Genomes and Genes
Affiliation: National Institutes of Health
- Additive cardioprotection by pharmacological postconditioning with hydrogen sulfide and nitric oxide donors in mouse heart: S-sulfhydration vs. S-nitrosylationJunhui Sun
Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10 Room 8N206, Bethesda, MD 20892, USA
Cardiovasc Res 110:96-106. 2016..Thus, part of the benefit of NaHS is an increase in SNO, and the magnitude of the protective effect is related to the magnitude of the increase in SNO. ..
- Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondriaJunhui Sun
Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bldg10 Rm8N206, Bethesda, MD 20892, USA
Cardiovasc Res 106:227-36. 2015....
- Essential role of nitric oxide in acute ischemic preconditioning: S-nitros(yl)ation versus sGC/cGMP/PKG signaling?Junhui Sun
Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 54:105-12. 2013..In conclusion, these results suggest that the protective effect of NO is not related primarily to activation of the sGC/cGMP/PKG signaling pathway, but rather through SNO signaling in IPC-induced acute cardioprotection...
- Disruption of caveolae blocks ischemic preconditioning-mediated S-nitrosylation of mitochondrial proteinsJunhui Sun
Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Antioxid Redox Signal 16:45-56. 2012..Mitochondria are key regulators of preconditioning, and most proteins showing an increase in SNO with IPC are mitochondrial. The aim of this study was to address how IPC transduces NO/SNO signaling to mitochondria in the heart...
- Protein S-nitrosylation: a role of nitric oxide signaling in cardiac ischemic preconditioningJunhui Sun
Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Sheng Li Xue Bao 59:544-52. 2007..Thus, protein S-nitrosylation is emerging as an important contributor to cardioprotection in IPC, providing protection from cellular oxidative and nitrosative stress...
- Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heartJunhui Sun
Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bldg 10 Rm 8N206, Bethesda, MD 20892, USA
Am J Physiol Heart Circ Physiol 299:H1309-17. 2010..Taken together, the distribution of CaSR in caveolae along with NPS2143-blockade of IPC-induced cardioprotective signaling suggest that the activation of CaSR during IPC is cardioprotective by a process involving caveolae...
- The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporterXin Pan
1 Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA 2 National Center of Biomedical Analysis, Beijing 100850, China 3
Nat Cell Biol 15:1464-72. 2013..Taken together, these results clarify how acute alterations in mitochondrial matrix calcium can regulate mammalian physiology. ..
- Measurement of S-nitrosylation occupancy in the myocardium with cysteine-reactive tandem mass tags: short communicationMark J Kohr
Laboratory of Cardiac Physiology, Systems Biology Center, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
Circ Res 111:1308-12. 2012..However, little is known with regard to the percentage of a given protein that is modified by SNO (ie, SNO occupancy). Current methods allow for the relative quantification of SNO levels, but not for the determination of SNO occupancy...
- S-nitrosylation: a radical way to protect the heartElizabeth Murphy
Cardiac Physiology Section, Systems Biology Center, NHLBI, NIH, Bethesda, MD 20892, USA
J Mol Cell Cardiol 52:568-77. 2012..The role of nitric oxide synthase uncoupling in cardioprotection will also be addressed. This article is part of a Special Section entitled "Post-translational Modification."..
- Cyclophilin D modulates mitochondrial acetylomeTiffany Tuyen M Nguyen
From the Systems Biology Center T T M N, S M, J S, E M, Division of Cardiovascular Sciences R W, Proteomics Core Facility Y C, G W, M G, and Center for Molecular Medicine M N S, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD and Department of Pathology, Johns Hopkins Medical Center, Baltimore, MD C S
Circ Res 113:1308-19. 2013..As acetylation has been shown to regulate metabolism, we tested whether changes in protein acetylation might play a role in these metabolic changes in CypD(-/-) hearts...
