Anthony F Suffredini

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Biomarker discovery in serum from patients with carotid atherosclerosis
    Thomas J DeGraba
    Neurology Department, National Naval Medical Center, Bethesda, MD, USA
    Cerebrovasc Dis Extra 1:115-29. 2011
  2. doi request reprint Novel therapies for septic shock over the past 4 decades
    Anthony F Suffredini
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bldg 10, Rm 2C145, Bethesda, MD 20892, USA
    JAMA 306:194-9. 2011
  3. pmc Protein expression profiles distinguish between experimental invasive pulmonary aspergillosis and Pseudomonas pneumonia
    Denise A Gonzales
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1662, USA
    Proteomics 10:4270-80. 2010
  4. pmc Apolipoprotein A-I and serum amyloid A plasma levels are biomarkers of acute painful episodes in patients with sickle cell disease
    Ashaunta Tumblin
    Pulmonary Brance, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Haematologica 95:1467-72. 2010
  5. ncbi request reprint Gene expression profiles of peripheral blood leukocytes after endotoxin challenge in humans
    Shefali Talwar
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1662, USA
    Physiol Genomics 25:203-15. 2006
  6. ncbi request reprint A canine model of septic shock: balancing animal welfare and scientific relevance
    Peter C Minneci
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Heart Circ Physiol 293:H2487-500. 2007
  7. ncbi request reprint Quality control of serum albumin depletion for proteomic analysis
    Nitin Seam
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1662, USA
    Clin Chem 53:1915-20. 2007
  8. pmc Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease
    Nalini Raghavachari
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, MD 20892 1454, USA
    Circulation 115:1551-62. 2007
  9. pmc Bundled care for septic shock: an analysis of clinical trials
    Amisha V Barochia
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 38:668-78. 2010
  10. pmc The individual survival benefits of tumor necrosis factor soluble receptor and fluid administration are not additive in a rat sepsis model
    Ping Qiu
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 2C145, Bethesda, MD 20892, USA
    Intensive Care Med 37:1688-95. 2011

