room 3N228 Bethesda, Maryland 20892, USA
Biol Psychiatry 58:263-4. 2005- Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 alleleTrey Sunderland
National Institute of Mental Health, Geriatric Psychiatry Branch, Building 10, Room 3N228, 9000 Rockville Pike, Bethesda, MD 20892, USA
Biol Psychiatry 56:670-6. 2004..We tested these CSF markers in groups of subjects with AD and healthy older control subjects, using the absence or presence of the APOE epsilon4 allele as a predictive variable in the search for possible prognostic biomarkers of AD... - Biomarkers in the diagnosis of Alzheimer's disease: are we ready?Trey Sunderland
Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
J Geriatr Psychiatry Neurol 19:172-9. 2006..The current biomarker approaches to diagnosis are reviewed along with a special emphasis on near-term recommendations and further research directions... - The use of biomarkers in the elderly: current and future challengesTrey Sunderland
Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 58:272-6. 2005..While some progress has been made in the search for adequate biomarkers in the elderly, in particular with Alzheimer disease, much more work is needed before these potential biomarkers can be reliably used in clinical practice... - Stability of CSF beta-amyloid(1-42) and tau levels by APOE genotype in Alzheimer patientsEdward D Huey
Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
Dement Geriatr Cogn Disord 22:48-53. 2006..Cerebrospinal fluid (CSF) measures of beta-amyloid(1-42 )and tau differ between patients with Alzheimer's Disease (AD) and elderly normal controls. The effect of time and APOE genotype on these biomarkers continues to be elucidated... - Age and APOE-epsilon4 genotype influence the effect of physostigmine infusion on the in-vivo distribution volume of the muscarinic-2-receptor dependent tracer [18F]FP-TZTPRobert M Cohen
Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Synapse 60:86-92. 2006.... - Context-specific memory and apolipoprotein E (ApoE) epsilon 4: cognitive evidence from the NIMH prospective study of risk for Alzheimer's diseaseJames A Levy
Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Int Neuropsychol Soc 10:362-70. 2004.... - Scaling of visuospatial attention undergoes differential longitudinal change as a function of APOE genotype prior to old age: results from the NIMH BIOCARD studyP M Greenwood
Cognitive Science Laboratory, Catholic University of America, Washington, DC, and Geriatric Psychiatry Branch, National Institute of Mental Health, USA
Neuropsychology 19:830-40. 2005..However, cognitive decline in midlife associated with a gene modulating neuronal response to insult argues that the concept of an AD prodrome includes factors that allow as well as cause AD... - Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer diseaseTrey Sunderland
Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
JAMA 289:2094-103. 2003..The search for antemortem biomarkers is intense and has focused on cerebrospinal fluid (CSF) beta-amyloid1-42 and tau proteins... 
Failing compensatory mechanisms during working memory in older apolipoprotein E-epsilon4 healthy adultsFrancesca M Filbey
Geriatric Psychiatry Branch, NIMH, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Brain Imaging Behav 4:177-88. 2010..This effect, however, appears to diminish with age...- Hippocampal atrophy in the healthy is initially linear and independent of ageRobert M Cohen
Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Clinical Research Center 2 5362, MSC 1274, 10 Center Drive, Bethesda MD 20892 1274, USA
Neurobiol Aging 27:1385-94. 2006.... - Effects of previous major depressive illness on cognition in Alzheimer disease patientsH Eleanor Cannon-Spoor
Geriatric Psychiatry Branch, NIMH, Bethesda, MD 20892 1274, USA
Am J Geriatr Psychiatry 13:312-8. 2005.... - Views of potential subjects toward proposed regulations for clinical research with adults unable to consentDave Wendler
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
Am J Psychiatry 159:585-91. 2002..The authors' goal was to assess healthy individuals' attitudes toward five of the most prominent proposed safeguards regarding the consent process for research with adults unable to consent... - Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-epsilon4 alleleRobert M Cohen
Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Synapse 49:150-6. 2003..65, P < 0.06). A lower concentration of acetylcholine in the synapse of APOE-epsilon4+ older individuals is a likely explanation for the greater [(18)F]FP-TZTP distribution volumes... - A magnetoencephalography spatiotemporal analysis of neural activities during feature bindingFrancesca M Filbey
Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Neuroreport 16:1747-52. 2005..Theta band synchronization was observed in many of these same areas, but also in other areas not noted to have increased theta band power suggesting a broad network of regions subserving the encoding phase of feature binding... - Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late lifeDennis S Charney
National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Arch Gen Psychiatry 60:664-72. 2003.... - The apolipoprotein E gene, attention, and brain functionRaja Parasuraman
Cognitive Science Laboratory, Catholic University of America, Washington, DC 20064, USA
Neuropsychology 16:254-74. 2002.... - A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's diseaseGeorge S Zubenko
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room E1230, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Psychiatry 160:857-66. 2003.... - Effects of apolipoprotein E genotype on spatial attention, working memory, and their interaction in healthy, middle-aged adults: results From the National Institute of Mental Health's BIOCARD studyP M Greenwood
Cognitive Science Laboratory, Catholic University of America, Washington, DC, USA
Neuropsychology 19:199-211. 2005..Effects of APOE genotype on component processes of cognition in healthy, middle-aged adults is consistent with the emergence in adulthood of an APOE-epsilon4 cognitive phenotype... - Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairmentKatharina Buerger
Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
Neurosci Lett 391:48-50. 2005..Our study indicates that the apoE epsilon4 carrier status should be considered when CSF P-tau(231P) is evaluated as biomarker candidate of AD in MCI subjects... - Apolipoprotein E and category fluency: evidence for reduced semantic access in healthy normal controls at risk for developing Alzheimer's diseaseVirginia M Rosen
Department of Psychology, Syracuse University, 430 Huntington Hall, Syracuse, NY 13244, USA
Neuropsychologia 43:647-58. 2005.... - Proteomic approaches in drug discovery and developmentHolly D Soares
Pfizer Global Research and Development, Groton, CT 06340, USA
Int Rev Neurobiol 61:97-126. 2004 - Reminiscence group activities and discourse interaction in Alzheimer's diseaseSharon E Moss
Research Resources and Advocacy, Speech, Language, Hearing Science and Research Unit, American Speech-Language-Hearing Association, 10801 Rockville Pike, Rockville, MD 20852, USA
J Gerontol Nurs 28:36-44. 2002..Results are discussed in terms of their relevance to gerontological nurses managing patients with AD... - Alzheimer diseaseTrey Sunderland
South Med J 98:588-9. 2005 - Children of persons with Alzheimer disease: what does the future hold?Lissy Jarvik
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
Alzheimer Dis Assoc Disord 22:6-20. 2008..We examine the state of knowledge with respect to risk and protective factors for AD and recommend a research agenda with special emphasis on AD offspring... - Development of subtle psychotic symptoms with memantine: a case reportEdward D Huey
J Clin Psychiatry 66:658-9. 2005