- Preconditioning results in S-nitrosylation of proteins involved in regulation of mitochondrial energetics and calcium transportJunhui Sun
NHLBI, NIH, Vascular Medicine Branch, Bethesda, MD 20892, USA
Circ Res 101:1155-63. 2007..IPC and GSNO produced a similar pattern of S-nitrosylation modification and cardiac protection against ischemia/reperfusion injury, suggesting that protein S-nitrosylation may play an important cardioprotective role in heart...
- Molecular Signature of Nitroso-Redox Balance in Idiopathic Dilated CardiomyopathiesSara Menazza
Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD S M, J S, E M
J Am Heart Assoc 4:e002251. 2015..To test this hypothesis, we investigated the occurrence of protein S-nitrosylation (SNO) and oxidation in biopsies from explanted dilated cardiomyopathy and nonfailing donor male and female human hearts...
- Myristoylated methionine sulfoxide reductase A protects the heart from ischemia-reperfusion injuryHang Zhao
Laboratory of Biochemistry, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
Am J Physiol Heart Circ Physiol 301:H1513-8. 2011..We conclude that cytosolic MsrA protects the heart from ischemia-reperfusion damage. The requirement for myristoylation suggests that MsrA must interact with a hydrophobic domain to provide protection...
- Protein S-nitrosylation and cardioprotectionJunhui Sun
Translational Medicine Branch, NHLBI, NIH, 10 Center Dr, Room 7N112, Bethesda, MD 20892, USA
Circ Res 106:285-96. 2010..A better understanding of the mechanism regulating protein S-nitrosylation and its role in cardioprotection will provide us new therapeutic opportunities and targets for interventions in cardiovascular diseases...
- Characterization of the cardiac succinylome and its role in ischemia-reperfusion injuryJennifer A Boylston
Systems Biology Center, NHLBI, NIH, Bethesda, MD, United States
J Mol Cell Cardiol 88:73-81. 2015....
- The ins and outs of mitochondrial calciumToren Finkel
From the Center for Molecular Medicine T F, K M H, Julia Liu, Jie Liu and Systems Biology Center S M, R J P, J S, E M, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD and Laboratory of Cell Biology, National Center of Biomedical Analysis, Beijing, China X P
Circ Res 116:1810-9. 2015....
- Mechanism of cardioprotection: what can we learn from females?Elizabeth Murphy
NHLBI, NIH, Room 8N202, Building 10, 10 Center Drive, Bethesda, MD, USA
Pediatr Cardiol 32:354-9. 2011..It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed...
- S-nitrosylation: NO-related redox signaling to protect against oxidative stressJunhui Sun
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Antioxid Redox Signal 8:1693-705. 2006..However, oxidative stress and the resultant dysfunction of NO signaling have been implicated in the pathogenesis of cardiovascular diseases...
- The NAD-dependent deacetylase SIRT2 is required for programmed necrosisNisha Narayan
Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892, USA
Nature 492:199-204. 2012....
- Estrogen receptor activation and cardioprotection in ischemia reperfusion injuryAnne M Deschamps
National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Trends Cardiovasc Med 20:73-8. 2010..In this review, we will focus on the signaling pathways leading to cardioprotection in ischemia reperfusion injury after ER activation and discuss the possibility and promise of specific ER modulators to treat ischemic heart diseases...
- Acute erythropoietin cardioprotection is mediated by endothelial responseRuifeng Teng
Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1822, USA
Basic Res Cardiol 106:343-54. 2011..The immediate response of coronary artery endothelial cells to Epo stimulation by NO production may be a critical mechanism underlying this Epo cardioprotection...
- Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respirationSruti Shiva
Vascular Medicine Branch, Clinical Center National Institutes of Health, Bethesda, MD 20892 1662, USA
Circ Res 100:654-61. 2007....
- Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell NecroptosisWei Lu
Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 11:e0147792. 2016..PGAM5 promotion of mitophagy may represent a therapeutic target for stroke, myocardial infarction and other diseases caused by oxidative damage and necroptosis. ..