Collaborators

Detail Information

Publications22

  1. pmc Biomarker discovery in serum from patients with carotid atherosclerosis
    Thomas J DeGraba
    Neurology Department, National Naval Medical Center, Bethesda, MD, USA
    Cerebrovasc Dis Extra 1:115-29. 2011
    ..These patients were compared with healthy matched controls...
  2. doi request reprint Novel therapies for septic shock over the past 4 decades
    Anthony F Suffredini
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bldg 10, Rm 2C145, Bethesda, MD 20892, USA
    JAMA 306:194-9. 2011
    ..In this Grand Rounds, we summarize the results of the clinical trials conducted during the last 4 decades, discuss some lessons learned, and suggest possible directions for future investigation...
  3. pmc Protein expression profiles distinguish between experimental invasive pulmonary aspergillosis and Pseudomonas pneumonia
    Denise A Gonzales
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1662, USA
    Proteomics 10:4270-80. 2010
    ..Haptoglobin, apolipoprotein A1, transthyretin, and C-reactive protein are differentially expressed in these infections suggesting important contributions to host defense against IPA...
  4. pmc Apolipoprotein A-I and serum amyloid A plasma levels are biomarkers of acute painful episodes in patients with sickle cell disease
    Ashaunta Tumblin
    Pulmonary Brance, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Haematologica 95:1467-72. 2010
    ..Acute painful episodes are the clinical hallmark of sickle cell disease and have been linked to morbidity and mortality in the sickle cell population...
  5. ncbi request reprint Gene expression profiles of peripheral blood leukocytes after endotoxin challenge in humans
    Shefali Talwar
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1662, USA
    Physiol Genomics 25:203-15. 2006
    ..These results indicate that a single intravascular exposure to endotoxin produces a large but temporally short perturbation of the blood transcriptome...
  6. ncbi request reprint A canine model of septic shock: balancing animal welfare and scientific relevance
    Peter C Minneci
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Heart Circ Physiol 293:H2487-500. 2007
    ..The integration into this model of both specific and supportive titrated therapies routinely used in septic patients may provide a more realistic setting to evaluate therapies for sepsis...
  7. ncbi request reprint Quality control of serum albumin depletion for proteomic analysis
    Nitin Seam
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1662, USA
    Clin Chem 53:1915-20. 2007
    ..We examined the reproducibility of albumin immunodepletion and describe a method of QC for this process...
  8. pmc Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease
    Nalini Raghavachari
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, MD 20892 1454, USA
    Circulation 115:1551-62. 2007
    ..Recent functional studies of platelets in patients with sickle cell disease reveal a basally activated state, which suggests that pathological platelet activation may contribute to sickle cell disease vasculopathy...
  9. pmc Bundled care for septic shock: an analysis of clinical trials
    Amisha V Barochia
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 38:668-78. 2010
    ..Valid bundles require effective components with additive benefits. Proponents encourage evaluation of bundles, both as a whole and based on the performance of each component...
  10. pmc The individual survival benefits of tumor necrosis factor soluble receptor and fluid administration are not additive in a rat sepsis model
    Ping Qiu
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 2C145, Bethesda, MD 20892, USA
    Intensive Care Med 37:1688-95. 2011
    ..However fluid support-itself beneficial-is standard clinically but rarely employed in preclinical sepsis models. We hypothesized that these therapies may not have additive benefit...
  11. doi request reprint Protein biomarkers in patients with subarachnoid hemorrhage, vasospasm, and delayed ischemic neurological deficits
    Paul A Nyquist
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Acta Neurochir Suppl 115:23-5. 2013
    ..Future studies in larger sample populations are needed to evaluate these biomarkers further as representative of biosystems involved in vasospasm and DIND or as potential biomarkers predictive of risk associated with disease...
  12. pmc Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease
    Susan Yuditskaya
    Pulmonary and Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1476, USA
    Blood 113:1122-8. 2009
    ..These results imply a relationship of apolipoproteins to the development of PAH vasculopathy in SCD, potentially involving an unexpected mechanistic parallel to atherosclerosis, another proliferative vasculopathy...
  13. pmc The proteome of sickle cell disease: insights from exploratory proteomic profiling
    Susan Yuditskaya
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Expert Rev Proteomics 7:833-48. 2010
    ..Exploratory proteomic profiling is a valuable source of hypothesis generation for the cellular and molecular pathophysiology of sickle cell disease...
  14. pmc Dexamethasone enhances ATP-induced inflammatory responses in endothelial cells
    Yi Ding
    Critical Care Medicine Department, Clinical Center and Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institutes of Health, Bethesda, Maryland 20892 1662, USA
    J Pharmacol Exp Ther 335:693-702. 2010
    ..These data define a novel positive feedback loop of glucocorticoids and ATP-induced endothelial inflammation...
  15. ncbi request reprint Proteomic analysis of inflammatory biomarkers in bronchoalveolar lavage
    Carlos de Torre
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Proteomics 6:3949-57. 2006
    ..This pattern was also found in ARDS BAL after immunoblot analysis. These approaches will be useful to improve current methods of monitoring lung inflammation and to identify new therapeutic targets...
  16. pmc Rapid induction of autoantibodies during ARDS and septic shock
    Peter D Burbelo
    Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Transl Med 8:97. 2010
    ....
  17. ncbi request reprint Randomization in clinical trials of titrated therapies: unintended consequences of using fixed treatment protocols
    Katherine J Deans
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Crit Care Med 35:1509-16. 2007
    ..The practice misalignments created by such designs may have unintended effects on trial results and safety...
  18. pmc A systematic review and pooled analysis of CPR-associated cardiovascular and thoracic injuries
    Andrew C Miller
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States Electronic address
    Resuscitation 85:724-31. 2014
    ..We then describe a systematic review with pooled data analysis of CPR-associated cardiovascular, pulmonary, pleural, and thoracic wall injuries...
  19. pmc Inhaled anticoagulation regimens for the treatment of smoke inhalation-associated acute lung injury: a systematic review
    Andrew C Miller
    1Department of Critical Care Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 2Department of Internal Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pittsburgh Medical Center, Pittsburgh, PA 3Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, James A Haley Veteran s Hospital and University of South Florida, Tampa, FL
    Crit Care Med 42:413-9. 2014
    ....
  20. pmc Impaired HCV clearance in HIV/HCV coinfected subjects treated with PegIFN and RBV due to interference of IFN signaling by IFNαR2a
    Yu Jin Lee
    1 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
    J Interferon Cytokine Res 34:28-34. 2014
    ..In this regard, the transgenic mice model simulated nonresponders to IFNα therapy and provides valuable insights into the role of sIFNαR2a-IFNα interactions in vivo. ..
  21. ncbi request reprint Influence of IFN-gamma on gene expression in normal human bronchial epithelial cells: modulation of IFN-gamma effects by dexamethasone
    Rafal Pawliczak
    Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892, USA
    Physiol Genomics 23:28-45. 2005
    ..Dex had little effect on the immediate early response to IFN-gamma but a significant effect on the late responses...
  22. ncbi request reprint Proteomics
    Gerard T Hoehn
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 33:S444-8. 2005